Anatolian Journal of Cardiology最新文献

{"title":"The Level of Gut Microbiota-Derived TMAO in Acute Myocardial Infarction and Its Prognostic Value.","authors":"Ming Jiang, Shijie Xu, Ya Zhou, Minghao Liu","doi":"10.14744/AnatolJCardiol.2026.6143","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6143","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the relationship of plasma trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, with both disease severity and short-term prognosis in acute myocardial infarction (AMI) patients.</p><p><strong>Methods: </strong>This retrospective observational study was performed at a single center and comprised 60 AMI patients along with 30 controls with angiographically normal or near-normal coronary arteries (stenosis <20% in all major epicardial vessels). Plasma TMAO levels were measured at admission via high-performance liquid chromatography-tandem mass spectrometry. The severity of coronary artery disease was graded according to the Gensini score. Patients were followed up for 6 months after discharge, and the occurrence of major adverse cardiovascular events (MACEs) within this period was ascertained retrospectively from hospital electronic medical records and routine cardiology follow-up documentation.</p><p><strong>Results: </strong>Compared to controls, AMI patients had significantly higher plasma TMAO levels (median 5.80 vs. 2.10 μmol/L, P < .001). Consistent with its elevation, TMAO demonstrated a strong positive correlation with the Gensini score (rs = 0.998, P < .001) and peak troponin I (rs = 0.996, P < .001). A high TMAO level (>5.80 μmol/L) was ndependently associated with an increased risk of 6-month MACE (hazard ratio = 2.45, 95% CI: 1.38-4.35, P = .002). Furthermore, incorporating TMAO into traditional clinical models enhanced their predictive performance, yielding a modest yet statistically significant improvement in the area under the curve from 0.880 to 0.884 (P = .012).</p><p><strong>Conclusion: </strong>Elevated plasma TMAO is associated with more severe coronary artery disease, greater myocardial injury, and worse short-term prognosis in AMI patients, offering incremental prognostic value beyond conventional risk factors.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Cardiovascular Risk Calculation Systems and the New PREVENT Model.","authors":"Yasemin Atıcı, Makbule Beyza Şen, Doğan Yücel","doi":"10.14744/AnatolJCardiol.2026.6049","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6049","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVD) are a largely preventable cause of death worldwide. There are many risk factors that influence CVD, some of which are modifi-able and others non-modifiable. Several systems, such as the widely used Framingham, Reynolds, and the most recently developed Predicting Risk of Cardiovascular Disease EVENTs (PREVENT), are used to calculate an individual's CVD risk based on the effects of these risk factors.</p><p><strong>Methods: </strong>This study compared CVD risk scores calculated using the Framingham, Reynolds, and PREVENT systems. The risk factors common to these 3 systems were determined to be age, gender, smoking status, high-density lipoprotein cholesterol, total cholesterol, and systolic blood pressure, and the effects of these risk factors on CVD risk were evaluated. The numerical risk scores obtained because of the effects of risk factors were presented comparatively in tables created based on gender and smoking status.</p><p><strong>Results: </strong>According to the results obtained, it was observed that the PREVENT system provides more individualized results by including renal, metabolic, and social markers in the calculation and provides a more detailed assessment by also considering the age of risk.</p><p><strong>Conclusion: </strong>These features may enable PREVENT to classify both low- and high-risk patients more clearly. This classification of patients may contribute to changing the course of CVD, a major global disease, by enabling appropriate interventions and treatments.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Stop Dual-Valve Transcatheter Intervention: Simultaneous Mitral TEER and K-Clip Tricuspid Annuloplasty.","authors":"Xinyu Li, Zhengchun Yu","doi":"10.14744/AnatolJCardiol.2026.6653","DOIUrl":"10.14744/AnatolJCardiol.2026.6653","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Albumin-Bilirubin Score Predicts In-Hospital Mortality in Patients with HFrEF Presenting with Acute Heart Failure.","authors":"Vedat Hekimsoy, Veysel Ozan Tanık, Kürşat Akbuğa, Alperen Taş, Ali Sezgin, Çağatay Tunca, Yusuf Bozkurt Şahin, Yusuf Taşkın, Bülent Özlek","doi":"10.14744/AnatolJCardiol.2026.6089","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6089","url":null,"abstract":"<p><strong>Background: </strong>Patients with heart failure and reduced ejection fraction presenting with acute heart failure (HFrEF-AHF) carry a high in-hospital mortality. Conventional predictors do not fully capture the interplay between hepatic dysfunction, systemic inflammation, and nutritional decline. The platelet-albumin-bilirubin (PALBI) score, originally developed in hepatology, may offer incremental prognostic information in this setting.