Annals of Neurosciences最新文献

{"title":"A Prospective Study on Clinical Profile and the Utility of 72-h Holter Monitoring in Acute Ischaemic Stroke and Transient Ischaemic Attack (TIA) Patients.","authors":"P Sri Harshitha, Nikith Ampar, Mukund A Prabhu, Arvind N Prabhu, Sharath P S","doi":"10.1177/09727531261430099","DOIUrl":"10.1177/09727531261430099","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is a major cause of recurrent ischaemic stroke, yet detection after acute events is often suboptimal, particularly in resource-limited settings.</p><p><strong>Purpose: </strong>This study aims to assess the clinical profile and the utility of 72-h Holter monitoring in determining AF and other cardiac arrhythmias in acute ischaemic stroke and transient ischaemic attack (TIA) patients.</p><p><strong>Methods: </strong>In this prospective observational study, 200 consecutive patients with acute ischaemic stroke/TIA underwent detailed clinical evaluation, laboratory profiling, neuroimaging, echocardiography and continuous electrocardiogram (ECG) monitoring (72-h Holter). Stroke subtyping followed trial of ORG 10172 in acute stroke treatment (TOAST) criteria. Predictors of newly detected AF were identified via univariate and multivariate logistic regression. Ethical approval was obtained, and informed consent was secured.</p><p><strong>Results: </strong>Among 200 patients with acute ischaemic stroke or TIA (mean age 63.9 ± 12.4 years; 69% male), 72-h Holter monitoring detected AF/flutter in 20.5%, with 70.7% of these showing clinically significant episodes (≥30 s). Other arrhythmias included supraventricular tachycardia (SVT) (12.5%), ventricular ectopics (16.0%) and atrioventricular (AV) block (4.5%). Holter findings led to treatment modification in 20%, primarily the initiation of anticoagulation. Compared with non-AF patients, those with AF were older (≥60 years: 90.2%, <i>p</i> = .002), had higher rates of diabetes (68.3%), hypertension (85.4%), chronic kidney disease (CKD) (43.9%) and left atrial enlargement (LAE) (29.2% vs 1.9%, <i>p</i> = .01). AF patients presented with higher median National Institutes of Health Stroke Scale (NIHSS) [8 vs 6, <i>p</i> = .04] and more severe infarcts, with posterior (48.8% vs 27.0%) and multi-territory (19.5% vs 5.3%) involvement. Independent predictors of AF included CKD (aOR 4.91), left atrium (LA) enlargement (aOR 5.18), multi-territory infarcts (aOR 12.35), posterior circulation infarcts (aOR 3.74) and tachycardia >100 bpm at admission (aOR 4.78).</p><p><strong>Conclusion: </strong>72-hour Holter monitoring demonstrated high clinical utility in detecting AF and other clinically significant arrhythmias in acute ischaemic stroke and TIA patients, with direct therapeutic impact through timely initiation of anticoagulation. Importantly, the identification of SVT in 12.5% of patients, particularly those with a higher arrhythmic burden, highlights a potential preclinical substrate of atrial cardiopathy that may precede overt AF. These findings support the incorporation of extended Holter monitoring into post-stroke evaluation, especially for high-risk groups, both to optimise etiological classification and to enable personalised secondary prevention strategies that reduce the risk of recurrent cerebrovascular events.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261430099"},"PeriodicalIF":2.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium Exposure May Induce Potential Brain Tumour Initiation by Regulating SHH, GLI1, BMI1 and P53 in the SHH-GLI1 Cell Signalling Pathway.","authors":"Swalih P Ahmed, Intezar Ali, Mehdi H Shahi","doi":"10.1177/09727531261421799","DOIUrl":"10.1177/09727531261421799","url":null,"abstract":"<p><strong>Background: </strong>Cadmium, a toxic heavy metal, poses a significant risk to human health. Its potential to contribute to brain tumorigenesis is a growing concern. Brain tumours are notoriously difficult to treat due to their aggressive nature, poor prognosis and resistance to conventional therapies.</p><p><strong>Purpose: </strong>To investigate the impact of cadmium exposure on brain tumour development, focusing on its influence on the Sonic Hedgehog (SHH)-glioma-associated oncogene 1 (GLI1) signalling pathway and the stem cell marker B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1).</p><p><strong>Methods: </strong>A total of 25 Wistar rats of 200-250 g body weight range were classified into five groups: Test groups one and two were orally administered with cadmium chloride in drinking water (30 mg/L, 60 mg/L). Positive controls one and two were administered orally with zinc in drinking water (30 mg/L and 60 mg/L) and the negative control group rats received double-distilled water continuously for 28 days. We calculated the rat's water intake each week. From the third to the fourth week, we observed behavioural changes using an open field test (OFT). The animals were sacrificed on day 29. Thereafter, the brain and hindbrain were separated for further assessment, including real-time reverse transcription polymerase chain reaction (RT-PCR) to measure gene expression levels of key genes in the SHH-GLI1 signalling pathway and stem cell markers.