Shetty Shyvi Ravindra, Ahlam Abdul Rahman, Rashmi R Aithal, Sonal Bhat, Akshatha D
{"title":"Comparison of Single Intraoperative Dose of Dexamethasone on Glycemic Profile in Postoperative Diabetic and Non-diabetic Patients.","authors":"Shetty Shyvi Ravindra, Ahlam Abdul Rahman, Rashmi R Aithal, Sonal Bhat, Akshatha D","doi":"10.5812/aapm-161467","DOIUrl":"10.5812/aapm-161467","url":null,"abstract":"<p><strong>Background: </strong>This is a prospective observational study. Dexamethasone is commonly associated with postoperative hyperglycemia. There is limited data on the glycemic effect of dexamethasone among the diabetic population.</p><p><strong>Objectives: </strong>In the current investigation, postoperative glucose levels were measured in both diabetic and non-diabetic individuals, and then a single dose of intraoperative dexamethasone was administered.</p><p><strong>Methods: </strong>A total of 86 participants, with ASA I/II, were categorized into two groups: Diabetic and non-diabetic. Each group consisted of 43 individuals. The participants' ages ranged from 18 to 70 years. During the operation, a single dosage of dexamethasone, with a maximum of 8 milligrams, was provided intraoperatively. \"Postoperative nausea and vomiting\" (PONV), random blood glucose (RBG), and pain ratings were recorded before surgery, immediately after surgery, after 12 hours, and 24 hours following surgery. Preoperative blood glucose levels were also recorded. The \"Chi-square test and the unpaired <i>t</i>-test\" were used for comparison and to analyze the data. A significance level of P < 0.05 was deemed significant.</p><p><strong>Results: </strong>There was a statistically significant variance in RBG levels between diabetics and non-diabetics (P = 0.001). At various time periods, there was no correlation between the severity of PONV and diabetes among the participants. At various time intervals, the length of the procedure and the pain levels were equivalent to one another. In each group, there was a significant rise in RBG up to 12 hours, followed by a decline after 24 hours to a level similar to preoperative values.</p><p><strong>Conclusions: </strong>A single dose of intraoperative \"dexamethasone\" was associated with transient hyperglycemia postoperatively up to 12 hours, which was more pronounced among the diabetic population and without major adverse effects like PONV in either group.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e161467"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effective Pain Management in Polyarteritis Nodosa (PAN) Utilizing Lumbar Sympathetic Blocks: A Case Report.","authors":"Masood Mohseni, Behnaz Karimi, Farnad Imani","doi":"10.5812/aapm-144910","DOIUrl":"10.5812/aapm-144910","url":null,"abstract":"<p><strong>Introduction: </strong>We presented a 39-year-old man with polyarteritis nodosa (PAN) experienced significant leg pain unresponsive to oral medications.</p><p><strong>Case presentation: </strong>Two sequential lumbar sympathetic blocks with ropivacaine and triamcinolone resulted in over 70% pain reduction (NRS 9-10 to NRS 3) over a three-month follow-up period.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first report showing the efficacy of lumbar sympathetic block in controlling PAN-associated pain.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e144910"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multimodal Regional Anesthesia Combining Spinal and Erector Spinae Plane Block for Spine Surgery in a High-Risk Patient with Systemic Sclerosis: A Case Report.","authors":"Alireza Shakeri, Jina Behjati","doi":"10.5812/aapm-160051","DOIUrl":"10.5812/aapm-160051","url":null,"abstract":"<p><strong>Introduction: </strong>The erector spinae plane block (ESPB) is a novel regional anesthesia technique that is increasingly incorporated into multimodal analgesia as part of enhanced recovery after surgery (ERAS) pathways in various surgical procedures, including spine surgery.</p><p><strong>Case presentation: </strong>We report the successful use of spinal anesthesia (SA), ESPB, and magnesium sulfate in a high-risk patient with systemic sclerosis and pulmonary fibrosis undergoing laminectomy. A multimodal approach was selected due to the patient's underlying condition. This strategy minimized respiratory complications associated with general anesthesia while providing effective surgical anesthesia and postoperative pain control without opioid-related complications.</p><p><strong>Conclusions: </strong>Our case highlights the utility of ESPB, not only for postoperative pain management but also as a valuable adjunct to primary anesthesia, especially in high-risk patients.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e160051"},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Mohammad Seyed Alshohadaei, Fereshteh Baghizadeh
