Annals of Neurosciences最新文献

{"title":"Vaping Versus Smoking: Effects on Attention and Executive Functioning in Young Adults.","authors":"Nandini Lahoty, Srishty Yadav, Dinesh Chhabra","doi":"10.1177/09727531261491532","DOIUrl":"10.1177/09727531261491532","url":null,"abstract":"<p><strong>Background: </strong>Tobacco smoking remains a major global public health concern, with approximately 1.25 billion adults using tobacco worldwide. Electronic cigarettes (e-cigarettes or vapes) have gained popularity among an estimated 82 million users globally. Emerging evidence suggests that both cigarette smoking and vaping are associated with alterations in cognitive functioning; however, comparative evidence regarding their effects on attention and executive functioning remains limited.</p><p><strong>Purpose: </strong>The present study aimed to compare selective attention and executive functioning among cigarette smokers, e-cigarette smokers and non-smokers.</p><p><strong>Methods: </strong>A non-experimental, cross-sectional between-groups design was employed. Using purposive and snowball sampling, 90 participants were recruited and categorised into three groups: cigarette smokers (<i>M</i> _age = 21.73), e-cigarette smokers (<i>Mage</i> = 21.77) and non-smokers (<i>M</i> _age = 21.90), with 30 participants (15 males and 15 females) in each group. Selective attention was assessed using the online Stroop Test administered via PsyToolkit, while executive functioning was measured using the Behaviour Rating Inventory of Executive Function-Adult Version, including the Behavioural Regulation Index, Metacognition Index and Global Executive Composite (GEC).</p><p><strong>Results: </strong>E-cigarette smokers demonstrated comparatively stronger performance in attentional control, self-monitoring and working memory than cigarette smokers. Cigarette smokers exhibited the fastest Stroop performance and showed stronger inhibitory control and emotional regulation. Non-smokers outperformed both smoking groups on cognitive flexibility (shifting), planning and organisation, metacognitive abilities and overall executive functioning as reflected by GEC scores.</p><p><strong>Conclusion: </strong>Distinct patterns of cognitive functioning were observed across cigarette smokers, e-cigarette smokers and non-smokers. While vaping was associated with relatively better performance in selected executive domains than cigarette smoking, non-smokers consistently demonstrated superior overall executive functioning. These findings contribute to the growing evidence on the cognitive correlates of smoking behaviours and underscore the need for longitudinal research to examine their long-term neurocognitive consequences.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261491532"},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalography Changes in Emotional Recognition: A Signal Processing Approach Using Wavelet Features.","authors":"Beulah Snowin, Philo Hazeena, Lakshmi Narasimhan","doi":"10.1177/09727531261483432","DOIUrl":"10.1177/09727531261483432","url":null,"abstract":"<p><strong>Background: </strong>motion recognition using electroencephalography (EEG) has gained significant attention in the fields of affective computing and human-computer interaction due to its ability to capture real-time neural responses. EEG signal variations associated with emotional states can be analysed using wavelet-based signal processing within the arousal-valence framework.</p><p><strong>Purpose: </strong>This study aims to analyse EEG signal variations associated with emotional states using a wavelet-based signal processing approach within the arousal-valence framework.</p><p><strong>Methods: </strong>A prospective observational study was conducted on 48 healthy participants. Emotional states were induced using image, video and music stimuli categorised under the arousal-valence model. EEG signals were recorded using the standard 10-20 electrode placement system. The acquired signals were pre-processed and analysed using discrete wavelet transform (DWT) to extract time-frequency features, including energy and entropy. Statistical analysis was performed to evaluate hemispheric differences and gender-based variations.</p><p><strong>Results: </strong>Differences in EEG activity were observed between the left and right hemispheres across multiple emotional states (p < .05). Video and music stimuli produced stronger and more distinguishable EEG responses compared to image-based stimuli. Negative emotions demonstrated higher discriminative patterns than positive emotions. Gender-based variations were also observed in EEG responses.