Annals of Neurosciences最新文献

{"title":"Time Lost Is Brain Lost: Insights into Acute Ischaemic Stroke Delays in a Tertiary Care Super-speciality Centre in Jharkhand.","authors":"Tannu Kumari, Yuvraj Sinha, Amit Kumar, Anupa Prasad, Ganesh Chauhan, Lakhan Majhee, Vivek Verma, Surendra Kumar","doi":"10.1177/09727531261452861","DOIUrl":"10.1177/09727531261452861","url":null,"abstract":"<p><strong>Background: </strong>Early hospital arrival is essential for timely thrombolysis in acute ischaemic stroke. However, many patients in low-resource settings continue to reach tertiary care centres beyond the recommended treatment window.</p><p><strong>Purpose: </strong>To evaluate pre-hospital and in-hospital delays among patients with acute ischaemic stroke in Jharkhand and identify factors associated with timely hospital arrival.</p><p><strong>Methods: </strong>A prospective observational study included 237 consecutive patients with acute ischaemic stroke admitted to a tertiary care hospital in Ranchi (July 2022-August 2024). Patients were classified as early (≤4.5 h) or delayed (>4.5 h), and multivariable logistic regression identified predictors of early hospital arrival.</p><p><strong>Results: </strong>Only 15 patients (6.3%) reached the hospital within 4.5 h. Most were men, older adults and from rural, socio-economically disadvantaged backgrounds. Most (85.7%) first visited a nearby non-specialist healthcare facility, while awareness of stroke symptoms (14.0%) and thrombolysis (5.5%) was poor. Timely arrival was less likely after visiting a nearby healthcare facility (aOR 0.005, <i>p</i> < .001) but more likely with higher socio-economic status (aOR 17.02, <i>p</i> = .016) and ambulance availability (aOR 6.11, <i>p</i> = .021).</p><p><strong>Conclusion: </strong>Improving ambulance services, referral pathways and public awareness may reduce delays and improve timely stroke treatment.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261452861"},"PeriodicalIF":3.1,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Targeting of Peroxisome \u2028Proliferator-activated Receptors for Prevention \u2028of Radiation-induced Cognitive Decline.","authors":"Shubham Ghanekar, Jemema Agnes Tripena Raj, Gokula Krishnan Thiruselvan, Rucha Kulkarni, Mustafa Soni, Abhishek Chatterjee, Ishan Patro, Jayant S Goda","doi":"10.1177/09727531261452006","DOIUrl":"10.1177/09727531261452006","url":null,"abstract":"<p><strong>Background: </strong>Radiation-induced cognitive decline (RICD) is a common and debilitating late effect of cranial radiotherapy, particularly in long-term survivors of brain tumours and paediatric cancers. Despite advances in conformal radiation delivery and supportive care, progressive impairments in memory, attention and executive function continue to limit quality of life. Increasing evidence indicates that RICD is driven not by acute neuronal loss but by persistent neuroinflammation, oxidative stress, vascular dysfunction and metabolic failure within cognitive circuits. These converging processes highlight the need for disease-modifying targets that can regulate multiple pathological domains simultaneously.</p><p><strong>Summary: </strong>Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that integrate inflammatory control, redox balance, lipid metabolism and mitochondrial function across neurons, glia and the neurovascular unit. Preclinical studies demonstrate that PPARγ and PPARα agonists, including pioglitazone and fenofibrate, prevent or attenuate cognitive decline after fractionated whole-brain irradiation even when structural injury persists. PPARβ/δ agonists suppress radiation-induced neuroinflammation, while emerging evidence suggests that ligands capable of stabilising white matter and glial phenotypes may further enhance cognitive resilience. In parallel, phytochemical PPAR modulators, dual-isoform ligands, and advanced delivery strategies expand the therapeutic landscape beyond first-generation metabolic drugs.</p><p><strong>Key message: </strong>PPARs represent an integrative, circuit-level target for modifying the delayed trajectory of radiation-induced brain injury. Strategic deployment of PPAR-directed therapies during and after cranial radiotherapy offers a biologically grounded and clinically actionable approach to preserving long-term cognitive function in brain tumour survivors.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261452006"},"PeriodicalIF":3.