</p><p><strong>Methods: </strong>A total of 401 patients hospitalized with HFrEF-AHF were retrospectively studied. Baseline demographic, clinical, and laboratory data were collected. Platelet-albumin-bilirubin and albumin-bilirubin (ALBI) scores were calculated. The primary endpoint was all-cause in-hospital mortality.</p><p><strong>Results: </strong>In-hospital mortality occurred in 47 patients (11.7%). Non-survivors were older, more frequently had chronic kidney disease (CKD), and showed lower albumin but higher bilirubin and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Both PALBI and ALBI were significantly higher in non-survivors. In multivariable Cox analysis, PALBI independently predicted mortality (hazard ratio = 2.638, 95% CI: 1.177-4.099, P < .001), along with age, CKD, and NT-proBNP. Receiver operating characteristic analysis showed that PALBI demonstrated slightly better performance than conventional predictors and, compared with ALBI (area under the curve = 0.737 vs. 0.708), yielded a modest but significant net reclassification improvement (~10%). Kaplan-Meier curves demonstrated clear separation in survival across PALBI strata (log-rank, P < .001), and restricted cubic spline analysis confirmed a graded, continuous association with risk.</p><p><strong>Conclusion: </strong>The PALBI score independently predicts in-hospital mortality in patients with HFrEF-AHF and may represent a simple and clinically useful tool for early risk stratification. External validation in larger, multicenter cohorts is warranted.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricuspid Valve Function After Add-On Pacing/Sensing Lead vs ICD Lead Implantation for Failed IS-1/DF-1 ICD Leads: A Single-Center Experience.","authors":"Büşra Kuru Görgülü, Ömer Akbulut, Ali Timuçin Altın, İrem Dinçer, Emir Baskovski","doi":"10.14744/AnatolJCardiol.2026.5878","DOIUrl":"10.14744/AnatolJCardiol.2026.5878","url":null,"abstract":"<p><strong>Background: </strong>The development or progression of tricuspid regurgitation (TR) following the implantation of cardiac implantable electronic devices (CIED) represents a significant concern. Although the link between transvalvular lead placement and TR is well established, the patient-related and lead-related factors that predispose patients to develop TR remain unclear. This study aimed to evaluate the effect of additional pacing/sensing leads (PSL) or implantable cardioverter defibrillator (ICD) leads on tricuspid valve function in patients with lead failure.</p><p><strong>Methods: </strong>In this retrospective, single-center, case-control study, all ICD implantation patients, in cases performed by one of these authors, presenting with lead failure were screened. The degree of TR on pre- and post-procedural echocardiograms of patients who underwent additional PSL or ICD lead implantation is compared.</p><p><strong>Results: </strong>The study comprised a total of 52 patients; 28 patients received PSL, and 24 patients received ICD electrodes. A non-significant increase in the degree of TR was observed in patients who underwent new ICD lead implantation (P = .059). The degree of TR observed in patients who underwent new PSL implantation was found to be comparable to the pre-procedure levels (P = .180). However, no statistically significant differences were observed between the 2 groups with respect to change in TR degree (P = .123).</p><p><strong>Conclusion: </strong>This study is the first analysis comparing the effect of ICD electrode addition with PSL addition without lead extraction on right ventricular and tricuspid valve function in patients with lead failure. This study provides the first comparative analysis of PSL versus ICD lead addition in patients with lead failure. The findings suggest that additional leads, whether PSL or ICD, do not significantly worsen tricuspid valve function. The addition of PSL to the IS-1/DF-1 ICD lead with standard high-voltage leads may be a viable treatment option, as it yields similar results to a new ICD lead implantation in terms of right heart function.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Year Outcomes and Predictors of Recurrence After High-Power Radiofrequency Ablation for Atrial Fibrillation: A Single-Center Experience With 480 Patients.","authors":"Abdulkadir Uslu, Ayhan Küp, Mehmet Çelik, Serdar Demir, Kamil Gülşen, Gültekin Günhan Demir, Gizem Ertürk, Ahmet Özderya, Mehmet Semih Belpınar, Şeyhmus Külahçıoğlu, Doğan Şen, Baver Bozan, Halit Eminoğlu, Alper Kepez","doi":"10.14744/AnatolJCardiol.2026.6202","DOIUrl":"10.14744/AnatolJCardiol.2026.6202","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) catheter ablation is a cornerstone rhythm-control intervention in symptomatic patients. Despite technological improvements, recurrence remains a critical determinant of long-term success, particularly in persistent AF. This study aimed to evaluate the 2-year clinical outcomes of high-power radiofrequency (RF) ablation performed in a high-volume single center and to identify predictors of AF recurrence in patients undergoing catheter ablation.