</p><p><strong>Conclusion: </strong>Wavelet-based EEG feature analysis provides meaningful and discriminative information for emotion recognition and may provide a robust feature set for future machine learning-based emotion recognition systems. Further studies incorporating classification algorithms and larger data sets are required to validate their predictive performance.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261483432"},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle Cerebral Artery Occlusion-induced Deficits in Fine Skilled Motor Movement and Its Recovery Following Combined Treatment with Sodium Valproate and CIMT.","authors":"Rini P G, Yoganarasimha Doreswamy, Laxmi T R","doi":"10.1177/09727531261491531","DOIUrl":"10.1177/09727531261491531","url":null,"abstract":"<p><strong>Background: </strong>Preclinical studies have shown that sodium valproic acid (VPA) has neuroprotective properties following ischaemic injury. However, its compatibility as an adjuvant therapy with physical rehabilitation in ischaemic stroke recovery, with underlying neurophysiological mechanisms, has not been explored yet.</p><p><strong>Purpose: </strong>The present study has investigated the advantage of combination therapy over monotherapy in ameliorating ischaemic stroke-induced deficits in skilled fine motor movements with associated changes in local and interhemispheric neural connectivity.</p><p><strong>Methods: </strong>Cerebral ischaemic stroke was induced by 60 min of middle cerebral artery occlusion in adult male Sprague-Dawley rats. VPA (300 mg/kg, subcutaneously, twice daily) was administered within 3 h after reperfusion and continued for 7 days, followed by constraint-induced movement therapy (CIMT) for another week (6 h/day). The ischaemic stroke phenotype was assessed based on neurological deficits, gait, forelimb use, rotarod stay time, reach success and infarct volume. Functional recovery, with associated changes in neural activities, was carried out by analysing the local field potential signals from the first reach success during the reach-to-grasp task on day 8 and day 15 post-stroke. Cortical oscillations were analysed at delta (0-4 Hz), theta (4-8 and 8-12 Hz) and beta (12-20 Hz) during the first reach success.</p><p><strong>Results: </strong>Combination therapy after ischaemic stroke significantly improved motor and neurological functions compared to monotherapy and vehicle controls. The neural oscillations revealed a significant increase in theta power in the injured motor cortex after combination therapy when compared to that with monotherapy and control groups. The significant increase in the cross-correlation between hemispheres in the combination therapy group over monotherapy indicating an increased synchronised functional connectivity between the injured (left) and uninjured motor (right) cortices. Interestingly, VPA as monotherapy did not significantly reduce infarct volume compared to the vehicle controls. Furthermore, the therapeutic efficacy of monotherapies with VPA and early-onset CIMT (initiated immediately post-stroke) showed limited efficacy in promoting motor and neurological recovery.</p><p><strong>Conclusion: </strong>In conclusion, the study demonstrates that VPA combined with physical rehabilitative training (CIMT) enhances functional recovery by enhancing inter-hemispheric functional connectivity and represents a promising therapeutic strategy to alleviate persistent post-stroke motor deficits.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261491531"},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Quality Among Married Indian Couples: A Narrative Review.","authors":"Akanksha Mendiratta, Pankaj Singh, Navin Kumar","doi":"10.1177/09727531261491529","DOIUrl":"10.1177/09727531261491529","url":null,"abstract":"<p><strong>Background: </strong>Indian marriages have traditionally been understood as fulfilling religious commitments, forming alliances between families and fostering companionship between spouses. However, relationship quality in such marriages is shaped by structural and cultural factors that Western models of marriage, which consider only the dyadic relationship, do not account for. This narrative review examines relationship quality among married Indian couples across three themes: caste and joint-family structure; communication and conflict; and intimacy, identity and sexual satisfaction, to understand how relationship quality is shaped beyond the couple.