Anatomical Science International最新文献

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Morphometric evaluation of the orbital region for sex determination in a Saudi Arabian population using 3DCT images 利用 3DCT 图像对沙特阿拉伯人眼眶区域进行形态学评估,以确定其性别。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-09-18 DOI: 10.1007/s12565-023-00742-6
Vasanthakumar Packirisamy, Khaled Aljarrah, Satheesha B. Nayak
{"title":"Morphometric evaluation of the orbital region for sex determination in a Saudi Arabian population using 3DCT images","authors":"Vasanthakumar Packirisamy,&nbsp;Khaled Aljarrah,&nbsp;Satheesha B. Nayak","doi":"10.1007/s12565-023-00742-6","DOIUrl":"10.1007/s12565-023-00742-6","url":null,"abstract":"<div><p>In forensic anthropology, the analysis of variations in the orbitometric features plays a crucial role in identifying the sex of a skull detached from its skeleton. Therefore, it is essential to create population-specific values to maximize the accuracy rate of sex estimation. The objective of this study was to evaluate the orbital region morphometrically for sex determination in a Saudi Arabian population using CT scan images. This study included 456 CT images (228 males and 228 females; age range, 18–58 years). Six orbital measurements and the orbital index of both sides were evaluated to determine sexual dimorphism and laterality using an independent <i>t</i>-test. Sex was estimated using discriminant function analysis. Based on the orbital index, the orbit was classified into megasemes, mesosemes, and microsemes. All the measurements were significantly greater in males than females, but the orbital index showed no significant sexual dimorphism. No significant asymmetry was found in all orbital dimensions. The univariate discriminant function of the orbital measurements showed an accuracy rate between 83.8 and 70%. The multivariate analysis classified the orbital dimensions into male (93%) and female (92.1%) to the highest level of accuracy. In Saudis, the megaseme category was the most prevalent form of orbit. The right orbit height (83.8%), left orbit height (80.7%), right orbit width (79.4%), and left orbit height (79.4%) were the most reliable variables that could be used in sex determination. According to multivariate analysis, the overall accuracy rate for determining sex was 92.1%. While the present study data may not be used alone for sexing a complete skull, there must be various occasions in which this new standard will contribute to determining sex in forensic contexts.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"118 - 126"},"PeriodicalIF":1.2,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10340609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues dystonin 同工酶在维持神经、肌肉和皮肤组织中的作用。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-08-21 DOI: 10.1007/s12565-023-00739-1
Nozomu Yoshioka
{"title":"Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues","authors":"Nozomu Yoshioka","doi":"10.1007/s12565-023-00739-1","DOIUrl":"10.1007/s12565-023-00739-1","url":null,"abstract":"<div><p>Dystonin (<i>DST</i>), also known as bullous pemphigoid antigen 1 (<i>BPAG1</i>), encodes cytoskeletal linker proteins belonging to the plakin family. The <i>DST</i> gene produces several isoforms, including DST-a, DST-b, and DST-e, which are expressed in neural, muscle, and cutaneous tissues, respectively. Pathogenic <i>DST</i> mutations cause hereditary sensory and autonomic neuropathy type 6 (HSAN-VI) and epidermolysis bullosa simplex (EBS); therefore, it is important to elucidate the roles of DST isoforms in multiple organs. Recently, we have used several <i>Dst</i> mutant mouse strains, in which the expression of Dst isoforms is disrupted in distinct patterns, to gain new insight into how DST functions in multiple tissues. This review provides an overview of the roles played by tissue-specific DST isoforms in neural, muscle, and cutaneous tissues.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"7 - 16"},"PeriodicalIF":1.2,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical measurements of trigeminal ganglion: a cadaver study 三叉神经节的解剖测量:尸体研究。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-08-21 DOI: 10.1007/s12565-023-00740-8
