{"title":"Philtrum morphology and its dental correlates: a cross-sectional study of sex and age variation.","authors":"Rehab Eltarhoni, Roger Soames, Clare Lamb","doi":"10.1007/s12565-025-00913-7","DOIUrl":"10.1007/s12565-025-00913-7","url":null,"abstract":"<p><p>The philtrum is a key perioral landmark contributing to facial aesthetics. While sex, age, and ancestry influence philtrum morphology, its relationship with underlying dental structures remains underexplored. This study aimed to classify philtrum morphology, quantify its dimensions in an adult cohort, and examine associations with sex, age, and upper dental measurements. The study cohort consisted of 99 adults of European background (71 females, 28 males). Anthropometric assessment was conducted using digital calipers and standardized frontal photography. Philtrum morphology was classified by two independent observers. Statistical analyses included t-tests, correlations, and multiple regression, with additional predictive modelling using machine learning. Parallel morphology was the most common (55.7%). Philtrum height and width were significantly greater in males than females (p < 0.001). Philtrum width and height showed moderate positive correlations with age. In females, central incisor lengths showed moderate negative correlations with age. Multiple regression identified sex and first premolar width as significant predictors of philtrum width and sex, age, and upper central incisor length as predictors of philtrum height. Machine learning models substantially improved predictive accuracy compared to multiple regression, explaining 72% of the variance in philtrum width and 58% in philtrum height. Inter-observer agreement for morphological classification was high. These findings indicate that philtrum morphology varies with sex and age and is associated with underlying dental structures. The study contributes to understanding soft tissue-hard tissue relationships and provides reference data with relevance to aesthetic, orthodontic, and reconstructive contexts.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hegong Wang, Shangpeng Cheng, Chongjun Xu, Dongzhe Sun, Li Du, Zhaodong Li, Hui Chen, Ping Wang
{"title":"Classification of the extracranial middle meningeal artery: a human dry skull, dissection and 3D CTA study.","authors":"Hegong Wang, Shangpeng Cheng, Chongjun Xu, Dongzhe Sun, Li Du, Zhaodong Li, Hui Chen, Ping Wang","doi":"10.1007/s12565-025-00910-w","DOIUrl":"https://doi.org/10.1007/s12565-025-00910-w","url":null,"abstract":"<p><p>Unexpected treatment failures can occur during middle meningeal artery embolization (MMAE) in the treatment of chronic subdural hematoma cases. This study aimed to classify variations in the anatomy of the extracranial MMA (exMMA) to improve MMAE. Five heads from body donors, 300 dry skulls, and 162 head and neck CT angiography (CTA) images were used to evaluate the overall features of the exMMA. Body donors dissection were incorporated to comprehensive exMMA representation. The distal features of the exMMA were determined by evaluating the outer osseous grooves of the foramen spinosum of the skulls. Measurements of the exMMA were performed using CTA. The angles between the maxillary artery and the exMMA were 109.5° ± 32.5° (left) and 117.1° ± 34.3° (right) (p < 0.05). The angle between the exMMA and the skull base was greater on the left side (79.24° ± 4.21°, p = 0.0017). The diameters of the exMMA were 1.45 ± 0.12 mm (left) and 1.44 ± 0.13 mm (right) (p = 0.82). Multiple types of accessorial foramen spinosum provided the paths for the accessorial MMA. In the new classification, five types were identified. Type A was the most common (73.15%) and represented an easily accessible MMAE type. This was followed by type C (25.62%, difficult to accessible), type D (18.83%, very difficult to accessible), type B (1.23%, fairly accessible), and type E (0.17%, inaccessible). Varying levels of interventional difficulty occur within the exMMAs classification. Careful preoperative evaluations should be performed before MMAE to determine the type of exMMA and potential interventional difficulty.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extra-hepatic arterial branching pattern in the common marmoset (Callithrix jacchus).","authors":"Tetsuhito Kigata, Keiko Moriya-Ito, Yoshiko Honda, Kohei Himeno","doi":"10.1007/s12565-025-00911-9","DOIUrl":"https://doi.org/10.1007/s12565-025-00911-9","url":null,"abstract":"<p><p>The common marmoset (Callithrix jacchus) is a valuable laboratory animal offering various advantageous characteristics, including ease of husbandry and phylogenetic proximity to humans. However, anatomical knowledge of the common marmoset remains inadequate despite its recognized value as a laboratory animal. The livers of primate species have been reported to exhibit species-specific patterns of arterial supply, an