Algal Research-Biomass Biofuels and Bioproducts最新文献

{"title":"Responses to arsenic stress by the Andean benthic-extremophile cyanobacteria Rivularia halophila","authors":"Eliana Soto Rueda ,&nbsp;Laura Borgnino ,&nbsp;Gonzalo Bia ,&nbsp;Pedro I. Gil ,&nbsp;Mariano Bisbal ,&nbsp;Nicole Pietrasiak ,&nbsp;Estela C. Mlewski","doi":"10.1016/j.algal.2023.103286","DOIUrl":"https://doi.org/10.1016/j.algal.2023.103286","url":null,"abstract":"<div><p><span>Microorganisms living in naturally arsenic (As)-enriched environments exposed to extreme conditions play an active role in As mobility by influencing chemical speciation or inducing dissolution of As-bearing phases. In this work, the cyanobacterium </span><span><span><em>Rivularia</em><em> </em></span><em>halophila</em></span> was evaluated in its capability to tolerate, accumulate and biotransform As species. <em>R. halophila</em> was isolated from a hypersaline and high-altitude Andean Lake characterized by high geogenic As content in the sediments and water. Cultures of <em>R. halophila</em> were exposed to concentrations of As(V) and As(III) up to 15,000 and 200 ppm, respectively. Results showed that <em>R. halophila</em><span><span> effectively tolerated high As doses (IC50: 8500 and 70 ppm for As(V) and As(III) respectively), responding with a gradual decrease in growth and chlorophyll content. Cell damage and reactive oxygen species (ROS) only significantly increased at 5000 ppm of As(V) and 20 ppm of As(III), demonstrating an extreme adaptation to both As species. Moreover, As accumulation was significantly higher in As(III) treatment (i.e., 9.500 ppm) than in As(V) (i.e., 480 ppm). The main representative As-bearing phases in the biomass fractions were determined using micro-focused X-ray photoelectron spectroscopy. Three main As-bearing phases were identified: arsenate, arsenite and As(III)-S (mostly associated with sulfur). The redox evolution of As-bearing phases in the biomass fractions, coupled with increase of bulk As content and ROS activity, suggest that active </span>bioaccumulation and transformation of As by </span><em>R halophila</em> occurs during environmental stress conditions.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103286"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49819826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of biorefinery processing conditions on the bioactive properties of fucoidan extracts from Saccharina latissima on SHK-1 cells","authors":"Leszek Michalak ,&nbsp;Byron Morales-Lange ,&nbsp;Ruth Montero ,&nbsp;Svein Jarle Horn ,&nbsp;Liv Torunn Mydland ,&nbsp;Margareth Øverland","doi":"10.1016/j.algal.2023.103221","DOIUrl":"10.1016/j.algal.2023.103221","url":null,"abstract":"<div><p><span><span><span>Fucoidans<span> from brown macroalgae<span><span> exhibit a wide array of bioactivities, from antioxidant to immunostimulatory effects. Their specific effects and efficacy depend on the </span>molecular weight<span> and structure of the polysaccharide chains, which in turn depends on the seaweed species and the methods used for fucoidan extraction and </span></span></span></span>purification<span>. In this study, a bench scale, three factor, three level full factorial experiment was used to determine the relationship between the extraction parameters (duration, hydrochloric acid<span> concentration in extraction liquor, and temperature), the sulfation<span> level and fucoidan yield. Three of the extractions representing the least severe and most severe extractions as well as a calculated sweet spot were scaled up to a pilot biorefinery (5 kg biomass per extraction). To evaluate the potential of using these complex polysaccharides as functional ingredients in salmon aquaculture, bioactivity of the three different fucoidan preparations was examined by in vitro assays with cultures of </span></span></span></span>Atlantic salmon<span><span> head kidney cells (SHK-1). All pilot extraction products induced an increase in SHK1 </span>cell viability. In addition, “Too careful” also induced an upregulation of </span></span><em>il1-β</em> and <em>sod1</em><span>, both immune-related biomarkers. Interestingly, the expression of these biomarkers showed a positive correlation in SHK-1 cells stimulated with products from both “Too careful” and “Sweet spot” extractions. The data presented here show the extent of shift in bioactivity resulting from changes in the extraction severity in fucoidan biorefining and present the potential for fucoidan application as an immunostimulant for salmon cells.