Anatolian Journal of Cardiology最新文献

{"title":"T1 Mapping In Differentiating Healthy And Pathological Myocardium.","authors":"Sena Bozer Uludağ, Sena Ünal, Elif Peker, Çağlar Uzun","doi":"10.14744/AnatolJCardiol.2026.6183","DOIUrl":"10.14744/AnatolJCardiol.2026.6183","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify the optimal measurement location and technique for native T1 mapping to establish a standardized approach. We evaluated the diagnostic performance of various T1 mapping measurement approaches by comparing non-ischemic dilated cardiomyopathy (NIDCM) and hypertrophic cardiomyopathy (HCM) cohorts with a control group.</p><p><strong>Methods: </strong>We retrospectively reviewed patients who underwent 1.5T cardiac magnetic resonance (CMR) with standardized protocol functional sequences, T1 mapping, and late gadolinium enhancement (LGE) between November 2016 and January 2023. A total of 143 subjects (61 NIDCM, 60 HCM, and 22 controls) were grouped based on CMR findings. Native T1 mapping images were acquired in basal, midventricular, and apical short-axis slices. Regions of interest were drawn in both the whole left ventricular myocardium (SAX) and the interventricular septum. Diagnostic yield and optimal cut-off values for native T1 were investigated.</p><p><strong>Results: </strong>Native T1 values were significantly higher than the control group for six different measurement approaches (p<0.05). Basal SAX and basal septal measurements provided the highest diagnostic accuracy values for both groups. Statistical analysis revealed that T1 values could differentiate between healthy and diseased myocardium, with a diagnostic accuracy of 86% for NIDCM and 73.4% for HCM. Furthermore, T1 values correlated with measures of global systolic function and left ventricular remodeling.</p><p><strong>Conclusion: </strong>Our study shows that native T1 mapping using a streamlined single-slice acquisition with a septal measurement technique achieves diagnostic performance comparable to multi-slice protocols while reducing measurement heterogeneity. This optimization facilitates a time-efficient workflow and improves patient comfort without compromising diagnostic accuracy.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13276478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations Regarding the Combined Use of Erectile Dysfunction and Frontal QRS-T Angle for Predicting Coronary Artery Disease Severity.","authors":"Burak Oymak","doi":"10.14744/AnatolJCardiol.2026.6364","DOIUrl":"10.14744/AnatolJCardiol.2026.6364","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor: \"Methodological Considerations Regarding the Combined Use of Erectile Dysfunction and Frontal QRS-T Angle for Predicting Coronary Artery Disease Severity\".","authors":"Pınar Özmen Yıldız, Mert Hamza Özbilen","doi":"10.14744/AnatolJCardiol.2026.6473","DOIUrl":"10.14744/AnatolJCardiol.2026.6473","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Perforation During Percutaneous Coronary Intervention: A Two-Center Real-World Case Series and Review of Management Strategies.","authors":"Fahrettin Turna, Asım Enhoş, Oğuzhan Abanoz, Mehmet Şirin Yıldız, Mahmut Uluganyan","doi":"10.14744/AnatolJCardiol.2026.6160","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6160","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery perforation (CAP) is a rare life-threatening complication of percutaneous coronary intervention (PCI). Although several risk factors for CAP have been described, real-world multicenter studies analyzing the clinical outcomes remain limited. This study presents a comprehensive 2-center evaluation of CAP, focusing on angiographic severity, management strategies, and short- and long-term outcomes.</p><p><strong>Methods: </strong>In this study, patients of CAP were included and perforations were classified according to the Ellis system. Primary outcomes were procedural success, cardiac tamponade, pericardiocentesis, cardiogenic shock, and 30-day mortality. Secondary outcomes were late mortality and ejection fraction at the end of first month.