</p><p><strong>Methods: </strong>This retrospective observational study included 480 consecutive adults who underwent RF catheter ablation for AF between January 2021 and December 2024. The patients were categorized based on AF recurrence, defined as >30-second episodes detected during 48- to 72-hour Holter at 6, 12, 24, and 36 months.</p><p><strong>Results: </strong>The cohort had a mean age of 59.8 ± 11.5 years, 56.3% were male, and 55.2% had persistent AF. The overall recurrence rate was 14.5% over an average follow-up duration of 23.8 ± 9.2 months. The recurrence rate was 9.2% in paroxysmal AF and 20% in persistent AF. The left atrial diameter was significantly larger in recurrence-positive patients (43.1 ± 6.5 mm vs 41.4 ± 5.5 mm, P = .023). Additionally, mitral regurgitation (MR) was more prevalent in the recurrence-positive group, particularly in patients with ≥grade 3 MR (18.6% vs. 6.4%, P = .004). Independent predictors of recurrence were symptom duration (odds ratio [OR] = 1.01, P = .006, 95% CI: 1.00-1.02) and prior direct current cardioversion (OR = 3.12, P < .001, 95% CI: 2.34-4.10). The complication rate was 2.0%.</p><p><strong>Conclusion: </strong>High-power RF ablation in an experienced center resulted in high sinus rhythm maintenance and low recurrence at 2 years. Individualized treatment strategies may have contributed to the low recurrence rates.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Cholesterol Inflammatory Index: A Predictor of Cardiovascular-Kidney-Metabolic Syndrome; Insights from NHANES and CHARLS Cohorts.","authors":"Mengchen Zhang, Linlin Huang, Tian Zhang, Guobin Song, Xiaobin Ren, Lijuan Zhang, Aiyun Han","doi":"10.14744/AnatolJCardiol.2026.6609","DOIUrl":"10.14744/AnatolJCardiol.2026.6609","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic syndrome (CKM) is a multi-organ metabolic disorder with an increased risk of morbidity and mortality among populations worldwide. Identifying effective biomarkers for early risk assessment is important. The residual cholesterol (RC) inflammatory index (RCII), which is derived from the combination of RC and C-reactive protein (CRP), represents a novel biomarker that captures the interplay between dyslipidemia and systemic inflammation. The interaction between RCII and CKM risk in the general populations of the US and China and evaluated its dose-response pattern, nonlinear relationship, and subgroup variations were evaluated.</p><p><strong>Methods: </strong>Data were retrieved by accessing 2 nationally representative cohorts: the US National Health and Nutrition Examination Survey (NHANES, n = 10,669) and the China Health and Retirement Longitudinal Study (CHARLS, n = 9,496). Multivariate logistic regression models (Model 1-3) were constructed to determine the relationship between RCII (as a continuous and quartile-categorized variable) and CKM. Progressive adjustments were made for demographic, socioeconomic, lifestyle, and anthropometric factors. In addition, a restricted cubic spline (RCS) analysis was conducted to examine nonlinearity and stratified analyses to assess effect modification across subgroups.</p><p><strong>Results: </strong>Increased RCII was significantly linked with increased CKM risk in both models. In fully adjusted models, each 1-unit increment in RCII was associated with a 4% increase in CKM risk in NHANES (odds ratio (OR) = 1.04, 95% CI: 1.03-1.06, P < .001) and a 3% increase in CHARLS (OR = 1.03, 95% CI: 1.02-1.05, P < .001). Quartile analysis revealed a strong dose-response pattern. In CHARLS, individuals in the highest quartile (Q4) exhibited a 9.60-fold higher CKM risk compared with that in Q1 (95% CI: 7.83-11.80). RCS models confirmed a nonlinear, upward-sloping relationship between RCII and CKM risk in both datasets. Subgroup analysis revealed robust associations across most strata, with a significant interaction by race in NHANES and by hypertension, diabetes, stroke, and smoking status in CHARLS.</p><p><strong>Conclusion: </strong>RCII exhibited an independent and positive association with CKM risk in the US and Chinese populations, with consistent dose-response and nonlinear trends. This index may be a practical and integrative biomarker for identifying individuals with an increased CKM risk, particularly during the early stages of metabolic dysregulation. Prospective studies are warranted to validate their predictive performance and establish clinically relevant thresholds for risk stratification.