Anatolian Journal of Cardiology最新文献

{"title":"Rare Diseases and Congenital Heart Diseases: A Call for Genetic Insight.","authors":"Hande Kaymakçalan Çelebiler","doi":"10.14744/AnatolJCardiol.2025.5297","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5297","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Pedunculated Right Atrial Hemangioma Was Initially Misdiagnosed as Myxoma.","authors":"Chen Chen, Yafeng He, Xiaojing Ma, Juan Xia, Qian Song, Junyi Gao","doi":"10.14744/AnatolJCardiol.2025.5286","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5286","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Landscape of Human Left and Right Atria Associated with Atrial Fibrillation.","authors":"Günseli Çubukçuoğlu Deniz","doi":"10.14744/AnatolJCardiol.2025.5215","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5215","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is the most common acquired cardiac rhythm disorder and has become a notable public health concern. Investigating the left versus right atrium (RA) transcriptome in AF is crucial because it provides insights into the gene expression changes that drive the molecular mechanisms underlying AF, potentially leading to targeted therapies and better patient outcomes. In this study, it is proposed that variances in the transcriptomic profiles between the human left atrium (LA) and RA, as well as alterations in molecular pathways, could offer potential targets for the onset and persistence of AF.</p><p><strong>Methods: </strong>Here transcriptomes of LA and RA of patients (n = 31) undergoing mitral valve surgery were compared. Microarrays proceeded on the Affymetrix platform. Bioinformatic analyses were done on Partek Genomics Suite. Gene ontology, KEGG pathway, and functional enrichment analysis was conducted using differentially expressed genes on WebGestalt.</p><p><strong>Results: </strong>Notably, transforming growth factor-β (TGF-β) and peroxisome proliferator-activated receptors signaling pathways were enriched commonly. Claudin 18, which encodes a tight junction transmembrane protein, was one of the most upregulated genes in LA. PITX2 (paired like homeodomain 2) gene upregulation in LA is also involved in TGF-β signaling. Alongside the upregulation of TGF-β signaling, overexpression of extracellular matrix proteins like collagen, vitronectin, fibronectin, and thrombospondin also points out the cardiac fibrosis process preceded in LA, where AF originates.</p><p><strong>Conclusions: </strong>In brief, comparisons of the AF-related transcriptomic landscapes of LA and RA propose targets for novel therapeutic and/or preventive strategies. This study highlights clinical evidence of genetic-based cardiac remodeling that could guide future therapeutic and preventive strategies.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Gut Microbiota Using VSL#3 and Its Impact on Aortic Parameters in a Rat Model.","authors":"Mehzat Altun, Uğur Küçük, Nuray Yıldırım","doi":"10.14744/AnatolJCardiol.2025.5048","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5048","url":null,"abstract":"<p><strong>Background: </strong>The increase in aortic stiffness is a significant parameter of cardiovascular diseases (CVDs), posing a substantial global health challenge and economic burden. The gut microbiota and its homeostasis, directly and indirectly, influence CVD. This study investigated the extent to which alterations in the gut microbiota can affect aortic parameters in a rat model through the administration of VSL#3.</p><p><strong>Methods: </strong>Twelve male Wistar rats were divided into VSL#3-treated and control groups. Cardiac function, aortic systolic, and diastolic values were assessed via echocardiography on day 0 and day 42, and fecal specimens were simultaneously collected from each rat. The formation and composition of the gut microbial flora were profiled using 16S rDNA gene sequencing.</p><p><strong>Results: </strong>Differences in bacterial density, as indicated by Chao analysis, exhibited statistical significance (P = .037) between the 2 groups. Additionally, in the VSL#3-treated group, significant improvements were observed in aortic systolic and diastolic diameters, as well as in aortic strain parameters, compared to the control group.</p><p><strong>Conclusion: </strong>This research highlights the potential of gut microbiome modulation, specifically through VSL#3 administration, as a promising strategy to improve aortic parameters, suggesting a novel avenue for cardiovascular health interventions.