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Smokeless Tobacco Consumption on Handgrip Strength and Surface Electromyographic Parameters in Obese Adult Males.","authors":"Zainab Noorain, Ashish Arvind, Ekanki Samui, Kumar Sarvottam, Amarpreet Kaur, Ratnesh N Gajbhiye, Anil Gangwar","doi":"10.1177/09727531261462990","DOIUrl":"10.1177/09727531261462990","url":null,"abstract":"<p><strong>Background: </strong>Obesity has a detrimental effect on skeletal muscle mass and performance. Despite the widespread use of smokeless tobacco, particularly in India, limited information is available regarding its effect on neuromuscular performance and electromyographic characteristics in obese individuals.</p><p><strong>Purpose: </strong>To estimate the effect of tobacco chewing on the electrical and mechanical equivalents of muscle performance among apparently healthy obese male tobacco chewers.</p><p><strong>Methods: </strong>A total of 80 male participants aged 40-60 years were recruited for this study. The participants, based on their chewing habit, were grouped into cases (tobacco chewers for more than 5 years = 40) and controls (non-chewers = 40). Anthropometric measurements such as height (m), weight (kg) and body mass index were taken. Electromyography (EMG) and handgrip strength assessments were conducted on all participants. Surface EMG of upper limb muscles: flexor digitorum profundus (FDP), flexor digitorum superficialis (FDS) and extensor carpi radialis (ECR) were recorded bilaterally during maximum voluntary contraction (MVC) as well as during endurance time (ET).</p><p><strong>Result: </strong>ET of a non-chewers was higher than that of a tobacco chewer in both hands (<i>p</i> = .006 and .00, respectively). A significant increase in root mean square values was noted in the left-hand FDP (<i>p</i> = .039) and ECR muscles (<i>p</i> = .014) during MVC among tobacco chewers.</p><p><strong>Conclusion: </strong>The study shows that tobacco chewing may be associated with altered muscle endurance and selective neuromuscular activation patterns.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261462990"},"PeriodicalIF":3.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vitamin B12, Folate and Homocysteine in Modulating Cognitive Functions and the Brain's White Matter Hyperintensity in Alzheimer's Disease.","authors":"Ram Prakash Sah, Vidya Cs, Shubha Jayaram, Anshu Kumar Yadav, Pratibha Pereira, Jagdeesh Damodaran","doi":"10.1177/09727531261457693","DOIUrl":"10.1177/09727531261457693","url":null,"abstract":"<p><strong>Background: </strong>Deficiency of vitamin B12 and folate as surrogate factors attributed to cognitive deterioration among older adults with Alzheimer's disease (AD). Increased homocysteine levels >15 µmol/L (hyperhomocysteinaemia) due to insufficiency of vitamin B12 contribute to damage to the small blood vessels in the brain and aggravate the white matter lesion.</p><p><strong>Purpose: </strong>The study aimed to determine the impact of B12, folic acid and homocysteine in modulating cognitive functions and white matter hyperintensity in AD.</p><p><strong>Methods: </strong>A case-control study of a total number of 82 patients (41 AD patients and 41 controls) was recruited. The cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA), and white matter hyperintensity was marked by magnetic resonance imaging studies. The levels of vitamin B12, folic acid and homocysteine in serum were also assessed.</p><p><strong>Results: </strong>The noticeable changes were observed in the cognitive scores and levels of B12, folic acid and homocysteine in AD and controls and found statistically significant (<i>p</i> < .001). Spearman's rank correlations revealed that cognitive functions (MoCA score) showed a direct correlation with B12 (<i>ρ</i> = 0.513, <i>p</i> < .001). Conversely, MoCA was moderately negatively correlated with homocysteine (<i>ρ</i> = -0.422, <i>p</i> < .001). Participants with B12 deficiency showed a significantly higher frequency of white-matter hyperintensities (WMH) (<i>χ</i>² = 4.654, <i>p</i> = .031; Fisher's exact <i>p</i> = .048).</p><p><strong>Conclusion: </strong>Nutrient deficiencies, especially B12, have a disruptive impact on cognitive domains and WMH in AD, which could be considered as key indicators to identify the disease severity among older adults. Recommendations of vitamin B12 plus supplements might be connected to clinical and public health initiatives to halt the rate of progression of cognitive decline in AD.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261457693"},"PeriodicalIF":3.