Algal Research-Biomass Biofuels and Bioproducts最新文献

{"title":"How sticky is sticky? A note on gametophyte adherence of the macroalga Saccharina latissima (Phaeophyceae)","authors":"Eoghan Mánus Cunningham ,&nbsp;Pamela J. Walsh ,&nbsp;Louise Kregting","doi":"10.1016/j.algal.2025.104138","DOIUrl":"10.1016/j.algal.2025.104138","url":null,"abstract":"<div><div>Temperate marine systems are ideal environments for expanding global seaweed aquaculture, yet high costs, particularly from macroalgal nursery facilities, have become a limiting factor for industry development. Recent research has explored the use of binder-seeding, whereby juvenile kelp life stages are seeded directly onto rope using adhesive solutions and deployed directly at sea. This method is used to reduce our reliance on nursery facilities and reduce aquaculture costs. While binder-seeding has shown mixed results, a more simplistic approach by Klaus Lüning has received less attention. Klaus Lüning (1979) commented that kelp gametophytes were naturally ‘sticky’ and attach to substrata within ‘a short time’, potentially highlighting a natural and more cost-effective seeding technique. Here, we explored the natural adherence of <em>Saccharina latissima</em> gametophytes to aquaculture twine. Cultures were sprayed onto twine and left to adhere for eight increasing time periods, before being submerged in seawater and measured after 10 weeks of growth. Gametophytes were found to adhere and grow successfully on twine after immediate submergence in seawater, however significant differences in sporophyte lengths and density after 10 weeks growth were observed among time treatments. Sporophyte lengths and densities were found to be highest when the culture was left to adhere for 30 min prior to submergence in seawater, potentially highlighting a time-sensitive sweet spot for natural gametophyte seeding. Further, we confirm that Lüning's observation of kelp gametophytes sticking to substrata after a ‘short time’ was in fact ‘immediate’, thereby shorter than previously thought.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104138"},"PeriodicalIF":4.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contradictive effects of light on diarrhetic shellfish toxin production-depending on photosynthetic status and photoprotection ability of Prorocentrum lima strains","authors":"Heng Chen ,&nbsp;Ruiwang Wei ,&nbsp;Zehui Huang ,&nbsp;Hua Zhang ,&nbsp;Kaixuan Huang ,&nbsp;Songhui Lu","doi":"10.1016/j.algal.2025.104135","DOIUrl":"10.1016/j.algal.2025.104135","url":null,"abstract":"<div><h3>Introduction</h3><div>Diarrhetic shellfish toxins (DST), including okadaic acid (OA) and its analogues, are potent inhibitors of protein phosphatases and can be transported via food chain, potentially leading to human poisoning. Their biosynthesis in <em>Prorocentrum</em> and <em>Dinophysis</em> genera is light-dependent; however, it can be inhibited by high or ultraviolet radiation (UV) in our recent study.</div></div><div><h3>Methods</h3><div>Based on the hypothesis that photosynthetic status is relevant to DST production, two <em>Prorocentrum lima</em> strains (SD4, light-tolerant; DS4G4, light-sensitive) were exposed to different light conditions (12–400 μmol photons m⁻² s⁻¹, with/without UV-A) for 30 days.</div></div><div><h3>Results</h3><div>Initially, photosynthetic activity (<em>F</em>_<em>v</em><em>/fm</em>) was inhibited by high light/UV-A, then recovered. Notably, the DST production rate (<em>R</em>_tox) decreased exponentially with increasing light on day 6, more significantly in strain DS4G4. During photoacclimation (day 6 – day 18), <em>R</em>_tox increased and attained a maximum (<em>R</em>_max), which in all cases was exponentially increased with light intensity. Under PAR conditions, the half-light saturation intensity (<em>I</em>_k) for <em>R</em>_max of OA did not surpass 25 μmol photons m⁻² s⁻¹ in both strains, highlighting the relatively low light requirements for DST production. Additionally, on day 6, chlorophyll <em>a</em> production rate (<em>R</em>_{Chl a}) demonstrated different correlations with <em>R</em>_tox under low and high light.</div></div><div><h3>Conclusion</h3><div>DST production is tightly associated with photosynthetic status and strain-specific photoprotection ability. The inhibition of DST by light is an inevitable phenomenon, and the underlying relationship between toxin production and photoinhibition process was further explored and discussed.