Comparison of the Effects of Isoflurane and Propofol as Anesthesia Maintenance on Plasma Mitochondrial DNA Levels in Posterior Spinal Fusion Surgeries.

Q2 Medicine
Anesthesiology and Pain Medicine Pub Date : 2025-06-02 eCollection Date: 2025-06-30 DOI:10.5812/aapm-161767
Faranak Behnaz, Mehrak Erfanian, Azita Chegini
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引用次数: 0

Abstract

Background: Tissue injury resulting from surgical procedures leads to the release of various inflammatory agents, such as mitochondrial DNA (mt-DNA). This can trigger inflammatory mechanisms that may harm different organs.

Objectives: In this study, we investigated the effects of isoflurane and propofol on mt-DNA levels during posterior spinal fusion (PSF) surgery.

Methods: After meeting the inclusion criteria, 40 patients scheduled for PSF surgery were enrolled in a prospective randomized controlled clinical trial and randomly divided into groups receiving propofol or isoflurane for maintenance of anesthesia. Mitochondrial DNA levels were measured before surgery, one hour after induction of anesthesia, in the recovery unit, and 24 hours post-surgery.

Results: There was no statistically significant difference between groups regarding age, gender, and mt-DNA levels prior to surgery (P-value > 0.05). However, mt-DNA levels were significantly higher in the isoflurane group one hour after induction of anesthesia (P-value = 0.001), in the recovery unit (P-value = 0.042), and 24 hours after surgery (P-value = 0.018).

Conclusions: Propofol was superior to isoflurane, as demonstrated by a lesser elevation in plasma levels of mt-DNA in PSF patients.

异氟醚与异丙酚维持麻醉对后路脊柱融合术血浆线粒体DNA水平影响的比较。
背景:由外科手术引起的组织损伤导致各种炎症因子的释放,如线粒体DNA (mt-DNA)。这会引发炎症机制,损害不同的器官。目的:在本研究中,我们探讨异氟醚和异丙酚对后路脊柱融合术(PSF)中mt-DNA水平的影响。方法:将符合纳入标准的40例PSF手术患者纳入前瞻性随机对照临床试验,随机分为异丙酚组和异氟醚组维持麻醉。分别在手术前、麻醉诱导后1小时、恢复病房和术后24小时测量线粒体DNA水平。结果:两组患者术前年龄、性别、mt-DNA水平差异无统计学意义(p值0.05)。然而,异氟醚组在麻醉诱导后1小时(p值= 0.001)、恢复单元(p值= 0.042)和术后24小时(p值= 0.018)mt-DNA水平均显著升高。结论:异丙酚优于异氟醚,PSF患者血浆mt-DNA水平升高较少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Anesthesiology and Pain Medicine
Anesthesiology and Pain Medicine Medicine-Anesthesiology and Pain Medicine
CiteScore
4.60
自引率
0.00%
发文量
49
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