Journal of atherosclerosis research最新文献_第2页

Human pancreatic elastolytic enzymes and atherosclerosis and lung emphysema in elderly people 老年人胰弹性酶与动脉粥样硬化和肺气肿的关系

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80041-4

W.A. Loeven

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引用次数: 25

Relative immunity to arteriosclerosis in rabbits during the hair-shedding period 兔脱毛期对动脉硬化的相对免疫

Journal of atherosclerosis research Pub Date : 1969-11-01 DOI: 10.1016/S0368-1319(69)80039-6

P. Helin, I. Lorenzen, C. Garbarsch, M.E. Matthiesen

{"title":"Relative immunity to arteriosclerosis in rabbits during the hair-shedding period","authors":"P. Helin, I. Lorenzen, C. Garbarsch, M.E. Matthiesen","doi":"10.1016/S0368-1319(69)80039-6","DOIUrl":"10.1016/S0368-1319(69)80039-6","url":null,"abstract":"<div>The extent and severity of arteriosclerosis in rabbit aorta induced by exposure to short periods of systemic hypoxia for two weeks were studied during the hair-shedding period (September through December). Two series of experiments were carried out in relation to two different shedding periods with an interval of 1 year. The entire study involved 152 rabbits. Three experiments were performed in shedding and three in nonshedding periods. While shedding, the rabbits exposed to hypoxia developed slight gross arteriosclerosis in contrast to the severe arteriosclerosis that developed while the animals were not shedding. Qualitatively, the gross and microscopic changes did not differ during and outside the shedding periods. Comparison of the biochemical changes in the aortic acid mucopolysaccharides and collagen induced by the systemic hypoxia during the shedding and nonshedding periods showed no statistically significant differences. The resistance to arteriosclerosis during shedding may be due to hormonal factors, which also may be of importance to the development of arteriosclerosis in other species. Furthermore, the phenomenon has to be taken into consideration in experimental studies of rabbit arteriosclerosis.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 359-369"},"PeriodicalIF":0.0,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80039-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15349929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The effect of colchicine on human platelet behaviour 秋水仙碱对人血小板行为的影响

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80012-8

G.D. Soppitt, J.R.A. Mitchell

引用次数: 19

Relative absence of triglycerides in coronary atherosclerotic lesions 冠状动脉粥样硬化病变中甘油三酯的相对缺乏

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80003-7

Y.H. Abdulla , C.W.M. Adams, O.B. Bayliss

引用次数: 15

Hypothesis 假设

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80013-X

D.F. Davies

引用次数: 41

The role of lactation and weaning in the pathogenesis of arteriosclerosis in female breeder rats 哺乳和断奶在雌性繁殖大鼠动脉硬化发病机制中的作用

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80004-9

J.T. Judd, B.C. Wexler

{"title":"The role of lactation and weaning in the pathogenesis of arteriosclerosis in female breeder rats","authors":"J.T. Judd, B.C. Wexler","doi":"10.1016/S0368-1319(69)80004-9","DOIUrl":"10.1016/S0368-1319(69)80004-9","url":null,"abstract":"<div>Female breeder rats develop spontaneous arteriosclerosis if they are actively and repeatedly bred. Females which nursed large litters following each pregnancy appeared to develop the most severe arterial disease as well as other degenerative changes. In order to determine how the degree of lactational activity would affect the pathogenesis of the arterial disease female breeder rats were provided with many, few or no pups during the lactation phase following each of 4 pregnancies. To test the effect of abrupt cessation of milk removal vs. complete removal of milk, breeder females were provided with many pups to nurse following each of 4 pregnancies. However, in some cases the young were removed suddenly, i.e., forced weaning, after 23 days of lactation, whereas some females were permitted to nurse their young until they gave up nursing voluntarily, i.e., natural weaning. A special group of breeders completed 1 pregnancy only but was provided with nursing pups for an extended period of time, i.e., 100 days.The results of these experiments demonstrated, that female breeders which had experienced one or several pregnancies and which had lactated actively followed by abrupt weaning of the young developed grossly visible arteriosclerosis characterized by severe calcific complications. On the other hand, breeders which were permitted to suckle their young until they were weaned naturally were completely free of the severe calcific arterial involvement. However, early microscopic intimal mucopolysaccharide accumulations capped by collagen could be found in all breeders. These intimal lesions are believed to be the forerunners of the more complicated lesions and are believed to be associated with the gestational phase of the reproductive cycle.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 2","pages":"Pages 153-172"},"PeriodicalIF":0.0,"publicationDate":"1969-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80004-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16465310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

The incorporation of glucose and palmitic acid into lipids in human arterial intima and media in vitro 葡萄糖和棕榈酸在体外人动脉内膜和介质中的脂质掺入

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80006-2

S. Björkerud, F. Huth

{"title":"The incorporation of glucose and palmitic acid into lipids in human arterial intima and media in vitro","authors":"S. Björkerud, F. Huth","doi":"10.1016/S0368-1319(69)80006-2","DOIUrl":"10.1016/S0368-1319(69)80006-2","url":null,"abstract":"<div>The incorporation into lipids of [14C]glucose and [14C]palmitate with and without unlabelled glucose in defined samples of apparently normal, fresh human intima and media was measured in vitro. After incubation of the intima samples with [14C]-glucose about 50 % and 15 % of the label occurred in triglycerides and lecithin, respectively. A moderate degree of activity was found in phosphatidyl inositol and cholesterol and/or diglyceride; in other lipid classes the activity was low with the exception of a varying degree of label in free fatty acids. After incubation with [14C]palmitate the distribution of label was similar but the proportion of label in triglycerides and lecithin was reversed and the degree of labelling of sphingomyelin was higher. After addition of unlabelled glucose the above differences for the [14C]-glucose and [14C]palmitate precursors were partially levelled out. The differences were less pronounced for the media samples. The rates of incorporation of the respective precursors were similar in intima and media both on a dry weight and DNA basis.The distribution of label in triglycerides and lecithin after incubation with [14C]palmitate agrees well with results obtained by others for species susceptible to experimentally induced or spontaneous atherosclerosis but deviates from more atherosclerosis-resistant species. It is possible that this correlation reflects important factors for the formation of atherosclerosis.</div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 2","pages":"Pages 179-191"},"PeriodicalIF":0.0,"publicationDate":"1969-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80006-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16465312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Influence of lactose feeding on cholesterol absorption and metabolism 乳糖饲喂对胆固醇吸收和代谢的影响

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80008-6

N. Irotamo, N. Takeuchi

引用次数: 8

Fibrinogen levels in patients suffering from acute myocardial infarction 急性心肌梗死患者的纤维蛋白原水平

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80016-5

J.A. Hashmi, N. Afroze, S.A. Syed

引用次数: 2

Metabolism of [1-14C] acetate in guinea pigs with chronic vitamin C hyposaturation 慢性维生素C低饱和豚鼠[1-14C]醋酸盐的代谢

Journal of atherosclerosis research Pub Date : 1969-09-10 DOI: 10.1016/S0368-1319(69)80015-3

E. Ginter, R. Nemec

引用次数: 12