Annals of Neurosciences最新文献

{"title":"Neurofilaments: A Promising Diagnostic and Prognostic Biomarker in Multiple Sclerosis.","authors":"Deepali Mathur, Shivangi Vikas Mishra, Soumyashree Rout, Ramesh Kandimalla, Francisco José López-Iranzo, Gerardo López-Rodas, Rohin Vinayak, Bonaventura Casanova, Bikash Kumar Mishra","doi":"10.1177/09727531261421804","DOIUrl":"https://doi.org/10.1177/09727531261421804","url":null,"abstract":"<p><strong>Background: </strong>Axonal damage results in permanent cognitive and physical disability during the early as well as progressive stages of multiple sclerosis (MS). However, the mechanism of axonal damage may vary during different stages of MS. The extent and severity of the disease can be estimated by various clinical tests and imaging. However, these measures lack sensitivity and accuracy for understanding subclinical disease activity. Therefore, there is a need for a promising biomarker that can reflect on clinical and subclinical disease activities and have additional diagnostic applications, such as studying MS pathology, disease severity, and rate of relapse.</p><p><strong>Summary: </strong>Neurofilaments (NFs) are released into the extracellular fluid following axonal insult, and hence, measuring them can help understand the severity of neuro-axonal damage, particularly during early stages of the disease. It can, therefore, serve as a promising biomarker in MS.</p><p><strong>Key message: </strong>This review discusses NFs' biology and its correlation with disease activity, which may have clinical applicability in the diagnosis and prognosis of MS. Furthermore, their levels in response to treatment are also discussed, which can assist in the development of therapeutic strategies.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261421804"},"PeriodicalIF":2.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Trauma on Sleep Quality: Examining the Role of Nightmares in Cognitive Impairment.","authors":"Saranya T S, Sera Mary Soloman, Sandeep Kumar Gupta, Sebnem Yucel, Recep Yucel","doi":"10.1177/09727531261436606","DOIUrl":"https://doi.org/10.1177/09727531261436606","url":null,"abstract":"<p><strong>Background: </strong>Trauma has a profound impact on both psychological and physiological functioning, with sleep disturbances-particularly nightmares-emerging as one of the most commonly reported symptoms. These sleep disruptions often co-occur with cognitive difficulties, affecting memory and attention.</p><p><strong>Purpose: </strong>The present study aimed to explore the relationship between trauma history, nightmare frequency and their effects on cognitive functions such as memory and concentration among young adults aged 18-30.</p><p><strong>Methods: </strong>A sample of 22 participants was surveyed using a structured questionnaire designed to assess trauma exposure, sleep quality, nightmare frequency and self-reported cognitive performance. Data were analysed to identify associations between trauma experiences, sleep disturbances and cognitive outcomes.</p><p><strong>Results: </strong>Individuals with a history of trauma reported more frequent nightmares and poorer sleep quality. A notable association was observed between frequent nightmares and cognitive difficulties, particularly memory lapses and problems with concentration. Participants experiencing regular nightmares also reported higher levels of daytime impairment, indicating a link between nocturnal distress and reduced cognitive efficiency.</p><p><strong>Conclusion: </strong>The findings highlight the significance of recognising nightmares not only as a symptom of trauma but also as a contributing factor to cognitive challenges. Integrating sleep-focused interventions into trauma-informed care may enhance cognitive well-being and overall functioning among affected individuals. This study adds to the growing evidence underscoring the interconnectedness of trauma, sleep and cognitive health.