</p><p><strong>Results: </strong>Water intake decreased in both the test and the positive control groups. The OFT analysis revealed significant behavioural changes in all parameters of both the test and positive control groups compared to the negative control group, including movement patterns, speed, travel distance, activity levels and freezing behaviour. Gene expression indicates increased SHH, GLI1, BMI1 and tumour protein 53 (TP53) expression in both the test and positive control groups.</p><p><strong>Conclusion: </strong>Cadmium exposure may initiate and promote brain tumour development by regulating SHH, GLI1, BMI1 and TP53. This may disrupt the normal regulatory mechanisms of the SHH-GLI1 pathway.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261421799"},"PeriodicalIF":2.4,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Bioenergetic Therapy Model with Neuropsychopharmacological Interventions in Long-standing Treatment-resistant Schizophrenia: Case Series and Review of Literature.","authors":"Praveen Khairkar, Divya Chadha, Ashwini Kamble, Archish Khivsara, Rohan Modi, Rajesh Khairkar","doi":"10.1177/09727531251409878","DOIUrl":"10.1177/09727531251409878","url":null,"abstract":"<p><strong>Background: </strong>The bioenergetic therapy model combines holistic somatic therapy with psychotherapy, addressing both physical and emotional aspects of healing. In cases of long-standing treatment-resistant schizophrenia (TRS), which may persist for over two decades, finding effective therapeutic strategies remain a significant challenge. Despite numerous treatment options, no existing reports integrate somatosensory therapy with neuropsychopharmacological interventions for these complex cases.</p><p><strong>Purpose: </strong>To demonstrate the integration of bioenergetic therapy with neuropsychopharmacological interventions in managing long-standing treatment-resistant schizophrenic cases.</p><p><strong>Methods: </strong>Two cases of long-standing schizophrenia were illustrated for how we integrated somatosensory bioenergetics principles with neuropsychopharmacology. They had emotional and/or physical abuse in addition to psychotic symptoms without any pre-morbid schizoid/paranoid traits or psychiatric history of substance abuse, and presented to us with complaints of high sensitivity to rejection, persecutory delusions, third-person auditory hallucinations, irritability, episodic aggression, psychomotor retardation, disturbed sleep, and declining professional performance.</p><p><strong>Results: </strong>A systematic cognitive deficit evaluation, slow building of clozapine (100 mg/day), integration of somatosensory therapy, family system therapy model and cognitive enhancement therapy were integrated. This integration of somatosensory therapy with neuropsychopharmacological interventions led to a significant improvement over a four-week period. Notable recovery was observed in the experience of being touched for rebuilding maternal trust and developing a therapeutic rapport.</p><p><strong>Conclusion: </strong>Integration of multiple system bioenergetic model in chronic TRS adds another novel way to its management which is an advanced extrapolation of the Bio-Psycho-Social model of schizophrenia. Bioenergetic analysis facilitated a unique somatic psychotherapy that combined cognitive feelings, somatic, and psychomotor functions. To our knowledge, this represents the first successful application of bioenergetic analytical integration in schizophrenia with marked behavioural resistance.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531251409878"},"PeriodicalIF":2.4,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Therapeutic Strategies to Enhance ;Neuroplasticity in Parkinson's Disease: ;Implications for Slowing Disease Progression ;and Promoting Recovery.","authors":"Saranya Ts, Gayathri Raj, Kevimeno Kiso","doi":"10.1177/09727531251375180","DOIUrl":"10.1177/09727531251375180","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in motor symptoms such as tremor, rigidity and bradykinesia, along with cognitive impairments. While conventional research has largely focused on pathological degeneration, recent advances highlight the role of neuroplasticity-the brain's ability to reorganise and adapt neural circuits-as a potential mechanism for functional recovery and disease modification.</p><p><strong>Summary: </strong>This review examines therapeutic strategies that enhance neuroplasticity in chronic Parkinson's disease mouse models. Key approaches discussed include neurotrophic factor (NTF) administration, deep brain stimulation (DBS), stem cell-based therapies and physical exercise. Evidence from experimental studies suggests that NTFs support dopaminergic neuron survival and synaptic repair, DBS modulates dysfunctional neural circuits and promotes adaptive plasticity, stem cell therapies offer both neuronal replacement and neurotrophic support, and physical exercise stimulates endogenous neuroplastic processes such as neurogenesis and synaptic reorganisation. Despite promising findings, variations in experimental design, disease severity and outcome measures across studies limit direct comparison and translation of results.