{"title":"Is Training Working Memory in Children with Learning Disabilities a Viable Solution? A Systematic Review","authors":"Priya Srikanth Rao, Manoj K. Pandey, Prabha Mishra, Seema Deshmukh, Masroor Jahan, Shivananda Manohar J","doi":"10.1177/09727531231198639","DOIUrl":"https://doi.org/10.1177/09727531231198639","url":null,"abstract":"Background Working memory (WM) is one of the most influential cognitive functions in encoding, registering, and retrieving information. It influences the learning process in children. Its role becomes essential, especially in a child with a learning disability (LD). Researchers worldwide are giving much prominence to WM, especially in devising cognitive retraining strategies for better cognitive functioning and academic attainment in these children. This current study aims to explore globally used instruments to measure this construct and review effective WM training models in the cognitive rehabilitation of children with LD. This study used a systematic review, availing the elaborate “Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA)” guidelines. Summary The databases of Google Scholar, PubMed, and Web of Science were searched thoroughly, and those studies, which met the inclusion criteria, were considered for this review. Out of 770 studies found with keywords, only six met the inclusion criteria and were selected for a detailed analysis. The outcome of the current review provides trustworthy evidence of poor performance, especially in tasks involving verbal and executive WM in children with all types of learning disabilities (LD) and difficulties. The studies reviewed support the hypothesis that WM can improve with training and significantly improve children’s academic attainment. Key Message Further this review recommends that research and efforts must go into devising these cognitive training techniques. Children have high cerebral plasticity; hence, using cognitive training (emphasizing WM training and other cognitive functions) with them would enhance their cognitive functioning and capacity, improving their academic performance.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135854773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiomics Approach Reveal Novel Insights in FUS Driven Juvenile Amyotrophic Lateral Sclerosis: A Family Quartet Analysis","authors":"Sagar Verma, Shiffali Khurana, Mandaville Gourie-Devi, Ish Anand, Yuvraj Vats, Arpita Singh, Manivannan Jothiramajayam, Pallavi Kshetrapal, Ankkita Sharma, Saima Wajid, Nirmal Kumar Ganguly, Pradip Chakraborti, Vibha Taneja","doi":"10.1177/09727531231194399","DOIUrl":"https://doi.org/10.1177/09727531231194399","url":null,"abstract":"Background Juvenile amyotrophic lateral sclerosis (JALS) is a rare and severe form of motor neuron disease characterized by progressive loss of upper and lower motor neurons with an early onset (<25 years). Purpose Due to complex etiology and clinical heterogeneity, it is indispensable to unravel molecular mechanisms underlying JALS pathology. The study aimed to identify disease-specific signatures in a 14-years-old sporadic JALS patient. Methods Genomic, transcriptomic, and metabolomic analysis of proband and first-degree relatives (FDR). Results Exome sequencing identified a novel de novo frameshift variation (c.1465dupG: p.D490Gfs*26) in the fused in sarcoma (FUS) gene in proband. Interestingly, rare and potentially deleterious, disease-modifying variations in DDHD domain containing 1 (DDHD1) and fibrillin 2 (FBN2) were observed. Differentially expressed genes (DGEs) enriched in neuromuscular transmission and inflammatory response were identified by RNA-sequencing. In addition, alterations in purine and pyrimidine, vitamin B6, and sphingolipid metabolism reflect the involvement of inflammatory process in disease pathobiology. Conclusion Our findings suggest the involvement of multiple genetic factors coupled with hampered neuromuscular transmission and systemic inflammation in the onset and disease course of JALS.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135899587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the Neurobiology of Specific Learning Disorders: Insights from Cognitive Neuroscience.","authors":"Satvinder Singh Saini, Krishan Kumar, Akshay Anand","doi":"10.1177/09727531231211052","DOIUrl":"https://doi.org/10.1177/09727531231211052","url":null,"abstract":"","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 4","pages":"217-218"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madhan Shrinivasamurthy, Shreeshail V Benakanal, Nagaraj Kakanahalli
{"title":"The Study of Clinical Phenotypes and Analysis of Mutations in L1 Syndrome","authors":"Madhan Shrinivasamurthy, Shreeshail V Benakanal, Nagaraj Kakanahalli","doi":"10.1177/09727531231185224","DOIUrl":"https://doi.org/10.1177/09727531231185224","url":null,"abstract":"Background L1CAM protein plays a crucial role during early development and mutations in L1CAM cause L1 syndrome. L1 syndrome demonstrates a highly variable presentation within and between families. The clinical symptoms of L1 syndrome include mental retardation, hydrocephalus, spasticity, aphasia, and adducted thumb. Mutations in L1CAM gene were found to affect structurally essential key residues in extracellular region of L1 leading to changes in protein binding properties. In most cases, these mutations create unexpected phenotypes which need to be understood thoroughly. Purpose The L1 syndrome patients were identified by various phenotypes like mental retardation, hydrocephalus, aphasia, spasticity, adducted