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261436606"},"PeriodicalIF":2.4,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Follow-up Study of Peripheral Neurological and Biochemical Involvement in Gestational and Overt Diabetes Mellitus.","authors":"Akriti Kapila Sharma, Ashwini Mahadule, Sunita Mittal, Latika Mohan, Anissa Atif Mirza, Anupama Bahadur, Gauri Mittal","doi":"10.1177/09727531261435737","DOIUrl":"https://doi.org/10.1177/09727531261435737","url":null,"abstract":"<p><strong>Background: </strong>'Hyperglycaemia in pregnancy' (HIP) is one of the most common antenatal complications, affecting about one in six pregnancies globally. HIP is sub-classified into two categories, namely 'gestational diabetes mellitus' (GDM) and 'overt diabetes mellitus' (ODM). Pregnancy is characterised by the accumulation of adipose tissue and a growing placenta, acting as endocrine organs, thus intensifying the hyperglycaemic environment and building up oxidative stress by dysregulation of metabolic pathways, instigating peripheral neuropathy.</p><p><strong>Purpose: </strong>Due to paucity in existing literature on neurological influences of GDM and ODM, this follow-up study was planned to detect subclinical peripheral neuropathy by nerve conduction studies (NCS) and its correlation with biochemical parameters among them.</p><p><strong>Methods: </strong>Thirty-nine pregnant women were divided into three groups: control, GDM and ODM. The NCS (sural and ulnar nerves) and biochemical parameters, that is, fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), serum fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), serum chromium, serum N-carboxy-methyl lysine, total cholesterol, low-density lipoprotein, triglycerides and high-density lipoprotein, were recorded during different stages of gestation, that is, 24-28 weeks (first visit), 32-38 weeks (second visit) and 6-12 weeks after parturition (third visit).</p><p><strong>Results: </strong>Nerve conduction studies reveal significant alterations in diabetic pregnant groups compared to control pregnant women, particularly in sensory latencies and amplitudes of the sural and ulnar nerves. Significant hyperglycaemia (FPG, HbA1c), hyperinsulinaemia, and elevated HOMA-IR in GDM and ODM groups confirm insulin resistance and poor glycaemic control during pregnancy and postpartum. Chromium levels were markedly lower in diabetics (<i>p</i> = .001).</p><p><strong>Conclusion: </strong>This study necessitates ongoing metabolic and neurological monitoring in GDM and ODM after childbirth. Early screening and focused interventions, including micronutrient supplementation and lifestyle modifications, may help avert progression to overt neuropathy and mitigate long-term complications.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261435737"},"PeriodicalIF":2.4,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"India-China Collaboration in Healthcare, Education and Research: Unique Opportunities and a Framework for Constructive Bilateral Engagement.","authors":"Sunil Saini","doi":"10.1177/09727531261438252","DOIUrl":"https://doi.org/10.1177/09727531261438252","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261438252"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet Addiction and Its Association with Depression, Anxiety and Quality of Life Among School-going Adolescents: A Cross-sectional Study.","authors":"Amandeep Panghal, Jitendra Jeenger, Manu Sharma, D M Mathur","doi":"10.1177/09727531261429277","DOIUrl":"https://doi.org/10.1177/09727531261429277","url":null,"abstract":"<p><strong>Background: </strong>This study aims to determine the prevalence of internet addiction and explore its relationship with depression, anxiety and quality of life among adolescents.</p><p><strong>Purpose: </strong>To determine the prevalence of Internet addiction and to study its relationship with depression, anxiety and quality of life among adolescents.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 4,057 school students, aged 12-17 years. Sociodemographic information was collected using a tailored proforma. Young's Internet Addiction Test (IAT) was employed to evaluate internet addiction, while Beck's Depression Inventory (BDI) and Beck's Anxiety Inventory (BAI) were used to assess depression and anxiety, respectively. The Short Form-36 (SF-36) questionnaire measured the quality of life.</p><p><strong>Results: </strong>Among the 4,057 adolescents surveyed, 41.2% exhibited mild internet addiction, 16.9% moderate and 1.5% severe internet addiction. The prevalence of internet addiction was significantly higher in males compared to females. A positive correlation was found between the IAT scores and the scores on BDI and BAI. Age, gender, educational level and depression emerged as significant factors associated with internet addiction.