</span></p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103221"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47699729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omics integration for in-depth understanding of the low-carbon co-culture platform system of Chlorella vulgaris-Escherichia coli","authors":"Hui Liu,&nbsp;Mo Xian,&nbsp;Yujin Cao,&nbsp;Jing Guo,&nbsp;Lijun Kan,&nbsp;Xin Xu","doi":"10.1016/j.algal.2023.103252","DOIUrl":"10.1016/j.algal.2023.103252","url":null,"abstract":"<div><p><span><span><span>Many fuels and chemicals can be commercially produced by microbial processes<span> to substitute the petrochemical processes. However, the microbial processes suffer from the instability, low efficiency or discontinuous cultures. The continuous culture can greatly increase the productivity and reduce costs for the microbial production. The challenges for the application of continuous culture in industry are high contamination risk and </span></span>strain degeneration<span><span>. The co-culture system of photoautotrophs and </span>heterotrophs is probably able to solve bottlenecks of </span></span>microbial culture. The micro-ecological balance can be achieved for the continuous microbial culture by the co-culture of photoautotrophs and heterotrophs. Here, a system for the co-cultivation of </span><span><em>Chlorella vulgaris</em></span> and <em>Escherichia coli</em><span> was established for the biosynthesis<span> of isoprene. Compared with axenic culture, the isoprene production in the co-culture process was improved 10-fold to 0.6 g/L and the fermentation was prolonged from 100 h to 350 h. </span></span><em>C. vulgaris</em> promoted the isoprene synthesis and <em>E. coli</em> growth, while <em>E. coli</em> restricted <em>C. vulgaris</em> growth. The interactions between <em>E. coli</em> and <em>C. vulgaris</em> were closely associated with oxidative pressure from photomixotrophic metabolism. The consumption of exogenous glucose resulted in excess photomixotrophic electrons and subsequently resultant toxic reactive oxygen species (ROS). The oxidative pressure was reflected by the high activity of intracellular antioxidative (CysK, CysE, SerA, AhpC, AhpF) and repair (YtfE, NfuA, YebG) systems. <em>C. vulgaris</em> might protect <em>E. coli</em> against the oxidative pressure and improve the growth of <em>E. coli</em> through the inter-species cross-feeding. The biosynthesis of cysteine was greatly up-regulated in <em>C. vulgaris</em> to reduce ROS, and the cysteine necessary for antioxidation in <em>E. coli</em> might be provided by <em>C. vulgaris</em>. This study on the co-culture of <em>C. vulgaris</em> and <em>E. coli</em> is significant for revealing the common interactions between photoautotrophs and heterotrophs for the continuous culture.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103252"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45624841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valorisation strategies for brown seaweed biomass production in a European context","authors":"Joseph P. Bennett ,&nbsp;Laura F. Robinson ,&nbsp;Leonardo D. Gomez","doi":"10.1016/j.algal.2023.103248","DOIUrl":"https://doi.org/10.1016/j.algal.2023.103248","url":null,"abstract":"<div><p>Phaeophyta (brown algae) represent a significant proportion of macroalgal production worldwide. While there are around 1500 species of brown algae, biomass production originates from only a small number of species. Production is far greater in Asia where seaweed farming is part of the cultural background, where the primary use is for human consumption, and where growing conditions are significantly different from the European contexts. With all of this in mind, the cost of European seaweed aquaculture production is not currently economically viable if brown algae biomass were to be produced purely as bulk feedstock for agricultural fertilizers or animal feeds. This review focuses on three target brown algae species (<em>Laminaria digitata</em>, <em>Saccharina latissima</em> and <em>Alaria esculenta</em>), investigating the potential uses for these seaweeds as both bulk feedstock and also for the production of higher value extracted components in the following areas: hydrocolloids, animal feed, chemical production through fermentation, human foodstuffs, agricultural applications, cosmetics and pharmaceutical applications.