Annals of Neurosciences最新文献

{"title":"Exploring Psychopathology with Brain Fingerprinting Technique.","authors":"Anand Pratap Singh, Aakriti Varshney","doi":"10.1177/09727531261478463","DOIUrl":"10.1177/09727531261478463","url":null,"abstract":"<p><p>In the exploration of psychopathology, the most discussed anecdote which always remained contradictory was the notion of 'functional vs biological' perspective of psychopathology. With the same anecdote, the present study attempted to reflect the clarity on the issue by taking a paradigmatic move in exploring the psychopathology with the help of Brain Fingerprinting Technique (BFT). BFT computes a mathematical and statistical algorithm for determination of information through presentation of stimuli. This presentation of stimuli leads to generation of P300-MERMER brainwave to determine the information. The same argument of real vs virtual experiential contexts pertaining to certain psychiatric conditions was applied in the present study. With the help of data analysis, it was proven that no biological evidence of fingerprinting with respect to delusional beliefs, perception of auditory stimuli in hallucinatory behaviour and real loss of information in case of dissociative amnesia was observed in the brain. Rather, in first two conditions the mathematical and statistical algorithm computed 'information absent' and in third condition it computed as 'information present' respectively. The above observations helped in substantiating the diagnoses of the patients with scientific sanctity and physiological correlates. The present study could be able to expand the horizon of applications of BFT in few of the psychiatric conditions such as delusional disorders, hallucinatory behaviours, and dissociative amnesia.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261478463"},"PeriodicalIF":3.1,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIS Versus End-tidal Anaesthetic Gas Concentration-guided General Anaesthesia for Prevention of Intraoperative Awareness in Elective Surgery: A Randomised Controlled Trial.","authors":"Shiv Lal Soni, Goverdhan Dutt Puri, Kiran Jangra, Amitabh Dutta, Nitin Sethi, Shayam Charan Meena, Suman Arora, Kamal Kajal, Akhilesh Sharma, Narender Kaloria, Ajay Singh, Venkata Ganesh","doi":"10.1177/09727531261477576","DOIUrl":"10.1177/09727531261477576","url":null,"abstract":"<p><strong>Background: </strong>Awareness during general anaesthesia (GA) is a rare but serious complication, affecting 0.15%-0.2% of patients, with potential psychological consequences such as post-traumatic stress disorder (PTSD). Bispectral index (BIS) monitoring, which uses electroencephalography (EEG)-derived metrics to assess anaesthesia depth, has shown promise in reducing intraoperative awareness, though its universal adoption remains limited due to mixed evidence.</p><p><strong>Purpose: </strong>This study aimed to compare BIS-guided and end-tidal anaesthetic gas concentration (ETAG)-guided techniques in a randomised controlled trial conducted in India, addressing gaps in existing literature, particularly among Asian populations.</p><p><strong>Methods: </strong>A total of 674 patients, aged 18-65 years, undergoing elective surgeries were randomised into two groups: BIS (<i>n</i> = 341) and ETAG (<i>n</i> = 333). The assessment of intraoperative awareness in both study groups was conducted using two distinct methods. Two independent interviewers, both blinded to the study conditions, carried out these assessments. The first method involved the modified Brice interview, while the second employed the Michigan Awareness Classification Instrument.</p><p><strong>Results: </strong>Awareness incidence was 0.58% in the BIS group and 0.90% in the ETAG group (<i>p</i> = .63), with no statistically significant differences. Secondary outcomes, including time to eye opening, extubation, hospital stay duration and incidence of postoperative nausea and vomiting (PONV), were also comparable. Both methods provided equivalent anaesthetic depth and haemodynamic stability.</p><p><strong>Conclusion: </strong>This randomised trial found that neither BIS nor minimum alveolar concentration (MAC) demonstrated superiority in terms of intraoperative awareness. Future research should focus on high-risk populations, explore stringent BIS targets (e.g., BIS <50) and explore the cost-effectiveness of these monitoring techniques in various clinical settings.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261477576"},"PeriodicalIF":3.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Short-term Rehabilitation on Chronic Stress-induced Brain Alterations and Associated Cognitive Deficits.","authors":"Shilpa Borehalli Mayegowda, B S Shankaranarayana Rao","doi":"10.1177/09727531261478790","DOIUrl":"10.1177/09727531261478790","url":null,"abstract":"<p><strong>Background: </strong>Persistent stress is frequently comorbid with major depressive disorder and anxiety, leading to significant psychological and behavioural impairments. However, the neurophysiological mechanisms underlying stress reversal remain poorly understood. Although several reversal strategies, including pharmacological antidepressants, brain stimulation therapies and nutritional interventions, have been explored, their outcomes remain inconsistent.</p><p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness of rehabilitation as a non-pharmacological intervention for reversing stress-induced behavioural and neurobiological alterations.