Anatolian Journal of Cardiology最新文献

{"title":"Clinical Outcomes of Transcatheter Aortic Valve Replacement in Patients with Various Flow-Gradient and Ejection Fraction Profiles.","authors":"Yoshiyuki Yamashita, Massimo Baudo, Serge Sicouri, Roberto Rodriguez, Eric M Gnall, Paul M Coady, Scott M Goldman, William A Gray, Basel Ramlawi","doi":"10.14744/AnatolJCardiol.2025.5157","DOIUrl":"10.14744/AnatolJCardiol.2025.5157","url":null,"abstract":"<p><strong>Background: </strong>To compare the clinical outcomes of transcatheter aortic valve replace-ment (TAVR) for severe aortic stenosis (AS) in patients with different flow-gradient and left ventricular ejection fraction (EF) profiles.</p><p><strong>Methods: </strong>Patients with severe AS who underwent TAVR with newer generation valves (Sapien3/3 Ultra, Evolut Pro/Pro+/FX) were retrospectively analyzed. Patients were divided into 5 groups: normal-flow high-gradient (NF-HG) AS (stroke volume index ≥ 35 mL/m2 and mean pressure gradient ≥ 40 mm Hg), low-flow high-gradient (LF-HG) with preserved EF (pEF, ≥ 50%), LF-HG with reduced EF (rEF), low-flow low-gradient (LF-LG) with pEF, and LF-LG with rEF.</p><p><strong>Results: </strong>A total of 846 patients were included in this study (NF-HG, n = 458; LF-HG with pEF, n = 142; LF-HG with rEF, n = 50; LF-LG with pEF, n = 113; LF-LG with rEF, n = 83). For the entire cohort, the median age was 82 years, and the periprocedural mortality rate was 2.1% with the highest rate in the LF-LG with rEF AS (7.2%). The 1-year and 5-year mortality rates were 13% and 51%, respectively. Multivariable Cox regression analysis showed higher all-cause mortality in the LF-HG with pEF (hazard ratio 1.42 [95% CI: 1.02-1.98]), LF-LG with pEF (1.84 [1.32-2.55]), and LF-LG with rEF (1.78 [1.22-2.61]) groups compared with the NF-HG group. Cardiovascular death rates were significantly higher in the LF-LG groups, but not in the LF-HG groups.</p><p><strong>Conclusion: </strong>In addition to both LF-LG with pEF and rEF AS, LF-HG with pEF AS had a higher all-cause mortality rate after TAVR compared to NF-HG AS.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atatürk's (1881-1938) Heart Disease: A Qualitative Research.","authors":"Arif Hüdai Köken, Mahmut Bolat, İbrahim Etem Çelik","doi":"10.14744/AnatolJCardiol.2025.5379","DOIUrl":"10.14744/AnatolJCardiol.2025.5379","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to examine Atatürk's heart disease through historical documents and evaluate it in the context of the medical capabilities of the time and current cardiology knowledge. The symptoms, diagnosis, and treatment of his condition, along with physicians' practices, were retrospectively analyzed.</p><p><strong>Methods: </strong>Qualitative research methods (document analysis and case study) were employed. Primary sources such as memoirs, newspapers from the period, and official records related to Atatürk's health were examined. The data were thematically analyzed and interpreted by comparing the medical understanding of the era with contemporary cardiology guidelines.</p><p><strong>Results: </strong>Atatürk experienced 2 cardiac episodes in 1923 and 1927, both characterized by chest pain radiating to the left arm. Due to limited scientific knowledge and the absence of modern diagnostic tools (e.g., ECG, cardiac troponin, echocardiography, angiography), diagnosis was based solely on clinical observation and physical examination. His diagnosis was labeled Angine de Poitrine (angina pectoris), reflecting the terminology of the period. However, in light of current medical knowledge, these episodes can be reinterpreted as acute coronary syndrome (either unstable angina or acute myocardial infarction).</p><p><strong>Conclusion: </strong>This study is one of the first systematic evaluations of Atatürk's heart disease from both historical and cardiological perspectives. It also highlights the evolution of diagnostic and treatment methods in cardiology and underscores the value of historical research in understanding the progression of medical knowledge.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Whole Blood Viscosity to Predict Stent Restenosis in Patients with Coronary Artery Disease.","authors":"Yunus Çalapkulu, Mehmet Erdoğan, Abdullah Nabi Aslan, Nihal Akar, Serkan Bulguroğlu, Burak Kardeşler, Mehmet Akif Erdöl","doi":"10.14744/AnatolJCardiol.2025.5407","DOIUrl":"10.14744/AnatolJCardiol.2025.5407","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the relationship between whole blood viscosity (WBV) and in-stent restenosis (ISR) in patients with prior coronary stent implantation who underwent coronary angiography (CAG) for chronic coronary syndrome (CCS).