Anatolian Journal of Cardiology最新文献_第2页

Rethinking Risk Stratification in Emergency Department Patients with Nonsustained Atrial Fibrillation. 重新思考急诊科非持续性心房颤动患者的风险分层。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5608

Yalçın Gölcük

引用次数: 0

Selection of Common Genes Associated with Rheumatoid Arthritis and Cardiovascular Disease via a Network- and Pathway-Based Approach. 通过基于网络和通路的方法选择与类风湿关节炎和心血管疾病相关的常见基因。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5375

Yaobang Bai, Yunpeng Bai, Zhenhua Wu, Qingliang Chen, Nan Jiang

{"title":"Selection of Common Genes Associated with Rheumatoid Arthritis and Cardiovascular Disease via a Network- and Pathway-Based Approach.","authors":"Yaobang Bai, Yunpeng Bai, Zhenhua Wu, Qingliang Chen, Nan Jiang","doi":"10.14744/AnatolJCardiol.2025.5375","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5375","url":null,"abstract":"Background: Patients with rheumatoid arthritis (RA) have an increased risk of developing cardiovascular disease (CVD). However, the mechanisms underlying the comorbidity between RA and CVD remain poorly understood. This study aimed to identify the shared genes between RA and CVD and to explore their functional relationships.Methods: Rheumatoid arthritis- and CVD-associated genes were obtained from the DisGeNET and Malacards databases, respectively. Shared genes between the 2 diseases were identified, and gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using WebGestalt and Cytoscape (v3.9.0). To further investigate potential molecular interactions, protein-protein interaction networks were constructed based on data from the STRING database. Finally, the in silico Tabula Muris single-cell transcriptomic dataset was used to assess the tissue-specific expression of candidate genes and evaluate their potential roles in specific tissues and cell types.Results: A total of 108 genes were shared between RA and CVD, out of the 898 and 552 genes identified for each condition. Functional enrichment analysis showed that these shared genes were predominantly associated with inflammation and immune response-related pathways. Among them, 42 candidate genes were identified, of which 7 (i.e., IFNG, CCL5, CXCL10, FN1, EGFR, CXCL1, and CD44) were highlighted based on their strong connectivity and biological relevance. For validation, the validation, Tabula Muris single-cell transcriptomic dataset revealed that these genes were highly expressed in mouse cardiac tissues.Conclusion: Seven shared genes associated with both RA and CVD were identified, which may contribute to the comorbidity between the 2 diseases.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulation of Serum miR-212-3p Serves as a Biomarker to Predict Disease Onset and Short-Term Prognosis in Acute Coronary Syndrome Patients. 血清miR-212-3p失调可作为预测急性冠状动脉综合征患者发病和短期预后的生物标志物

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5306

Binyan Luo, Wen Du, Gaxue Jiang, Chenliang Pan, Jizhe Xu, Bo Zhang, Ming Bai, Feifei Zhao

{"title":"Dysregulation of Serum miR-212-3p Serves as a Biomarker to Predict Disease Onset and Short-Term Prognosis in Acute Coronary Syndrome Patients.","authors":"Binyan Luo, Wen Du, Gaxue Jiang, Chenliang Pan, Jizhe Xu, Bo Zhang, Ming Bai, Feifei Zhao","doi":"10.14744/AnatolJCardiol.2025.5306","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5306","url":null,"abstract":"Objective: This study was conducted to investigate the clinical value of microRNA (miR)-212-3p in acute coronary syndrome (ACS) patients.Methods: This study involved 128 ACS patients and 110 patients with coronary arterial atherosclerosis. Real-time fluorescence quantitative polymerase chain reaction was employed to measure serum miR-212-3p levels and assessed its correlation with disease severity. The diagnostic efficacy of miR-212-3p was evaluated through receiver operating characteristic (ROC) curve and logistic regression modeling. Furthermore, Kaplan-Meier and Cox regression analyses were utilized to determine the predictive value of miR-212-3p for the occurrence of major adverse cardiovascular events (MACE).Results: The serum miR-212-3p was elevated in ACS patients, with levels in acute myocardial infarction (AMI) patients being greater than unstable angina pectoris (UAP) patients. Serum miR-212-3p demonstrated considerable diagnostic utility in the identification of ACS patients and in differentiating between AMI and UAP cases. Furthermore, miR-212-3p levels correlated with myocardial injury markers [cardiac troponin I (cTnI), high-sensitivity C-reactive protein (hs-CRP), and creatine kinase-MB (CK-MB)], as well as with coronary artery scores (Gensini and SYNTAX). Elevated levels of miR-212-3p were asso-ciated with MACE incidence. Serum miR-212-3p, cTnI, Gensini, and SYNTAX score served as independent risk factors for MACE occurrence, with higher expression of miR-212-3p being linked to a poorer clinical prognosis.Conclusion: Serum miR-212-3p might serve as a non-invasive biomarker for ACS diagnosis and MACE prediction and as a supplementary molecular tool in clinical practice.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Letter to the Editor: "Comment on: Self-Expanding Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Stenosis Undergoing Prosthetic Mitral Valve Replacement: A Single-Center Experience". 回复编者：“关于经导管自体扩张主动脉瓣置换术治疗重度主动脉瓣狭窄患者：单中心经验的评论”