</p><p><strong>Methods: </strong>Chronic stress was induced in rats, followed by short-term rehabilitation through standard housing conditions without additional physical or behavioural enrichment. Behavioural assessments, including learning and memory tests, the open field test (OFT) and the elevated plus maze (EPM), were conducted to evaluate cognitive, exploratory and anxiety-like behaviours. Morphological changes in specific brain regions were examined and correlated with molecular markers, including neurotrophic factors and astrocytic markers.</p><p><strong>Results: </strong>Short-term sedentary rehabilitation failed to reverse stress-induced behavioural abnormalities and brain region alterations. Chronically stressed rats exhibited significant learning and memory deficits, reduced exploratory behaviour in the OFT, and altered anxiety-like behaviour in the EPM. These behavioural impairments were accompanied by morphological changes and dysregulation of neurotrophic and astrocytic markers, indicating insufficient neuroplastic recovery under sedentary rehabilitation conditions.</p><p><strong>Conclusion: </strong>The findings highlight the limited efficacy of short-term, non-enriched rehabilitation in reversing chronic stress-induced neurobehavioural alterations. The study underscores the importance of lifestyle-based therapeutic approaches, including behavioural, physical and relaxation therapies, for effective stress reversal. Interventions such as social support, exercise, enriched environments, and task-based learning-analogous to cognitive behavioural therapy-may offer greater neuroprotective and restorative benefits. These findings provide translational relevance for developing social rehabilitation strategies in clinical conditions associated with overwhelming stress and stress-related cognitive deficits.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261478790"},"PeriodicalIF":3.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Before Dengue Is Implicated as the Cause of Polyradiculitis, the Infection Must Be Confirmed by Nucleic Acid Amplification Testing or Cell Cultures.","authors":"Josef Finsterer","doi":"10.1177/09727531261483449","DOIUrl":"10.1177/09727531261483449","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261483449"},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Cognitive Behavioural Therapy in Reducing Depression and Anxiety Among University Students: An Experimental Study.","authors":"Bhawna Gurnani, Shubhagata Awasthi","doi":"10.1177/09727531261472209","DOIUrl":"10.1177/09727531261472209","url":null,"abstract":"<p><strong>Background: </strong>Depression and anxiety are among the most prevalent mental health problems affecting university students and are associated with impaired academic performance, emotional distress and reduced quality of life. Cognitive behavioural therapy (CBT) is an evidence-based intervention that has demonstrated effectiveness in reducing symptoms of depression and anxiety; however, intervention-based studies among Indian university students remain limited.</p><p><strong>Purpose: </strong>The present study aimed to evaluate the effectiveness of CBT in reducing symptoms of depression and anxiety among university students from medical, paramedical and non-medical academic streams.</p><p><strong>Methods: </strong>A total of 600 university students were screened using the Depression Anxiety Stress Scale-21 (DASS-21). Of these, 180 students meeting the inclusion criteria and exhibiting mild to moderate symptoms of depression and/or anxiety were selected for the study. Participants were randomly assigned to a CBT intervention group (<i>n</i> = 90) or a control group (<i>n</i> = 90). The intervention group received an eight-session structured CBT programme, while the control group continued routine academic activities. Depression and anxiety levels were assessed before and after the intervention using the DASS-21. Data were analysed using repeated measures analysis of variance (RM-ANOVA).</p><p><strong>Results: </strong>The CBT group demonstrated significant reductions in both depression and anxiety scores from pre-test to post-test, whereas the control group showed minimal change. RM-ANOVA revealed significant main effects of time and significant time × group interaction effects for both depression and anxiety (<i>p</i> < .001), indicating that improvements were significantly greater among participants who received CBT.</p><p><strong>Conclusion: </strong>The findings provide empirical evidence supporting the effectiveness of CBT in reducing depression and anxiety among university students. The results highlight the potential value of integrating structured CBT-based mental health interventions within higher education institutions to promote psychological well-being and academic functioning.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261472209"},"PeriodicalIF":3.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baroreflex-dependent Cardiovascular Autonomic Reactivity is Deranged in Young Adult Mild COVID-19 Survivors.","authors":"Ayan Roy, Dinu S Chandran, Ashok Jaryal, Manish Soneja, Ambuj Roy, Kishore Kumar Deepak","doi":"10.1177/09727531261477282","DOIUrl":"10.1177/09727531261477282","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 has subacute as well as long-term effects defined as long COVID on multiple organ systems. Emerging literature suggests long-term effects of COVID-19 on the autonomic nervous system in survivors, the mechanistic basis of which is currently not delineated.