{"title":"Expanding on \"Analyzing Patterns in Anesthesiology Residents' Exam Performance Using Data Mining Techniques\".","authors":"Seyed Mohammad Seyed Alshohadaei, Fereshteh Baghizadeh","doi":"10.5812/aapm-159478","DOIUrl":"10.5812/aapm-159478","url":null,"abstract":"","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e159478"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf Nabil Saleh, Sherif F Ibrahim, Yasmeen A Sayed, Mohammed Mawad Alsaid A, Karim Ahmed Sedky Abdelrahman, Mohamed Mahmoud Abdelaziz Aly, Mohammed Abdulgadir Ageel, Ahmed Gamal Salah Elsawy, Mohamed Elsayed Mahmoud, Amr M Hilal
{"title":"Enhanced Postoperative Pain Management: A Comparative Analysis of Ultrasound-Guided Quadratus Lumborum Block Versus Intraperitoneal and Periportal Bupivacaine Infiltration Following Laparoscopic Cholecystectomy: A Randomized Double-Blind Study.","authors":"Ashraf Nabil Saleh, Sherif F Ibrahim, Yasmeen A Sayed, Mohammed Mawad Alsaid A, Karim Ahmed Sedky Abdelrahman, Mohamed Mahmoud Abdelaziz Aly, Mohammed Abdulgadir Ageel, Ahmed Gamal Salah Elsawy, Mohamed Elsayed Mahmoud, Amr M Hilal","doi":"10.5812/aapm-159545","DOIUrl":"10.5812/aapm-159545","url":null,"abstract":"<p><strong>Background: </strong>Inadequately managed acute pain following abdominal surgery can lead to patient discomfort, anxiety, respiratory issues, delirium, myocardial ischemia, prolonged hospital stays, and persistent pain.</p><p><strong>Objectives: </strong>This research compares the quadratus lumborum (QL) block to intraperitoneal and periportal bupivacaine infiltration for postoperative analgesia after laparoscopic cholecystectomy.</p><p><strong>Methods: </strong>This randomized double-blind study included seventy patients aged 21 to 60 years, randomly selected from Ain Shams University Hospital between March 2022 and March 2023, scheduled for elective laparoscopic cholecystectomy. The patients were divided into two groups of 35 based on postoperative pain management: Group A received intraperitoneal and periportal infiltration, while group B underwent the QL block, with details on placement and duration.</p><p><strong>Results: </strong>The results indicated a substantial decrease in Visual Analogue Scale (VAS) scores at 6 hours postoperatively, with group B exhibiting a median pain level of 3 [IQR 3 - 5] compared to group A's median of 5 [IQR 5 - 6], yielding a P-value of less than 0.001. The data indicate that group B had significantly enhanced postoperative analgesia within the initial 6 hours, both in a static condition and during movement. Moreover, patients in group B required fewer postoperative analgesics during the first 24 hours following surgery compared to group A.</p><p><strong>Conclusions: </strong>Following laparoscopic cholecystectomy, the QL block proved more effective than intraperitoneal and periportal bupivacaine infiltration in reducing postoperative pain scores for 6 hours and in reducing total opioid and analgesic use for 24 hours postoperatively.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e159545"},"PeriodicalIF":0.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Hosein Ghanbarpour, Ali Dabbagh, Alireza Jahangirifard, Navid Shafigh, Mina Fani, Kamal Fani
{"title":"The Effect of Intraoperative Dexmedetomidine on Postoperative Delirium Sedation Agitation Score in cardiac surgery.","authors":"Mohammad Hosein Ghanbarpour, Ali Dabbagh, Alireza Jahangirifard, Navid Shafigh, Mina Fani, Kamal Fani","doi":"10.5812/aapm-156544","DOIUrl":"10.5812/aapm-156544","url":null,"abstract":"<p><strong>Background: </strong>Postoperative delirium is a significant problem that deteriorates the cognitive state of patients after cardiac surgery, which can be a short- or long-term complication.</p><p><strong>Objectives: </strong>This study was conducted to evaluate the efficacy of dexmedetomidine, commenced simultaneously with anesthesia induction and continued throughout the surgical operation, on postoperative delirium after cardiac surgery with cardiopulmonary bypass.</p><p><strong>Methods: </strong>This randomized, double-blind, case-control trial was conducted on sixty-one patients undergoing cardiac surgery. The patients were randomly divided into dexmedetomidine (case) and normal saline (control) groups. The primary outcome was the incidence of delirium, as screened by the Confusion Assessment Method for the ICU (CAM-ICU).</p><p><strong>Results: </strong>There was no distinction in CAM-ICU outcomes between the two groups at 6 and 24 hours postoperatively. However, the difference in non-positive CAM-ICU results was statistically significant at 24 hours for +1 and -1 Richmond Agitation-Sedation Scale scores.</p><p><strong>Conclusions: </strong>Starting dexmedetomidine before cardiopulmonary bypass did not significantly affect the delirium rate based on CAM-ICU assessments. Further research examining larger groups is necessary to clarify the efficacy of perioperative dexmedetomidine on postoperative delirium.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e156544"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maedeh Karimian, Ali Dabbagh, Parisa Sezari, Kamal Fani, Marzieh Shahrabi, Alireza Shakeri