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5667

Ahmet Kıvrak, Ahmet Hakan Ateş, Can Menemencioğlu, Mert Doğan, Mehmet Levent Şahiner, Ergün Barış Kaya, Kudret Aytemir

引用次数: 0

Reevaluating Prognostic Nutritional Index in Post-Coronary Artery Bypass Graft Surgery Mortality: A Call for Caution. 重新评估冠状动脉搭桥术后死亡率的预后营养指数：一个谨慎的呼吁。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5654

Kürşat Akbuğa, Bülent Özlek, Veysel Ozan Tanık

引用次数: 0

Reply to Letter to the Editor: "Rethinking Risk Stratification in Emergency Department Patients with Nonsustained Atrial Fibrillation". 回复编辑：“重新思考急诊科非持续性心房颤动患者的风险分层”。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5611

Ece Yurtseven, Dilek Ural, Kurtuluş Karaüzüm, İrem Yılmaz, Yengi Umut Çelikyurt, Kaan Hancı, Müjdat Aktaş, Ümit Yaşar Sinan, Serdar Küçükoğlu, Ayşen Ağaçdiken Ağır

引用次数: 0

Left Atrial Appendage Closure in a Hemophilia B Patient with Atrial Fibrillation. B型血友病合并心房颤动患者左心耳关闭1例。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.4167

Yunus Emre Özbebek, Ahmet Göktuğ Ertem

引用次数: 0

The Increase in Pediatric Postural Orthostatic Tachycardia Syndrome During the Pandemic May be due to Autonomic Neuropathy as a Complication of SARS-CoV-2 infection. 大流行期间儿童体位性站立性心动过速综合征的增加可能是由于自主神经病变作为SARS-CoV-2感染的并发症。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5761

Sinda Zarrouk, Josef Finsterer

引用次数: 0

Reply to Letter to the Editor: "Reevaluating Prognostic Nutritional Index in Post-Coronary Artery Bypass Grafting Mortality: A Call for Caution". 回复给编辑的信：“重新评估冠状动脉搭桥术后死亡率的预后营养指数：谨慎的呼吁”。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-18 DOI: 10.14744/AnatolJCardiol.2025.5653

Burak Toprak, Abdulkadir Bilgiç

引用次数: 0

Transportation Noise and Cardiovascular Health: Evidence, Mechanisms, and Policy Imperatives. 交通噪音与心血管健康：证据、机制和政策要求。

IF 1.5 4区医学

Anatolian Journal of Cardiology Pub Date : 2025-09-08 DOI: 10.14744/AnatolJCardiol.2025.5755

Thomas Münzel, Marin Kuntic, Andreas Daiber, Mette Sørensen

{"title":"Transportation Noise and Cardiovascular Health: Evidence, Mechanisms, and Policy Imperatives.","authors":"Thomas Münzel, Marin Kuntic, Andreas Daiber, Mette Sørensen","doi":"10.14744/AnatolJCardiol.2025.5755","DOIUrl":"10.14744/AnatolJCardiol.2025.5755","url":null,"abstract":"Environmental noise, particularly from road, rail, and aircraft traffic, is now firmly recognized as a widespread risk factor for cardiovascular disease. About 1 in 3 Europeans is exposed to chronic noise exposure above the guideline thresholds recommended by the World Health Organization (WHO), thus contributing substantially to cardiovascular morbidity and mortality. Robust evidence from recent meta-analyses links transportation noise to ischemic heart disease, heart failure, stroke, hypertension, and type 2 diabetes mellitus. Findings from experimental studies in both humans and animal models reveal biologically plausible mechanisms involving sympathetic nervous system activation, oxidative stress, inflammation, endothelial dysfunction, and disruption of circadian rhythms. The adverse health effects are particularly pronounced for nighttime noise, which disrupts restorative sleep and alters neurohormonal balance. Emerging research using the exposome framework highlights the cumulative toll of environmental stressors, including noise, on vulnerable populations. This review combines the latest evidence from epidemiology, mechanistic research, and intervention studies and outlines a road-map for incorporating noise into cardiovascular prevention strategies. Figures illustrate key concepts such as the noise reaction model, oxidative stress pathways, and practical mitigation measures. The conclusion calls for noise to be treated as a fully recognized cardiovascular risk factor-in parallel with traditional risks-and to address it through coordinated efforts in urban planning, public health policy, and clinical practice.","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0