thumb, etc., and the patients or mental retardation (MR) children who had more than three symptoms. This study aimed to screen mutations in multiple exons by Sanger sequencing. Methods The present study employed primers which are designed for specific exons of L1CAM gene to amplify and sequence the amplified product to detect the mutations in L1 syndrome patients by the Sanger sequencing. Chi-square test was used to determine the mutation detection rate with the number of L1 syndrome phenotypes and several i n silico programs were used to investigate potential effects of the variants. Results The nine different mutations in six patients. The mutation detection rate was high (83.33%) in patients with more than one L1 syndrome phenotype and in patients with more than one affected member in a family compared to patients with single phenotypes and negative family history (16.6%). Conclusion The mutation detection rate was related to the presence of typical L1 syndrome phenotypes and the family history. Screening of L1CAM gene mutations in the Indian population is much needed to analyze the mutations and understand the mechanism underlying L1 disease. The present study has identified some novel mutations which are implicated in alterations in various biological functions during development leading to pathogenesis of L1 syndrome.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. K. Praveen, Saikat Das, Manish Gupta, Deepti Joshi, Hemlata Panwar
{"title":"Primary Spinal Intradural Extramedullary Ewing’s Sarcoma/Peripheral Neuroectodermal Tumour Masquerading Clinically as a Neurogenic Tumour: A Case Report and Review of Literature","authors":"B. K. Praveen, Saikat Das, Manish Gupta, Deepti Joshi, Hemlata Panwar","doi":"10.1177/09727531231190979","DOIUrl":"https://doi.org/10.1177/09727531231190979","url":null,"abstract":"Ewing’s Sarcomas (ES)/Peripheral neuroectodermal tumour (pPNET) are heterogenous group of rare, highly malignant, undifferentiated primitive round-cell neoplasms of neuroectodermal origin. pPNETs are seldom observed to involve the spine of which Spinal Intradural Extramedullary Extraosseous Primary ES/pPNET are extremely rare. We report a case of a 23-year-old male with complaints of low backache and hip pain radiating to the left inguinal region for four months. Radiology findings were suggestive of a neurogenic tumour. Cytomorphology, histomorphology and immunohistochemistry evaluation were done. Diagnosis was consistent with ES/pPNET. Careful correlation between clinical history, cytomorphology, histopathology, immunohistochemical and molecular analysis can help to distinguish primary spinal ES/PNET from other primary spinal tumours and will help clinicians to start treatment at the earliest.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134970526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Augmenting Trait Meta-Mood: An Intervention to Enhance Psychological Well-being and Academic Achievement in Adolescents","authors":"Vijay Rana, Pragyan Dangwal, P. C. Mishra","doi":"10.1177/09727531231194898","DOIUrl":"https://doi.org/10.1177/09727531231194898","url":null,"abstract":"Background The period of adolescence is a crucial phase of development marked by significant transformations in emotional experiences, cognitive processes, and social interactions. Throughout this stage, individuals encounter diverse challenges that can influence their psychological well-being and academic performance. Existing research has highlighted the importance of trait meta-mood, which involves the ability to understand and regulate one’s own emotions, in shaping overall functioning during adolescence. However, there is a lack of comprehensive interventions specifically focusing on enhancing trait meta-mood in this population. Thus, this study aims to address this gap by investigating the effectiveness of an intervention program designed to improve trait meta-mood in adolescents. Purpose The purpose of this study is to evaluate the effects of the intervention program on academic achievement, psychological well-being, and trait meta-mood in adolescents. Methods The study employed a pre- and post-experimental design. Participants included adolescents aged 15–17 years. The intervention program consisted of a series of workshops and activities aimed at promoting self-awareness, emotional regulation, and positive cognitive strategies. Pre- and post-intervention measures were used to assess academic achievement, psychological well-being, and trait meta-mood. Results The findings of this study indicate that the intervention program significantly enhanced academic achievement, psychological well-being, and trait meta-mood of adolescents. Participants who underwent the intervention demonstrated improved self-awareness, emotional regulation skills, and positive cognitive strategies. Moreover, these improvements were associated with higher levels of psychological well-being and academic achievement. Conclusion The results suggest that the intervention program designed to enhance trait meta-mood in adolescents is effective in improving academic achievement, psychological well-being, and trait meta-mood. The findings highlight the importance of promoting self-awareness, emotional regulation, and positive cognitive strategies in interventions targeting adolescents, as they contribute to overall well-being and academic success.","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"98 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135784731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcarpal Motor