{"title":"The Magnitude of Anesthesiology Residents Burnout at Shahid Beheshti University of Medical Sciences: A Cross-Sectional Study.","authors":"Maedeh Karimian, Ali Dabbagh, Parisa Sezari, Kamal Fani, Marzieh Shahrabi, Alireza Shakeri","doi":"10.5812/aapm-159987","DOIUrl":"10.5812/aapm-159987","url":null,"abstract":"<p><strong>Background: </strong>Burnout is a psychological syndrome characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment, particularly prevalent among anesthesiology residents due to their demanding work environment.</p><p><strong>Objectives: </strong>This study aimed to assess the prevalence of burnout and its associations with depression, sleep quality, and quality of life among anesthesiology residents at Shahid Beheshti University of Medical Sciences.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 2023 with 51 anesthesiology residents. Validated Persian versions of standardized tools, including the Maslach Burnout Inventory (MBI), Patient Health Questionnaire-9 (PHQ-9), Epworth Sleepiness Scale (ESS), STOP-Bang test, and World Health Organization (WHO) Quality of Life (WHOQOL-BREF) Questionnaire, were used to measure burnout, depression, sleep quality, and quality of life. Descriptive statistics and correlation analyses explored associations between these variables.</p><p><strong>Results: </strong>Burnout was highly prevalent: 41.2% of residents experienced severe emotional exhaustion, 66.7% exhibited high depersonalization, and 100% reported reduced personal accomplishment. Severe depression affected 17.65% of participants, correlating strongly with all burnout dimensions. Emotional exhaustion was significantly associated with increased daytime sleepiness (r = 0.470, P < 0.001), while burnout severity inversely impacted physical, psychological, and social quality of life. Emotional support emerged as a critical protective factor against burnout. Exploratory analyses revealed no significant gender differences in burnout, depression, or sleep quality, though small effect sizes suggested trends toward higher emotional exhaustion and depression among female residents.</p><p><strong>Conclusions: </strong>The study highlights the alarming prevalence of burnout among anesthesiology residents, driven by occupational stress, sleep disturbances, and mental health challenges. These findings align with research in other high-stress specialties, such as emergency medicine and surgery, but also underscore unique stressors faced by anesthesiology residents. Targeted interventions, such as optimizing work conditions, enhancing emotional support, and addressing mental health and sleep issues, are urgently needed. Longitudinal and comparative studies are recommended to further explore burnout progression and develop specialty-specific strategies to improve resident well-being and patient care outcomes.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 2","pages":"e159987"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyoid Cricoid Distance-Based Method Versus Weight‑Based Method for Choosing the Appropriate Size for Classic Laryngeal Mask Airway Selection in Adults.","authors":"Dariush Abtahi, Ardeshir Tajbakhsh, Shahram Sayadi, Mohsen Shojaeian, Gholamali Arab Hesarsheneh, Soudeh Tabashi","doi":"10.5812/aapm-157335","DOIUrl":"10.5812/aapm-157335","url":null,"abstract":"<p><strong>Background: </strong>Selecting the appropriate sizes for laryngeal mask airways (LMAs) has become a concern for anesthesiologists. Traditionally, size selection has relied on factors like patient weight and gender. Nevertheless, emerging research indicates that incorporating anthropometric data could benefit the identification of the optimal LMA size for individual patients.</p><p><strong>Objectives: </strong>This randomized controlled trial aims to compare the effectiveness of LMA size selection based on weight against that determined by measuring the hyoid-cricoid distance (HCD).</p><p><strong>Methods: </strong>A total of 64 patients scheduled for eye surgery under general anesthesia were randomly assigned to two groups, each consisting of 32 participants. In the \"W group\", the size of the LMA was chosen based on the manufacturer's guidelines, which relied exclusively on the patient's weight. Conversely, in the \"HCD group\", the selection of LMA size was based on measuring the HCD. We compared postoperative complications and the ease of LMA insertion in these groups.</p><p><strong>Results: </strong>Data from 28 patients in the W group and 30 in the HCD group were analyzed. The incidence of postoperative complications was comparable between groups, with 16 patients in the W group and 12 in the HCD group experiencing complications (P = 0.1). Additionally, metrics such as the number of attempts, time to insertion, ease of insertion, peak airway pressure, and abnormal curve shape showed no statistically significant differences (P > 0.05).</p><p><strong>Conclusions: </strong>Based on the findings in this study, the method for selecting LMA size based on HCD did not statistically reduce airway complications nor did it facilitate the insertion process. We recommend conducting larger studies to further investigate this topic.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 1","pages":"e157335"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Arefi, Seyed Reza Saidian, Mohamadreza Mokhtari, Daryoush Eliaspour