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103248"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49779554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pasta goes green: Consumer preferences for spirulina-enriched pasta in Italy","authors":"Tommaso Fantechi,&nbsp;Caterina Contini,&nbsp;Leonardo Casini","doi":"10.1016/j.algal.2023.103275","DOIUrl":"https://doi.org/10.1016/j.algal.2023.103275","url":null,"abstract":"<div><p>The increasing interest in functional foods has led to research into nutraceutical sources, which has resulted in the discovery of microalgae, particularly spirulina, as a promising option. Spirulina is unique for its high protein content, essential amino acids, and rich mineral and vitamin content. Additionally, spirulina cultivation is environmentally friendly as it requires only a small area and has minimal emissions. However, despite the significant potential of spirulina-based products, their market penetration remains low due to investment costs. Therefore, assessing market interest and consumer preferences is crucial for promoting development. To understand consumer interest in spirulina-based products, a study was conducted using a representative sample of 326 Italians who participated in a choice experiment involving a pack of pasta that could be spirulina-enriched or not. The study findings indicate that there is a substantial consumer segment interested in spirulina-based pasta and willing to pay an average premium of €1.28 for a 1-kg package. This segment comprises prevalently young, physically active, well-educated men, who are interested in healthy eating and open to trying new foods. They primarily have a plant-based diet and good familiarity with functional foods.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103275"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49779781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new omega-3 rich euglenoid Eutreptiella sp. from the Korean coastal waters","authors":"Sungmo Kang ,&nbsp;Ki-Hyun Kim ,&nbsp;Namhyun Chung ,&nbsp;Zhun Li","doi":"10.1016/j.algal.2023.103296","DOIUrl":"https://doi.org/10.1016/j.algal.2023.103296","url":null,"abstract":"<div><p>Euglenoids, the primary producers of fatty acids (FAs), are used in functional foods, feeds, and biofuels. Long-chain polyunsaturated FAs (LC-PUFAs) such as eicosapentaenoic acid and docosahexaenoic acid (DHA) are crucial for human health. The primary commercial source of LC-PUFA is fish; however, its heavy metal bioconcentration is concerning. Globally declining wild-harvested fish stocks is another recently recognized serious problem. Herein, the morphology, molecular phylogeny, matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectroscopy, and FA compositions of an unspecified euglenoid strain KCTC 19016P isolated from the Korean coastal waters were examined. The vegetative cells were longitudinally spindle-shaped with a truncated apex and a tail-like extension at the anterior and posterior ends, respectively and had two unequal flagella. They had distinct red eyespots, numerous chloroplasts, and paramylon granules. Pellicular cell striations were easily observed using a scanning electron microscope. Phylogenetic analyses based on nuclear and chloroplast small-subunit ribosomal RNA sequences revealed that <em>Eutreptiella</em> sp. KCTC 19016P was nested within the <em>Eutreptiella</em> clade and was closely related to <em>Eutreptiella marina</em> (AY703209). Using the MALDI-TOF spectrum analysis, we differentiated between <em>Eutreptiella</em> sp. KCTC 19016P and the related NIES strains, thereby confirming their taxonomic similarities. <em>Eutreptiella</em> sp. KCTC 19016P growth was observed for 30 days; the maximum growth rate and doubling time was 0.50 ± 0.05 day⁻¹ and 1.40 ± 0.15 day, respectively. <em>Eutreptiella</em> sp. KCTC 19016P had a relatively high monounsaturated FA percentage compared to the other species. The omega-3 FA content in <em>Eutreptiella</em> sp. KCTC 19016P was significantly higher than that of the other strains, as determined using ordinary one-way analysis of variance (<em>P</em> &lt; 0.0001). Among the four euglenoids, <em>Eutreptiella</em> sp. KCTC 19016P had the highest α-linolenic acid and DHA contents. Thus, this new isolate could potentially be used in aquaculture and nutraceuticals without the risks associated with consuming fish.