Journal of atherosclerosis research最新文献

The relationship between diffuse intimal thickening, medial enzyme failure and intimal lipid deposition in various human arteries 人各种动脉弥漫性内膜增厚、内侧酶衰竭与内膜脂质沉积的关系

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80036-0

C.W.M. Adams, O.B. Bayliss

{"title":"The relationship between diffuse intimal thickening, medial enzyme failure and intimal lipid deposition in various human arteries","authors":"C.W.M. Adams, O.B. Bayliss","doi":"10.1016/S0368-1319(69)80036-0","DOIUrl":"10.1016/S0368-1319(69)80036-0","url":null,"abstract":"<div>The relationship between diffuse intimal thickening and zonal loss of medial enzyme activity was studied in 23 human aortas, from the 1st to the 10th decade of life, by means of the NADH-tetrazolium reductase-Van Gieson histoenzymic method. This relationship, together with the relationship to lipid accumulation, was examined with the histoenzymic NADH-TR and ATPase-Oil Red 0 methods in the aorta, coronary, internal carotid, middle cerebral, femoral, popliteal, axillary and brachial arteries in a fuither 8 subjects.At a critical intimal thickness of 0.15 mm the aortic media showed enzymic loss in its middle zone. In the other arteries examined this critical intimal thickness for medial enzyme loss varied from 0.2–0.45 mm. Intracellular lipid (the “fatty streak”) was noted in some relatively unthickened intimas, where the tunica media showed no enzyme loss. Extracellular diffuse intimal lipid was only observed where enzyme activity was impaired in the tunica media. In a few cases diffuse intimal thickening and medial enzyme loss were seen in the absence of intimal lipid accumulation.These results support the hypothesis that progressive diffuse intimal thickening over-extends nutritional perfusion from the lumen to the inner and middle zones of the tunica media. The resulting failure of energy-producing metabolism in the media would impair the local synthesis of lipotrophic agents (phospholipid and protein) that are required for transporting cholesterol. Reduced outward transport of cholesterol would lead to the accumulation of cholesterol in the inner arterial layers, as in atherosclerosis.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 327-339"},"PeriodicalIF":0.0,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80036-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15349927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs 慢性维生素缺乏症C对豚鼠胆固醇代谢和动脉粥样硬化的影响

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80037-2

E. Ginter, J. Babala, J. Červeň

{"title":"The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs","authors":"E. Ginter, J. Babala, J. Červeň","doi":"10.1016/S0368-1319(69)80037-2","DOIUrl":"10.1016/S0368-1319(69)80037-2","url":null,"abstract":"<div>Guinea pigs with varying intakes of ascorbic acid (0.5, 5 and 50 mg per 24 h) were receiving an atherogenic diet with addition of 0.3 % cholesterol during 140 days. In guinea pigs with a chronic deficiency of vitamin C (0.5 mg for 24 h) a significantly higher accumulation of cholesterol in liver, adrenal glands and small intestine was observed in comparison with the group receiving 50 mg of vitamin C for 24 h. Concentrations of cholesterol in the same organs of the group receiving 5 mg of vitamin C per 24 h were within these extreme data. A significantly negative correlation was confirmed to exist between cholesterol concentration in liver, adrenal glands and small intestine and saturation of tissues with vitamin C; with decreasing saturation of tissues with vitamin C, the accumulation of cholesterol in the relevant tissue was increasing. Cholesterol levels in brain and blood serum were not significantly influenced by differing intake of vitamin C. The most advanced atheromatous changes were found in aorta and coronary arteries of the hypovitaminous group (0.5 mg of vitamin C per 24 h). High doses of vitamin C (50 mg per 24 h) did not prevent the appearance of morphological changes in vascular system but only slowed down the process of atheromatous reconstruction.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 341-352"},"PeriodicalIF":0.0,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80037-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16448247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Studies on new nicotinic acid ester derivatives 新型烟酸酯衍生物的研究

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80042-6

Y. Aso, Y. Abe, K. Higo, T. Naruke, T. Irikura

引用次数: 4

Suppression of lipid synthesis in cultured aortic cells by laminaran sulfate 硫酸层酰胺对培养主动脉细胞脂质合成的抑制作用

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80040-2

K. Murata

引用次数: 3

The effect of N-(α-methylbenzyl)linoleamide on cholesterol metabolism in rats N-(α-甲基苄基)亚油酰胺对大鼠胆固醇代谢的影响