Xiang Zhang, Yong Bai, Jianfei Hou, Wenbin Chen, Kailiang Cheng, Longjin Zi, Ping Wang
{"title":"Anatomical measurements of trigeminal ganglion: a cadaver study","authors":"Xiang Zhang,&nbsp;Yong Bai,&nbsp;Jianfei Hou,&nbsp;Wenbin Chen,&nbsp;Kailiang Cheng,&nbsp;Longjin Zi,&nbsp;Ping Wang","doi":"10.1007/s12565-023-00740-8","DOIUrl":"10.1007/s12565-023-00740-8","url":null,"abstract":"<div><p>It is difficult to obtain specific information regarding the trigeminal ganglion (TG), especially pediatric TG. The aim of present study was to determine the parameters of the TG and assist in the neuroablative treatment of trigeminal neuralgia (TN). Thirty-seven sides of cadaver heads that had undergone gross anatomical examination were included, with 29 sides of adults and 8 sides of infants. The distance and angles were measured among 12 points, with nine points adjacent to the TG and three points on the foramen ovale (FO). The three points on FO were represented as three different surgical approaches for TN: posterior FO approach (PFO), lateral FO approach (LFO), and anterior FO approach (AFO). A high similarity was found in pediatric TG. No statistical difference was detected in either the distance or the angles between the 12 points. Statistical difference was found in adult heads in some of the distances, which included PFO to point 5 (17.97 ± 3.35 mm in the left and 15.52 ± 2.28 mm in the right; <i>p</i> = 0.03) and LFO to point 5 and point 8. Moreover, the angle for PFO to point 5 showed a statistically significant difference (60.10 ± 14.02 in the left and 46.63 ± 10.48 in the right; <i>p</i> = 0.01). These findings revealed that surgical neuroablation for patients with TN should be performed more carefully when the PFO or LFO approach is adopted, with a precise preoperative evaluation to avoid corneal complications. Two safety radiofrequency rhizotomy points are also presented to deal with two different kinds of TN.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"98 - 105"},"PeriodicalIF":1.2,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anomalous origin of the left suprarenal, inferior phrenic arteries and left ovarian artery in a human cadaver 一具人体尸体的左肾上动脉、膈下动脉和左卵巢动脉的异常起源。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-08-11 DOI: 10.1007/s12565-023-00738-2
Zhicheng He, Lixin Ma, Wenyi Dan, Xinyi Cai, Hongrong Liu, Liyi Mao, Xuan Zhou, Guohui Li, Chugui Ding, Tao Wang
{"title":"Anomalous origin of the left suprarenal, inferior phrenic arteries and left ovarian artery in a human cadaver","authors":"Zhicheng He,&nbsp;Lixin Ma,&nbsp;Wenyi Dan,&nbsp;Xinyi Cai,&nbsp;Hongrong Liu,&nbsp;Liyi Mao,&nbsp;Xuan Zhou,&nbsp;Guohui Li,&nbsp;Chugui Ding,&nbsp;Tao Wang","doi":"10.1007/s12565-023-00738-2","DOIUrl":"10.1007/s12565-023-00738-2","url":null,"abstract":"<div><p>This report addresses three variants identified within a female cadaver. Specifically, these were an anomalous origin of the right suprarenal artery, an abnormal bilateral ovarian vein branch, and a arterial tortuosity of the left ovarian artery. Indeed, the cadaver evinced abnormal origins in the case of the middle suprarenal artery (MSA), right inferior phrenic artery (IPA), and the renal capsule artery (emanating from the right renal artery). The MSA and IPA shared a common trunk with the inferior suprarenal artery. It was additionally observed that the right ovarian vein anastomoses the branches from the right kidney posterior inferior along with those to the renal fat capsule. Abnormal origin was evident in the case of the left ovarian artery, and arterial tortuosity was apparent in the lower region of the vessels. This report addresses both the clinical import of these variations and their likely causes. In the subdiaphragmatic region, surgical success and prognosis may be impacted by such anomalies; accordingly surgeons must be aware of anatomical variants of the ovarian and suprarenal arteries.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"146 - 150"},"PeriodicalIF":1.2,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9972407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facial nerve dissection in parotid surgery: a microscopic investigation study 腮腺手术中的面神经剥离:一项显微镜调查研究。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-08-02 DOI: 10.1007/s12565-023-00737-3