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103296"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49819480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable nuclear transformation methods for Euglena gracilis and its application to a related Euglenida","authors":"Masami Nakazawa ,&nbsp;Hiroko Andoh ,&nbsp;Hiromi Tsujii ,&nbsp;Katsumi Amada ,&nbsp;Hitomi Okuno ,&nbsp;Yusuke Gejima ,&nbsp;Kumi Iizuka ,&nbsp;Daiki Haruguchi ,&nbsp;Moe Maruyama ,&nbsp;Yuichiro Kashiyama ,&nbsp;Mitsuhiro Ueda ,&nbsp;Kazutaka Miyatake ,&nbsp;Tatsuji Sakamoto","doi":"10.1016/j.algal.2023.103292","DOIUrl":"https://doi.org/10.1016/j.algal.2023.103292","url":null,"abstract":"<div><p><span>Euglenida<span> is a taxonomic group of single-celled flagellates that have a variety of nutrient uptake strategies, making this an excellent model for studying the evolutionary acquisition of secondary chloroplasts. Among Euglenida, </span></span><span><em>Euglena gracilis</em></span><span><span> is the most extensively studied at the biochemical and molecular levels. However, the lack of a widely adopted method of </span>nuclear genome<span> transformation has hindered genetic<span> studies in this organism. Herein, we present a novel nuclear transformation electroporation method that utilizes the 5′ adjacent region sequences of endogenous genes in </span></span></span><em>E. gracilis</em><span>. We used a NanoLuc reporter to evaluate promoter activity to identify four endogenous promoter candidates with superior luciferase transcriptional activity compared with the activity of the commonly used CaMV 35S promoter in </span><em>E. gracilis</em><span> nuclear transformation methods. We used G418 selection to obtain stable </span><em>E. gracilis</em><span> transformants harboring the transgene in their genomic DNA. Furthermore, we extended the applicability of our method to </span><span><em>Rapaza </em><em>viridis</em></span>, a kleptoplastic species in Euglenida. Introduction of the DNA constructs developed for <em>E. gracilis</em> into <em>R. viridis</em><span> via electroporation generated stable G418-resistant strains exhibiting robust luciferase activity. The introduced promoter sequences functioned effectively, and accurate 5′ end modifications of mRNA were observed in both </span><em>E. gracilis</em> and <em>R. viridis</em> transformants. These findings demonstrate the broad applicability of our nuclear transformation method across multiple Euglenida species, facilitating molecular biology and genetic diversity studies in this taxonomic group.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103292"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49819825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of elevated CO2, temperatures and nitrogen availabilities on the physiological responses of the aragnonite-calcified species Dichotomaria marginata (Rhodophyta, Nemaliales)","authors":"Ana Lívia N.L. Ribeiro,&nbsp;Nair S. Yokoya","doi":"10.1016/j.algal.2023.103250","DOIUrl":"https://doi.org/10.1016/j.algal.2023.103250","url":null,"abstract":"<div><p>Studies reporting the effects of elevated CO₂<span><span><span>, temperatures and nitrogen availabilities on calcified </span>macroalgae have generally focused on the impact on marine calcifiers with </span>skeletons<span> of high‑magnesium calcite, but little is known about the physiology and metabolism of aragonite-calcified species, such as </span></span><em>Dichotomaria marginata</em> (J.Ellis &amp; Solander) Lamarck. Therefore, our study aimed to assess the combined effects of three temperatures (low, 21 °C; intermediate, 25 °C; and high, 30 °C), three CO₂ concentrations (WC - without CO₂<span> addition; ambient air, addition of 380 ppm; and high, addition of 1000 ppm) and three nitrogen availabilities in seawater (without addition of nitrate, WN; intermediate nitrate, 125; and high nitrate, 500 μM; or without addition of ammonium, WA; intermediate ammonium, 50; and high ammonium, 100 μM) on growth and physiological responses<span> (contents of total protein and pigments<span>, thallus contents of C, H and N, calcification and photosynthetic performance) of </span></span></span><em>D. marginata</em> cultured in laboratory-controlled conditions. In general, optimal values of variables were observed in 125 and 500 μM of nitrate, or 50 and 100 μM of ammonium, and WC and 380 ppm of CO₂ at all temperatures. However, the highest CO₂ (1000 ppm) and temperature (30 °C) negatively affected the growth rate, photosynthetic performance and calcification of <em>D. marginata</em><span><span>, but maintained its metabolism by nitrogen assimilation (phycobiliproteins and total soluble proteins), and stored carbon and hydrogen. The decrease in calcification, due to </span>aragonite<span> dissolution, may have caused a decrease in the growth rate since the fresh biomass reduced, even though the thallus remained alive and pigmented. The present study is the first to evaluate the physiological and biochemical responses of </span></span><em>D. marginata</em><span>, an aragonite-calcified red alga, exposed to environmental stressors related to the global climate changes.