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148576864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dialectical Behaviour Therapy on Deviant Eating Attitudes and Mental Health of Adolescents: A Case Report.","authors":"Divya Rai, Manju Agrawal, Rushi, S Z H Zaidi, Nandini Sharma","doi":"10.1177/09727531261459759","DOIUrl":"10.1177/09727531261459759","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Eating attitude can be defined as beliefs, thoughts, feelings, behaviour and relationship with food. It can impact a person's food choices and health status. A deviant eating attitude is a maladaptive pattern of thoughts and behaviours related to food consumption, which can include periods of inconsistent eating, ranging from overeating to undereating, dietary restriction, emotional eating and preoccupation with food and body weight. These concerns may be visible in the form of emotional dysregulation, anxiety, depression, low self-esteem and interpersonal difficulties. The deviant eating attitude can lead to psychological distress, as individuals may use restrictive eating patterns to cope with overwhelming emotions and life stresses, further deteriorating their overall mental health. Dialectical behaviour therapy (DBT) plays a key role in addressing this vicious cycle by targeting the core emotional and behavioural patterns which maintain disturbed eating disorder. DBT reduces the shame and self-stigma that affect the eating cycle and fosters genuine engagement with the therapeutic process. Through DBT, an individual can learn about mindfulness, distress tolerance, emotion regulation and interpersonal effectiveness. It facilitates individuals to recognise and manage uncomfortable emotions without resorting to dysfunctional eating patterns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The study aimed to explore the therapeutic effect of DBT on deviant eating attitude, along with mental health in adolescents.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A single case report method was used in the current study. The tools used in the study were case history, Mental Status Examination, Eating Attitudes Test-26, developed by David M. Garner, and Mental Health Inventory, developed by A. K. Srivastava. A total number of 14 sessions of DBT were given, and the pre- and post-therapy assessments were conducted. A case of a 15-year-old female presented with the chief complaints of concerns with her weight and physical looks, high consumption of junk food, disturbed sleep routine, disturbed interpersonal relationship, anger outburst, low self-esteem, irritability and reduced academic performance since the last 2 years, which increased significantly in the last 6 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The pre- and post-assessments were conducted, and they indicated relief in the symptoms reported by the client. She reported improved focus and increased motivation for academic goals. She also reported improved social relationships with improved mood and regulated sleep than before. She reported a reduction in the consumption of junk food. Her interpersonal skills improved significantly, allowing her to express her thoughts and feelings more effectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Findings support DBT as an effective mode of intervention that targets deviant eating attitudes and improves mental health by strengthening emotion regulation, increas","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261459759"},"PeriodicalIF":3.1,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Concept of Mind in Health Disease and Perfection with Understanding of Brain in Ayurveda and Darshanas-A Review.","authors":"Uma Shankar Prasad Adluri","doi":"10.1177/09727531261428825","DOIUrl":"10.1177/09727531261428825","url":null,"abstract":"<p><strong>Background: </strong>Mental diseases have been rising at an unprecedented rate across all age groups worldwide and are predicted to be one of the biggest health challenges of thus century. Despite significant advances, lot remains to be understood in modern sciences. In this scenario, Ayurveda along with the sankhya, yoga and vedanta darshanas constitute an invaluable treasure house of understanding regarding various aspects of human mind.</p><p><strong>Summary: </strong>These sources discuss mind extensively, including its creation, anatomy, location, functioning based on the three maha gunas of satva, rajas and tamas; role of prana, role of tridoshas of vata, pitta kapha;organization into different types of satvas or personality types, its functional states, various modifications it can undergo through the process of yoga; its relationship with body, brain and senses; its perfected state through yoga and its final release. The sources also teach us invaluable information regarding a normal mind, different ways and disciplines needed to keep it healthy and the benefits of following these disciplines. Finally, the different types of diseases that are possible are explored with a brief review of various treatment modalities and principals involved.