Tsuyoshi Jinnin, Sugiko Futaki, Azumi Hirata, Hiroko Kuwabara, Masaaki Higashino, Yoichi Kondo, Ryo Kawata
{"title":"Facial nerve dissection in parotid surgery: a microscopic investigation study","authors":"Tsuyoshi Jinnin,&nbsp;Sugiko Futaki,&nbsp;Azumi Hirata,&nbsp;Hiroko Kuwabara,&nbsp;Masaaki Higashino,&nbsp;Yoichi Kondo,&nbsp;Ryo Kawata","doi":"10.1007/s12565-023-00737-3","DOIUrl":"10.1007/s12565-023-00737-3","url":null,"abstract":"<div><p>In parotid surgery, it is crucial to identify and preserve the facial nerve, which runs through the parotid gland. The purpose of this study was to histologically clarify two clinical questions: whether “superficial” and “deep” lobes exist anatomically and what are the structures surrounding facial nerve. Parotid gland tissues were obtained from dissection of donated cadavers. The gland was cut perpendicular to the facial nerve plane at 5 mm intervals, and the pieces were embedded in paraffin, thinly sliced, and stained. The morphology of the nerve was observed at each site, and the relationships between the thickness of the perineural tissue (defined as the tissue between the groups of nerve fasciculi and the glandular parenchyma), nerve diameter, and distance from the proximal end of the nerve were examined. In addition, the dissection layer was examined histologically in isolated parotid tissues. The interlobular connective tissue was spread like a mesh within the parotid gland and subdivided the glandular parenchyma. The facial nerve was located in the interlobular connective tissue, and its course was not restricted to the boundary plane between the superficial and deep lobes. The thickness of the perineural tissue decreased with increasing distance from the proximal end of the nerve. The dissection layer was clarified that located in the perineural tissue. The perineural tissue is thinner in more distal regions, which may make dissection more difficult there. No particular anatomical structure appears to separate the superficial and deep lobes.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"90 - 97"},"PeriodicalIF":1.2,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9920841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical variations of foramen of the diaphragma sellae and neighboring structures: a cadaveric study 膈椎孔及邻近结构的解剖变异:尸体研究。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-07-27 DOI: 10.1007/s12565-023-00736-4
Tufan Ay, Ugur Berk Akdag, Mustafa Faruk Kilincli, Eren Ogut, Cagatay Barut
{"title":"Anatomical variations of foramen of the diaphragma sellae and neighboring structures: a cadaveric study","authors":"Tufan Ay,&nbsp;Ugur Berk Akdag,&nbsp;Mustafa Faruk Kilincli,&nbsp;Eren Ogut,&nbsp;Cagatay Barut","doi":"10.1007/s12565-023-00736-4","DOIUrl":"10.1007/s12565-023-00736-4","url":null,"abstract":"<div><p>The aim of our study was to examine the variations and types of foramen of diaphragma sellae (FDS) and their relationship with nearby surgical landmarks on cadavers.Twenty adult (9 male, 11 female) formalin-fixed cadaveric heads were bilaterally used to analyze the anatomical relationships around the supradiaphragmatic region of sella turcica. Lengths and distances of nearby surgical landmarks were measured by a digital microcaliper. SPSS version 25 was used to analyze the comparison between genders and body sides. Dorsum sellae distances to tuberculum sellae and the optic chiasm(OC) were higher in males than females (<i>p</i> &lt; 0.05). Type 8 infundibulum passage was the most common variation with 50%. There was no finding related to types 1–4 of infundibulum passage. Thus, the present study has indicated that the infundibulum passes mostly from the posterior half of the foramen. The shape of the foramen was irregular in 45%, circular in 20%, sagittally oval in 20%, and horizontally oval in 15% of the cases. The OC was noted normal in 60%, prefixed in 35%, and postfixed in 5% of the cases. Comprehensive anatomical knowledge about the types of the FDS and their neighboring structures is crucial for preoperative planning of sellar region diseases in terms of navigating the region when accessing the foramen. Discrimination of variations of FDS, OC, and pituitary stalk, their relationships, and differences between genders is useful to minimize potential surgical complications.