</p><p><strong>Summary: </strong>The review draws on attachment theory, social exchange theory and family systems theory, as well as on indigenous Indian thought and the feminist bargaining-power framework of Sen and Agarwal, alongside broader cultural and philosophical perspectives. It considers how structure and individual agency combine in the process of Indian marriage, drawing on narrative, empirical, theoretical, economic and philosophical sources, as well as Indian legal decisions. Caste and kinship structure a wife's bargaining power and household authority before dyadic interactions occur; communication and conflict are shaped by joint-family privacy rather than the dyad alone; and emotional intimacy and identity shape relationship quality, while sexual satisfaction remains comparatively unexplored in the Indian context. The review proposes two original theoretical constructs, active endurance, which extends Das's notion of endurance, and the aspiration-structure gap, to capture patterns evident in the literature but not yet formally theorised. It also notes neurobiological evidence, namely hypothalamic-pituitary-adrenal axis dysregulation in chronic marital distress and oxytocin's modulation of couple conflict, which warrants investigation in Indian samples.</p><p><strong>Key message: </strong>Therapy and policy addressing relationship quality in Indian marriages need to account for structural barriers, such as caste and household bargaining power, rather than focusing only on communication skills and attitudes, if they are to meaningfully improve relationship quality in this context.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261491529"},"PeriodicalIF":3.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclodextrin-enabled δ-Tocotrienol for Treating Stress and Memory Dysfunction: Molecular Insights, Biotechnological Applications and Biomanufacturing Implications.","authors":"Arpita Konar, Priyanshu Bhargava, Kazumi Hirano, Yoshiyuki Ishida, Daisuke Nakata, Keiji Terao, Sunil C Kaul, Renu Wadhwa","doi":"10.1177/09727531261479841","DOIUrl":"10.1177/09727531261479841","url":null,"abstract":"<p><strong>Background: </strong>Antioxidants possess substantial health benefits owing to their ability to alleviate cellular oxidative stress, reactive oxygen species generation and inflammation. Vitamins, dietary fatty acids, minerals, micronutrients and plant-derived flavonoids have attracted significant attention for their primary role in maintaining brain health by attenuating oxidative stress and neuroinflammation, the key culprits in neurodegenerative pathologies and age-related cognitive decline.</p><p><strong>Purpose: </strong>Vitamin E is a fat-soluble antioxidant with isomers categorised as tocopherols and tocotrienols. Delta-tocotrienol (δ-T3) is an isomer with an unsaturated isoprenoid side chain that confers better membrane penetration and enhanced bioactivities, including scavenging of free radicals, anti-inflammatory and cholesterol-lowering effects. However, the neurodifferentiation and neurocognitive potential of δ-T3 and its bioactive conjugate δ-T3-γCD beyond its classical antioxidant properties is not known.</p><p><strong>Methods: </strong>In the present study, using rodent-derived PC12 neuroblastoma and C6 glioblastoma cell lines, we assessed the <b>differentiation</b> potential of δ-T3 and its unique complex with γCyclodextrin (δ-T3-γCD). Further, an animal model of scopolamine (SC)-induced memory dysfunction was employed to evaluate the effect of δ-T3 and δ-T3-γCD on memory processes and key molecular markers.</p><p><strong>Results: </strong>Here, we report that brain-derived cells cultured in low, nontoxic doses of δ-T3 exhibit differentiation. In the SC-induced amnesic mouse model, δ-T3 reversed object recognition memory impairment, concomitantly increasing cortical and hippocampal neural progenitor and differentiation markers, mature neuron markers and neurotrophic factors. Of note, δ-T3-γCD (δ-T3 complexed with γCyclodextrin), containing only 20.7% δ-T3, showed a stronger effect.</p><p><strong>Conclusion: </strong>δ-T3 showed neurodifferentiation and anti-amnesic potential with improved efficacy when complexed with γCyclodextrin (δ-T3-γCD) in both cellular and mouse model systems. Cyclodextrin-enabled δ-T3 might be a useful resource for the treatment of stress- and age-related memory dysfunction.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261479841"},"PeriodicalIF":3.1,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation and Translation of the Brain Fog Scale into the Indian Psycho-Socio-Cultural Context.","authors":"Himanshi Khanna, Neeraj Panwar","doi":"10.1177/09727531261478726","DOIUrl":"https://doi.org/10.1177/09727531261478726","url":null,"abstract":"<p><strong>Background: </strong>Brain fog is a subjective experience characterised by forgetfulness, poor concentration, mental slowness, dissociation and fatigue, with individuals describing experiences such as a 'mental wall' over formerly simple tasks. During and after the 2019 pandemic, scientific enquiry into brain fog was revived, explored and studied worldwide. Specifically, a large number of studies focused on the COVID-19 population and established strong associations with long COVID. Further, this in-depth research interest has led to the emergence of brain fog as a transdiagnostic factor.