Anatolian Journal of Cardiology最新文献

{"title":"Association Between Triglyceride-Glucose Index and Prognosis of Patients with Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction.","authors":"Lei Liu, Yi Zheng, Huihui Ma, Qian Liao, Ming Jiang Liu, Hongqiang Ren, Gary Tse, Ligang Ding, Wei Hua, Tong Liu, Xiaoping Li","doi":"10.14744/AnatolJCardiol.2025.5240","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5240","url":null,"abstract":"<p><strong>Background: </strong>The value of the triglyceride-glucose (TyG) index for predicting the prognosis in patients with hypertrophic cardiomyopathy (HCM) and heart failure with preserved ejection fraction (HFpEF) remains unexplored.</p><p><strong>Methods: </strong>Patients from 15 centers were included. The primary outcome was all-cause mortality. The secondary outcomes were cardiovascular mortality and sudden cardiac death (SCD). Restricted cubic spline analyses, multivariate Cox regression analyses, competing risk models, subgroup and mediation analyses were used to assess the relationship between the TyG index and outcomes.</p><p><strong>Results: </strong>A total of 1095 patients with HCM and HFpEF were included. During a median follow-up period of 69 months, 224 all-cause deaths, 142 cardiovascular deaths, and 56 SCDs occurred. Multivariable Cox regression showed that the highest TyG index quartile was associated with a lower incidence of all-cause (hazard ratio (HR) 0.74, 95% CI 0.56-0.99, P = .046) and cardiovascular mortality (HR 0.65, 95% CI 0.44-0.94, P = .024) compared to the lowest quartile. However, no significant association was found between the TyG index and SCD (HR 0.74, 95% CI 0.41-1.31, P = 0.300). The competing risk model confirmed a significant association between the TyG index and reduced cardiovascular mortality (HR, 0.56; 95%CI, 0.40-0.78, P = .001) but no significant association with SCD (HR, 0.69; 95% CI, 0.37-1.27, P = .230). Mediation analyses indicated N-terminal pro-B-type natriuretic peptide mediated the association between TyG index and cardiovascular survival, while serum creatinine had a suppression effect.</p><p><strong>Conclusion: </strong>A higher TyG index was associated with lower risks of all-cause and cardiovascular mortality but with no significant influence on SCD risk in patients with HCM and HFpEF.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Gut to Heart: Mendelian Randomization Study Reveals the Causal Relationship Between Gut Microbiota and N-Terminal Pro-B-Type Natriuretic Peptide.","authors":"Yingmei Wang, Jie Zheng, Junpeng Zhao, Yuhong Yao, Dongxue Gao, Wenjie Qi, Yanhong Liu, Jinyin Yan","doi":"10.14744/AnatolJCardiol.2025.5200","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5200","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to clarify the potential causal relationship between gut microbiota (GM) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Genome-wide association study of intestinal flora and NT-proBNP was conducted, and the instrumental variables (IVs) were screened out to assess the causal association between intestinal flora and NT-proBNP. The 2-sample MR analysis was performed using the inverse variance weighted (IVW), MR-Egger, weighted model and simple model methods, respectively, to assess the causal association between intestinal flora and NT-proBNP using the odds ratio. Sensitivity analyses were also performed using the leave-one-out method and MR-Egger intercept test. The MR-PRESSO global test was used to detect horizontal pleiotropy, and Cochran Q was used to detect heterogeneity. Finally, forest plots, scatter plots, and funnel plots of the IVs were generated.</p><p><strong>Results: </strong>Based on the IVW method, a total of 9 out of 104 GM genera were identified as causally associated with NT-proBNP levels (P < .05). The genera Holdemanella (β = -0.19, 95% CI: -0.36 to -0.01, P = .037), Coprococcus 2 (β = -0.27, 95% CI: -0.54 to 0.00, P = .047), Ruminococcaceae UCG 004 (β = -0.23, 95% CI: -0.45 to -0.02, P = .032), and Alistipes (β = -0.29, 95% CI: -0.55 to -0.03, P = .031) were negatively associated with NT-proBNP; genera Actinomyces (β = 0.22, 95% CI: 0.01-0.44, P = .042), Lachnospiraceae UCG 008 (β = 0.27, 95% CI: 0.1-0.44, P = .002), Eubacterium fissicatena group (β = 0.17, 95%CI: 0.01-0.32, P = .033), Eubacterium rectale group (β = 0.40, 95% CI: 0.13-0.67, P = .003), and Eubacterium ventriosum group (β = 0.26, 95% CI: 0.02-0.49, P = .032) were positively associated with NT-proBNP. In addition, the results of the sensitivity analysis of the leave-one-out method were stable, there was no horizontal multiplicity in the MR-Egger intercept test and the MR-PRESSO global test, and there was no heterogeneity in the Cochran Q-test.</p><p><strong>Conclusions: </strong>The study found the causal relationship between GM and NT-proBNP. As a clinical predictor of heart failure, NT-proBNP levels could potentially be modulated through clinical interventions involving GM, further reducing the risk of heart failure.