Conduction Velocity: Repeatability and Application in Carpal Tunnel Syndrome.","authors":"Pinaki Das, Parasar Ghosh, Subhankar Halder, Subhankar Kumar","doi":"10.1177/09727531221142399","DOIUrl":"https://doi.org/10.1177/09727531221142399","url":null,"abstract":"<p><strong>Background: </strong>Conduction velocity of the short segment of the median motor nerve, <i>across wrist</i> (transcarpal motor conduction velocity (TCMCV)), has been used to increase diagnostic yield in carpal tunnel syndrome (CTS). However, repeatability of this parameter has not been studied till date. It has not been used as an indicator of response to treatment. Using surface stimulation techniques, it is difficult to localize the sites of stimulation of transcarpal segment of median nerve in palm. As a result, small errors in measurements of TCMCV can be magnified and variability of TCMCV may occur on successive measurements. Despite this possible variation, TCMCV can be a useful tool for assessing response to therapy, if its repeatability is assessed and a cut-off value determined for a significant change in nerve conduction velocity.</p><p><strong>Purpose: </strong>In this study, it was determined whether TCMCV is repeatable. If found to be repeatable, we show a method to determine the cut-off value of the change in this parameter for it to be considered significant.</p><p><strong>Methods: </strong>Difference between values of TCMCV on successive measurements was obtained in hands of 26 controls. Repeatability of this parameter was determined in this control population following criteria of British Standards Institution. In 19 patients of CTS, treated with intracarpal steroid injection, pre-treatment and post-treatment values of TCMCV, and of symptom severity scale (SSS) and functional status scale (FSS), were obtained at 1, 2, and 3 months <i>after treatment</i>.</p><p><strong>Results: </strong>Repeat measurements of TCMCV were made in each hand of all controls. After applying criteria of British Standards Institution, to such recordings, TCMCV was found to be repeatable and the cut-off value for significant change determined. According to this cut-off value, 4 patients of CTS showed improvement in TCMCV, with <i>consistent</i> improvement in SSS and FSS. Change in TCMCV corroborated qualitatively with changes in SSS and FSS.</p><p><strong>Conclusion: </strong>Repeatability of TCMCV can be assessed by criteria of British Standards Institution and a cut-off value determined to use it as an indicator of response to treatment in CTS.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 3","pages":"154-162"},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/bd/10.1177_09727531221142399.PMC10540766.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of NeurosciencesPub Date : 2023-07-01Epub Date: 2023-05-29DOI: 10.1177/09727531231169629
Anumeha Bhagat, Shival Srivastav, Anita S Malhotra, Ravi Rohilla, Ajeet K Sidana, K K Deepak
{"title":"Role of Meditation in Ameliorating Examination Stress Induced Changes in Cardiovascular and Autonomic Functions.","authors":"Anumeha Bhagat, Shival Srivastav, Anita S Malhotra, Ravi Rohilla, Ajeet K Sidana, K K Deepak","doi":"10.1177/09727531231169629","DOIUrl":"https://doi.org/10.1177/09727531231169629","url":null,"abstract":"<p><strong>Background: </strong>Examination stress is a very well-known model of psychological stress in students. It induces changes in systolic (SBP) and diastolic blood pressure (DBP), along with changes in heart rate variability (HRV) and baroreflex sensitivity (BRS), due to autonomic perturbations.</p><p><strong>Purpose: </strong>To find out if Raj Yoga meditation (RYM) practice affects autonomic and cardiovascular function in healthy young subjects during periods of examination stress. Our primary objective was to evaluate the effect of one month of supervised RYM practice on ameliorating examination-induced changes in cardiovascular and autonomic function. The secondary objective was to measure the stress levels of medical students before and after RYM.</p><p><strong>Methods: </strong>Pre-training measurements of SBP, DBP, HRV, and BRS were done, and the Medical Student Stressor Questionnaire (MSSQ) was administered to 80 participants one month before examinations. They were then trained in RYM. Post-training assessment of the same parameters was done after examinations and also after two months.</p><p><strong>Results: </strong>In our study, RYM training decreased DBP (<i>p</i> = 0.01) but not SBP. BRS showed a trend towards an increase after RYM practice, but it was not statistically significant (<i>p</i> = 0.44). The standard deviation of the NN interval (SDNN) (<i>p</i> = 0.03), low-frequency (LF) nu (0.003), and high-frequency (HF) nu (0.04) showed a statistically significant change. Average RR, median RR, average rate, square root of the mean squared differences of successive NN intervals (RMSSD), pRR, total power, LF (µs<sup>2</sup>), and LF/HF ratio were not statistically significantly different between the three groups. There was a statistically significant decline in MSSQ scores for MSSQ I (<i>p</i> = 0.04), MSSQ II (<i>p</i> = 0.04), and MSSQ IV (<i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>Short-term practice of supervised RYM during stressful periods is protective for the cardiovascular and autonomic systems and decreases stress in medical students.