</p><p><strong>Key message: </strong>Neuroplasticity-based interventions represent a promising avenue for slowing disease progression and improving functional outcomes in Parkinson's disease. Integrating pharmacological, neuromodulatory and behavioural approaches may enhance therapeutic efficacy, though further research is required to standardise protocols and facilitate clinical translation.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531251375180"},"PeriodicalIF":2.4,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newfangled Combination Azilsartan and Ceftriaxone Exhibited Potential Effects in <i>In-Vitro</i> and <i>In-Vivo</i> Models of Cerebral Ischemia: A Comprehensive Pharmacological Investigation.","authors":"Gaddam Narasimha Rao, Srikanth Jupudi, Devarakonda Krishna Prasad, Jeyaram Bharathi J, Nagaprabhu Vn, Antony Justin","doi":"10.1177/09727531261417450","DOIUrl":"10.1177/09727531261417450","url":null,"abstract":"<p><strong>Background: </strong>Excitotoxicity is an early event of cerebral ischemia, which is mainly caused by neuroinflammation, oxidative stress, and dysfunction of Excitatory Amino Acid Transporter-2 (EAAT-2). Generally, tissue plasminogen activators (tPA's) and anticoagulant therapies are being used as first-line treatment options for cerebral ischemia, but they only restore the cerebral blood flow (CBF) and fail to attenuate the detrimental events associated with ischemic insult in neurons, resulting in neurodegeneration. Based on the earlier studies, we designed a novel combination for targeting neuroinflammatory and excitotoxicity cascades in cerebral ischemia.</p><p><strong>Methods: </strong>Angiotensin receptor blocker (ARB) Azilsartan (Azi) and a third-generation cephalosporin Ceftriaxone (Cef) were evaluated in in vitro oxygen glucose-deprived (OGD) primary astrocytes and N2a neuronal co-cultures model of cerebral ischemia. Further, the above combination was also investigated in the middle cerebral artery occlusion (MCAo) rat model of cerebral ischemia. Then, neuro-biochemical estimations and molecular techniques like flow cytometry, ELISA and gene expression studies were performed to elucidate the possible mechanism.</p><p><strong>Results: </strong>The novel combination ameliorated the neurodegeneration by downregulating the ROS, apoptosis, oxidative stress, and excitotoxicity cascades and also enhanced the level of antioxidant enzymes. Moreover, EAAT-2 gene expression was remarkably increased with the treatment with a novel combination of Azi and Cef than with the individual treatment. The above combination significantly reversed the behavioural dysfunction in ischemic rats, which evidences the beneficial effects.</p><p><strong>Conclusion: </strong>The repurposing of anti-hypertensive, Azi, and antibiotic Cef combination demonstrated an excellent neuroprotective potential, mediating through ameliorating neuroinflammation, excitotoxicity and oxidative stress in in vitro OGD-induced astrocyte-neuron co-culture as well as cerebral ischemic rat model.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261417450"},"PeriodicalIF":2.4,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Different Social Media Video Content Formats on Sustained Attention and Working Memory.","authors":"Gopal Chandra Mahakud, Apeksha Thapliyal","doi":"10.1177/09727531261424994","DOIUrl":"10.1177/09727531261424994","url":null,"abstract":"<p><strong>Background: </strong>Sludge content, also called 'overstimulation videos', is a novel social media content format that combines multiple, unrelated clips/videos/text posts that play simultaneously on a single, split screen. This kind of content has been shown to drive up user engagement on media sites due to its unpredictability and very short duration, which suits the cycle of 'doomscrolling', that is, persistent, aimless scrolling through media content that requires low cognitive effort and provides a variety of intermittent and fast stimulation.</p><p><strong>Purposes: </strong>The present study experimentally investigated the impact of sludge media content viewing on individuals' performance on tasks of sustained attention and working memory.</p><p><strong>Method: </strong>Participants with high media usage (<i>n</i> = 45) were randomly assigned to one of three experimental groups: those viewing (a) sludge media content, (b) regular short-video media content, and (c) no media content, while participants with low media usage (<i>n</i> = 3) were assigned to view sludge media content. All participants completed the continuous performance task for sustained attention assessment and the 2-Back task for working memory assessment before and after viewing. The performance of the groups before and after viewing the respective contents was then compared across the pre- and post-test conditions.</p><p><strong>Results: </strong>The results showed that while the three groups differed with respect to their performance on the sustained attention task following different forms of media content viewing, they did not differ with respect to the working memory task. Furthermore, sludge content viewing led to the greatest decline in scores from pre-test to post-test on the sustained attention task.