Anatolian Journal of Cardiology最新文献_第2页

The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease. 参与冠状动脉疾病和肺动脉高压的共同致病靶基因 CNTN1 具有诊断冠状动脉疾病的潜力。

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-08-01 DOI: 10.14744/AnatolJCardiol.2024.4331

Kun Cheng, Qixuan Zhai, Jieqiong Song, Bing Liu

{"title":"The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease.","authors":"Kun Cheng, Qixuan Zhai, Jieqiong Song, Bing Liu","doi":"10.14744/AnatolJCardiol.2024.4331","DOIUrl":"10.14744/AnatolJCardiol.2024.4331","url":null,"abstract":"Background: We aimed to find a gene for coronary artery disease (CAD) early diagnosis by detecting co-pathogenic target gene involved in CAD and pulmonary arterial hypertension (PAH).  Methods: Datasets were obtained from the Gene Expression Omnibus (GEO) database, including GSE113079, GSE113439, and GSE12288, to investigate gene expression patterns in cardiovascular diseases. Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify gene modules associated with clinical traits. Differential gene expression analysis and functional enrichment analysis were carried out. Protein-protein interaction (PPI) networks were constructed. JASPAR database and FIMO tool were utilized to predict transcription factor (TF) binding sites.  Results: Fifteen key genes were identified in CAD and PAH, with CNTN1 being prioritized for further investigation due to its high connectivity degree. Upstream regulation analysis identified potential TFs (DRGX, HOXD3, and RAX) and 7 miRNAs targeting CNTN1. The expression profile of CNTN1 was significantly upregulated in CAD samples, and ROC analysis indicated potential diagnostic value for CAD. CMap database analysis predicted potential targeted drugs for CAD.  Conclusion: CNTN1 was detected as a co-pathogenetic gene for CAD and PAH. It is highly expressed in CAD patients and has potential value for CAD diagnosis. CNTN1 is potentially regulated by 3 TFs and 7 miRNAs.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atherosclerosis Reviewed. 动脉粥样硬化回顾。

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-08-01 DOI: 10.14744/AnatolJCardiol.2024.8

Çetin Erol

引用次数: 0

Can Distal Radial Access Replace Conventional Radial Access for Coronary Catheterization? A Study Comparing Puncture Time, Attempts, Patient and Operator Comfort. 桡动脉远端入路能否取代冠状动脉导管术的传统桡动脉入路？一项比较穿刺时间、尝试次数、患者和操作者舒适度的研究。

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-24 DOI: 10.14744/AnatolJCardiol.2024.4363

Kanhai Lalani, Tom Devasia, Ganesh Paramasivam

{"title":"Can Distal Radial Access Replace Conventional Radial Access for Coronary Catheterization? A Study Comparing Puncture Time, Attempts, Patient and Operator Comfort.","authors":"Kanhai Lalani, Tom Devasia, Ganesh Paramasivam","doi":"10.14744/AnatolJCardiol.2024.4363","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2024.4363","url":null,"abstract":"Background: To compare distal (dTRA) and classical (cTRA) transradial approaches for coronary catheterization with respect to puncture attempts, puncture time, operator and patient comfort, and safety outcomes.Methods: In this prospective observational study, patients undergoing coronary catheterization for standard indications via dTRA or cTRA approaches from July 2019 to May 2020 were included. Clinicodemographic and laboratory characteristics were recorded. Puncture time, number of puncture attempts, operator and patient comfort on the visual analogue scale (VAS), and access site complications like hematoma and radial artery occlusion were recorded. Patients were analyzed in the same group as the initial puncture, even if there was a cross-over.Results: Of the 130 patients (40.8% women), 50.8% and 49.2% belonged to dTRA and cTRA groups, respectively. dTRA group required more than one puncture attempt more frequently than cTRA group (30.3% vs. 15.6%; P =.047); consequently, puncture time was longer (60s vs. 50s; P =.031, respectively). However, puncture time was comparable if the puncture was successful in the first attempt (47.5s vs. 45s; P =.492). Patient comfort was comparable (7.2 ± 0.9 vs. 7.2 ± 1.2; P =.852), but operator comfort was more with cTRA approach (8.3 ± 1.6 vs. 8.8 ± 1.2; P =.048). Post-procedure, cTRA had more minor bleeding than dTRA approach. There was no major bleeding in either group. The occurrence of radial artery occlusion was comparable in both groups.Conclusion: Although dTRA needed more attempts for successful puncture, puncture time was comparable with cTRA when puncture was successful on the first attempt. Therefore, one attempt at dTRA puncture could be a reasonable approach in patients undergoing coronary catheterization.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Everolimus Eluting Stent-induced Early Giant Multiple Coronary Artery Aneurysm Formation. 依维莫司洗脱支架诱发早期巨大多发性冠状动脉动脉瘤形成

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-23 DOI: 10.14744/AnatolJCardiol.2024.4623

Murat Akçay, Metin Çoksevim

引用次数: 0

The Interplay of Atherothrombotic Factors and the Evolving Landscape of Atherosclerotic Cardiovascular Disease: Comprehensive Insights from Recent Studies. 动脉粥样硬化性血栓形成因素的相互作用与动脉粥样硬化性心血管疾病的演变：最新研究的全面见解