</p><p><strong>Purpose: </strong>Over the past half-decade, given the said and established facts, the majority of scientific evidence has been contributed by researchers outside India. This highlights that brain fog is subjectively experienced worldwide, but its objective expression varies. Given the existing literature gap, the present article focuses on developing the psychometric properties of the Brain Fog Scale (BFS) and on adapting and translating it into Hindi.</p><p><strong>Methods: </strong>For this purpose, a set of data was collected from participants (<i>N</i> = 159) with a mean age of 32.5 years, including representation from both genders. Standardised measures, the original and translated forms of the BFS, along with quality of life (QoL), were administered.</p><p><strong>Results: </strong>Principal component analysis revealed a refined 26-item, two-component structure comprising Psychophysiological Brain Fog (PsyPhyBF) and Cognitive Brain Fog, accounting for 52.8% of the total variance. The adapted scale demonstrated excellent internal consistency, with Cronbach's alpha coefficients of 0.91 and 0.92 for the two components, respectively, and 0.95 for the overall scale. Both dimensions of brain fog demonstrated significant negative associations with QoL, with PsyPhyBF emerging as a significant predictor of poorer QoL.</p><p><strong>Conclusion: </strong>The findings support the reliability and construct validity of the adapted Hindi version of the BFS and highlight the importance of culturally sensitive assessment tools for understanding subjective cognitive experiences in diverse populations.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261478726"},"PeriodicalIF":3.1,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Transfer Learning Based Residual Networks for the Brain Tumours Detection.","authors":"Bhawana Maurya, Saroj Hiranwal, Akash Saxena","doi":"10.1177/09727531261478452","DOIUrl":"10.1177/09727531261478452","url":null,"abstract":"<p><strong>Background: </strong>Brain tumours are critical disease and require an accurate and reliable method to detect the tumours. Therefore, many researchers are opting for deep learning models to classify brain tumours precisely for large and complex data sets.</p><p><strong>Purpose: </strong>This study explores the usage and performance of deep learning models, ResNet50 and ResNet101, for identifying multi-class brain tumours from 7,023 magnetic resonance imaging (MRI) sourced from Kaggle.</p><p><strong>Methods: </strong>Two models are proposed: ResNet50 based on transfer learning and fine-tuning, which outperform the proposed transfer learning-based ResNet101.</p><p><strong>Results: </strong>Comprehensive assessments are performed on these proposed models based on performance metrics having accuracy, precision, recall and F1 score, to ascertain the model's capability to highlight class discrimination. By focusing on these whole evaluation criteria, the work demonstrates that the proposed ResNet50 architecture, with an accuracy of 99.23%, can be achieved and effectively applied to automated brain tumour diagnosis from MRI and makes reliable decision making in healthcare demanding classification tasks and from this robust model performance and exact classification capabilities.</p><p><strong>Conclusion: </strong>ResNet50 with transfer learning and fine-tuning is a better option for applications that need to make decisions quickly with less GPU because it is more efficient in terms of processing, uses less training time, with better tumour detection and classification accuracy compared to ResNet101.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261478452"},"PeriodicalIF":3.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Study the Effect of Nilotinib, a Tyrosine Kinase Inhibitor, on Learning and Memory and Its Comparison with Nitric Oxide Synthase Inhibitor in an Animal Model of Alzheimer's Disease.","authors":"Anurag Kumar, Nasreen Fatima, Pramod Kumar, Rajendra Nath, Amod Kumar Sachan, Rakesh Kumar Dixit, Rishi Pal","doi":"10.1177/09727531261470562","DOIUrl":"10.1177/09727531261470562","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a gradual neurodegenerative disorder presenting with cognitive and non-cognitive impairment. Currently approved therapies alleviate symptoms but do not modify disease progression and may be associated with adverse effects.</p><p><strong>Objective: </strong>This study aimed to compare the effect of nilotinib (a tyrosine kinase inhibitor) and <i>N</i> ^ω-nitro-l-arginine methyl ester (L-NAME, a nitric oxide synthase inhibitor) as agents that improve learning and memory processes in a scopolamine-induced rat model of AD with memantine.