</p><p><strong>Conclusion: </strong>The findings highlight an increased prevalence of internet addiction among adolescents, which is linked to increased levels of depression, anxiety and a lower quality of life. Further multicentric studies are essential to gain a more comprehensive understanding of this disorder.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261429277"},"PeriodicalIF":2.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictors of Psychiatric Comorbidities in Adults with Epilepsy: A Cross-sectional Study from a Tertiary Care Centre.","authors":"Shalini Shanthi, R Pradeep, Mahendra Javali, Chandrashekar Enuguri, Chintalapati Ashrith, Immani Soma Mani Giridhar, Anish Mehta, Purushottam Acharya","doi":"10.1177/09727531261422035","DOIUrl":"https://doi.org/10.1177/09727531261422035","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric comorbidities are among the most disabling non-seizure manifestations of epilepsy yet remain underrecognised in routine care, particularly in low- and middle-income settings. Understanding their clinical spectrum and correlates is vital for comprehensive epilepsy management.</p><p><strong>Purpose: </strong>To determine the prevalence and spectrum of psychiatric disorders in adults with epilepsy and evaluate their associations with seizure characteristics and antiseizure medication (ASM) use.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 98 adults (aged 18-65 years) attending a tertiary epilepsy clinic between January 2024 and February 2025. Psychiatric evaluation was performed using the Patient Health Questionnaire (PHQ-SADS), PHQ-9, the Generalised Anxiety Disorder-7 (GAD-7), the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Brief Psychiatric Rating Scale (BPRS), PHQ-15 and the Columbia Suicide Severity Rating Scale (C-SSRS). Associations between psychiatric symptoms and seizure-related variables (frequency, duration, aura, injury) and the ASM profile were analysed using Pearson correlation and ANOVA.</p><p><strong>Results: </strong>Overall, 59.2% of patients exhibited at least one psychiatric disorder. Depression (38.1%) and anxiety (19.1%) were the most common, followed by somatic symptom disorder (10.2%), suicidal ideation/behaviour (8.1%), obsessive-compulsive disorder (OCD) (7.2%) and psychosis (6.1%). Higher seizure frequency and longer epilepsy duration correlated significantly with depressive and anxiety symptom severity (<i>p</i> < .05). Aura and seizure-related injuries were associated with elevated affective scores. Polytherapy and older ASMs (phenytoin, carbamazepine) increased depressive risk, whereas newer agents showed better tolerability.</p><p><strong>Conclusion: </strong>Psychiatric comorbidities are highly prevalent among adults with epilepsy, strongly influenced by seizure burden rather than demographic variables. Routine mental health screening and integrated neuropsychiatric care should be integral to epilepsy management, particularly in resource-limited settings.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261422035"},"PeriodicalIF":2.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Repurposing in Neurological Disorders: A Clinical Trial Landscape.","authors":"Yukesh R, Sushil Sharma, Madhavrao C, Gaurav Manikrao Rangari, Arup Kumar Misra, Katiboina Srinivasa Rao, Boda Srikanth Nayak, Jyothi Vennela, Sarikonda Sandhyarani","doi":"10.1177/09727531261421807","DOIUrl":"https://doi.org/10.1177/09727531261421807","url":null,"abstract":"<p><strong>Background: </strong>Neurological disorders such as Alzheimer's disease (AD) and multiple sclerosis (MS) involve progressive nerve cell loss and current treatments mainly provide symptomatic relief without stopping disease progression. Drug repurposing offers a promising approach to address this gap. Metformin, a widely used oral anti-diabetic drug, is being studied in central nervous system (CNS) disorders due to its multiple effects, including activating the adenosine monophosphate-activated protein kinase (AMPK) pathway, supporting neuroprotection and promoting remyelination.</p><p><strong>Purpose: </strong>To systematically analyse the current clinical trial landscape of metformin repurposing in CNS disorders.