{"title":"Effect of clofibrate and high fat diets on adrenaline-induced lipolysis in isolated rat adipose tissue","authors":"M.G. Kokatnur, W.G. Blackard","doi":"10.1016/S0368-1319(69)80035-9","DOIUrl":null,"url":null,"abstract":"<div><p>Adipose tissue from rats fed high fat diets were found to exhibit significantly less adrenaline-induced FFA release than those from rats maintained on low fat commercial diet.</p><p>Addition of CPIB to the high fat diet reversed this suppression of adrenaline-induced FFA release by isolated adipose tissue. Supplementation of the diet with cholesterol-cholate also reversed the suppressive effect of high dietary fat on adrenaline-induced lipolysis <em>in vitro</em>.</p><p>Adrenaline-induced FFA release in adipose tissue seems to depend upon the metabolic status of the tissue as determined by previous nutrition of the animal.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 3","pages":"Pages 319-325"},"PeriodicalIF":0.0000,"publicationDate":"1969-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80035-9","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of atherosclerosis research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0368131969800359","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Adipose tissue from rats fed high fat diets were found to exhibit significantly less adrenaline-induced FFA release than those from rats maintained on low fat commercial diet.
Addition of CPIB to the high fat diet reversed this suppression of adrenaline-induced FFA release by isolated adipose tissue. Supplementation of the diet with cholesterol-cholate also reversed the suppressive effect of high dietary fat on adrenaline-induced lipolysis in vitro.
Adrenaline-induced FFA release in adipose tissue seems to depend upon the metabolic status of the tissue as determined by previous nutrition of the animal.
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