</p><p><strong>Methods: </strong>In this retrospective case-control study, 802 patients who underwent CAG with suspected ISR were included. In-stent restenosis was defined as ≥50% stenosis within the stent or within 5 mm of its edges. Patients were divided into an ISR group (n = 342) and a control group without ISR (n = 460). Whole blood viscosity was calculated using both high-shear rate viscosity (HSR) and low-shear rate viscosity (LSR).</p><p><strong>Results: </strong>Whole blood viscosity levels were significantly higher in the ISR group for both HSR (16.8 ± 1.0 vs. 15.6 ± 0.9 cP, P < .001) and LSR (83.1 ± 8.4 vs. 80.8 ± 8.0 cP, P < .001). Receiver-operating characteristic curve (ROC) analysis showed strong predictive power for ISR (area under the curve [AUC] 0.84 for LSR and 0.82 for HSR). Kaplan-Meier analysis demonstrated significantly lower ISR-free survival in patients with high WBV (P < .001). Multivariate Cox regression identified both HSR and LSR as independent predictors of ISR.</p><p><strong>Conclusion: </strong>Increased WBV is independently linked to ISR and may contribute to its development via endothelial inflammation and vascular remodeling. Whole blood viscosity demonstrates potential utility as a biomarker for the identification of CCS patients susceptible to ISR.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Dive into the Cardio-Pulmonary-Renal Interactions in Patients with Pulmonary Hypertension: Serum Creatinine Levels Even Within the Normal Range Related to Long-Term Survival.","authors":"Hacer Ceren Tokgöz, Aykun Hakgör, Seda Tanyeri Üzel, Barkın Kültürsay, Ahmet Sekban, Berhan Keskin, Ayhan Tosun, Çağdaş Buluş, Dicle Sırma, Şeyhmus Külahçıoğlu, Ali Karagöz, İbrahim Halil Tanboğa, Nihal Özdemir, Cihangir Kaymaz","doi":"10.14744/AnatolJCardiol.2025.3759","DOIUrl":"10.14744/AnatolJCardiol.2025.3759","url":null,"abstract":"<p><strong>Background: </strong>Renal function in patients with pulmonary hypertension (PH) can be disrupted due to hypotension, low cardiac output, and venous pressure overload because of the its dependency on the pressure gradient between systemic arterial and venous circulations. The aim was to investigate whether measures of venous and pulmonary circulations determine renal function in patients with PH.</p><p><strong>Methods: </strong>The single-center study group comprised 1071 patients with a hemodynamically confirmed PH diagnosis. Serum creatinine level was used for surrogate of renal perfusion status. Echocardiographic measures included left ventricle ejection fraction (LVEF), tricuspid annular plane excursion (TAPSE), and right atrial area (RAA). Hemodynamic parameters included mean aortic and pulmonary pressures (MAP and PAMP), pulmonary capillary wedge (PCWP) and right atrial pressure (RAP), transsystemic and transpulmonary pressure gradients (TSG and TPG), and pulmonary and systemic vascular resistances (PVR and SVR), respectively.</p><p><strong>Results: </strong>Serum creatinine was significantly associated with TSG, RAP, TPG, PAMP, PVR, PVR/SVR ratio, cardiac index, stroke volume index, mixed venous O2 Sat %, TAPSE, RAA, LVEF%, pericardial effusion and BNP/NT-ProBNP levels (P < .05 for all), but not with MAP, PCWP, and SVR. According to the creatinine tertiles, survival rates were significantly different between groups 1 vs. 3, and 2 vs. 3 (P = .001 for both).</p><p><strong>Conclusion: </strong>An integrative approach regarding cardio-pulmonary-renal interactions seems to provide a comprehensive perspective for circulatory status and renal function in patients with PH and congestive heart failure. More importantly, even small increases of serum creatinine levels within the normal range seems to be associated long-term survival differences.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Transient Receptor Potential Channel mRNA Expression in the Aortas of Patients with Hypertension.","authors":"Algül Dilara Dokumacı, Belgin Alaşehirli, Akif Serhat Balcıoğlu, Sibel Oğuzkan Balcı, Nadire Eser, İbrahim Seyfettin Çelik, Mehmet Acıpayam","doi":"10.14744/AnatolJCardiol.2025.5123","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5123","url":null,"abstract":"<p><strong>Background: </strong>Arterial hypertension (HT) is a major risk factor for cardiovascular disease; however, its underlying mechanisms, particularly in primary HT, remain largely unclear. This knowledge gap has hindered the development of effective treatment strategies. Transient receptor potential (TRP) channels, which play a critical role in signal transduction, have been implicated in HT based on previous studies in cell culture and animal models. This study is the first study to analyze aortic tissue from patients with primary HT.