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80043-8

H. Fukushima, S. Aono, Y. Nakamura, M. Endo, T. Imai

{"title":"The effect of N-(α-methylbenzyl)linoleamide on cholesterol metabolism in rats","authors":"H. Fukushima, S. Aono, Y. Nakamura, M. Endo, T. Imai","doi":"10.1016/S0368-1319(69)80043-8","DOIUrl":"10.1016/S0368-1319(69)80043-8","url":null,"abstract":"<div><ul><li>(1)The effect of dl-N-(α-methylbenzyl) linoleamide (MBLA) and its optically active isomers (d-MBLA and l-MBLA) on cholesterol metabolism was studied in rats. After administering MBLA, d-MBLA and l-BMLA with [4-14C]cholesterol, total [4-14C]cholesterol levels in the plasma and liver, and its ester ratio in the liver were markedly depressed after 4 h. After 8 h, the same results were obtained, and the esterified [4-14C]cholesterol ratio in the small intestine was also depressed, but there was no significant difference after 24 h. The inhibitory effect on plasma and liver [4-14C]cholesterol pools was in the order d-MBLA > MBLA > l-MBLA.</li><li>(2)The cholesterol-lowering effect of MBLA was not decreased after administering it for 4 weeks.</li><li>(3)After administering MBLA, d-MBLA and l-MBLA with [3H] cholesterol to thoracic-duct fistula rats, total [3H]cholesterol levels and its ester ratio in lymph were markedly depressed for 24 h. These results suggest that the cholesterol-lowering mechanism of these compounds is due to reduced cholesterol absorption from the intestines.</li><li>(4)Hepatic cholesterogenesis was accelerated when a diet containing 0.1 % of MBLA was administered for 1–2 weeks. The acceleration of cholesterol biosynthesis by inhibitors of cholesterol absorption is considered to be due to a homeostatic mechanism that maintains body cholesterol via a feedback control.</li></ul></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 403-414"},"PeriodicalIF":0.0,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80043-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16448255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

On the association of cigarette smoking with coronary and aortic atherosclerosis 吸烟与冠状动脉和主动脉粥样硬化的关系

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80034-7

J.P. Strong, M.L. Richards, H.C. McGill Jr, D.A. Eggen, M.T. McMurry

引用次数: 43

In vitro inhibition by metabolic antagonists of incorporation of [32P]phosphate into the major phospholipids of swine coronary and pulmonary arteries 代谢拮抗剂对猪冠状动脉和肺动脉主要磷脂中[32P]磷酸盐掺入的体外抑制作用

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80032-3

R.J. Morin

{"title":"In vitro inhibition by metabolic antagonists of incorporation of [32P]phosphate into the major phospholipids of swine coronary and pulmonary arteries","authors":"R.J. Morin","doi":"10.1016/S0368-1319(69)80032-3","DOIUrl":"10.1016/S0368-1319(69)80032-3","url":null,"abstract":"<div>Incorporation of [32P]phosphate into sphingomyelin, phosphatidyl choline, phosphatidyl serine and phosphatidyl ethanolamine of normal swine arteries was studied in vitro. Choline added to the media increased the specific activity in phosphatidyl choline, whereas ethanolamine had no significant effects. Addition of 2-amino-2-methyl-l-propanol in concentrations from 0.001–0.1 M inhibited incorporation of 32P into all the phospholipid classes; phosphatidyl choline was affected to a somewhat greater extent than the others. Ratios of choline to aminomethylpropanol in the media of 1:1 and 10:1 resulted in partial reversal of the inhibition; the reversal was nearly complete at a ratio of 100:1. The pulmonary artery seemed to be somewhat less sensitive than the coronary artery to inhibition of net phospholipid synthesis by aminomethylpropanol.Addition of 3-amino-l-propanol, dimethylaminoisopropanol and triethanol-amine in concentrations of 0.001, 0.01 and 0.1 M each resulted in inhibition of [32P]-phosphate incorporation into the phospholipids of the coronary arteries; there was little evidence of specific inhibition of any of the individual phospholipid classes studied.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 283-289"},"PeriodicalIF":0.0,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80032-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16448241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effects of four variations of a surfactant polymer on experimental atherosclerosis in rabbits 一种表面活性剂聚合物的四种变化对实验性动脉粥样硬化的影响

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80033-5

B.I. Weigensberg

{"title":"Effects of four variations of a surfactant polymer on experimental atherosclerosis in rabbits","authors":"B.I. Weigensberg","doi":"10.1016/S0368-1319(69)80033-5","DOIUrl":"10.1016/S0368-1319(69)80033-5","url":null,"abstract":"<div>Four variations in molecular structure of the surfactant polyoxyethylene alkyl phenol formaldehyde polymer were synthesized, purified and tested for their ability to modify the severity of aortic atherosclerosis induced in rabbits by feeding cholesterol and trans isomerized olive oil for 84 days in comparison with a placebo-treated control group. The four molecular variations studied were the 20 and 30 oxyethylated n-decyl phenol formaldehyde polymers and the 20 and 30 t-octyl phenol formaldehyde polymers. After 84 days on the cholesterol-rich diet, all the serum lipid fractions of the control group and of the surfactant-treated groups were markedly elevated. In comparison with the control group, the severity of aortic atherosclerosis was much less in the groups treated with the oxyethylated t-octyl surfactants. In contrast, there was no significant reduction in the severity of atherosclerosis in the group treated with the 30-oxyethylated n-decyl surfactant. The reduction in severity of atherosclerosis in the group treated with the 20-oxyethylated n-decyl surfactant was relatively slight.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 291-301"},"PeriodicalIF":0.0,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80033-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16448242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Studies of optimal conditions for the measurement of circulating endogenous lipoprotein lipase activity 循环内源性脂蛋白脂肪酶活性测定的最佳条件研究

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80038-4

H. Engelberg

引用次数: 3

Effect of clofibrate and high fat diets on adrenaline-induced lipolysis in isolated rat adipose tissue 氯贝特和高脂饲料对肾上腺素诱导的离体大鼠脂肪组织脂解的影响

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80035-9

M.G. Kokatnur, W.G. Blackard

引用次数: 6