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's Representation in Interventional Cardiology and Other Interventional Fields: Opportunities and Challenges.","authors":"Özge Çetinarslan, Şencan Acar, Işıl Yıldız Sönmez, Mehdi Zoghi","doi":"10.14744/AnatolJCardiol.2025.5249","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5249","url":null,"abstract":"<p><strong>Background: </strong>Gender disparities persist in procedure-intensive fields (interventional cardiology (IC), interventional radiology (IR), and interventional gastroenterology (IG)). Despite increasing gender balance in some medical specialties, interventional branches remain male-dominated, potentially limiting women's advancement. This study aimed to identify barriers, opportunities, and the impact of gender-based differences on practicing physicians in IC, IR, and IG in Türkiye, with the goal of informing policy and work-place reforms.</p><p><strong>Methods: </strong>The authors conducted a cross-sectional survey of 338 physicians (50% female) across 3 procedural specialties. Participants answered a 55-item electronic questionnaire that covering demographics, career satisfaction, professional conditions, and experienced challenges. The complete raw dataset is provided via an online link.</p><p><strong>Results: </strong>A total of 338 physicians from three procedural specialties responded (50% female overall). Women reported lower incomes, fewer mentorship opportunities, and more frequent workplace discrimination. Whereas men frequently cited \"wage suppression\" and \"long hours\" as deterrents, women underscored concerns about radiation exposure, emergency workloads, and gender bias. Although scientific productivity measures (e.g., publications) did not differ by gender, female respondents reported higher rates of emotional harassment and scheduling barriers (taking fewer annual leave days or attending fewer scientific events).</p><p><strong>Conclusion: </strong>Women's underrepresentation in interventional fields reflects systemic barriers, including perceived or real discrimination, physical demands, and limited structural support. Addressing these barriers, long or unpredictable work hours, radiation concerns, and workplace bias may foster a more inclusive environment. Institutional-level reforms and policy changes are essential to bridging gender gaps and improving retention in these critical specialties.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Guideline Recommendations and Clinical Outcomes of Different Stenting Techniques in Non-Left Main Bifurcation Lesions.","authors":"Serkan Kahraman, Muzaffer Değertekin, Can Yücel Karabay, Mehmet Akif Erdöl, Hasan Arı, Eser Durmaz, Ertuğrul Okuyan, Regayip Zehir, Ali Rıza Akyüz, Çağrı Yayla, İrfan Şahin, Cansu Ebren, Gökhan Demirci, Ahmet Güner, Yunus Emre Erata, Mustafa Ali Yavaş, Ahmet Göktuğ Ertem, Mustafa Azmi Sungur, Bilal Mete Ülker, Ahmet Ceyhun Cebeci, Ali Nural, Büşra Güvendi, Ahmet Oğuz Aslan, İshak Yılmaz, Ali Kemal Kalkan, Mehmet Ertürk","doi":"10.14744/AnatolJCardiol.2025.5258","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5258","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) for coronary bifurcation lesions (CBLs) is a challenging procedure. The optimal stenting technique is still debated. The importance of adherence to current guideline recommendations on clinical outcomes has not yet been clarified. The authors' aim is to investigate the impact of guideline recommendations on clinical outcomes in PCI of CBL.</p><p><strong>Methods: </strong>This was a retrospective, multicenter, observational registry that enrolled patients with true CBL undergoing PCI with provisional or 2-stent techniques. All techniques were evaluated according to the current guideline recommendations. The primary endpoint of the study was target lesion failure (TLF) as a composite endpoint of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI), and cardiac death.</p><p><strong>Results: </strong>A total of 1407 patients were enrolled, and the incidence of TLF, TLR, TVMI, and cardiac death were similar in provisional and 2-stent techniques. However, the incidence of TLF was higher in 2-stent (16.1%) compared to provisional (9.1%) if the guideline recommendations were not followed (HR:1.779; 95%CI: 1.187-2.668, P = .005). The incidence of TLF was lower in 2-stent (4.7%) compared to provisional (9.1%) if the guideline recommendations were followed (HR:0.501; 95% CI: 0.306-0.821, P = .005), mainly driven by reduced TLR (8.1% vs. 3.4%) (HR: 0.398; 95% CI: 0.228-0.696, P = .001) and TVMI (4.5% vs. 2.4%) (HR: 0.503; 95% CI: 0.250-1.011, P = .049).</p><p><strong>Conclusion: </strong>Adherence to current guideline recommendations is the main determinant of clinical outcomes in the PCI of CBLs rather than the selected techniques.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models in Intracardiac Electrogram Interpretation: A New Frontier in Cardiac Diagnostics for Pacemaker Patients.","authors":"Serdar Bozyel, Ahmet Berk Duman, Şadiye Nur Dalgıç, Abdülcebar Şipal, Faysal Şaylık, Şükriye Ebru Gölcük Önder, Metin Çağdaş, Tümer Erdem Güler, Tolga Aksu, Ulas Bağcı, Nurgül Keser","doi":"10.14744/AnatolJCardiol.2025.5238","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5238","url":null,"abstract":"<p><strong>Background: </strong>Interpreting intracardiac electrograms (EGMs) requires expertise that many cardiologists lack. Artificial intelligence models like ChatGPT-4o may improve diagnostic accuracy. This study evaluates ChatGPT-4o's performance in EGM interpretation across 4 scenarios (A-D) with increasing contextual information.