</p><p><strong>Conclusion: </strong>The findings thus indicated that sludge content viewing had a significant impact on sustained attention capacity but not working memory capacity.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261424994"},"PeriodicalIF":2.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrauterine Aluminium Exposure Due to Dietary Content Alters Social Behaviours in Wistar Rat Offsprings.","authors":"Lal D V Nair, Senthilkumar Sivanesan, Devika S Kumar","doi":"10.1177/09727531261425366","DOIUrl":"https://doi.org/10.1177/09727531261425366","url":null,"abstract":"<p><strong>Background: </strong>Neurodevelopmental disorders like autism are on the rise, with the role of genetics and epigenetics being increasingly cited as reasons or contributors. The environmental factors were found to be important as epigenetic modifiers, and pregnant mothers are incrementally exposed to many of these environmental factors, like aluminium (Al), known to damage neurons, even before delivery. However, its presence and persistence inside the central nervous system (CNS), leading to changes in the expression of behaviours, need further research. Hence, this animal study was conceived.</p><p><strong>Purpose: </strong>To evaluate the impact of early dietary exposure to Al in the brains of foetuses of pregnant rats and its subsequent effects on the neurobehaviour in their pups.</p><p><strong>Methods: </strong>Pregnant Wistar rats were divided into four groups (Gr1 receiving injection tetanus toxoid; Gr2 receiving tetanus toxoid + soy; Gr3 receiving tetanus toxoid + valproic acid and Gr4 receiving tetanus toxoid + soy + valproic acid). A few pups were sacrificed, and their brain Al and α-synuclein levels were assessed. Others were allowed to grow, and their behaviour, α-synuclein and Al levels were analysed.</p><p><strong>Results: </strong>α-synuclein was low in groups 3 and 4, with group 4 pups with abnormal socialisation behaviours exhibiting the lowest levels, suggesting ongoing neuronal injury. Brain Al in pups sacrificed immediately after birth suggests prenatal Al exposure, with the highest values in group 4, though all had elevated Al levels. Gr4 had impaired socialisation. Higher sociability indices were noted in groups 1 and 2 (0.36 and 0.3) compared to groups 3 and 4 (0.09 and 0.04). Groups 1 and 2 pups demonstrated intact social memory and novelty seeking. There was also a negative correlation between brain Al and α-synuclein levels and the socialisation index.</p><p><strong>Conclusion: </strong>Environmental factors like Al once enter the CNS remain in the brain even when invisible in blood and can induce changes in the growing brain, behaviour and socialisation.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261425366"},"PeriodicalIF":2.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-participation Rate and Recruitment Barriers in Offering Yoga Intervention for Depression: A Scoping Review.","authors":"Ayisha Siddeequa Ma, Amritha S, Suvarna Jyothi Kantipudi, Maheshkumar K, Vanishree Shriraam, Padmavathi R","doi":"10.1177/09727531261417791","DOIUrl":"https://doi.org/10.1177/09727531261417791","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common mental health condition that globally affects legions of people, though interventions such as yoga have emerged as a complementary treatment for treating it. Despite its potential therapeutic benefits, recruitment and retention in yoga-based interventions still remain a challenge, resulting in limiting their use in clinical settings.</p><p><strong>Summary: </strong>This scoping review aimed to identify and categorise the barriers contributing to non-participation and recruitment challenges in implementing yoga-based interventions for depression. Major databases such as PubMed, Embase, and Scopus were used for identifying the studies reporting on recruitment challenges in yoga interventions for depression.</p><p><strong>Original studies: </strong>(a) in which yoga served as the primary intervention, that measure any health outcomes, (b) which studied adults aged ≥18 years with mild/moderate depressive condition, and (c) RCT studies published in English were included. Of the 445 studies screened, only five met the eligibility criteria. Across studies, the yoga intervention varied in type, duration, method of delivery, and several key barriers like stigma about mental health, limited awareness of therapeutic benefits of yoga, cultural perceptions, and physical limitations that hindered the rate of participation were identified.</p><p><strong>Key messages: </strong>Addressing the recruitment barriers is essential to enhance the utilisation of complementary treatments like yoga for treating depression. Strategies like culturally sensitive community outreach with a flexible mode of delivery are required, and awareness of alternate treatment approaches like yoga with its potential benefits should be created to improve the participation rate. The review provides a foundation for designing inclusive and easily accessible yoga-based mental health programmes for treating depression and related conditions.