Annales de biologie clinique最新文献_第5页

Analytical performance of Abbott C-16000 analyser haemolysis index and its potential use in measuring plasma cell-free haemoglobin. 雅培C-16000分析仪溶血指数的分析性能及其在测量无浆细胞血红蛋白中的潜在用途。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-03-15 DOI: 10.1684/abc.2023.1785

Anne-Julie Schapira, Klara Lunte, Carole Hennequin, Stéphanie Vicca, Jean-Louis Beaudeux, Rana Alkoury, Valérie Nivet-Antoine, Alexandre Raynor, Charles-Henry Cottart

{"title":"Analytical performance of Abbott C-16000 analyser haemolysis index and its potential use in measuring plasma cell-free haemoglobin.","authors":"Anne-Julie Schapira, Klara Lunte, Carole Hennequin, Stéphanie Vicca, Jean-Louis Beaudeux, Rana Alkoury, Valérie Nivet-Antoine, Alexandre Raynor, Charles-Henry Cottart","doi":"10.1684/abc.2023.1785","DOIUrl":"https://doi.org/10.1684/abc.2023.1785","url":null,"abstract":"Purpose: Measurement of the haemolysis index (HI) is usually performed in clinical chemistry laboratories in order to inform about whether biological analyses are influenced by in vivo or in vitro haemolysis of the specimen. Our aim was to evaluate the analytical performance of Abbott C-16000 analyser HI measurement in order to determine whether this could be used to reliably measure cell-free haemoglobin (fHB) in plasma samples.Methods: The repeatability, reproducibility, lower limit of detection (LLOD) and lower limit of quantification (LLOQ) of C-16000 HI measurement were determined as well as the potential interference of bilirubin, triglycerides and myoglobin. C-16000 HI values of biological samples with various ranges of fHB were compared to those measured using the established reference method, second-derivate spectroscopy.Results: Results: C-16000 HI determination showed excellent linear correlation with the reference method (y = 1.0043x – 1.248, R² = 0.998), a broad analytical measurement range (400-20,000 mg/L; y = 0.9904x + 72.972, R² = 0.999), clinically relevant LLOD (56 mg/L) and LLOQ (84 mg/L), good repeatability (coefficient of variation (CV) = 1-15%) and good reproducibility (CV = 5-7%). No interference was observed with myoglobin at concentrations as high as 35,447 mg/L, unconjugated and conjugated bilirubin (at concentrations up to 500 mg/L and 375 mg/L, respectively) or triglycerides up to 6.8 mmol/L. However, a significant underestimation of fHB concentrations was observed at higher triglyceride levels.Conclusion: This study demonstrates that Abbott C-16000 analyser HI is reliable and accurately measures plasma fHB concentrations under pathophysiological conditions except when there are high blood concentrations of triglycerides.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"81 1","pages":"44-51"},"PeriodicalIF":0.5,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9172477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Achieve our ambitions 实现我们的抱负

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-03-15 DOI: 10.1684/abc.2023.1778

Katell Peoc'h

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Remerciements. 致谢。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-02-01 DOI: 10.1684/abc.2023.1793

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Evolution of attractiveness of Medical Biology to medical students in 2022 2022年医学生物学对医学生吸引力的演变

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1769

Marouan Bennani, Lionel Barrand, Florence Guillotin, Grégory Thomson, Carole Poupon, Kévin Cassinari

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Medical biology in France: evolution and issues 法国的医学生物学:进化和问题

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1775

Dominique Bonnefont-Rousselot, Marc Delpech, Philippe Chatron, Jean-Louis Gueant, Yves Le Bouc, François-Xavier Maquart, Bernard Massoubre, Nathalie Rives, Claude Vigneron

{"title":"Medical biology in France: evolution and issues","authors":"Dominique Bonnefont-Rousselot, Marc Delpech, Philippe Chatron, Jean-Louis Gueant, Yves Le Bouc, François-Xavier Maquart, Bernard Massoubre, Nathalie Rives, Claude Vigneron","doi":"10.1684/abc.2022.1775","DOIUrl":"https://doi.org/10.1684/abc.2022.1775","url":null,"abstract":"Medical biology is an essential part of patient care, both for the diagnosis and monitoring of diseases and for certain therapeutic advances. However, in recent years, it has been confronted with fundamental questions concerning its future. This report is the follow-up to the one published in 2018 by the National Academies of Medicine and Pharmacy and unfortunately only confirms a strong deterioration at all levels. The public authorities do not assume their role of regulator, thus allowing the excessive financialization of Medical Biology to grow considerably and lead to disproportionate groupings of Medical Biology Laboratories (MBL), destructive and sources of health risks. The result is that the Medical Biology Laboratories in towns, which are already known to be poorly distributed, are gradually becoming simple sampling sites, with patients finding themselves alone, often anxious, with their results sent to them by Internet without interpretation. Moreover, although progress in the field of Medical Biology is incredible and should constitute a major pole of attraction for young people, the disaffection of the discipline is total and worrying. Finally, innovation, in the context of current technological progress: connected devices, artificial intelligence and big data, represents a major challenge for the future. Here again, little or nothing is being done, even though the challenges are immense. After these alarming observations, the report will end with a series of recommendations aimed at optimizing the entry of MBL into a new era.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 6","pages":"551-564"},"PeriodicalIF":0.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Methemoglobin poisoning and interference on Sysmex® XN apparatus 高铁血红蛋白中毒及对Sysmex®XN仪器的干扰