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104135"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the potency of rice field cyanobacterial strains for plant growth promotion and root colonization by deciphering the molecular elicitors","authors":"Manickam Gayathri,&nbsp;Sumathy Shunmugam,&nbsp;Gangatharan Muralitharan","doi":"10.1016/j.algal.2025.104131","DOIUrl":"10.1016/j.algal.2025.104131","url":null,"abstract":"<div><div>Soil cyanobacteria collected from paddy fields across six diverse locations were evaluated for their plant growth-promoting potential, specifically through cyanobacterial extracellular products (CEP) influencing <em>Pisum sativum</em> L. germination and subsequent morphometric traits. Out of 20 tested strains, <em>Anabaena</em> sp. MBDU 902 demonstrated radicle and plumule lengths of 4.59 cm and 1.75 cm, respectively, while <em>Nostoc microscopicum</em> MBDU 102 exhibited enhanced radicle and plumule growth responses of 60 % and 80 %. Strain prioritization was achieved through Preference Ranking Organization Method for Enrichment Evaluation (PROMETHEE) and Graphical Analysis for Interactive Assistance (GAIA), where <em>Nostoc commune</em> MBDU 101 emerged as the most potent strain based on aggregate growth metrics. The bioactive extract of <em>Nostoc commune</em> MBDU 101 was purified and analyzed using Preparative High-Performance Liquid Chromatography (P-HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS), identifying key phytohormones, including Indole-3-butyric acid (IBA), Gibberellic acid, IAA conjugates, and long chain fatty acids, confirmed via agar slant bioassay. To elucidate its root association capabilities, hydroponic cultivation of <em>Zea mays</em> L. was conducted using <em>Nostoc commune</em> MBDU 101 culture and CEP, resulting in significant enhancement of seedling length, biomass, leaf dimensions, and lateral root development compared to control. Root colonization was validated through confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). Gas Chromatography-Mass Spectrometry (GC–MS) revealed signaling molecules in culture filtrates essential for root association, underscoring <em>Nostoc commune</em> MBDU 101 robust plant growth-promoting attributes.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104131"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of season, inoculum density and ammonia concentration on biomass abundance and ammonia utilization of a microalgal consortium for tertiary remediation of tannery wastewater and valorization of biomass","authors":"A. Ranjan,&nbsp;P.J. Welz","doi":"10.1016/j.algal.2025.104137","DOIUrl":"10.1016/j.algal.2025.104137","url":null,"abstract":"<div><div>Phyco-remediation has been advocated as a tertiary step for simultaneous remediation of tannery wastewater and valorization of microalgal biomass. This study was based on the hypothesis that climatic factors could be important functional determinants for system performance in open phyco-remediation systems subject to seasonal variations. In this study, ammonia utilization and biomass abundance obtained by a microalgal consortium (<em>Tetradesmus obliquus</em> CCAP 276/1A, <em>Tetradesmus obliquus</em> CPUT-L1, <em>Tetradesmus dimorphus</em> CPUT-L2, <em>Neochloris</em> sp. CPUT-W1) in treated tannery wastewater were measured under simulated winter, autumn/spring and summer conditions (temperature: 8.0 °C, 17.5 °C, 27.0 °C, respectively; photoperiod: 10:14 h, 12:12 h, 14:10 h light:dark, respectively) with varied initial ammonia (7.4 mg/L to 45.6 mg/L) and inoculum size (6 % vol./vol to 34 % vol./vol.) in 500 mL flasks (350 mL working volume) in shaking incubators at 160 rpm. Season had highly significant effects (<em>p</em> &lt; 0.0001) on both responses in an increasing continuum from winter to summer (biomass: 0.39 ± 0.06 g/L to 0.72 ± 0.07 g/L; ammonia utilization 1.7 ± 0.6 mg/day to 4.1 ± 1/6 mg/day). The inoculum size did not have significant effects on either response (<em>p</em> &gt; 0.5), while the initial ammonia concentration had a highly significant effect (<em>p</em> &lt; 0.0001) on the ammonia utilization rate, but not on biomass abundance. Despite the halo-tolerant nature of the microalgal strains, sodium removal efficiency was &lt;1 %, indicating that it is unlikely that phyco-remediation is feasible for removal of sodium in highly saline wastewaters. Overall, this study demonstrated the importance of studying microalgal growth and remediation under climatic conditions likely to be expected in the field with a view to pilot scale implementation.