</p><p><strong>Purpose: </strong>The study aimed to assess the cardiovascular autonomic functions in mild COVID-19 survivors and compare them with age- and sex-matched healthy controls.</p><p><strong>Methods: </strong>We recruited 34 young adult mild COVID-19 survivors. Autonomic function was assessed by cardiovascular autonomic reactivity tests at least 1 month after clinical recovery from acute COVID-19 infection. The responses were compared with those of 34 age- and sex-matched pre-COVID era healthy controls.</p><p><strong>Results: </strong>Mild COVID-19 survivors had significantly lower Valsalva ratio (1.578 ± 0.2747 vs 1.773 ± 0.3459; <i>p</i> = .0156) and displayed a greater fall in systolic blood pressure during head-up tilt test (-9.206 ± 7.121 vs 1.147 ± 8.457; <i>p</i> < .0001) in comparison to the healthy controls. Haemodynamic cardiovascular autonomic abnormalities were seen in 47% of COVID-19 survivors. Haemodynamic criteria of orthostatic hypotension were met in 12% of COVID-19 survivors, and postural orthostatic tachycardia syndrome haemodynamic criteria were met in 35% of COVID-19 survivors. Autonomic reflex responses to deep breathing, handgrip test and cold pressor test were found to be comparable between the two groups.</p><p><strong>Conclusion: </strong>Young adult mild COVID-19 survivors show lower cardiovagal and cardiovascular adrenergic responses to baroreflex-dependent autonomic reactivity as medium- to long-term autonomic sequelae. They have an intact non-baroreflex-dependent autonomic reactivity.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261477282"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Gut to Mind: Impact of Probiotics on Depression, Anxiety, Mood, Gut Microbiota, Sleep and Stress-A Systematic Review of RCTs.","authors":"Monalisa Das, Nooruddin Thajuddin, Gangatharan Muralitharan, Megha Pundeer, Ramesh Ponnusamy, Ankita Mishra, Priyanka Nayak","doi":"10.1177/09727531261478458","DOIUrl":"10.1177/09727531261478458","url":null,"abstract":"<p><strong>Background: </strong>Probiotic supplementation may influence mental health through the gut-brain axis, with potential effects on depression, anxiety, sleep, cognition, stress hormones, and gut microbial composition. This systematic review aimed to evaluate the effects of probiotics on psychological, physiological, and gut microbiome-related outcomes across diverse populations.</p><p><strong>Summary: </strong>A comprehensive search of PubMed, MEDLINE, PsycINFO, and ScienceDirect identified randomized controlled trials evaluating probiotic supplementation. Twenty RCTs were included, of which 15 were assessed as having a low risk of bias and five as having a high risk of bias. Commonly assessed outcomes included depression (<i>n</i> = 17), anxiety (<i>n</i> = 10), sleep quality (<i>n</i> = 9), stress (<i>n</i> = 6), cortisol (<i>n</i> = 7), cognitive function (<i>n</i> = 5), quality of life (<i>n</i> = 5), gut microbial composition (<i>n</i> = 11), and other neuroendocrine and inflammatory markers. Overall, probiotics were associated with improvements in depression, anxiety, sleep quality, mood, cognition, quality of life, and beneficial gut microbial populations, although findings for cortisol and stress-related outcomes were inconsistent.</p><p><strong>Key message: </strong>Probiotic supplementation may provide beneficial effects on psychological well-being and gut microbial composition. However, heterogeneity among interventions, populations, outcome measures, and study quality warrants further well-designed RCTs.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261478458"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experts' Perspectives on Psychosocial Needs of Couples Following Traumatic Brain Injury: A Qualitative Study from a Tertiary Care Centre.","authors":"Karthik Shetty, Thiruchengodu Raju Kanmani, Subhas Kanti Konar, Srikanth Pallerla","doi":"10.1177/09727531261477567","DOIUrl":"10.1177/09727531261477567","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) has an immense impact on families, particularly spouses, who face significant challenges such as changes in roles and responsibilities, relational dynamics and financial instability. The study aims to explore the psychosocial needs and concerns of couples coping with TBI from experts across various fields.</p><p><strong>Purpose: </strong>The study purpose was to explore the psychosocial needs and concerns of couples coping with TBI from experts across various fields.</p><p><strong>Methods: </strong>The current study adopted an exploratory qualitative approach, involving in-depth, face-to-face interviews with experts. Nine experts from six professional backgrounds were selected based on predefined inclusion and exclusion criteria. Eligibility criteria included a minimum of 5 years of expertise in TBI-related fields, proficiency in English and willingness to provide informed consent. The interviews were audio-recorded with the participants' consent.</p><p><strong>Results: </strong>Experts included neuropsychologists, psychiatric social workers, neurosurgeons, neuro-rehabilitation experts, physiotherapists and clinical nurses. A total of five themes have been identified, namely education needs, emotional needs, family needs, financial needs and support needs.</p><p><strong>Conclusion: </strong>The study on the psychosocial needs of couples from experts' perspectives in India is unique in nature. The results of this study will support the development and implementation of tailored psychosocial interventions specifically designed for couples in India. Various stakeholders engaged in the management of TBIs emphasised the critical importance of addressing the needs of these couples and ensuring the timely provision of personalised psychosocial support.