{"title":"MLS Laser Reduce Pain in Patients with Chronic Low Back Pain.","authors":"Sara Arefi, Seyed Reza Saidian, Mohamadreza Mokhtari, Daryoush Eliaspour","doi":"10.5812/aapm-158778","DOIUrl":"10.5812/aapm-158778","url":null,"abstract":"<p><strong>Background: </strong>The Multiwave Locked System (MLS) has been shown to reduce inflammation and enhance biostimulation.</p><p><strong>Objectives: </strong>The aim was to investigate the effect of using MLS laser in reducing pain severity in patients with chronic back pain.</p><p><strong>Methods: </strong>This randomized double-blind study was conducted on 30 patients (15 in each group) with chronic low back pain (LBP) who were referred to Imam Khomeini Hospital and diagnosed by a physical medicine specialist based on diagnostic criteria. The intervention group was treated with MLS multiple wave laser, performed 12 times, with patients receiving laser treatment twice a week. The control group was treated with exercise therapy. Pain intensity was evaluated using the Visual Analog Scale (VAS) before treatment and 6 weeks after treatment. Pain was analyzed before and after the intervention, both within and between groups.</p><p><strong>Results: </strong>Of the 30 evaluated patients, the mean and standard deviation of age (P = 0.392) and gender (P = 0.666) were not statistically significant between the two groups. The VAS value before treatment in the intervention and control groups was 7.66 ± 1.11 and 7.73 ± 1.16, respectively (P = 0.794). After treatment, the VAS values in the MLS and control groups were 5.60 ± 1.35 and 7.73 ± 1.16, respectively. Statistical evaluation showed a statistically significant difference between the two groups (P = 0.001), and the total change in VAS values was significant (P = 0.001).</p><p><strong>Conclusions: </strong>Multiwave Locked System laser can reduce the pain severity of chronic LBP, with the reduction rate in the intervention group being significantly higher than in the exercise group.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 1","pages":"e158778"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rabab Mohamed Mohamed, Ashraf Elsayed Elgahrib Abdalla, Mohsen M Eissa, Reda Khalil Abdelrahman, Mohamed Galal Flefel, Asmaa Abdelbadie, Jehan Mohammad Ezzat Hamed Darwish
{"title":"Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy.","authors":"Rabab Mohamed Mohamed, Ashraf Elsayed Elgahrib Abdalla, Mohsen M Eissa, Reda Khalil Abdelrahman, Mohamed Galal Flefel, Asmaa Abdelbadie, Jehan Mohammad Ezzat Hamed Darwish","doi":"10.5812/aapm-156833","DOIUrl":"10.5812/aapm-156833","url":null,"abstract":"<p><strong>Background: </strong>Propofol is commonly used for sedation during colonoscopy but often requires high doses.</p><p><strong>Objectives: </strong>This study aimed to compare the outcomes of propofol alone versus propofol combined with clonidine for colonoscopy sedation.</p><p><strong>Methods: </strong>In this randomized, double-blind controlled trial, 60 adult patients scheduled for elective colonoscopy were enrolled. Patients were divided into two groups: Group 1 (G1) received propofol alone, while group 2 (G2) received propofol plus 2 μg/kg clonidine intravenously over 10 minutes. Propofol infusion was initiated at 25 - 75 μg/kg/min IV for the first 10 - 15 minutes, then titrated to 25 - 50 μg/kg/min based on clinical response.</p><p><strong>Results: </strong>Sedation onset was significantly faster in G2 than in G1 (P = 0.001). The total propofol requirement was 22% lower in G2 (P = 0.001). Heart rate (HR) and mean arterial pressure (MAP) were significantly lower in G2 at induction and at the end of the procedure (P < 0.05). Patient satisfaction scores were higher in G2 (P = 0.042). The observer's assessment of alertness/sedation (OAA/S) score after induction was lower in G2 (P = 0.015), indicating deeper sedation. However, Aldrete scores in the post-anesthesia care unit (PACU) were lower in G2 (P = 0.001), suggesting a slower recovery.</p><p><strong>Conclusions: </strong>The addition of clonidine to propofol for colonoscopy sedation led to faster sedation onset, reduced propofol requirements, improved patient satisfaction, and deeper sedation, but with potentially prolonged recovery times.</p>","PeriodicalId":7841,"journal":{"name":"Anesthesiology and Pain Medicine","volume":"15 1","pages":"e156833"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}