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104137"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-assisted extraction of proteins and polysaccharides from seaweed: A comprehensive review of optimization strategies, comparative analysis and future perspectives","authors":"Manikandan Dhayalan,&nbsp;Anuchit Phanumartwiwath","doi":"10.1016/j.algal.2025.104136","DOIUrl":"10.1016/j.algal.2025.104136","url":null,"abstract":"<div><div>Seaweed, a vast and untapped marine resource, harbors an array of bioactive compounds with profound implications for human health, nutrition, and sustainability. This comprehensive review provides an in-depth examination of ultrasound-assisted extraction (UAE) technology, a transformative method to unlock the potential of seaweed derived compounds, offering unparalleled efficiency, selectivity, and environmental sustainability. The principles, mechanisms, and applications of UAE in seaweed processing are critically evaluated, revealing enhanced extraction yields, improved product quality, and reduced solvent usage. Hybrid extraction methods combining UAE with other technologies demonstrate synergistic improvements in extraction efficiency and selectivity, while pilot-scale studies and economic evaluations underscore UAE's scalability and commercial viability for industrial seaweed processing. Life cycle assessment and sustainability studies highlight the UAE's environmental benefits, including reduced energy consumption, solvent usage, and waste generation. Standardization and regulation of UAE-based seaweed extraction methods ensure quality, safety, and efficacy. The main outcome of this study was that UAE can increase extraction yields by 20–50 %. The solvent consumption by 30–50 %. Moreover, the integration of UAE with other extraction methods can increase extraction rates by 25–40 % and reduce the environmental footprint by 40 % compared to traditional methods. This wide-ranging review will help researchers, research-based industries and policymakers further unlock the potential of aquatic biomass-derived compounds. It provides a tactical structure for innovating the blue economy and endorsing a sustainable growth path.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104136"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrophotometric quantification of cyanobacterial extracellular polymeric substances (EPS) using safranin","authors":"Subhasmita Panigrahi,&nbsp;Nilotpala Pradhan","doi":"10.1016/j.algal.2025.104134","DOIUrl":"10.1016/j.algal.2025.104134","url":null,"abstract":"<div><div>EPS are synthesized by various microorganisms and they play crucial roles in microorganism's growth and survival within their ecosystem. Quantification of EPS in culture liquid is generally done through gravimetric analysis after precipitation using large quantities of ethanol or acetone. Such analyses with a small volume of culture filtrate are error-prone. This study introduces a straightforward spectrophotometer-based technique for quantifying dissolved EPS secreted by cells into the growth medium. Utilizing EPS extracted from <em>Synechocystis</em> sp. IMMT47, the method involves staining and precipitating cyanobacterial EPS secreted from cells, with safranin. Subsequently, the precipitated pellet after centrifugation was reconstituted in water and the absorbance of the filtrate solution was measured at 519 nm. The obtained linear relationship between the concentration of EPS and absorbance from this method is compared with the earlier reported alcian blue-based quantification approach. Conventional gravimetric quantification of EPS using acetone was used as a standard to compare the efficacy of analysis. The R² value was found to be 0.97 with a <em>p</em>-value of 0.33, showing no significant variation among the quantification methods. The presented assay proficiently quantifies dissolved extracellular polysaccharides by evaluating reconstituted absorbance. Compared to the conventional gravimetric and alcian blue-based methods, the safranin assay exhibited higher sensitivity and reproducibility for small-volume samples. This approach not only streamlines EPS quantification but also minimizes sample loss and reagent consumption. Given its simplicity, cost-effectiveness, and accessibility, this method holds promise for advancing microbial EPS research, particularly in ecological and biotechnological studies. This innovative method has significant potential for advancing research on the biogeochemistry of EPS in microorganisms.