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261477567"},"PeriodicalIF":3.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heartfulness Meditation-induced State and Trait Effects on Long-term, Short-term and Non-meditators Using Connectivity Analysis: An EEG Study on Prefrontal Cortex.","authors":"Anurag Shrivastava, Bikesh Kumar Singh, Deepeshwar Singh","doi":"10.1177/09727531261470953","DOIUrl":"10.1177/09727531261470953","url":null,"abstract":"<p><strong>Background: </strong>Heartfulness meditation (HM) is a heart-based meditation practice that features a unique yogic transmission that involves transfer of subtle energy from a certified, experienced meditator to an aspirant.</p><p><strong>Purpose: </strong>This study was conducted on HM practice to assess the state (momentary changes during meditation result in temporary physiological and neurological shifts) and trait (long-term personality changes developed with experience) effects on the brain using electroencephalogram (EEG) signal analysis.</p><p><strong>Methods: </strong>Thirty-four participants were recruited into three groups (long-term meditators [LTM], short-term meditators [STM] and non-meditators). EEG signals from the prefrontal cortex were recorded across four states: baseline, meditation, transmission and post-transmission. Functional connectivity and graph theory measures were calculated for each frequency band (delta, theta, alpha and beta). Within-group and between-group analyses were performed to quantify HM-induced state and trait effects. Significance level was tested through statistical analysis.</p><p><strong>Results: </strong>The results show improved coordination among brain networks, increased global and local efficiency, representing a positive state effect. While performing between-group analysis, significant trait changes were observed in the LTM group over frequency bands (delta, theta and alpha) of the EEG signal. These findings suggest that the altered EEG resulting from meditation reflects neurophysiological changes and functional integration of the brain network.</p><p><strong>Conclusion: </strong>The positive state and trait effects were observed for HM practice in the prefrontal cortex of the brain. Furthermore, the enhanced connectivity in EEG frequency bands may lead to significant neuroplastic changes. This finding provides insights into employing functional connectivity parameters as measures for quantifying meditation quality.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261470953"},"PeriodicalIF":3.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dual Regulatory Model Linking Alexithymia to Internet Addiction: Affective and Cognitive Pathways.","authors":"Gauri Nagyal, Smita Pandey","doi":"10.1177/09727531261476854","DOIUrl":"10.1177/09727531261476854","url":null,"abstract":"<p><strong>Background: </strong>Internet addiction is increasingly conceptualised as a disturbance in affective and cognitive self-regulation rather than excessive use. Alexithymia, characterised by impaired emotional awareness, may heighten vulnerability by reducing the ability to identify and regulate emotions, thereby increasing the chances of indulging in maladaptive coping behaviours such as internet addiction.</p><p><strong>Purpose: </strong>The study aimed to examine the mechanism underlying alexithymia and internet addiction by investigating the mediating roles of psychological distress (affective dysregulation) and mindfulness (cognitive-regulatory capacity) in college students.</p><p><strong>Methods: </strong>A cross-sectional, quantitative research study was carried out among college students (<i>n</i> = 316) recruited from universities in the Gandhinagar district, Gujarat. Ethical clearance was obtained from the Institutional Ethics Committee for the study. Convenience sampling was employed to select the participants. College students between 18 and 25 years of age were included in the study. Data were collected using the Internet Addiction Test (IAT), Toronto Alexithymia Scale (TAS-20), General Health Questionnaire (GHQ-12) and Mindfulness Attention Awareness Scale (MAAS). SPSS, Version 22, and Hayes' PROCESS macro (Model 4) were used to carry out descriptive statistics, correlation and mediation analyses.</p><p><strong>Results: </strong>Alexithymia was positively associated with internet addiction (<i>r</i> = 0.35, <i>p</i> < .05), and negatively associated with mindfulness (<i>r</i> = -0.63, <i>p</i> < .01). Psychological distress was positively associated with internet addiction (<i>r</i> = 0.64, <i>p</i> < .05). The indirect effects of alexithymia on internet addiction were significant via psychological distress (<i>B</i> = 0.130, 95% CI [0.059, 0.204]) and mindfulness (<i>B</i> = 0.108, 95% CI [0.027, 0.186]). The mediation model accounted for 50% of the variance in internet addiction. The direct effect remained significant, indicating partial mediation.</p><p><strong>Conclusion: </strong>The findings supported parallel dual-regulatory pathways in which alexithymia was linked to internet addiction, with psychological distress and mindfulness serving as significant statistical pathways. These results indicated the relevance of integrated self-regulation frameworks in understanding behavioural addictions.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261476854"},"PeriodicalIF":3.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}