understanding of which may be one important prerequisite to perform experiments. However, the arterial branching pattern in common marmosets has yet to be reported in detail. We thus dissected six male and nine female common marmosets to clarify the extra-hepatic arterial branching pattern using the latex injection method. The common marmoset liver received a single to triple arterial supply from the hepatic artery, left gastric artery, caudal phrenic artery, and celiac artery. In two cases, only the hepatic artery provided branches to the liver. The liver received a double arterial supply from the hepatic and caudal phrenic arteries in one case and from the hepatic and left gastric arteries in five cases. A triple arterial supply from the hepatic, left gastric, and celiac arteries was detected in one case, and from the hepatic, left gastric, and caudal phrenic arteries in six cases. The present study revealed characteristic patterns of arterial supply to the liver in the common marmoset, and may provide a prerequisite anatomical background for conducting experiments involving the liver in this species.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145585844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anatomical variations in the branches of the aortic arch in Japanese patients.","authors":"Satoshi Sakakibara, Takashi Yamauchi, Akira Marumoto","doi":"10.1007/s12565-025-00904-8","DOIUrl":"https://doi.org/10.1007/s12565-025-00904-8","url":null,"abstract":"<p><p>In aortic arch surgery, preoperative evaluation of variations in the aortic arch branching is necessary. The present study investigated variations in the aortic arch branches in Japanese patients using contrast-enhanced computed tomography. In this study, we included 2,923 Japanese patients who underwent computed tomography at our institution in 2022. The following eight types of variations in the aortic arch branching were observed. Type 1, with the brachiocephalic trunk, left common carotid artery, and left subclavian artery, was found in 2,541 patients (86.9%). Additionally, seven subtypes were found in 382 patients (13.1%) as follows: Type 2, the common trunk of brachiocephalic trunk and left common carotid artery (8.0%); Type 3, with the left vertebral artery, branching directly from the aortic arch between left common carotid artery and left subclavian artery (4.3%); Type 4, left vertebral artery branching directly from the aortic arch distal to left subclavian artery (0.1%); Type 5, aberrant right subclavian artery (0.5%); Type 6, the common trunk of bilateral common carotid arteries (0.1%); Type 7, the common trunk of left common carotid artery and left subclavian artery (0.01%); and Type 8, the right aortic arch complicated with aberrant left subclavian artery (0.1%). The subtypes of the variations in aortic arch branching were found in 13.1% of Japanese patients. In this study, only a few patients had aortic disease. Further studies are required to investigate the relationships between variations in the aortic arch branching and aortic disease.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Onur Bilge, Duygu Akin Saygin, Anil Didem Aydin Kabakci, Mustafa Buyukmumcu, Furkan Bulbul, Muhammed Furkan Kucuksen, Haluk Yaka, Mahmut Nedim Doral
{"title":"Three-dimensional morphology and shape variants of the fetal medial meniscus: anatomical and clinical implications.","authors":"Onur Bilge, Duygu Akin Saygin, Anil Didem Aydin Kabakci, Mustafa Buyukmumcu, Furkan Bulbul, Muhammed Furkan Kucuksen, Haluk Yaka, Mahmut Nedim Doral","doi":"10.1007/s12565-025-00905-7","DOIUrl":"https://doi.org/10.1007/s12565-025-00905-7","url":null,"abstract":"<p><p>This study aimed to examine the morphology of the fetal medial meniscus in cadavers, including both quantitative analysis and the identification of new shape variants. Fifty fetal cadavers were analyzed (36 from the second trimester, 13-25 weeks;14 from the third trimester,26-37 weeks). Of 53 available specimens, three with musculoskeletal malformations were excluded. Surgical microdissection under a stereomicroscope exposed the medial meniscus, which was measured using a calibrated digital caliper. Morphology was documented and classified into five primary types and five subtypes. Data were analyzed using SPSS version 21.0(IBM Corp., Armonk, NY, USA). Significant growth in all parameters was observed between the second and third trimesters, with notable morphological differences between male and female fetuses, emphasizing the influence of gestational age and sex. The study identified distinct medial meniscus shapes: 46% were sickle-shaped, 16% C-shaped, 13% crescent-shaped, 4% U-shaped, and 1% V-shaped. Additionally, 20% of medial menisci exhibited variant subtypes derived from the crescentic and C-shaped types. This study provides a novel and comprehensive evaluation of fetal medial meniscus morphology, identifying both previously known and new shape variants. These findings expand current anatomical knowledge and suggest that morphological diversity of the medial meniscus may have functional implications for knee joint biomechanics. This is the first study to describe three-dimensional fetal MM morphology, including five previously unclassified subtypes. Further research could clarify clinical implications of these morphological variants of fetal medial meniscus in orthopedic diagnosis and management across all age groups.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Sadra Pouladi, Nader Goodarzi, Sarang Soroori