</p><p><strong>Key message: </strong>Ayurveda and Darshanas provide extremely useful information to the exploring scientist, inquisitive physician or a traditional seeker; to understand, manage or unravel the human mind.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261428825"},"PeriodicalIF":3.1,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13364767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré Syndrome Following Dengue Infection: A Case Series with Review of Literature.","authors":"Satish Kumar, Neetu Sinha, Ashok Kumar, Abhay Ranjan","doi":"10.1177/09727531261457213","DOIUrl":"10.1177/09727531261457213","url":null,"abstract":"<p><strong>Background: </strong>Guillain-Barré syndrome (GBS) is a rare, immune-mediated disorder of the peripheral nerve and roots often triggered by infections.</p><p><strong>Purpose: </strong>We report clinical profile, electrophysiological variants and response to treatment in five cases of GBS patients following dengue fever.</p><p><strong>Methods: </strong>Patients fulfilling the National Institute of Neurological and Communicative Disorders and Stroke criteria for GBS following dengue infections were consecutively enrolled. Their demographic, biochemical and nerve conduction study (NCS) was done. According to NCS, they were categorised into acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, acute motor sensory axonal neuropathy (AMSAN), inexcitable motor nerve and equivocal. Disability was assessed using the 0-6 Guillain-Barré Syndrome Disability Scale or Hughes Functional Grading Scale.</p><p><strong>Results: </strong>Five patients of GBS following dengue fever were recruited (3 male and 2 female) with ages between 24 and 55 years. Diagnosis of dengue was based on serological evidence showing IgM and nonstructural protein 1 positivity. All the patients presented with an acute onset of progressive symmetrical flaccid paralysis. NCS showed a demyelinating pattern in four patients and an AMSAN pattern in one patient. All the patients were treated with intravenous immunoglobulin (IVIG) @2 g/kg/body weight given over 5 days. Modified Hughes grade at presentation was 4 in four patients, and one patient had a modified Hughes grade 5. At 1 month of follow-up, the patient with the AIDP variant showed good recovery and was able to ambulate unaided.</p><p><strong>Conclusion: </strong>GBS following dengue infection usually presents within 2 weeks of infection. In these patients, AIDP variant GBS are more common, and they show good response to IVIG treatment.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261457213"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Yogic Breathing and Relaxation Against Standard Lifestyle Interventions for Hypertension: A 12-week Randomised Trial.","authors":"Rajat Sharma, Monika Pathania, Ravi Kant, Praag Bhardwaj, Sumit Kalra, Drupad Das","doi":"10.1177/09727531261461022","DOIUrl":"10.1177/09727531261461022","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a major global health concern associated with substantial morbidity and mortality. Lifestyle interventions, including yoga-based stress management, are increasingly recognized as complementary approaches for blood pressure control..</p><p><strong>Purpose: </strong>To evaluate the effectiveness of a 12-week structured yogic breathing and relaxation programme compared with standard non-pharmacological care in adults with hypertension.</p><p><strong>Methods: </strong>In this randomized controlled trial at AIIMS Rishikesh, 66 adults with Stage 1 hypertension or elevated blood pressure were randomized to either a yoga intervention or standard care. The intervention group practised a validated 40-minute daily yoga module comprising pranayama and relaxation techniques. Primary outcomes were changes in systolic and diastolic blood pressure, while secondary outcomes included BMI, waist-to-hip ratio, sleep quality, perceived stress, and alcohol use.</p><p><strong>Results: </strong>After 12 weeks, the yoga group showed significant reductions in systolic (132.42 ± 3.96 to 124.06 ±4.11 mmHg; p <0.001) and diastolic blood pressure (84.42± 2.82 to 78.61 ± 3.89 mmHg; p <0.01), with significant improvements in perceived stress (p=0.001) and sleep quality (p = 0.019). BMI and waist-to-hip ratio showed clinically relevant but non-significant improvements.