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"75 - 89"},"PeriodicalIF":1.2,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphology variations with medial cuneiform in hallux valgus 拇指外翻时内侧楔形的形态变化。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-07-15 DOI: 10.1007/s12565-023-00734-6
Ruining Li, Kai Tan, Yun Xie, Fasheng Wang
{"title":"Morphology variations with medial cuneiform in hallux valgus","authors":"Ruining Li,&nbsp;Kai Tan,&nbsp;Yun Xie,&nbsp;Fasheng Wang","doi":"10.1007/s12565-023-00734-6","DOIUrl":"10.1007/s12565-023-00734-6","url":null,"abstract":"<div><p>The hypermobility of the first tarsometatarsal joint has been identified as a key factor in the development of hallux valgus. Previous research found a link between the tarsometatarsal joint obliquity and the hallux valgus angle. Nevertheless, most studies relied on radiographs that lack 3D evidence. This study used 3D analysis to investigate the morphological differences in the medial cuneiform between hallux valgus and normal feet. In this study, twenty-three hallux valgus feet and twenty-three normal feet were scanned with computed tomography and 3D models of medial cuneiforms were reconstructed. Medial cuneonavicular and the first tarsometatarsal joint surfaces of the medial cuneiform were manually extracted. To obtain the obliquity angle of the medial cuneiform and curvature of the medial cuneonavicular joint, the joint surfaces were approximated to planes and spheres. Furthermore, the orientations of two joint surfaces were accessed through a novel positioning method. No significant difference was found in the cuneiform obliquity between hallux valgus and normal feet. Hallux valgus and normal groups did not differ significantly in any of the medial cuneiform joint orientations. The medial cuneiform in hallux valgus had a larger curvature diameter of the medial cuneonavicular joint (<i>P</i> = 0.029), indicating a flatter surface. The results demonstrated that the generally supported atavism (i.e., tarsometatarsal joint obliquity) does not exist in the hallux valgus feet. A flatter medial cuneonavicular joint surface was found in hallux valgus feet. This study contributes to the comprehensive understanding of the etiological factors with hallux valgus.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"59 - 67"},"PeriodicalIF":1.2,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9782781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of P2X3 purinoceptor-immunoreactive sensory nerve endings in the carotid body of Japanese macaque (Macaca fuscata) 日本猕猴颈动脉体中具有 P2X3 嘌呤受体免疫反应的感觉神经末梢的分布。
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-07-06 DOI: 10.1007/s12565-023-00735-5
Takuya Yokoyama, Masato Hirakawa, Kei Mochizuki, Takashi Suzuki, Katsumi Nakajima, Tomoyuki Saino
{"title":"Distribution of P2X3 purinoceptor-immunoreactive sensory nerve endings in the carotid body of Japanese macaque (Macaca fuscata)","authors":"Takuya Yokoyama,&nbsp;Masato Hirakawa,&nbsp;Kei Mochizuki,&nbsp;Takashi Suzuki,&nbsp;Katsumi Nakajima,&nbsp;Tomoyuki Saino","doi":"10.1007/s12565-023-00735-5","DOIUrl":"10.1007/s12565-023-00735-5","url":null,"abstract":"<div><p>In the carotid body of laboratory rodents, adenosine 5′-triphosphate (ATP)-mediated transmission is regarded as critical for transmission from chemoreceptor type I cells to P2X3 purinoceptor-expressing sensory nerve endings. The present study investigated the distribution of P2X3-immunoreactive sensory nerve endings in the carotid body of the adult male Japanese monkey (<i>Macaca fuscata</i>) using multilabeling immunofluorescence. Immunoreactivity