Evaluation of Whole Blood Viscosity to Predict Stent Restenosis in Patients with Coronary Artery Disease.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Anatolian Journal of Cardiology Pub Date : 2025-05-29 DOI:10.14744/AnatolJCardiol.2025.5407

Yunus Çalapkulu, Mehmet Erdoğan, Abdullah Nabi Aslan, Nihal Akar, Serkan Bulguroğlu, Burak Kardeşler, Mehmet Akif Erdöl

{"title":"Evaluation of Whole Blood Viscosity to Predict Stent Restenosis in Patients with Coronary Artery Disease.","authors":"Yunus Çalapkulu, Mehmet Erdoğan, Abdullah Nabi Aslan, Nihal Akar, Serkan Bulguroğlu, Burak Kardeşler, Mehmet Akif Erdöl","doi":"10.14744/AnatolJCardiol.2025.5407","DOIUrl":null,"url":null,"abstract":"Background: This study investigated the relationship between whole blood viscosity (WBV) and in-stent restenosis (ISR) in patients with prior coronary stent implantation who underwent coronary angiography (CAG) for chronic coronary syndrome (CCS).Methods: In this retrospective case-control study, 802 patients who underwent CAG with suspected ISR were included. In-stent restenosis was defined as ≥50% stenosis within the stent or within 5 mm of its edges. Patients were divided into an ISR group (n = 342) and a control group without ISR (n = 460). Whole blood viscosity was calculated using both high-shear rate viscosity (HSR) and low-shear rate viscosity (LSR).Results: Whole blood viscosity levels were significantly higher in the ISR group for both HSR (16.8 ± 1.0 vs. 15.6 ± 0.9 cP, P < .001) and LSR (83.1 ± 8.4 vs. 80.8 ± 8.0 cP, P < .001). Receiver-operating characteristic curve (ROC) analysis showed strong predictive power for ISR (area under the curve [AUC] 0.84 for LSR and 0.82 for HSR). Kaplan-Meier analysis demonstrated significantly lower ISR-free survival in patients with high WBV (P < .001). Multivariate Cox regression identified both HSR and LSR as independent predictors of ISR.Conclusion: Increased WBV is independently linked to ISR and may contribute to its development via endothelial inflammation and vascular remodeling. Whole blood viscosity demonstrates potential utility as a biomarker for the identification of CCS patients susceptible to ISR.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417897/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anatolian Journal of Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14744/AnatolJCardiol.2025.5407","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: This study investigated the relationship between whole blood viscosity (WBV) and in-stent restenosis (ISR) in patients with prior coronary stent implantation who underwent coronary angiography (CAG) for chronic coronary syndrome (CCS).

Methods: In this retrospective case-control study, 802 patients who underwent CAG with suspected ISR were included. In-stent restenosis was defined as ≥50% stenosis within the stent or within 5 mm of its edges. Patients were divided into an ISR group (n = 342) and a control group without ISR (n = 460). Whole blood viscosity was calculated using both high-shear rate viscosity (HSR) and low-shear rate viscosity (LSR).

Results: Whole blood viscosity levels were significantly higher in the ISR group for both HSR (16.8 ± 1.0 vs. 15.6 ± 0.9 cP, P < .001) and LSR (83.1 ± 8.4 vs. 80.8 ± 8.0 cP, P < .001). Receiver-operating characteristic curve (ROC) analysis showed strong predictive power for ISR (area under the curve [AUC] 0.84 for LSR and 0.82 for HSR). Kaplan-Meier analysis demonstrated significantly lower ISR-free survival in patients with high WBV (P < .001). Multivariate Cox regression identified both HSR and LSR as independent predictors of ISR.

Conclusion: Increased WBV is independently linked to ISR and may contribute to its development via endothelial inflammation and vascular remodeling. Whole blood viscosity demonstrates potential utility as a biomarker for the identification of CCS patients susceptible to ISR.

Abstract Image

查看原文本刊更多论文

评价全血粘度预测冠状动脉疾病患者支架再狭窄。

背景：本研究探讨冠脉支架植入术后行冠脉造影（CAG）治疗慢性冠脉综合征（CCS）患者全血粘度（WBV）与支架内再狭窄（ISR）的关系。方法：本回顾性病例对照研究纳入802例疑似ISR的CAG患者。支架内再狭窄定义为支架内或支架边缘5mm内狭窄≥50%。将患者分为ISR组（n = 342）和无ISR组（n = 460）。采用高剪切速率粘度（HSR）和低剪切速率粘度（LSR）计算全血粘度。结果：ISR组HSR（16.8±1.0比15.6±0.9 cP, P < 0.001）和LSR（83.1±8.4比80.8±8.0 cP, P < 0.001）全血黏度水平均显著高于ISR组。受试者-工作特征曲线（ROC）分析显示对ISR有很强的预测能力（LSR的曲线下面积[AUC]为0.84，HSR为0.82）。Kaplan-Meier分析显示，高WBV患者的无isr生存率显著降低（P < 0.001）。多因素Cox回归发现，HSR和LSR是ISR的独立预测因子。结论：WBV增加与ISR独立相关，并可能通过内皮炎症和血管重构促进其发展。全血黏度作为鉴别CCS患者易患ISR的生物标志物具有潜在的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Anatolian Journal of Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.30

自引率

7.70%

发文量

270

审稿时长

12 weeks

期刊介绍： The Anatolian Journal of Cardiology is an international monthly periodical on cardiology published on independent, unbiased, double-blinded and peer-review principles. The journal’s publication language is English. The Anatolian Journal of Cardiology aims to publish qualified and original clinical, experimental and basic research on cardiology at the international level. The journal’s scope also covers editorial comments, reviews of innovations in medical education and practice, case reports, original images, scientific letters, educational articles, letters to the editor, articles on publication ethics, diagnostic puzzles, and issues in social cardiology. The target readership includes academic members, specialists, residents, and general practitioners working in the fields of adult cardiology, pediatric cardiology, cardiovascular surgery and internal medicine.