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1772

Benjamin Podvin, Elise Fournier, Quentin Bigourd, Jean-Maxime Devaux, Adélaïde Hardeman

引用次数: 0

Prevalence of microbial nosocomial infections in the resuscitation unit of the University Hospital of Annaba-Algeria 阿尔及利亚安纳巴大学医院复苏病房微生物医院感染的流行情况

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1766

Chahrazed Benzaid, Lazhari Tichati, Mahmoud Rouabhia, Sonia Akil Dahdouh

{"title":"Prevalence of microbial nosocomial infections in the resuscitation unit of the University Hospital of Annaba-Algeria","authors":"Chahrazed Benzaid, Lazhari Tichati, Mahmoud Rouabhia, Sonia Akil Dahdouh","doi":"10.1684/abc.2022.1766","DOIUrl":"https://doi.org/10.1684/abc.2022.1766","url":null,"abstract":"Nosocomial infections constitute a significant public health problem but are poorly controlled in our health structures, especially those associated with resuscitation care. The first objective of this study was to identify the different microbial strains present in different biological samples taken from patients staying in the resuscitation unit of the Annaba University Hospital Center. The second objective was to assess the antimicrobial sensitivity of isolated microbes from the patients’ samples, to determine the risk factors, the most incriminated microbial agents in nosocomial infections. During the study period from January 2013 to December 2016, we collected 1,151 biological samples from 1,938 patients admitted to Resuscitation Medical Service. The samples were subjected to different microbiological analyses. Our results showed that over 59% of the collected samples were microbiologically positive. The identified species include Candida albicans (115 cases) and Candida.sp (81 cases). The Gram-negative bacterial strains found in the samples included Acinetobacter baumannii (108 cases), Klebssiella pneumoniae (99 cases) Pseudomonas aeruginosa (79 cases), and Escherichia coli (73 cases). Gram positive bacteria included Staphylococcus aureus (94 cases) and Enterococcus faecalis (53 cases). The antibiogram analyses showed significant antibiotic resistance reaching 93.75% for ampicillin, but sensitivity to colistin reaching 81.81%. Moreover, the fungal strains are represented by the genus albicans, showing a significant resistance to antifungals, reaching 80% with miconazole. Conclusion. The nosocomial infections in the medical unit were caused by the candida genus and multi-resistant bacteria to various antibiotics and antifungals. The most important factor associated with these infections was the use of medical devices.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 6","pages":"527-536"},"PeriodicalIF":0.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10621887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of blood gas results obtained on Abbott i-Stat® and on Radiometer ABL 800 Flex® analyzers Impact for the clinical decision 雅培i-Stat®和Radiometer ABL 800 Flex®血气分析仪血气结果的比较对临床决策的影响

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1765

Romain Jouffroy, Maude Laney, Teddy Leguillier, Valérie Nivet-Antoine, Jean-Louis Beaudeux

{"title":"Comparison of blood gas results obtained on Abbott i-Stat® and on Radiometer ABL 800 Flex® analyzers Impact for the clinical decision","authors":"Romain Jouffroy, Maude Laney, Teddy Leguillier, Valérie Nivet-Antoine, Jean-Louis Beaudeux","doi":"10.1684/abc.2022.1765","DOIUrl":"https://doi.org/10.1684/abc.2022.1765","url":null,"abstract":"Background: Point of care testing (POCT) tests are needed to assess severity and to help for triage in hospital and in prehospital settings. Before their use, the analytical performances of POCTs have to be compared with central laboratory reference methods. In this study, we describe the comparability of results obtained by either the Abbott i-STAT® System POCT handheld device or the blood gases analyzer of the central laboratory of our hospital.Methods: Sample blood from 37 septic patients admitted to the intensive care unit (ICU) were assayed by Abbott i-STAT® System POCT and Radiometer ABL800 Flex® lab analyzer. Studied parameters were as follows: pH, pO2, pCO2, base excess (BE), HCO3- and lactate. Comparability was evaluated using Bland-Altman method. The clinical value for possible mismatch issued of values differences was also assessed.Results: Quite acceptable correlations in results of POCT and laboratory analyzer were observed with R² most of time above 0.85. Bland-Altman analysis showed a bias of 1.26% for Abbott i-STAT® System POCT vs laboratory.Conclusion: Abbott i-STAT® System POCT handheld device is comparable to Radiometer ABL800 Flex® lab analyzer and concordant with laboratory analysis. Abbott i-STAT® System POCT handled device could be used in the prehospital settings in order to evaluate the severity of sepsis.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 6","pages":"521-525"},"PeriodicalIF":0.5,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10621885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of two SARS-CoV-2 RT-PCR assays and implication of the instrument software on cycle threshold (Ct) value 两种SARS-CoV-2 RT-PCR检测方法的比较及仪器软件对周期阈值(Ct)的影响

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1771

Eric Farfour, Tiffany Pascreau, Sara Zia-Chahabi, Émilie Jolly, Patrice Ferrière, Laurence Mazaux, Marc Vasse

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Lu pour vous dans…. 为你读…

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-11-01 DOI: 10.1684/abc.2022.1776

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