{"title":"Comparative dental morphology of hamsters and Guinea pigs through µ-CT scanning and stereology.","authors":"Mohammad Sadra Pouladi, Nader Goodarzi, Sarang Soroori","doi":"10.1007/s12565-025-00909-3","DOIUrl":"https://doi.org/10.1007/s12565-025-00909-3","url":null,"abstract":"<p><p>This study aims to elucidate the morphometric and morphological details of teeth in the Syrian hamster (Mesocricetus auratus, Waterhouse, 1839) and guinea pig (Cavia porcellus, Linnaeus, 1758) using µ-CT and stereology (n = 5). Notably, the hamsters exhibited distinctive roots in their cheek teeth, in contrast to the guinea pigs, where the tooth body extended as a dental root into the alveolar socket, making anatomical diagnosis challenging. The first and second cheek teeth of the hamster had four roots, but the last one had three roots. The hamster incisor teeth had a more voluminous pulp cavity compared to those of guinea pigs. While the ratio differences of arch parameters and enamel thickness were not statistically significant (P ≥ 0.05). The enamel layer in guinea pig incisor teeth were significantly thicker than that in the hamster teeth (P ≤ 0.05). Regarding the dentine-tooth width, the difference between the upper incisor teeth of the hamster and guinea pig was significant (P ≤ 0.05). The ratio of pulp-tooth volume in all incisor teeth of the hamster was significantly higher than that in the guinea pig's teeth (P ≤ 0.05) indicating hamsters might have better regenerative dental health despite dietary variances. These insights contribute to deeper understanding of the evolutionary adaptations in rodent dentition and suggest improved information and methodologies for translational dental studies and selecting more appropriate animal models in dental research.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anatomical variations of the sciatic nerve: a literature review on morphology and clinical implications.","authors":"Bader Khawaji","doi":"10.1007/s12565-025-00908-4","DOIUrl":"https://doi.org/10.1007/s12565-025-00908-4","url":null,"abstract":"","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takutoshi Inoue, Toru Yamamoto, Norio Kitagawa, Joe Iwanaga
{"title":"Sternalis or rectus? An analysis of terminological usage based on case reports of the sternalis muscle.","authors":"Takutoshi Inoue, Toru Yamamoto, Norio Kitagawa, Joe Iwanaga","doi":"10.1007/s12565-025-00906-6","DOIUrl":"https://doi.org/10.1007/s12565-025-00906-6","url":null,"abstract":"<p><p>The sternalis muscle is a relatively rare anatomical variant that lies superficial to the pectoralis major muscle. In English-language literature, it is commonly referred as \"sternalis muscle\" or \"rectus sternalis.\" Although the second edition of the Terminologia Anatomica (TA) officially designates \"sternalis muscle\" as the standard term, terminological inconsistencies persist. This study investigated the actual usage of these terms based on a literature review of previously published case reports. We analyzed 77 articles comprising 92 cases, retrieved through PubMed and Google Scholar, examining the types of terms employed, their frequency, regional distribution, and temporal trends. As per the first and second editions of TA, the terms were categorized into two groups: the S group (\"sternalis muscle\" or \"sternalis\") and the R group (\"rectus sternalis\" or \"rectus sternalis muscle\"). Our analysis showed that unilateral cases and male patients were more frequently reported. Regionally, the highest number of reports originated from Asia. The frequency of S group usage exceeded that of R group usage by scale factors of 1.6, 2.3, and 3.8 in Asia, Europe and the Middle East, and North America, respectively. Furthermore, S group term usage increased after the release of the first edition of TA (TA1) and stabilized following the release of the second edition (TA2). These findings suggest that the TA-compliant term \"sternalis muscle\" has become dominant in English-language literature, supporting standardized anatomical nomenclature and facilitating consistent communication among anatomists and clinicians. This framework may also serve as a model for standardizing terminology related to other anatomical variants.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}