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261417791"},"PeriodicalIF":2.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating New Culture: The Role of Attachment Styles in the Adaptation of International Students in India.","authors":"Namita Srivastava, Purnima Awasthi, Madhurima Mukherjee, Ravi Pratap Pandey, S Z H Zaidi","doi":"10.1177/09727531261425823","DOIUrl":"https://doi.org/10.1177/09727531261425823","url":null,"abstract":"<p><strong>Background: </strong>International students frequently look for programmes that are not offered in their home countries in order to pursue high-quality education, cultural exposure, professional prospects and personal development while studying abroad. Understanding attachment styles enables people to better comprehend local norms and values, facilitating easier social interactions and minimising misunderstandings, even though adjusting to the host country might be difficult.</p><p><strong>Purpose: </strong>The present study aimed to explore the relationship between attachment styles and sociocultural adaptation among international students in the host country. The study's specific goal was to comprehend how different attachment styles affect international students' adjustment to new cultural customs, social norms and values.</p><p><strong>Methods: </strong>The study included 240 international students (male = 120 and female = 120) enrolled in various universities and educational institutions in Varanasi City, Uttar Pradesh, through purposive sampling. Participants were selected between the ages of 19 and 35 years. The Attachment Style Questionnaire (ASQ) and Revised Sociocultural Adaptation Scale (SCAS-R) were used in data collection.</p><p><strong>Results: </strong>The findings show that secure attachment style increased sociocultural adaptation, whereas insecure attachment styles decreased it among international students in the host country. A secure attachment style offers consolation, confidence and strong social bonds, all of which significantly enhance international students' sociocultural adaptation in India.</p><p><strong>Conclusion: </strong>Social integration of international students may be greatly aided by planning inclusive cultural activities that promote engagement, lower social barriers and create a friendly atmosphere. Educational institutions may foster cross-cultural understanding and improve the overall campus experience for both domestic and international students by giving priority to such efforts.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261425823"},"PeriodicalIF":2.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Meta-analysis to Identify Common Key Genes Across Ageing, Alzheimer's and Parkinson's Diseases.","authors":"Mona Chaurasiya, Sai Nikhith Cholleti, Gajendra Prasad, Vaibhav Vindal","doi":"10.1177/09727531261420619","DOIUrl":"10.1177/09727531261420619","url":null,"abstract":"<p><strong>Background: </strong>Ageing (AG) is associated with cognitive decline and an increased risk of developing neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD). While individual diseases have been widely studied, cross-condition convergence at the transcriptomic and regulatory levels has not been systematically defined.</p><p><strong>Objective: </strong>To identify a conserved molecular core shared across AG, AD and PD and to understand its functional and regulatory architecture using integrative network biology.</p><p><strong>Methods: </strong>Four independent human brain transcriptomic datasets (<i>n</i> = 173 samples) representing AG, AD and PD were analysed using false discovery rate correction (FDR < 0.05). Genes commonly dysregulated across all conditions were identified via intersection analysis. Functional enrichment, protein-protein interaction (PPI) network analysis, and microRNA (miRNA) regulatory mapping were performed using clusterProfiler, STRING and multiMiR frameworks.</p><p><strong>Results: </strong>A conserved set of 142 genes was identified across AG, AD and PD, with 94.4% exhibiting consistent directionality of regulation. AG clustered transcriptionally closer to AD than PD, while PD displayed stronger amplitude of dysregulation. Functional enrichment analysis revealed dominant involvement in synaptic signalling, axonal transport, vesicle trafficking and calcium homeostasis. Network analysis identified three essential regulatory hubs, CALM3, CDC42 and RAB3A. They are critical to neuronal signalling and cytoskeletal dynamics. miRNA analysis revealed coordinated regulation of hub genes by disease-associated miRNAs, including miR-29, miR-34, miR-7 and miR-195, and identified shared disease-associated regulators across AG, AD and PD conditions.</p><p><strong>Conclusion: </strong>This study defines a shared neurodegenerative molecular core that bridges physiological AG with pathological neurodegeneration. The integration of transcriptomic, network, and miRNA analyses reveals systems-level convergence and identifies key regulatory nodes as attractive targets for cross-disease therapeutic strategies.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261420619"},"PeriodicalIF":2.4,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}