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-16 DOI: 10.14744/AnatolJCardiol.2024.4632

Jamilah Alrahimi, Fatima Ali Ahmed, Dan Atar

{"title":"The Interplay of Atherothrombotic Factors and the Evolving Landscape of Atherosclerotic Cardiovascular Disease: Comprehensive Insights from Recent Studies.","authors":"Jamilah Alrahimi, Fatima Ali Ahmed, Dan Atar","doi":"10.14744/AnatolJCardiol.2024.4632","DOIUrl":"10.14744/AnatolJCardiol.2024.4632","url":null,"abstract":"The aim of the current work is to present a thorough recapitulation of the emerging understanding of atherosclerotic cardiovascular disease and recommending avenues for future studies. Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, influenced by a complex interplay of genetic, environmental, and atherothrombotic factors. Atherosclerosis, a multifaceted and dynamic process, is at the core of many CVDs. Recent studies have shed light on the multilayered nature of atherosclerosis and cardiovascular risk, emphasizing the need for a nuanced understanding of these diseases across different populations and disease mechanisms. This review synthesizes findings from 6 pivotal studies, shedding light on the intricate mechanisms underlying atherosclerotic cardiovascular events, the evolving understanding of atherosclerosis, and the potential pathways to attempt implementation in clinical practice. Insights into atherothrombotic factors, the role of macrophages, and the implications of aortic enlargement and coronary artery calcification underscore the complexity of CVD pathogenesis and highlight the need for comprehensive strategies in diagnosis, treatment, and prevention.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Renal Denervation on Gap Junction in High-Pacing-Induced Heart Failure Dogs. 肾脏去神经对高剂量诱导型心力衰竭犬间隙连接的影响

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-16 DOI: 10.14744/AnatolJCardiol.2024.3871

Xiaoyan Liang, Shuai Shang, Zechen Bai, Qing Wang, Yongqiang Fan, Jiasuoer Xiaokereti, Huasheng Lv, Xianhui Zhou, Yanmei Lu, Baopeng Tang

{"title":"Effects of Renal Denervation on Gap Junction in High-Pacing-Induced Heart Failure Dogs.","authors":"Xiaoyan Liang, Shuai Shang, Zechen Bai, Qing Wang, Yongqiang Fan, Jiasuoer Xiaokereti, Huasheng Lv, Xianhui Zhou, Yanmei Lu, Baopeng Tang","doi":"10.14744/AnatolJCardiol.2024.3871","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2024.3871","url":null,"abstract":"Background: Gap junction remodeling is an important cause of ventricular arrhythmia in heart failure. However, it remains unclear whether renal denervation (RDN) regulates gap junction remodeling in heart failure. To explore the effect of RDN on gap junction remodeling in dogs with high-pacing-induced heart failure.Methods: Fifteen dogs were randomly divided into control (n = 5), heart failure (HF) (n = 5), and RDN+HF (n = 5) group. A high-pacing-induced-heart failure model was established using rapid right ventricular pacing for 4 weeks. The RDN+HF group underwent surgical and chemical ablation of both renal arteries before 4 weeks rapid right ventricular pacing. After 4 weeks, echocardiography, High-Performance Liquid Chromatography-Mass Spectrometry test for norepinephrine and epinephrine, and pathological analysis were performed in the above 3 groups. Further, immunohistochemical staining was used to detect tyrosine hydroxylase, ChaT, connexin 43 (Cx43), and connexin 40 (Cx40). Connexin 43 and Cx40 expression was detected by western blotting. Transmission electron microscopy was used to observe the gap junction.Results: Compared to the control group, myocardial fibrosis and sympathetic hyperactivity were observed in the HF group. Immunohistochemical staining and western blotting showed that Cx40 expression and Cx43 expression was significantly reduced in the HF group. Compared with the HF group, the RDN+HF group showed reduced sympathetic hyperactivity, Cx40 expression, Cx40/Cx43 ratio, and increased Cx43 expression.Conclusion: Renal denervation alleviates gap junction remodeling in high-pacing-induced heart failure dogs.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiol/Disulfide Homeostasis: A New Oxidative Marker in Heart Failure Patients with Preserved Ejection Fraction. 硫醇/二硫化物平衡：保留射血分数的心力衰竭患者的新氧化标志物

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-12 DOI: 10.14744/AnatolJCardiol.2024.4187