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 3","pages":"188-196"},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/d9/10.1177_09727531231169629.PMC10540765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41098337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endometriosis and Depression: A Double Agony for Women.","authors":"Payal Kanwar Chandel, Pawan Kumar Maurya, Sajad Hussain, Divya Vashistha, Shreya Sharma","doi":"10.1177/09727531231152022","DOIUrl":"https://doi.org/10.1177/09727531231152022","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is defined as a condition in which a formation of abnormal endometrial tissue outside the uterus takes place. Irrespective of any ethnic and socioeconomic class, the prevalence of the diseases has been seen among women of reproductive age. Endometriosis has been seen adversely affect the physical, psychological, social, and career of women.</p><p><strong>Summary: </strong>This paper aims to identify and describe the experiences and outcomes of endometriosis healthcare by reviewing the existing literature on social and psychological effects of endometriosis. The study serves the purpose of providing insights on women's dual suffering (mental and social health) and critical comments on the present state of knowledge in order to make future recommendations for psycho-social research. The review included systematic search of the articles from various disciplines like, biology, psychology, sociology, anthropology, etc. A structured process of screening with specific inclusion and exclusion criteria was used to select the articles. The analysis of the articles resulted that woman diagnosed with endometriosis reported poor quality of life and the following symptoms such as anxiety, stress, Chronic Pelvic Pain (CPP), anxiety, dyspareunia, and dysmenorrhea. However, depression appears prominent among women diagnosed with endometriosis. There are few strategies mentioned that can be used to deal with endometriosis.</p><p><strong>Key message: </strong>The most promising causes of endometriosis include abnormality in immune functioning, atypical endometriotic growth, genetics, epigenetic, embryogenetic theory, and endocrine disruptors. The ill effects have been noted in the following domains of women's life such as work, close relationships, social well-being, and education, deteriorating their quality-of-life manifold. Psychological intervention is required to deal with the disorder as only medical treatment with pain may not be sufficient. Though, the condition can be improved by providing awareness regarding the severity of the disorder at the school and community levels.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 3","pages":"205-209"},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/97/10.1177_09727531231152022.PMC10540762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of NeurosciencesPub Date : 2023-07-01Epub Date: 2023-01-11DOI: 10.1177/09727531221144112
Arun Shirali, Yeshoda M, Priyanka Arun Shirali, Sarah
{"title":"Depression in Diabetes-The Hidden Bane.","authors":"Arun Shirali, Yeshoda M, Priyanka Arun Shirali, Sarah","doi":"10.1177/09727531221144112","DOIUrl":"https://doi.org/10.1177/09727531221144112","url":null,"abstract":"<p><strong>Background: </strong>In India, a number of diabetes patients are rising, around 41 million Indians are suffering from diabetes. The depressed mood of an individual restricts the performance of that individual-socially, financially, and health-wise.</p><p><strong>Purpose: </strong>Patients with diabetes having depression have shown worst diabetes outcomes in contrast to those suffering from type II diabetes mellitus (T2DM) only, perhaps due to neglect at retaining a specific dietary regimen to control blood sugar levels, and/or not complying with regular exercise, consistent lifestyle, and treatment course. Our study aimed to analyze the presence of undiagnosed depression among adult diabetes patients and correlate complications and duration of T2DM with depression.</p><p><strong>Methods: </strong>This cross-sectional observational study was conducted on diabetes cases visiting Out Patient Department (OPD) at Tertiary Care Hospital in South India. After obtaining ethics committee clearance, known diabetes adult patients on regular treatment fulfilling selection criteria, and willing to join in the study were randomly selected. Participants were interviewed, clinically examined and data pertaining to sociodemographic characteristics, comorbid conditions, clinical parameters etc., were collected. Depression was judged using the Hamilton Depression Rating Scale (HDRS17) questionnaire. The association of depression with glycemic control, duration, and comorbidities associated with T2DM was studied.</p><p><strong>Results: </strong>Of 224 T2DM patients studied, the average age was 58 years, with a Male-to-Female ratio 2:1. In total, 49 (22%) had undiagnosed depression, and 175 (78%) were not having clinically obvious depression. In our study, depression was significantly associated with older age, occurrence of complications like retinopathy, neuropathy, nephropathy, and heart disease, and duration of diabetes (<i>p</i> < .005).</p><p><strong>Conclusion: </strong>Almost a fifth of diabetes individuals had undiagnosed depression. Proper diagnosis of depression among T2DM patients and intervention at right time can change the prognosis for patients, preventing further morbidities.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":"30 3","pages":"163-168"},"PeriodicalIF":1.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/a6/10.1177_09727531221144112.PMC10540763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41098336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}