Annals of Neurosciences最新文献

{"title":"Amelioration of Glutamate-induced Toxicity by a New Thyrotropin-releasing Hormone (TRH) Analogue PYR-l-(2,5-Dibromo)-His-l-ProNH₂.","authors":"Mallikarjuna R Sunkara, Jitendra N Singh, C L Meena, A B Pant, Rahul Jain, Shyam S Sharma","doi":"10.1177/09727531241305505","DOIUrl":"https://doi.org/10.1177/09727531241305505","url":null,"abstract":"<p><strong>Background: </strong>Glutamate has been implicated in the pathophysiology of central nervous system diseases, including stroke.</p><p><strong>Purpose: </strong>In this study, the neuroprotective potential of the newly synthesised thyrotropin-releasing hormone (TRH) analogue [Pyr-l-(2,5-dibromo)-His-l-ProNH₂; NP-2376] against glutamate-induced injury model were investigated.</p><p><strong>Methods: </strong>Cortical neurons isolated from neonatal rats were used to evaluate the effects of the NP-2376. Cortical neurons were pre-treated with NP-2376 (6, 12 and 24 h) prior to glutamate (15 mM) exposure. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) assay, and oxidative stress by chloromethyl-2,7-dichlorodihydrofluorescein diacetate (DCFH-DA) and glutathione assays.</p><p><strong>Results: </strong>NP-2376 protected against glutamate-induced cortical neuron death and oxidative stress in a dose-dependent manner.</p><p><strong>Conclusions: </strong>This study demonstrates the neuroprotective potential of TRH analogue NP-2376 against glutamate-induced toxicity, which is attributed to a decrease in oxidative stress.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531241305505"},"PeriodicalIF":1.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Assessment of Smartphone Use on Brainstem Auditory Evoked Potentials in Healthy Young Adults in North India Short Title: Assessing BAEP Changes in Young Smartphone Users.","authors":"Ayushi Seth, Samir Kumar Singh, Anita Gupta, Hanjabam Barun Sharma","doi":"10.1177/09727531231193238","DOIUrl":"10.1177/09727531231193238","url":null,"abstract":"<p><strong>Background: </strong>A smartphone is an essential part of our daily existence. Smartphones are used by about 5.26 billion people.</p><p><strong>Purpose: </strong>The purpose of this study was to determine how the duration of smartphone use influenced brainstem auditory evoked potentials (BAEPs).</p><p><strong>Methods: </strong>BAEPs were measured using BERAGRAPH in 41 young healthy persons in an observational cross-sectional study.</p><p><strong>Results: </strong>When daily smartphone calling time is 60 minutes, there is a statistically insignificant difference in smartphone usage length (5 years and >5 years) between the two groups among BAEPs.</p><p><strong>Conclusion: </strong>Despite the <i>P</i>-value being insignificant, there is a positive relationship between smartphone use in years and absolute wave latencies and interpeak latencies of brainstem evoked potentials.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531231193238"},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurexin-3 is Elevated and Associated with Cognition Status and 4-Hydroxynonenal in Bipolar Disorder.","authors":"Guguloth Sudhakar, Hanumanthappa Nandeesha, Vikas Menon, Kothandan Saravanan","doi":"10.1177/09727531251322019","DOIUrl":"10.1177/09727531251322019","url":null,"abstract":"<p><strong>Background: </strong>Alteration in synaptic plasticity and oxidative stress is involved in the pathogenesis of bipolar disorder (BD).</p><p><strong>Purpose: </strong>The objectives of the study were to analyse neurexin-3 and 4-hydroxynonenal (4-HNE) levels in BD and their relation with cognitive scores and severity of the disease.</p><p><strong>Methods: </strong>Eighty-four BD patients and 84 healthy volunteers were enrolled. Neurexin-3 and 4-HNE were analysed by enzyme-linked immunosorbent assay (ELISA). Cognitive scores were determined using Addenbrooke's Cognitive Examination III (ACE-III) scores.</p><p><strong>Results: </strong>4-HNE (<i>p</i> < .001) and neurexin-3 (<i>p</i> < .001) were higher in BD cases in comparison with controls. 4-HNE was positively related to neurexin-3 (<i>p</i> = .048). Neurexin-3 was related to the total ACE-III score (<i>p</i> = .029), attention (<i>p</i> = .040) and fluency (<i>p</i> = .026) scores in BD cases. When multivariate analysis was done, neurexin-3 was related to ACE-III score in BD (<i>p</i> = .005).</p><p><strong>Conclusion: </strong>We conclude that neurexin-3 is increased and associated with 4-HNE and cognitive dysfunction in BD.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531251322019"},"PeriodicalIF":1.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trial Sequential Analysis and Meta-analysis of Intranasal Ketamine Versus Intranasal Opioids for Analgesia in Paediatric Patients.","authors":"Madhusudan Prasad Singh, Alok Singh, Ekta Krishna","doi":"10.1177/09727531251317292","DOIUrl":"10.1177/09727531251317292","url":null,"abstract":"<p><strong>Background: </strong>Ketamine (KT) is known to have analgesic and sedative effects. Intranasal (IN)/inhalational KT has been used in different trials involving paediatric patients for analgesic and anxiolytic function. The present meta-analysis was conducted to establish the role of IN/inhalational KT compared to that of inhalational opioids (OPs).