</p><p><strong>Results: </strong>Totally, 53 cases of CAP were identified. Ten patients had Ellis grade I, 30 patients had grade II, and 13 patients had grade III perforations. The rate of successful procedure was 100% in grade I, 90% in grade II, and 30.8% in grade III (P < .001). Hemodynamic compromise was observed predominantly in grade III perforations. Early mortality occurred in 7 patients (13.2%) and was strongly associated with severe Ellis grades (P < .001). Late mortality occurred in 5 patients (9.4%), and chronic renal insufficiency was identified as a significant predictor of mortality (P = .018). Ejection fraction was significantly lower in grade III perforations at the end of first month (P = .005).</p><p><strong>Conclusion: </strong>Increasing Ellis grade was strongly associated with procedural failure, hemodynamic instability, and early mortality, whereas late outcomes were predominantly influenced by systemic comorbidities rather than the severity of perforation. These findings underscore the importance of prompt intraprocedural management and comprehensive post-discharge care in patients with CAP.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric Acid-to-High-Density Lipoprotein Cholesterol Ratio and Coronary Slow Flow: An Integrative Marker of Microvascular Dysfunction.","authors":"Ramazan Astan, Eyyüp Erkiz, Erdoğan İlkay","doi":"10.14744/AnatolJCardiol.2026.6173","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6173","url":null,"abstract":"<p><strong>Background: </strong>Coronary slow flow (CSF) is an angiographic finding characterized by delayed distal vessel opacification despite normal epicardial coronary arteries. Its pathophysiology is multifactorial and involves microvascular dysfunction, endothelial impairment, and chronic inflammation. The uric acid-to-high-density lipoprotein (HDL) cholesterol ratio (UHR) has recently emerged as a novel composite biomarker reflecting both pro-oxidant and anti-inflammatory balance. This study aimed to evaluate the relationship between UHR and CSF.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, 218 patients with normal or near-normal coronary arteries on angiography were analyzed. Patients were divided into 2 groups according to the presence of CSF based on thrombolysis in myocardial infarction (TIMI) frame count. Demographic, clinical, and laboratory parameters were compared between groups. Receiver operating characteristic (ROC) analysis was used to determine the discriminatory performance of UHR, and multiple logistic regression was performed to identify independent predictors of CSF.</p><p><strong>Results: </strong>The mean UHR value was significantly higher in the CSF group compared with the control group (0.13 ± 0.04 vs. 0.09 ± 0.04, P < .001). Receiver operating characteristic analysis demonstrated that a UHR cut-off >0.107 predicted CSF with moderate discriminatory ability (area under the curve (AUC) = 0.733, 95% CI: 0.66-0.79, P < .001), with 73.5% sensitivity and 76.2% specificity. Multiple analyses suggested that UHR was independently associated with CSF (OR 1.20 per 0.01-unit increase, 95% CI 1.09-1.31, P < .001).</p><p><strong>Conclusion: </strong>Elevated UHR was independently associated with CSF and may represent a readily available biomarker reflecting the metabolic-inflammatory balance contributing to coronary microvascular dysfunction. These findings should be interpreted as associative and hypothesis-generating.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Electrophysiological Assessment of Peripheral Nerve Function After Transradial Angiography: A Prospective Study.","authors":"Taner Dandinoğlu, Hüseyin Kozan, Altuğ Güner, Olgun Deniz, Erkan Kaya","doi":"10.14744/AnatolJCardiol.2026.6273","DOIUrl":"10.14744/AnatolJCardiol.2026.6273","url":null,"abstract":"<p><strong>Background: </strong>Transradial angiography (TRA) is widely used in contemporary coronary procedures. Although clinically apparent peripheral nerve injury after TRA is uncommon, subclinical nerve involvement may go unrecognized. This study aimed to objectively assess peripheral nerve function after TRA using neurological examination, standardized neuropathic pain questionnaires, and nerve conduction studies (NCS).</p><p><strong>Methods: </strong>This prospective, single-center observational study included consecutive patients undergoing transradial coronary angiography. A total of 107 patients were analyzed. Neurological examination was performed within 24-48 hours after the procedure. Neuropathic symptoms were evaluated using the Douleur Neuropathique en 4 (DN4) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) questionnaires. Bilateral nerve conduction studies of the median, ulnar, and radial nerves were performed 1 month after TRA, and side-to-side comparisons were conducted.