</p><p><strong>Methods: </strong>Data were collected exclusively from ClinicalTrials.gov. The search focused on neurological, neurodegenerative and neurodevelopmental conditions while excluding trials mainly targeting type 2 diabetes or cancer. After screening, 23 clinical studies were selected. Extracted data emphasised disease types, therapeutic goals and measurable neurobiological and functional outcomes.</p><p><strong>Results: </strong>Research on metformin in CNS disorders is active, with over two-thirds of trials being completed (<i>N</i> = 7, 30.4%) or recruiting (<i>N</i> = 9). Most studied conditions include MS (<i>N</i> = 5), schizophrenia/psychosis (<i>N</i> = 4) and fragile X syndrome (FXS) (<i>N</i> = 4), highlighting interest in neurodevelopmental and demyelinating repair. Trials use functional outcomes such as the Timed 25-Foot Walk Test (T25FWT) and the MATRICS Consensus Cognitive Battery (MCCB), along with advanced biomarkers such as diffusion tensor imaging (DTI) for white matter integrity and molecular markers such as neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP).</p><p><strong>Conclusion: </strong>This analysis shows growing interest in repurposing metformin as a potential disease-modifying therapy for CNS disorders, with a focus on neurorepair and biomarker-based assessment. Larger, well-designed randomised controlled trials are still needed to confirm efficacy in humans.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261421807"},"PeriodicalIF":2.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-compassion, Gratitude, PERMA-based Well-being and Anxiety Among College Students: Correlational Analyses.","authors":"Phalguni Soin, Mustafa Nadeem Kirmani","doi":"10.1177/09727531261424949","DOIUrl":"10.1177/09727531261424949","url":null,"abstract":"<p><strong>Background: </strong>Anxiety is highly prevalent among college students due to academic pressures and developmental transitions. Positive psychological constructs such as self-compassion, gratitude, and PERMA-based well-being may function as protective factors that promote resilience and psychological adjustment.</p><p><strong>Purpose: </strong>The present study aimed to examine the relationships between self-compassion, gratitude, PERMA-based well-being, and anxiety among college students and to determine whether these positive psychological variables significantly predict anxiety levels.</p><p><strong>Method: </strong>A quantitative correlational research design was employed. The sample comprised 89 college students aged 18-25 years from universities in the Delhi-NCR region, selected using purposive and convenience sampling. Participants completed standardised measures including the Self-compassion Scale (SCS; Neff, 2003, <i>Self Identity</i>, 2, 3, 223-250), the Gratitude Questionnaire-6 (GQ-6; McCullough et al., 2002, <i>Journal of Personality and Social Psychology</i>, 82, 1, 112-127), the PERMA Profiler (Butler & Kern, 2016, <i>International Journal of Wellbeing</i>, 6, 3, 1-48) and the Beck Anxiety Inventory (BAI; Beck et al., 1988, <i>Journal of Consulting and Clinical Psychology</i>, 56, 6, 893-897). Data were analysed using Pearson's correlation and multiple linear regression analyses.</p><p><strong>Results: </strong>Pearson's correlation analyses revealed significant negative associations between anxiety and self-compassion (<i>r</i> = -0.79, <i>p</i> < .01), gratitude (<i>r</i> = -0.78, <i>p</i> < .01), and PERMA-based well-being (<i>r</i> = -0.89, <i>p</i> < .01). In the multiple linear regression model, PERMA-based well-being emerged as the only significant independent predictor of anxiety (<i>β</i> = -0.81, <i>p</i> < .001).</p><p><strong>Conclusion: </strong>The results highlight the vital role of self-compassion, gratitude and well-being in reducing anxiety and promoting psychological resilience among young adults. Incorporating these strengths into college-based mental health programmes may enhance emotional regulation and holistic well-being in this population.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261424949"},"PeriodicalIF":2.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness, Metacognition and Neuropsychological Functioning in Indian Men with Opioid Dependence: Implications for Addiction Recovery and Rehabilitation.","authors":"Hemant Kashyap, Lalhmingmawii Khiangte, Nandan Kumar Thakur, Sunita Purty, Kalpana Randhawa, Karuna Kashyap, Khushpreet Kaur, Abhilasha Agarwal, Vinod Kumar Shanwal","doi":"10.1177/09727531261424995","DOIUrl":"10.1177/09727531261424995","url":null,"abstract":"<p><strong>Background: </strong>Neuropsychological functioning, metacognitive awareness and mindfulness are central to self-regulatory processes operating across cognitive and affective domains. Although global research on these constructs has increased, integrated evidence from non-Western contexts, particularly India, remains limited.