</p><p><strong>Summary: </strong>A systematic literature search was performed through the Cochrane Library, Pub Med and ClinicalTrials.gov databases from inception to February 2024 using the following keywords: inhalational OR IN OR nebulised' and 'ketamine' and 'analgesia'. Randomised clinical trials published in English that analysed the efficacy and safety of inhalational KT either alone or as an adjunct to the standard of care (SoC) compared to OP in paediatric patients undergoing various procedures were included in the analysis. The important outcomes included patients who were pain responders, required rescue analgesics, achieved mild-moderate sedation and experienced any adverse events (AEs), dizziness, nausea/vomiting or unpleasant taste. A trial sequential analysis (TSA) was also performed. The analysis included seven studies with 489 paediatric patients. In the KT group, a smaller number of patients were pain responders and required rescue analgesics (RR = 0.94; 95% CI = 0.78-1.13; <i>P</i> = .52 and RR = 0.80; 95% CI = 0.44-1.43; <i>P</i> = .45, respectively). Similarly, more patients in the KT group achieved mild-moderate sedation and experienced any AEs (RR = 1.44; 95% CI = 0.95-2.18; <i>P</i> = .09; and RR = 1.99; 95% CI = 1.47-2.69; <i>P</i> < .00001, respectively). A greater number of patients experienced dizziness (RR = 5.47; 95% CI = 3.12-9.58; <i>P</i> < .00001) and an unpleasant taste (RR = 2.91; 95% CI = 1.51-5.61; <i>P</i> = .001) in the KT group. In the meta-analysis, the required information size (RIS) could not be obtained.</p><p><strong>Key message: </strong>KT had efficacy outcomes comparable to those of OP, but KT had very high adverse effects. OP seems to have better tolerability than KT. However, as the number of patients was less than the RIS, it was not possible to draw any conclusions.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531251317292"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Mind Sound Resonance Technique (MSRT) on Cognitive and Psychophysiological Functions in College Students: A Randomised Controlled Study.","authors":"Sushanta Kumar Mohanty, Amit Kumar Singh, Subarna Surajita Mohanty, Krishna Dwivedi, Raghuram Nagaratana, Hongasandra Ramarao Nagendra, Deepeshwar Singh","doi":"10.1177/09727531251316696","DOIUrl":"https://doi.org/10.1177/09727531251316696","url":null,"abstract":"<p><strong>Background: </strong>College students face stressors like academic workload, competition, time management and financial concerns, which affect their psychological, physiological and cognitive functions. Meditation techniques can help mitigate these challenges.</p><p><strong>Objective: </strong>The study aimed to investigate the influence of the Mind Sound Resonance Technique (MSRT), a meditation method, on cognitive functions and psychophysiological variables among college students.</p><p><strong>Methods: </strong>Fifty experienced yoga practitioners (aged 19-30 years, with 30 of them being female) participated in a randomised controlled study. The subjects were split into two groups at random: the meditation group (<i>n</i> = 25) and the supine rest (SR) group (<i>n</i> = 25). Participants in the meditation group underwent one month of MSRT training, whereas those in the SR group rested supine for the same amount of time. Self-reported psychological assessments and the Stroop-colour word test were collected at baseline and after one month of intervention. On both days (day 1 and day 30), a continuous electrocardiogram (ECG) was also recorded for heart rate variability (HRV) at rest (pre-task), during task and post-task.</p><p><strong>Results: </strong>The MSRT group exhibited significant changes in HRV at baseline, during the Stroop task and post-task conditions, along with significant cognitive and psychological changes. The study found significant differences in cognitive tasks [accuracy rate (<i>P</i> < .05), reaction time (<i>P</i> < .05)] and HRV (<i>P</i> < .05) between the MSRT and SR groups. No significant change was observed in the SR group.</p><p><strong>Conclusion: </strong>MSRT appears to have the potential to enhance cognitive and psychophysiological functions in college students. In this regard, MSRT may be implemented to alleviate the effects of stressful environments and improve the overall well-being of college students.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531251316696"},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locus of Control in Patients with Mild-to-Moderate Ulcerative Colitis: A Comparative Study.","authors":"Shaini Suraj, Anand Prakash, Pradeep Patil, Deepa Sangolkar, Nayna Rane","doi":"10.1177/09727531241309758","DOIUrl":"10.1177/09727531241309758","url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis (UC) is a chronic condition characterised by inflammation of the large intestine, causing an impact on a patient's psychological well-being. Earlier research has demonstrated the important role of locus of control (LOC) in facing the challenges brought out by many gastrointestinal system diseases.</p><p><strong>Purpose: </strong>The aim of this research is to assess LOC in patients with mild-to-moderate UC as compared to non-UC individuals. This study also explored the impact of various demographic variables: age, gender, education level, type of family, working status, socio-economic status (SES), marital status and region of residence, on LOC among UC patients.