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right-Sided Infective Endocarditis: A 6-Year Retrospective Cohort Study from a Tertiary Care Center in Türkiye.","authors":"Bedia Mutay Suntur, Gülhan Yüksel, İbrahim Halil Kurt, Ömer Faruk Doğan, Şerafettin Demir","doi":"10.14744/AnatolJCardiol.2026.6054","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6054","url":null,"abstract":"<p><strong>Background: </strong>With evolving risk factors, the frequency of right-sided infective endocarditis (RSIE) is increasing. Despite its distinct clinical features, data on RSIE remain limited, and no dedicated cohort has been reported from Türkiye. This study aimed to describe the epidemiological and clinical characteristics of RSIE and identify factors associated with mortality in a tertiary-care center.</p><p><strong>Methods: </strong>This retrospective cohort study evaluated 65 adult patients diagnosed with definite RSIE between January 2018 and January 2024. Demographic data, risk factors, echocardiographic findings, causative microorganisms, and outcomes were analyzed. Statistical comparisons were performed between intravenous drug use (IVDU) and non-IVDU groups.</p><p><strong>Results: </strong>The cohort was predominantly male (76.9%) with a median age of 36 years. Intravenous drug use was the primary risk factor (55.4%), followed by central venous catheters (24.6%) and hemodialysis (23.1%). Staphylococcus aureus was the leading causative agent (79%). Septic pulmonary embolism was detected in 81.6% of patients. The overall in-hospital mortality rate was 26.2%. Mortality was significantly lower in IVDU patients than in non-IVDU patients (17.4% vs. 44%; P = .036); however, multiple regression analysis identified hemodialysis as an independent predictor of mortality (OR = 6.72, 95% CI: 1.27-35.42; P = .025). Multiple Cox regression analysis further demonstrated that hemoglobin level and age were independent predictors of mortality.</p><p><strong>Conclusion: </strong>Although IVDU patients demonstrated higher survival rates-likely attributable to a younger age profile and fewer comorbidities-RSIE remains a critical condition requiring high clinical suspicion and early intervention. RSIE in this region is strongly associated with IVDU and typically presents with respiratory symptoms due to septic pulmonary emboli.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dirty Earth-Diseased Hearts.","authors":"Çetin Erol","doi":"10.14744/AnatolJCardiol.2026.7","DOIUrl":"10.14744/AnatolJCardiol.2026.7","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":"30 7","pages":"410"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Direct Oral Anticoagulants and Low-Molecular-Weight Heparins in Cancer Patients with Nonvalvular Atrial Fibrillation: Insights from a Single-Center Experience.","authors":"İmran Ceren, Yusuf Ziya Şener, Kemal Göçer, Hatice Gülgün Fırat, Kardelen Ohtaroğlu Tokdil, Fatih Yıldız, Fadime Bozduman Habip, Eser Açıkgöz, Öztürk Ateş, Demet Menekşe Gerede Uludağ, Elif Eroğlu Büyüköner","doi":"10.14744/AnatolJCardiol.2026.5923","DOIUrl":"10.14744/AnatolJCardiol.2026.5923","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is frequently encountered in patients with cancer and poses challenges for anticoagulant management. The present study was conducted to compare clinical outcomes associated with direct oral anticoagulants (DOACs) and low-molecular-weight heparin (LMWH) in individuals with active malignancy and nonvalvular AF (NVAF).</p><p><strong>Methods: </strong>Data from patients with active cancer who received LMWH or DOACs for NVAF were retrospectively screened. Efficacy, safety, and survival outcomes were analyzed.</p><p><strong>Results: </strong>The study enrolled 222 patients, of whom 25.7% received LMWH and 74.3% received DOACs. Cancer stage, type, and treatment were comparable between groups. The DOAC group had higher CHA2DS2-VA (3.13 ± 1.21 vs. 2.42 ± 1.33; P < .001) and HAS-BLED scores (2.13 ± 0.83 vs. 1.84 ± 0.79; P = .022). The primary composite endpoint occurred more frequently in the LMWH group (17.5% vs. 12.1%; log-rank P = .036). Myocardial infarction was significantly higher in the LMWH group (8.8% vs. 1.8%; log-rank P = .003), while rates of ischemic stroke (3.5% vs. 6.7%; log-rank P = .927) and venous thromboembolism (5.3% vs. 4.8%; P = .537) were similar. Any bleeding (17.5% vs. 13.3%; log-rank P = .039) and major bleeding (7.0% vs. 1.8%; log-rank P = .010) were more frequent with LMWH, whereas clinically relevant non-major bleeding was comparable (10.5% vs. 11.5%; log-rank P = .359). All-cause mortality was significantly higher in the LMWH group (75.4% vs. 49.1%; log-rank P < .001), and LMWH use independently predicted mortality (hazard ratio = 2.14, P < .001, 95%CI: 1.45-3.17).</p><p><strong>Conclusion: </strong>Although unmeasured confounders such as drug adherence and selection bias cannot be excluded due to the retrospective design, DOACs appear to be more effective and safer than LMWH in cancer patients with AF.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}