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Spandan Smartphone-Based Electrocardiogram for Arrhythmia Detection: A Cross-Sectional Study in a Large Patient Cohort.","authors":"Sahil Mahajan, Salil Garg, Yogendra Singh, Richa Sharma, Tanuj Bhatia, Nitin Chandola, Deeksha Agarwal","doi":"10.14744/AnatolJCardiol.2025.4853","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.4853","url":null,"abstract":"<p><strong>Background: </strong>To assess the diagnostic accuracy of the Spandan Lead II smartphone-based electrocardiogram (ECG) device regarding cardiac arrhythmia, compared with that of the only lead II ECG strip from the gold-standard ECG machine (BPL ECG machine) and the diagnosis by a cardiologist.</p><p><strong>Methods: </strong>The study, conducted from August 2, 2022, to June 2, 2023, in the local hospital, included 2799 participants aged 20 years and above. This was a single-blinded, cross-sectional study comparing the Spandan ECG device against the Gold Standard ECG and was diagnosed by a cardiologist. Participants referred for ECG testing by a cardiologist were included, and those with a pacemaker and/or ECG artifacts were excluded. To avoid any bias, the diagnosis was blinded to the cardiologist. Sensitivity, specificity, predictive values, F-score, and Matthew's correlation coefficient of the Spandan device were the parameters on which accuracy was studied.</p><p><strong>Results: </strong>Among 2799 participants (843 females, 1,956 males), the Spandan ECG system demonstrated high accuracy compared to the gold standard ECG machine, with sensitivity (95.5%), specificity (96.3%), positive predictive value (93.2%), negative predictive value (97.6%), F-Score (0.94), and a P = .913, for P > .001. It identified all arrhythmias without discrepancies and closely aligned with the gold standard ECG, which had slightly lower performance metrics. The study concluded that the Spandan Lead II ECG system is clinically applicable, especially in resource-limited settings.</p><p><strong>Conclusion: </strong>The Spandan lead II smartphone-based ECG device offers high accuracy in diagnosing cardiac arrhythmias, comparable to standard ECG machines. Its portability, affordability, and ease of use make it a valuable tool for timely diagnosis in almost all clinical and non-clinical settings.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrosing Mediastinitis and Complete Right Pulmonary Artery Occlusion.","authors":"Furkan Ufuk","doi":"10.14744/AnatolJCardiol.2025.5259","DOIUrl":"10.14744/AnatolJCardiol.2025.5259","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological Findings in Patients with Early Recurrence During Blanking Period Following Atrial Fibrillation Ablation.","authors":"Cem Çöteli, Can Menemencioğlu, Ahmet Hakan Ateş, Hikmet Yorgun, Kudret Aytemir","doi":"10.14744/AnatolJCardiol.2025.5084","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5084","url":null,"abstract":"<p><strong>Background: </strong>Atrial tachyarrhythmias (ATa) during the blanking period (BP) may predict late recurrences of arrhythmia. This study evaluates the outcomes of redo procedures during BP in patients with early recurrence after catheter ablation (CA) for atrial fibrillation (AF).</p><p><strong>Methods: </strong>This retrospective study included patients undergoing redo procedures within 3 months of their initial CA due to severely symptomatic ATa episodes. Baseline data, medications, and procedural details of initial and redo CAs were analyzed from medical records.</p><p><strong>Results: </strong>Among 64 patients, 37 underwent cryoballoon (CB) and 27 underwent radiofrequency (RF) ablation. In the CB group, additional low-voltage areas beyond pulmonary veins, cavo tricuspid isthmus (CTI)-dependent flutter (27%), and left atrial reentrant tachycardia (30%) were common. Pulmonary vein reconnection was observed in 43%. In the RF group, left atrial macro/micro reentrant tachycardia (63%), CTI-dependent flutter (22%), and pulmonary vein reconnection (33%) were common causes of symptomatic ATas. After 12 months, 85.9% of patients (n = 55) were free from ATa following redo procedures.</p><p><strong>Conclusion: </strong>Symptomatic ATas during BP often stem from substrates unrelated to the initial ablation, particularly in CB and pulmonary vein isolation-only RF groups. These findings suggest the need to reevaluate BP definitions, as select patients may benefit from early redo procedures to enhance long-term outcomes.