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted for a period of two months. The tool used was Multidimensional Health Locus of Control (MHLC). A chi-squared test was used to investigate the LOC among individuals with UC (100 patients) in comparison to a control group of non-UC (100) healthy individuals. The age group was between 30 and 50 years.</p><p><strong>Results: </strong>In the UC group, 31% endorsed an internal LOC, while 40% attributed outcomes to chance, and 29% believed in powerful others. A chi-square test indicated a significant association between LOC and UC, χ²(2) = 38.1, <i>P</i> < .001. These findings suggest that individuals with UC are more likely to attribute outcomes to external factors, such as chance or powerful others, rather than their own actions. A positive effect of SES, region and working status on LOC was seen.</p><p><strong>Conclusion: </strong>The observed tendency towards external LOC highlights the need for targeted interventions aimed at enhancing patients' sense of agency and control over their health. Healthcare professionals can help people with these chronic conditions live better lives and achieve better results by enabling them to actively participate in their health.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531241309758"},"PeriodicalIF":1.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Visit-to-visit Repeatability of Autonomic Neuropathy Assessment Measures in Healthy Subjects.","authors":"Annie S Jose, Shival Srivastav, Bharati Mehta","doi":"10.1177/09727531241310034","DOIUrl":"10.1177/09727531241310034","url":null,"abstract":"<p><strong>Background: </strong>Autonomic neuropathy assessment is needed for the diagnosis and prognostication of different clinical disorders. Heart rate variability (HRV) and autonomic reactivity assessment by Ewing's battery of tests form the cornerstones of laboratory assessment of cardiac autonomic neuropathy evaluation.</p><p><strong>Purpose: </strong>While these tests are routinely used, there are conflicting reports regarding the visit-to-visit repeatability of these tests. Therefore, we assessed autonomic measures derived using aforementioned tests on multiple visits in healthy subjects.</p><p><strong>Methods: </strong>We enrolled 31 healthy subjects and performed autonomic function evaluation on five visits by assessment of HRV and autonomic reactivity on day 1 forenoon and afternoon, next day, one week later and one month later. Repeatability assessment was evaluated using Intraclass correlation coefficients. Values were defined as moderate, good and excellent based on previously reported criteria.</p><p><strong>Results: </strong>Thirty-one subjects completed all five visits (17 males, 14 females; mean age = 29 ± 5.44 years). While time-domain measures demonstrated good to excellent repeatability, frequency-domain measures were only moderately repeatable. Autonomic reactivity indices also displayed good to excellent repeatability with the exception of blood pressure response to orthostatic challenge which was moderately repeatable.</p><p><strong>Conclusion: </strong>We recommend that sole reliance on frequency domain metrics for HRV assessment should be avoided. HRV indices and autonomic reactivity measures may continue to be used for cardiac autonomic neuropathy assessment.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531241310034"},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal Ideation and Resilience Among Orphan and Non-orphan Adolescents in the Indian City of Pune.","authors":"Tintisha Basu, Pragyan Dangwal, Mahesh Deokar","doi":"10.1177/09727531241312733","DOIUrl":"10.1177/09727531241312733","url":null,"abstract":"<p><strong>Background: </strong>Fostering a healthy upbringing is of utmost importance to an individual and a supportive family system helps them grow holistically. Adolescence is an important stage for an individual to grow and form strong bonds with their peers.</p><p><strong>Purpose: </strong>The objective of the current study was to ascertain the level of self-esteem, resilience and suicidal ideation among orphan and non-orphan adolescents. Gender differences in self-esteem, resilience and suicidal ideation were also studied.</p><p><strong>Method: </strong>A sample of 160 adolescents (80 orphan and 80 non-orphan adolescents) comprising of equal number of male and female participants in the age group of 15-18 years were included in the study. Data was collected from adolescent orphans and non-orphans going to government schools in the urban sector in Pune, Maharashtra.</p><p><strong>Results: </strong>Means, S. Ds, Pearson's correlation and t-test were calculated: Mean resilience score was found to be significantly (<i>P</i> = .048) higher among orphans (129.73 + 29.53) as compared to non-orphans (120.39 + 29.70). Mean self-esteem and suicidal ideation did not vary significantly among orphans and non-orphans. The mean self-esteem score was significantly higher (<i>P</i> = .048) among females (27.61 + 4.09) as compared to males (26.43 + 3.41). There was no significant gender difference in resilience and suicidal ideation scores. The high resilience scores emphasise the need to study ways to enhance well-being among both orphans and non-orphan adolescents to foster a healthy fulfilling upbringing.