</p><p><strong>Purpose: </strong>The purpose of this study was to assess and compare neuropsychological functioning, metacognitive awareness and mindfulness in adult Indian men diagnosed with opioid dependence (OD) and healthy male controls. The study also examined the relationships among these constructs within the OD group.</p><p><strong>Methods: </strong>A total of 200 adult men aged 25-45 years (mean age = 35 years, SD = 5) participated in the study. The sample included 100 participants diagnosed with OD according to International Classification of Diseases-11 (ICD-11) criteria and 100 healthy controls without a history of substance use disorders. Standardised instruments were used to assess neuropsychological functioning, metacognition and mindfulness. Group differences were analysed using multivariate analysis of variance (MANOVA) with Bonferroni-corrected univariate analyses. Correlation and multiple regression analyses were conducted within the OD group while controlling for demographic variables.</p><p><strong>Results: </strong>Men with OD demonstrated significantly poorer neuropsychological functioning, lower metacognitive awareness and reduced mindfulness compared to controls (all <i>p</i> < .05). Within the OD group, both mindfulness and metacognitive awareness showed positive correlations with neuropsychological functioning. After adjusting for demographic factors, metacognitive awareness exhibited a stronger association with neuropsychological functioning than mindfulness.</p><p><strong>Conclusion: </strong>The findings indicate pronounced self-regulatory deficits in individuals with OD. The results support the inclusion of metacognitive and mindfulness-based components in assessment and rehabilitation programmes, particularly within South Asian cultural contexts.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261424995"},"PeriodicalIF":2.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear of Missing Out and Executive Functions: The Role of Self-regulation as a Mediator.","authors":"Akashdeep Ghosal, Surekha Chukkali, Oindrila Mukherjee, Vardhini Krishnamurthy","doi":"10.1177/09727531261429764","DOIUrl":"10.1177/09727531261429764","url":null,"abstract":"<p><strong>Background: </strong>The fear of missing out (FoMO) is characterised by constant worry about missing out on rewarding experiences. However, the worry arising from FoMO affects both self-regulation and executive functioning.</p><p><strong>Purpose: </strong>The main purpose of the study was to explore the relationship between FoMO and executive functioning, keeping self-regulation as the mediating variable.</p><p><strong>Methods: </strong>A cross-sectional correlational design was used. The sample size was 455 university students with an age range of 18-24 years. The Fear of Missing Out Scale, Short Self-Regulation Questionnaire and Executive Skills Questionnaire were used. Regression analysis was done using Statistical Package for the Social Sciences v26, and mediation analysis results were obtained through PROCESS Macro (Model 4).</p><p><strong>Results: </strong>Regression results pointed out that FoMO explained 18% of variance in executive functioning (<i>β</i> = -0.43, <i>p</i> < .001) and 16% of variance in self-regulation (<i>β</i> = -0.39, <i>p</i> < .001). Higher FoMO was related to poorer self-regulation and executive functions. Mediation analysis revealed that self-regulation partially mediated the FoMO-executive functioning relationship, with significant indirect effects (<i>B</i> = -0.66, SE = 0.07, 95% CI [-0.83, -0.52]) and direct effects (<i>B</i> = -0.83, SE = 0.13, 95% CI [-1.10, -0.56]).</p><p><strong>Conclusion: </strong>FoMO negatively affects both self-regulation and executive functions, with self-regulation acting as a significant mediator through both direct and indirect pathways. These findings suggest the need for building self-regulatory skills to protect oneself from FoMO's negative effects.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261429764"},"PeriodicalIF":2.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}