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104134"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response pattern of marine macroalgae Gracilariopsis heteroclada to three fluoroquinolones and the cause-effect relationship of dose, growth, toxicity and sorption","authors":"Kun Lin ,&nbsp;Youyou Guo ,&nbsp;Rong Xin ,&nbsp;Enyi Xie ,&nbsp;Xuefeng Wang ,&nbsp;Jianjun Cui ,&nbsp;Jinhui Wu ,&nbsp;Zhaowei Huang ,&nbsp;Yong Liu ,&nbsp;Shaoliang Lyu ,&nbsp;Sipan Wang ,&nbsp;Yongjian Huang ,&nbsp;Xinyi Chen ,&nbsp;Jiawei Liao","doi":"10.1016/j.algal.2025.104133","DOIUrl":"10.1016/j.algal.2025.104133","url":null,"abstract":"<div><div>Fluoroquinolone (FQ) antibiotics, as emerging micropollutants, have been shown to inhibit the growth of aquatic plants. Conversely, these affected plants simultaneously exhibit FQ uptake capacity. However, the response patterns and removal efficiency of macroalgae exposed to FQs, and the cause-effect relationships between these processes, remain unclear. This study investigated the growth and toxicity responses of <em>Gracilariopsis heteroclada</em> to norfloxacin, enrofloxacin, and lomefloxacin over 96 h exposure at doses of 0–128 mg/L. Residual FQ concentrations in seawater were determined after 72 h. Structural equation modeling was applied to explore the relationships between initial dose, algal responses, and FQ sorption. Growth response patterns of <em>G. heteroclada</em> under each FQ exposure followed hormetic effects, with bell-shaped or Hill dose-response curves. FQs exhibited limited toxicity to <em>G. heteroclada</em>, with most toxicity curves indicating a lack of 50 % inhibition before 96 h. After 72 h, FQ removal rates ranged from 54.18 % ± 6.10 % to 97.93 % ± 0.17 %. Norfloxacin showed the highest removal rate and enrofloxacin the lowest. Growth response was the primary factor directly influenced FQ sorption (regression coefficient: 7.044), while toxicity had an inverse effect (−1.683). The specific growth rate acted as both cause and effect of the removal rate and terminal concentration, and the percent inhibition of the specific growth rate served as an important mediating variable. These findings suggest that environmental trace levels of FQs can stimulate the growth of <em>G. heteroclada</em>, which demonstrated strong tolerance to high FQ concentrations. However, reduced removal efficiencies at environmentally relevant doses and acute exposure constrain bioremediation applications, while chronic exposure risks necessitate further ecotoxicity assessments.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104133"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-Phycocyanin mitigates alcoholic liver injury in mice via gut microbiota informatics and liver metabolomics","authors":"Lin Sun ,&nbsp;Meng Zhao ,&nbsp;Xian Yang ,&nbsp;Xinyue Li ,&nbsp;Xiaomei Wang ,&nbsp;Zhongshan Zhang","doi":"10.1016/j.algal.2025.104130","DOIUrl":"10.1016/j.algal.2025.104130","url":null,"abstract":"<div><div>C-Phycocyanin (C-PC) is a water-soluble natural product used as a blue pigment derived from <em>Spirulina platensis</em>. However, the effects of C-PC on alcoholic liver injury and hepatic metabolism had not been fully explored. In this study, we combined microbiome and metabolomics analyses to explore the effects of C-PC on gut microbiota and hepatic metabolism. Results showed that C-PC dose-dependently reduced alcohol-induced elevations of AST and ALT levels. In addition, C-PC facilitated alcohol detoxification by increasing the activity of ADH and ALDH, as well as antioxidant enzymes such as SOD and reducing MDA levels. C-PC significantly improved the pathological state of the liver in mice and reversed alcohol-induced disturbances in gut microbiota. Moreover, C-PC improved alterations in hepatic metabolites, including characteristic metabolites such as berberine and ponasterone, and modulated key metabolic pathways, particularly nitrogen metabolism. These findings provide a novel approach for the development of innovative hepatoprotective agents utilizing C-PC.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"91 ","pages":"Article 104130"},"PeriodicalIF":4.