</p><p><strong>Conclusion: </strong>The study goes on to show that a similar upbringing would foster similar results in individuals, irrespective of their backgrounds. Since self-esteem and suicidal ideation are similar among orphans and non-orphans, further research would help identify the various factors that foster self-esteem and resilience among these adolescents and likewise plan interventions in the future.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531241312733"},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Neuro-vascular Presynaptic Signalling in STROKE: Evidence and Therapeutic Implications.","authors":"Shimantika Maikap, Alexandra Lucaciu, Aheli Chakraborty, Roxane Isabelle Kestner, Rajkumar Vutukuri, Anil Annamneedi","doi":"10.1177/09727531241310048","DOIUrl":"10.1177/09727531241310048","url":null,"abstract":"<p><strong>Background: </strong>Stroke is one of the leading causes of death and long-term adult disability worldwide. Stroke causes neurodegeneration and impairs synaptic function. Understanding the role of synaptic proteins and associated signalling pathways in stroke pathology could offer insights into therapeutic approaches as well as improving rehabilitation-related treatment regimes.</p><p><strong>Purpose: </strong>The current study aims to analyse synaptic transcriptome changes in acute and long-term post-stroke (1 day, 7 day timepoints), especially focusing on pre- and postsynaptic genes.</p><p><strong>Methods: </strong>We performed data mining of the recent mRNA sequence from isolated mouse brain micro-vessels (MBMVs) after transient middle cerebral artery occlusion (tMCAO) stroke model. Using the SynGO (Synaptic Gene Ontologies and annotations) bioinformatics platform we assessed synaptic protein expression and associated pathways, and compared synaptic protein changes at 1 day and 7 day post-stroke.</p><p><strong>Results: </strong>Enrichment analysis of the MBMVs identified significant alterations in the expression of genes related to synaptic physiology, synaptic transmission, neuronal structure, and organisation. We identified that the synaptic changes observed at the 7 day timepoint were initiated by the regulation of specific presynaptic candidates 1 day (24h) post-stroke, highlighting the significance of presynaptic regulation in mediating organising of synaptic structures and physiology. Analysis of transcriptomic data from human postmortem stroke brains confirmed similar presynaptic signalling patterns.</p><p><strong>Conclusion: </strong>Our findings identify the changes in presynaptic gene regulation in micro-vessels following ischaemic stroke. Targeting presynaptic active zone protein signalling could represent a promising therapeutic target in mitigating ischaemic stroke.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531241310048"},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Psychosocial, Academic, and Psychological Issues Faced by University Students in India.","authors":"Mubashir Gull, Navneet Kaur, Wael M F Abuhasan, Suneetha Kandi, Sidharth Murali Nair","doi":"10.1177/09727531241306571","DOIUrl":"10.1177/09727531241306571","url":null,"abstract":"<p><strong>Background: </strong>University students confront a wide range of issues during their pursuit of education. Understanding these issues is essential for developing effective treatments and support systems.</p><p><strong>Purpose: </strong>This study aims to delineate the landscape of scholarly literature pertaining to psychosocial, academic, and psychological issues among university students. It further identifies key journals and publishing trends within the fields, thereby significantly contributing to this domain. Additionally, this study outlines the scientific field networks that offer theoretical and conceptual foundations for exploring the psychosocial, academic, and psychological challenges faced by university students. Furthermore, it also intends to systematically categorise various types of problems encountered by university students in India.</p><p><strong>Methods: </strong>To systematically gather and investigate the problems encountered by students in higher education, this study utilises bibliometric analysis, highlighting topics related to mental health. Data were extracted from Scopus and Web of Sciences databases.</p><p><strong>Results: </strong>The analysis of the literature yielded 12 overarching categories related to challenges faced by university students: stress, academic stress, depression, anxiety, internet/ smartphone addiction/ gaming disorder, low self-esteem, loneliness, insomnia, suicidal ideations, eating disorders, drug addiction, adjustment issues.</p><p><strong>Conclusion: </strong>Academic institutions should prioritise student mental health, as it affects academic performance and can lead to psychological disorders. Universities need Guidance and Counselling Cells staffed with professionals to help students manage psychosocial, academic, and psychological challenges.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531241306571"},"PeriodicalIF":1.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}