</p><p><strong>Conclusion: </strong>A 12-week yogic breathing and relaxation programme effectively reduced blood pressure and improved lifestyle parameters, supporting its integration into hypertension management. Further long-term studies are warranted.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261461022"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13350069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Perinatal Stress to Schizophrenia: The Emerging Role of Glial Pathology.","authors":"Tiyasha Sarkar, Nisha Patro, Ishan Patro","doi":"10.1177/09727531261445799","DOIUrl":"10.1177/09727531261445799","url":null,"abstract":"<p><strong>Background: </strong>Glia are the non-excitable cells of the brain, which, upon hyperstimulation, give rise to neuropsychiatric disorders. Recent evidence suggests that they are highly reactive cells, which makes them prone to environmental stimuli and early-life stressors. Upon excessive or chronic stimulation through exposure to stressors, these cells become responsible for causing neurological damage, which leads to neuropsychiatric disorders like schizophrenia, a global burden with no definite interventions.</p><p><strong>Purpose: </strong>Perinatal stressors such as protein malnourishment, immunological disturbances, toxins, parental separation and abuse play a major role in negatively changing the cytoarchitecture and homeostasis of both neurons and glial cells (astrocytes, microglia and oligodendrocytes), finally degrading both cognitive and behavioural abilities. Effects of excessive glial activation and/or degeneration result in neuroinflammation, memory loss, anxiety, depression and hyperactivity-like symptoms in adult individuals, which contribute to the manifestation of schizophrenic pathology.</p><p><strong>Conclusion: </strong>Therefore, it is believed that perinatal stressor-associated negative changes in glia can predispose an individual to develop this disorder later in life. This review summarises current evidence on how diverse early-life stressors influence glial cells, which could contribute to the neurobiological mechanism underlying schizophrenia.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261445799"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13350076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Customised Yoga Therapy Module for People Living with Early Parkinsonism.","authors":"Lourdu Mary, Prabha Adhikari, Udayakumara K","doi":"10.1177/09727531261461074","DOIUrl":"10.1177/09727531261461074","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a neurological degenerative condition affecting motor and non-motor functions of everyday life. While early management focuses on functional mobility and rehabilitation, evidence supports that yogic interventions as adjuvant therapy are applied yet limited in clinical practice. This study developed a customised yoga therapy module (CYTM) for motor and non-motor conditions, particularly for people with mild to moderate PD.</p><p><strong>Purpose: </strong>To develop a patient-friendly, symptom-specific, 24-week CYTM for people living with early Parkinsonism of Hoehn and Yahr staging scale I-III.</p><p><strong>Methods: </strong>The study follows a five-phased methodological development, which comprises a literature search, conceptualisation and development of a 24-week CYTM for early PD, evaluation with validation by the subject/panel experts, and relevance, along with a phase-wise operational method. The relevance of selected practices was validated with the item-level content validity index (I-CVI) and scale-level (S)-CVI/AVR/UA.</p><p><strong>Results: </strong>The executed five-phased methodological framework, and the newly developed CYTM comprises 29 practices to improve the functional changes of people with early PD. Experts' ratings yielded I-CVI (>0.91), scale-level content validity index of the average (S-CVI/AVR) (>0.995) with average and scale-level content validity index based on universal agreement (S-CVI/UA) (Universal Agreement) >0.941.</p><p><strong>Conclusion: </strong>As per the expert's opinion, the newly developed, symptom-specific, participant-friendly CYTM could be an appropriate practice for people living with mild to moderate PD. This CYTM will be evaluated by a non-randomised controlled clinical trial to establish its effectiveness.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531261461074"},"PeriodicalIF":3.1,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}