for P2X3 was detected in nerve endings associated with chemoreceptor type I cells immunoreactive for synaptophysin. Spherical or flattened terminal parts of P2X3-immunoreactive nerve endings were in close apposition to the perinuclear cytoplasm of synaptophysin-immunoreactive type I cells. Immunoreactivity for ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2), which hydrolyzes extracellular ATP, was localized in the cell body and cytoplasmic processes of S100B-immunoreactive cells. NTPDase2-immunoreactive cells surrounded P2X3-immunoreactive terminal parts and synaptophysin-immunoreactive type I cells, but did not intrude into attachment surfaces between terminal parts and type I cells. These results suggest ATP-mediated transmission between type I cells and sensory nerve endings in the carotid body of the Japanese monkey, as well as those of rodents.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"68 - 74"},"PeriodicalIF":1.2,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9756515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
If text recycling refers to self-plagiarism, how does ChatGPT induce plagiarism? Originality for future science 如果文本回收指的是自我剽窃,那么ChatGPT是如何诱导剽窃的?未来科学的独创性
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-07-03 DOI: 10.1007/s12565-023-00732-8
Sén Takeda
{"title":"If text recycling refers to self-plagiarism, how does ChatGPT induce plagiarism? Originality for future science","authors":"Sén Takeda","doi":"10.1007/s12565-023-00732-8","DOIUrl":"10.1007/s12565-023-00732-8","url":null,"abstract":"","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"98 4","pages":"471 - 472"},"PeriodicalIF":1.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9920484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of pseudoephedrine on rat fetal bone development: evaluation by three different methods 伪麻黄碱对大鼠胎儿骨骼发育的影响:通过三种不同方法进行评估
IF 1.2 4区 医学
Anatomical Science International Pub Date : 2023-06-30 DOI: 10.1007/s12565-023-00733-7
Hüseyin Yiğit, Esra Balcıoğlu, İlyas Uçar, Muhammet Değermenci, Gözde Özge Önder, Tayfun Ceylan, Erdoğan Unur
{"title":"Effects of pseudoephedrine on rat fetal bone development: evaluation by three different methods","authors":"Hüseyin Yiğit,&nbsp;Esra Balcıoğlu,&nbsp;İlyas Uçar,&nbsp;Muhammet Değermenci,&nbsp;Gözde Özge Önder,&nbsp;Tayfun Ceylan,&nbsp;Erdoğan Unur","doi":"10.1007/s12565-023-00733-7","DOIUrl":"10.1007/s12565-023-00733-7","url":null,"abstract":"<div><p>Pseudoephedrine (PSE) is an agent that is contained in common cold medications. The agent, which is used to treat cold and cough, is the fourth most prescribed drug group in some countries. During pregnancy, expectant mothers use PSE for colds and other reasons. One out of every four expectant mothers use PSE alone or in combination with other medicines for various reasons. This study was aimed to investigate effects of PSE on long bones development in rat during fetal growth. Pregnant rats were divided into five groups: control and four experimental groups (25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg PSE). Between 1 and 20 days of pregnancy, PSE was given to them by gavage. Weights and heights of fetuses isolated by cesarean on the 21st day were measured. Ossification of femur and humerus was examined by three different methods mentioned earlier. Depending on the dose increase, all morphometric data, ossification rate and bone length of the fetuses were decreased. Besides, it was determined that the amount of Calcium in the bone tissue decreased in the analyzes made with SEM–EDX Analysis. The data obtained from this study reveal that the use of PSE during pregnancy disrupts the existing balance in the bone and negatively affects ossification due to the dose increase. In conclusion, we present descriptive and novel data on the effects of PSE use during pregnancy on the bone development of rat fetal long bones.</p></div>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":"99 1","pages":"48 - 58"},"PeriodicalIF":1.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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