</p><p><strong>Results: </strong>Side-to-side differences were observed in selected nerve conduction parameters. These electrophysiological changes predominantly involved the radial nerve on the procedure side, characterized by lower sensory amplitude, reduced conduction velocity, and decreased motor amplitude (P < .05). Median and ulnar nerve conduction findings were largely comparable between sides. Douleur Neuropathique en 4 and LANSS scores were in normal ranges and not associated with nerve conduction parameters. No clinically evident local or neurological complications were detected during follow-up.</p><p><strong>Conclusion: </strong>Transradial angiography may be associated with mild, procedure-side predominant radial nerve conduction changes detectable by NCS, without clinically evident neuropathy. Objective electrophysiological assessment may therefore help identify underrecognized subclinical nerve involvement following TRA.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor: \"Stiffness or Reflection? A Critical Appraisal of Energy Drink Induced Vascular Changes\".","authors":"Salim Yaşar, Muhammed Geneş, Özkan Eravcı, Ahmet Arslan, Hülya Şirin, Suat Görmel, Serdar Fırtına, Mehmet Sadık Karpat, Cem Barçın, Murat Çelik","doi":"10.14744/AnatolJCardiol.2026.6399","DOIUrl":"10.14744/AnatolJCardiol.2026.6399","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Association Between Apical Periodontitis and Cardiovascular Disease: A Narrative Review of Evidence and Clinical Implications.","authors":"Yiyun Liang, Xuan Chen, Xiaoxia Yang, Lei Huang, Xiaxue Chen, Xiaoling Qiu","doi":"10.14744/AnatolJCardiol.2026.6298","DOIUrl":"10.14744/AnatolJCardiol.2026.6298","url":null,"abstract":"<p><p>Apical periodontitis (AP) affects 52% of adults globally, yet its systemic cardiovascu-lar implications remain understudied compared to periodontal disease. This narrative review synthesizes current evidence on the potential bidirectional association between apical periodontitis and cardiovascular disease (CVD), examining proposed mechanistic pathways and clinical implications. A comprehensive literature search was conducted using PubMed, Web of Science, and Scopus databases, including clinical studies, animal models, and mechanistic investigations. Epidemiological evidence suggests that patients with apical periodontitis have a 1.38-5.3 times higher risk of cardiovascular disease com-pared to controls. Three major pathways are proposed to explain the potential link from apical periodontitis to cardiovascular disease: bacterial translocation through oral-gut axis disruption, systemic inflammation characterized by elevated interleukin-1β, inter-leukin-6, tumor necrosis factor-α, and C-reactive protein, and oxidative stress-induced endothelial dysfunction. Conversely, emerging evidence indicates that cardiovascular disease accelerates periapical lesion progression through RANKL/RANK/OPG pathway dysregulation, microcirculatory compromise, and enhanced macrophage M1 polariza-tion. Root canal treatment significantly reduces systemic inflammatory markers with parallel improvements in flow-mediated dilation, suggesting a potential cardiovascular benefit. While substantial evidence supports bidirectional associations, definitive causal relationships require prospective validation through large-scale cohort studies and ran-domized controlled trials examining whether endodontic intervention reduces cardiovas-cular event rates.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13276470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor: \"Remarkable Indices in Predicting Atherosclerotic Cardiovascular Disease\".","authors":"Xuecheng Song, Xinghong Lin, Xin Xu, Yongming He","doi":"10.14744/AnatolJCardiol.2026.6181","DOIUrl":"10.14744/AnatolJCardiol.2026.6181","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lp(a), Artificial Intelligence, Hypertrophic Cardiomyopathy….","authors":"Çetin Erol","doi":"10.14744/AnatolJCardiol.2026.5","DOIUrl":"10.14744/AnatolJCardiol.2026.5","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":"30 5","pages":"285"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}