</p><p><strong>Methods: </strong>Twenty EGM cases from The EHRA Book of Pacemaker, ICD, and CRT Troubleshooting were analyzed using ChatGPT-4o. Ten predefined features were assessed in Scenarios A and B, while Scenarios C and D required 20 correct responses per scenario across all cases. Performance was evaluated over 2 months using McNemar's test, Cohen's Kappa, and Prevalence- and Bias-Adjusted Kappa (PABAK).</p><p><strong>Results: </strong>Providing clinical context enhanced ChatGPT-4o's accuracy, improving from 57% (Scenario A) to 66% (Scenario B). \"No Answer\" rates decreased from 19.5% to 8%, while false responses increased from 8.5% to 11%, suggesting occasional misinterpretation. Agreement in Scenario A showed high reliability for atrial activity (κ = 0.7) and synchronization (κ = 0.7), but poor for chamber (κ = -0.26). In Scenario B, understanding achieved near-perfect agreement (Prevalence-Adjustment and Bias-Adjustment Kappa (PABAK) = 1), while ventricular activity remained unreliable (κ = -0.11). In Scenarios C (30%) and D (25%), accuracy was lower, and agreement between baseline and second-month responses remained fair (κ = 0.285 and 0.3, respectively), indicating limited consistency in complex decision-making tasks.</p><p><strong>Conclusion: </strong>This study provides the first systematic evaluation of ChatGPT-4o in EGM interpretation, demonstrating promising accuracy and reliability in structured tasks. While the model integrated contextual data well, its adaptability to complex cases was limited. Further optimization and validation are needed before clinical use.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of Traditional Chinese Medicine Nursing Care in Cardiovascular Patients.","authors":"Danhua Xu, Yuehao Lu, Ping Xu, Liang Yin, Jiaxin Zhao, Ya Hou","doi":"10.14744/AnatolJCardiol.2025.5091","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5091","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to probe the clinical effect of traditional Chinese medicine (TCM) nursing care in cardiovascular patients.</p><p><strong>Methods: </strong>A total of 120 patients with cardiovascular disease were randomized into a control group (n = 60) as well as a research group (n = 60). Patients in the control group received routine nursing care. Patients in the research group accepted TCM nursing care. The Hamilton Depression Scale, Hamilton Anxiety Scale, and SF-36 scores, sleep quality, occurrence of complications, as well as patients' satisfaction in both groups were compared.</p><p><strong>Results: </strong>Hamilton Depression Scale, Hamilton Anxiety Scale, and Short Form-36 Health Survey (SF-36) scores of both groups showed no significance before nursing care (P = .907 and P = .962). Hamilton Anxiety Scale and HAMD scores of the research group were lower relative to the control group after nursing care (P < .001). SF-36 scores in the research group compared to the control group were elevated after nursing care (P = .000). Total sleep quality scores in the research group were lower relative to the control group (P < .001). The incidence of complications in the research group was lessened relative to the control group (P = .013). The patients' satisfaction in the research group was elevated relative to the control group (P = .003).</p><p><strong>Conclusion: </strong>The use of TCM nursing care in patients with cardiovascular diseases can significantly relieve patients' negative emotions, improve patients' quality of life as well as sleep quality, reduce the incidence of complications, and have certain clinical application value.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Selection Bias and Risk Factors in COVID-19 and CAD Research: Critical Considerations.","authors":"Yusuf Hoşoğlu, Ayşe Hoşoğlu","doi":"10.14744/AnatolJCardiol.2025.5443","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5443","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Anatomical Variant of Adolescent Persistent Truncus Arteriosus: Multimodal Imaging-Guided Surgical Strategy and Outcome.","authors":"Jie Wang, Ping Hu, Xiao-Jing Ma","doi":"10.14744/AnatolJCardiol.2025.5445","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5445","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor: \"Tricuspid Regurgitation Worsening After Pericardiectomy in Tuberculosis Constrictive Pericarditis: An Overlooked Prognostic Concern\".","authors":"Shuzhen Wang, Jing Guo, Kunyue Tan, Lijuan Zhang, Shuangshuang Yan, Li Zhang, Wei Wang, Qiuyi Cai, Feng Xiong","doi":"10.14744/AnatolJCardiol.2025.5469","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5469","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality Imaging of a Rare Case: Coexistence of Left Circumflex Artery Aneurysm and Coronary-Cameral Fistula.","authors":"Uğur Nadir Karakulak, Necla Özer","doi":"10.14744/AnatolJCardiol.2025.5492","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5492","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}