Zeynep Şeyma Turinay Ertop, Abdullah Nabi Aslan, Salim Neşelioğlu, Tahir Durmaz

{"title":"Thiol/Disulfide Homeostasis: A New Oxidative Marker in Heart Failure Patients with Preserved Ejection Fraction.","authors":"Zeynep Şeyma Turinay Ertop, Abdullah Nabi Aslan, Salim Neşelioğlu, Tahir Durmaz","doi":"10.14744/AnatolJCardiol.2024.4187","DOIUrl":"10.14744/AnatolJCardiol.2024.4187","url":null,"abstract":"Background: It is suggested that myocardial dysfunction in heart failure patients may result from increased oxidative stress-related membrane changes. Thiol/disulfide homeostasis is a new oxidative stress indicator. The aim of this study was to evaluate serum thiol levels and thiol/disulfide homeostasis in patients with heart failure with preserved ejection fraction (HFpEF).Methods: Eighty-four overweight patients who applied to our clinic between November 2016 and February 2018 and diagnosed with hypertension and left ventricule concentric hypertrophy with normal systolic function are included in the study. Forty-two patients who were asymptomatic and had normal N terminal pro-B type natriuretic peptide (NT-proBNP) levels (≤125) were in the control group. Forty-two patients who have cardiac failure symptoms and have high NT-roBNP levels (>125) were in the patient group.Results: Native thiol, total thiol, and disulfide values of the patient group are found to be significantly lower than the control group (P =.001; P <.001; P =.041 respectively). There is a statictically significant negative correlation between native thiol, total thiol values, and NT-proBNP. There is a statictically significant negative correlation between native thiol, total thiol values, and carbohydrate antigen 125 (CA-125) values.Conclusion: As far as we know from literature, this is the first study on HFpEF and thiol/disulfide homeostasis. It is found that native, total thiol, and disulfide values are low in HFpEF patients and that there is a negative correlation between native, total thiol values and NT-proBNP, CA-125 values. It can be said that oxidant/antioxidant balance is impaired in patients with HFpEF and that larger, randomized studies are needed in order to use oxidant/antioxidant balance in diagnosis and treatment of HFpEF.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Letter to the Editor: 'Large Language Models: Could They Be the Next Generation of Clinical Decision Support Systems in Cardiovascular Diseases?' 回复致编辑的信："大型语言模型：它们能否成为心血管疾病临床决策支持系统的下一代？

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-01 DOI: 10.14744/AnatolJCardiol.2024.4471

Serdar Bozyel, Evrim Şimşek, Duygu Koçyiğit Burunkaya, Arda Güler, Yetkin Korkmaz, Mehmet Şeker, Mehmet Ertürk, Nurgül Keser

引用次数: 0

Pyroptosis Apoptosis, Radial Artery Angiography…. 裂解凋亡、桡动脉血管造影....

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-01 DOI: 10.14744/AnatolJCardiol.2024.7

Çetin Erol

引用次数: 0

Renal Denervation Ameliorates Cardiomyocyte Apoptosis in Myocardial Ischemia-Reperfusion Injury Through Regulating Mitochondria-Endoplasmic Reticulum Contact. 肾脏去神经通过调节线粒体-内质网接触改善心肌缺血再灌注损伤中的心肌细胞凋亡

IF 1.4 4区医学

Anatolian Journal of Cardiology Pub Date : 2024-07-01 DOI: 10.14744/AnatolJCardiol.2024.3579

Zheng Zhao, Faquan Li, Yiyao Jiang, Chengzhi Lu

{"title":"Renal Denervation Ameliorates Cardiomyocyte Apoptosis in Myocardial Ischemia-Reperfusion Injury Through Regulating Mitochondria-Endoplasmic Reticulum Contact.","authors":"Zheng Zhao, Faquan Li, Yiyao Jiang, Chengzhi Lu","doi":"10.14744/AnatolJCardiol.2024.3579","DOIUrl":"10.14744/AnatolJCardiol.2024.3579","url":null,"abstract":"Background: Myocardial ischemia-reperfusion injury (I/R) has been improved with drugs and effective reperfusion, but it still cannot be prevented.Methods: To investigate whether renal denervation (RDN) reduces cardiomyocyte apoptosis by ameliorating endoplasmic reticulum stress, 60 male specific pathogen-free (SPF) Wistar rats were randomly divided into 6 groups (n = 6). We established the I/R rat model by ligating the left anterior descending artery. The I/R+ angiotensin receptor neprilysin inhibitors (ARNI) group received ARNIs for 2 weeks until euthanasia.Results: The I/R+RDN and I/R+ARNI groups have significantly ameliorated left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) and reversed expansion of the left ventricular end-systolic diameter (LVSD) and left ventricular end diastolic diameter (LVDD) compared to the I/R group. The levels of norepinephrine (NE), angiotensin II, and aldosterone (ALD) increased significantly in the I/R group, but decreased significantly after RDN and ARNI intervention. In the I/R+RDN and I/R+ARNI groups, the myocardial tissue edema was alleviated. The infarct size was smaller in the I/R+RDN and I/R+ARNI groups compared to the I/R group. Apoptosis of cardiomyocytes and fibroblasts in myocardial tissue increased significantly in the I/R group, which was greatly diminished by RDN and ARNI. The expression of Bax, caspase-3, CHOP, PERK, and ATF4 protein was significantly increased in the I/R group, which compared to other groups, and the level of CHOP, PERK, and ATF4 gene expression increased. After RDN intervention, these expression levels recovered to varying degrees.Conclusion: The effect of RDN may be associated with regulating the endoplasmic reticulum stress PERK/ATF4 signaling pathway.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0