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricuspid Regurgitation in Tuberculous Constrictive Pericarditis Underwent Pericardiectomy.","authors":"Shuzhen Wang, Jing Guo, Kunyue Tan, Lijuan Zhang, Shuangshuang Yan, Li Zhang, Wei Wang, Qiuyi Cai, Feng Xiong","doi":"10.14744/AnatolJCardiol.2025.4822","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.4822","url":null,"abstract":"<p><strong>Background: </strong>The presence of constrictive pericarditis (CP) in conjunction with tricuspid regurgitation (TR) and the worsening of TR following pericardiectomy are associated with a reduction in patient survival. The purpose of this study was to investigate the prevalence of tuberculous CP in conjunction with TR, the incidence of worsening regurgitation following pericardiectomy, and the analysis of associated factors.</p><p><strong>Methods: </strong>Seventy-five consecutive patients who underwent pericardiectomy for tuberculous CP at the institution between January 2021 and December 2023 were retrospectively analyzed. Their clinical, imaging, and hemodynamic characteristics were analyzed.</p><p><strong>Results: </strong>Among the 75 patients with tuberculous CP, 29 patients (38.7%) had mild or greater TR preoperatively and 27 patients (36%) had worsening TR after pericardiectomy. In patients with worsening TR, the pericardial thickness of the right ventricular (RV) lateral wall was significantly thickened preoperatively, and there was a reduction in the tricuspid annular plane systolic excursion (TAPSE), right ventricle S' tissue Doppler velocity (S'), and right ventricle fractional area change (FAC) postoperatively. The preoperative inferior vena cava diameter and the postoperative right atrial and RV basal diameters were significantly larger in patients with worsening TR compared with patients with non-worsening TR, whereas the TAPSE, S', and FAC were significantly lower before and after the surgery (P < .05). The FAC [OR = 0.354; 95% CI (0.165-0.761), P = .008] and pericardial thickness of the RV lateral wall [OR = 1.887; 95% CI (1.206-2.953), P = .005] were independently associated with worsening TR.</p><p><strong>Conclusion: </strong>Patients with tuberculous CP often have coexisting TR, and pericardiectomy can lead to worsening TR. The pericardial thickness of the RV lateral wall and FAC are independently associated with worsening TR following pericardiectomy.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Cardiac Arrest in an Adolescent with X-Linked Ichthyosis.","authors":"Hatice Mutlu, Can Kayıhan, Arzu Ay, Merve Havan, Mehmet Gökhan Ramoğlu, Tayfun Uçar, Tanıl Kendirli","doi":"10.14744/AnatolJCardiol.2025.4903","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.4903","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Macrophages in Pulmonary Hypertension: A Focus on High-altitude Pulmonary Hypertension.","authors":"Wende Ma, Yumei Ma, Yuting Bai, Xiaoling Su","doi":"10.14744/AnatolJCardiol.2025.5013","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2025.5013","url":null,"abstract":"<p><p>High-altitude pulmonary hypertension (HAPH) is a condition characterized by elevated pulmonary arterial pressure exceeding normal physiological values, resulting from a combination of high-altitude low-pressure, hypoxic environments, genetic susceptibility, immune dysfunction, and neurogenic disturbances. This condition predominantly manifests as right heart failure, severely impacting quality of life and life expectancy. Macrophages, as one of the most prevalent innate immune cells, have been increasingly recognized for their crucial role in the pathogenesis of HAPH. The low-pressure and hypoxic environment, along with other etiological factors, lead to metabolic abnormalities in tissue cells and the microenvironment. This results in increased secretion of chemokines, cytokines, and growth factors in the microenvironment, which promote the proliferation of tissue-resident macrophages and the differentiation of monocytes recruited from the blood into macrophages. This exacerbates the inflammatory cascade, further promoting cell proliferation, tissue repair, and inhibition of apoptosis. These processes contribute to the migration and proliferation of pulmonary arterial smooth muscle cells, endothelial cells, and fibroblasts, leading to vascular remodeling and ultimately the development of pulmonary arterial hypertension. This review examines the role of macrophage-mediated immune responses in high-altitude pulmonary arterial hypertension, with a focus on hypoxia as a key feature.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}