</p><p><strong>Methods: </strong>Ascending aortic tissue samples, reflecting central blood pressure (BP), were collected from patients with chronic HT (n = 59) and normotensive controls (n = 22) undergoing coronary artery bypass graft surgery. Transient receptor potential channel mRNA expression was analyzed using quantitative real-time polymerase chain reaction. Subgroup analyses were performed to assess the influence of demographic characteristics, biochemical parameters, antihypertensive medications, and coexisting cardiometabolic conditions on gene expression.</p><p><strong>Results: </strong>Although no significant differences were observed in TRPC1 and TRPV3 mRNA expression between HT and control groups, TRPC6, TRPV1, TRPV2, TRPV4, and TRPM8 mRNA levels were significantly lower in patients with HT. TRPC6 expression showed a positive correlation with age, while TRPV1 expression demonstrated a negative correlation with diastolic BP.</p><p><strong>Conclusion: </strong>These findings suggest that TRP channels could serve as potential therapeutic targets for HT and contribute to a better understanding of its pathogenesis.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Optimal Antiplatelet Therapy in Type 2 Diabetes Mellitus Patients with Small Diameter Stents?","authors":"Koray Kalenderoğlu, Tufan Çınar, Mert İlker Hayıroğlu","doi":"10.14744/AnatolJCardiol.2025.5347","DOIUrl":"10.14744/AnatolJCardiol.2025.5347","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Infection, Vaccination, and Severe Coronary Artery Disease: Comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.14744/AnatolJCardiol.2025.5378","DOIUrl":"10.14744/AnatolJCardiol.2025.5378","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor: \"COVID-19 Infection, Vaccination, and Severe Coronary Artery Disease: Comment\".","authors":"Esma Çetinkaya, Ayşe Taş","doi":"10.14744/AnatolJCardiol.2025.5367","DOIUrl":"10.14744/AnatolJCardiol.2025.5367","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Coated Balloons vs. Plain Balloon Angioplasty for Side Branch Management in Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis.","authors":"Mustafa Bilal Özbay, Serhat Değirmen, Ayşenur Güllü, Bede Nnaemeka Nriagu, Yasin Özen, Çağrı Yayla","doi":"10.14744/AnatolJCardiol.2025.5296","DOIUrl":"10.14744/AnatolJCardiol.2025.5296","url":null,"abstract":"<p><strong>Background: </strong>Bifurcation lesions pose unique challenges during percutaneous coronary intervention (PCI) and are associated with suboptimal outcomes. The standard approach involves provisional stenting of the main branch (MB) with plain balloon angioplasty (BA) for compromised side branches (SBs). It remains unclear whether drug-coated balloon (DCB) or plain balloon angioplasty pose a better strategy to treat SB in bifurcation lesions. This systematic review and meta-analysis compared the efficacy of DCB versus BA in managing SBs of bifurcation lesions.</p><p><strong>Methods: </strong>MEDLINE, Cochrane, and EMBASE databases were searched for randomized controlled trials (RCTs) comparing DCB and BA for treating bifurcation lesions. Outcomes included SB late lumen loss (LLL), major adverse cardiovascular events (MACE), all-cause mortality, myocardial infarction (MI), and target lesion revascularization (TLR).</p><p><strong>Results: </strong>Five RCTs were included, encompassing 1,255 patients, of whom 628 (50.4%) underwent DCB angioplasty; 946 (75.4%) were male, and the mean age was 63.5 years. Drug-coated balloons significantly reduced MI risk (risk ratio [RR] = 0.56, 95% CI: 0.35-0.88, P = .010). DCB use resulted in similar LLL in the SB compared with BA (mean difference (MD) = -0.12 mm, 95% CI: -0.24-0.01, P = .070). No significant differences were observed in TLR (RR = 1.19, 95% CI: 0.45-3.14, P = .720), MACE (RR = 0.70, 95% CI: 0.48-1.02, P = .070), and all-cause mortality (RR = 2.35, 95% CI: 0.61-9.00, P = .210).</p><p><strong>Conclusion: </strong>In this meta-analysis of RCTs, DCB significantly reduced MI without affecting LLL, TLR, MACE, and all-cause mortality compared with BA in the SB of bifurcation lesions.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutant p.Val114Ala Transthyretin-Related Cardiac Amyloidosis with Heart Failure and Right Bundle Branch Block.","authors":"Selda Murat, Sinem Kocagil, İlknur Ak Sivrikoz, Hava Üsküdar Teke, Halit Emre Yalvaç, Rabia Okumuş, Oğuz Çilingir, Yüksel Çavuşoğlu","doi":"10.14744/AnatolJCardiol.2025.5150","DOIUrl":"10.14744/AnatolJCardiol.2025.5150","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}