</p><p><strong>Methods: </strong>Thirty adult male Wistar rats were randomly assigned to five groups (<i>n</i> = 6 in each group). Scopolamine hydrobromide 3 mg/kg i.p. once daily for 7 days was used to induce AD-like cognitive deficits. Behavioural testing (elevated plus maze [EPM] and Morris water maze [MWM]) was performed on days 8 and 9. From day 10, rats were treated with nilotinib (10 mg/kg p.o.), L-NAME (10 mg/kg i.p.), memantine (10 mg/kg p.o.) or saline for 21 days. Behavioural testing was repeated on days 29 and 30. Then, animals were sacrificed, and brain homogenates were prepared for estimation of acetylcholinesterase (AChE), amyloid-beta 1-42 (Aβ1-42) and PARK-7 levels.</p><p><strong>Results: </strong>Scopolamine increased transfer latency in the EPM and escape latency in the MWM and increased AChE and Aβ1-42 levels, but it decreased PARK-7. Both nilotinib and L-NAME significantly reduced transfer latency and escape latency compared to scopolamine (all <i>p</i> < .001). Both treatments reduced AChE and Aβ1-42 levels and increased PARK-7. Nilotinib produced significantly greater improvements than L-NAME (<i>p</i> < .01) with effects comparable to memantine.</p><p><strong>Conclusion: </strong>Nilotinib and L-NAME improved cognitive function and modulated cholinergic, amyloid and autophagy-related markers in a rat model of AD. Nilotinib demonstrated superior efficacy to L-NAME and may represent a potential therapeutic strategy for AD. Further studies are warranted to evaluate long-term effects and clinical applicability.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261470562"},"PeriodicalIF":3.1,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience with Tenecteplase in Treatment of Acute Ischaemic Stroke in Window: Analysis and Outcomes at a Tertiary Care Institute in Central India.","authors":"Priyanka V Kashyap, Vaibhav O P Pandey","doi":"10.1177/09727531261479824","DOIUrl":"https://doi.org/10.1177/09727531261479824","url":null,"abstract":"<p><strong>Background: </strong>Intravenous thrombolysis with alteplase has been the standard for acute ischaemic stroke (AIS) within 4.5 h, but tenecteplase (TNK) is gaining promising corner in intravenous thrombolysis with some unique features and superior efficacy in large vessel occlusion (LVO).</p><p><strong>Purpose: </strong>This study evaluates real-world TNK outcomes at a Central Indian tertiary centre.</p><p><strong>Methods: </strong>This ambispective single-centre study included 36 AIS patients presenting within <4.5 h of onset, meeting inclusion criteria (age >18 years, National Institutes of Health Stroke Scale (NIHSS)-assessed, blood pressure <185/110 mmHg, no contraindications). Weight-based TNK (0.25 mg/kg bolus) was administered. NIHSS was noted at admission, 48 h, 7 days and discharge; modified Rankin Scale at discharge and at 90 days was also recorded. Demographics, comorbidities, vessel angiography status and complications were analysed using descriptive statistics and <i>t</i>-tests (<i>p</i> < .05 significant).</p><p><strong>Results: </strong>The mean age was 57.67 ± 14.32 years, and 75% of patients were males. Hypertension (61.1%) and smoking (30.6%) were the predominant comorbidities. Mild stroke (NIHSS 1-5) occurred in 58.33% of cases, and LVOs were present in 27.78% (bilateral internal carotid artery (ICA) in 13.89%, middle cerebral artery M1/M2 in 13.89%). Patients with bilateral ICA occlusions experienced a mean NIHSS reduction of 6 points, compared to 3.5 points in others (<i>p</i> = .0188). Successful thrombolysis with TNK was achieved in 77.78% of cases. Complications included haemorrhagic transformation in 8.33% and mortality in 8.33% (unrelated to TNK). Age and comorbidities did not predict outcomes (<i>p</i> > .05).</p><p><strong>Conclusion: </strong>TNK use had robust success in lowering NIHSS scores, particularly in LVOs, with excellent safety, being a single bolus, more cost-effective, no time wastage for infusion preparation supporting its preference over standard alteplase. TNK may be a better choice in resource-limited set-up. Multicentre trials are needed for its widespread adoption and also for its conjunctive use with mechanical thrombectomy.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261479824"},"PeriodicalIF":3.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The Cognitive Cost of AI: How AI Anxiety and Attitudes Influence Decision Fatigue in Daily Technology Use\".","authors":"","doi":"10.1177/09727531261489932","DOIUrl":"https://doi.org/10.1177/09727531261489932","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/09727531251359872.].</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261489932"},"PeriodicalIF":3.1,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}