</span></p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103250"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49872889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From green to orange: The change in biochemical composition of phototrophic-mixotrophic Chromochloris zofingiensis in pilot-scale photobioreactors","authors":"Eleanor E. Wood ,&nbsp;Michael E. Ross ,&nbsp;Sébastien Jubeau ,&nbsp;Valéria Montalescot ,&nbsp;Karen MacKechnie ,&nbsp;Ryan E. Marchington ,&nbsp;Matthew P. Davey ,&nbsp;Sharon McNeill ,&nbsp;Callum Hamilton ,&nbsp;Michele S. Stanley","doi":"10.1016/j.algal.2023.103238","DOIUrl":"10.1016/j.algal.2023.103238","url":null,"abstract":"<div><p>Upscaling algal cultures from laboratory to pilot-scale provides important biological and technical insights for larger industrial applications. This is particularly important when screening novel algal species to enter the biochemical and nutraceutical markets. One such novel species is <em>Chromochloris zofingiensis</em>. This species has been identified as a potential industrial competitor to <em>Haematococcus</em> sp. for natural astaxanthin production, due to higher biomass concentrations and quantity of product per unit volume. To test the scalability potential <em>C. zofingiensis</em> was cultured using a phototrophic-mixotrophic approach in 65 L photobioreactors. The biomass increased from 0.05 to 0.51 g/L DW during a 15 day phototrophic phase. The subsequent mixotrophic phase induced carotenogenesis and turned the cells from green to orange. This altered the composition of the biomass and increased the biomass concentration from 0.65 to 5.13 g/L in 8 days. Astaxanthin is the primary compound of interest in this biomass and its concentration per culture increased during the mixotrophic phase; 0, 12.7, and 14.7 mgDW/L on days 0, 5, and 8, respectively. The highest protein, carbohydrate, and lipid concentrations per culture were recorded on day 5 (570, 1760, and 3715 mgDW/L, respectively). This study reports the largest scale use of mixotrophic cultivation of <em>C. zofingiensis</em> available in the literature where astaxanthin production was initiated using glucose (30 g/L), nitrogen deprivation, and a continuous photoperiod with an increased light intensity (245 μmol/m²/s)<em>.</em> The findings demonstrate the potential for further scaling to obtain high biomass concentrations at industrial volumes for production of astaxanthin along with additional products as part of a biorefinery process.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103238"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46272552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of bioactive molecules from photosynthetic microorganisms on Leishmania spp.: A review","authors":"Sabrina Swan Souza da Silva ,&nbsp;Alexsandra Frazão de Andrade ,&nbsp;Milena de Paiva-Cavalcanti ,&nbsp;João Carlos Monteiro de Carvalho ,&nbsp;Daniela de Araújo Viana-Marques ,&nbsp;Carolina de Albuquerque Lima Duarte ,&nbsp;Ana Lúcia Figueiredo Porto ,&nbsp;Raquel Pedrosa Bezerra","doi":"10.1016/j.algal.2023.103241","DOIUrl":"10.1016/j.algal.2023.103241","url":null,"abstract":"<div><p><span>Leishmaniasis is an infectious disease caused by protozoan parasites from the </span><span><em>Leishmania</em></span><span><span> genus, representing a significant global public health issue that affects thousands of individuals daily. The existing treatment options are primarily based on pentavalent antimonials<span>. However, adverse side effects, resistance, and ineffectiveness are frequently being reported. Microorganisms, such as microalgae and </span></span>cyanobacteria, synthesize a broad range of compounds that could potentially serve as candidates for new drug development, given their rapid growth and minimal nutritional requirements. Among these, cyanobacteria have been the most extensively studied, while only one study has examined three genera of microalgae (</span><span><em>Nannochloris</em></span> spp., <em>Picochlorum</em> sp., and <em>Desmochloris</em><span> sp.). To date, only phenolic<span> compounds, carotenoids, and peptides have demonstrated </span></span><em>in vitro</em> leishmanicidal activity, with peptides being the most promising source for the development of future pharmacological products against <em>Leishmania</em>.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"75 ","pages":"Article 103241"},"PeriodicalIF":5.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42013284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}