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored illumination augmenting growth and phycocyanin production by Spirulina platensis: A mixture design approach","authors":"Taraneh Sadat Ghoreyshi,&nbsp;Fereshteh Naeimpoor","doi":"10.1016/j.algal.2025.104129","DOIUrl":"10.1016/j.algal.2025.104129","url":null,"abstract":"<div><div>To enhance biomass and pigments production by <em>Spirulina platensis</em>, a cyanobacterium known for its high phycocyanin formation, monochromatic (100), balanced (50–50) and disproportionate (70–30) dichromatic lightings of red (R), white (W) and blue (B) were examined in a 1-L glass photobioreactor. Preliminary experiments showed the positive effect of monochromatic light intensity (50, 100 and 200 μmol/m².s) on growth, with the highest biomass (3.95 g/L) belonging to red at intensity of 200 μmol/m².s. A simplex mixture design was subsequently applied to investigate biomass, phycocyanin, chlorophyll <em>a</em> and carotenoids concentrations as well as nutrients removal under the designed lightings at total intensity of 200 μmol/m².s over 30 days. The highest concentration of biomass (8.8 g/L), phycocyanin (1.41 mg/mL), chlorophyll <em>a</em> (0.118 mg/mL), and carotenoids (0.0345 mg/mL) corresponded to dichromatic red and blue lighting (70R-30B), showing that a small proportion of blue light alongside red is crucial for enhancing both growth and pigments production. Although the lowest concentrations belonged to monochromatic blue, phycocyanin content and nutrients (nitrate and phosphate) uptake yields on biomass were the highest for this strategy, showing the adverse effect of decreasing blue in dichromatic red and blue lighting on the overall pigments content of cell. This phenomenon can be attributed to the high photon energy of blue light, which induces cellular stress and subsequently triggers an upregulation of phycocyanin biosynthesis as a protective response. Since cultivation at industrial-scale requires the highest pigments productivity rather than cell contents of pigments, 70R-30B proved itself as the most economical strategy.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"90 ","pages":"Article 104129"},"PeriodicalIF":4.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmetic potential of agar oligosaccharides: anti-melanogenesis and photoprotective effects","authors":"Lei Wang ,&nbsp;Fengqi Yang ,&nbsp;Xiaoting Fu ,&nbsp;Young-Sang Kim ,&nbsp;Xin Gao ,&nbsp;You-Jin Jeon","doi":"10.1016/j.algal.2025.104132","DOIUrl":"10.1016/j.algal.2025.104132","url":null,"abstract":"<div><div>Agaro-oligosaccharides obtained from red seaweeds have attracted increasing attention in the areas of pharmaceutical, functional food, and cosmetic. Our previous studies have investigated the antioxidant and anti-inflammatory activities of the agaro-oligosaccharides prepared using the agar extracted from <em>Gracilaria lemaneiformis</em> (AO). The findings demonstrate that AO exhibits potent antioxidant and anti-inflammatory activities, highlighting its potential as a valuable ingredient for applications in the cosmetic industry. To further explore the cosmetic potential of AO, its skin-whitening and UV-protective effects were systematically evaluated in the present study. The results indicate that AO significantly inhibited tyrosinase activity and suppressed the alpha-melanocyte-stimulating hormone (α-MSH)-stimulated melanin synthesis by inhibitory intracellular tyrosinase activity in mouse melanoma cells (B16F10 cells). Furthermore, AO improved the viability of ultraviolet B (UVB)-irradiated immortalized human keratinocytes (HaCaT cells) from 45 % to 69.71 % at a concentration of 50 μg/mL. This effect is mediated through the protection of cells against apoptosis by scavenging intracellular reactive oxygen species (ROS) in HaCaT cells. Furthermore, AO significantly alleviated oxidative stress by decreasing intracellular ROS accumulation and enhanced collagen content through the inhibition of matrix metalloproteinase (MMPs) expression in UVB-exposed human dermal fibroblasts (HDF cells). The findings indicate that AO exhibits in vitro skin-whitening and anti-wrinkle potential, suggesting its potential as a valuable ingredient in the formulation of skincare products.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"91 ","pages":"Article 104132"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}