Anais brasileiros de dermatologia最新文献_第5页

Thin and in situ melanoma: an update for the dermatologist 薄和原位黑色素瘤：皮肤科医生的更新

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-04-30 DOI: 10.1016/j.abd.2026.501349

João Renato Vianna Gontijo , Flávia Vasques Bittencourt , Jacob H. Nelson , Lucas Campos Garcia , Sancy A. Leachman

{"title":"Thin and in situ melanoma: an update for the dermatologist","authors":"João Renato Vianna Gontijo , Flávia Vasques Bittencourt , Jacob H. Nelson , Lucas Campos Garcia , Sancy A. Leachman","doi":"10.1016/j.abd.2026.501349","DOIUrl":"10.1016/j.abd.2026.501349","url":null,"abstract":"<div><h3>Background</h3><div>Thin melanoma (TM, ≤1.0 mm Breslow thickness) and Melanoma In Situ (MIS) constitute the majority of melanoma diagnoses worldwide and are responsible for melanoma-related deaths in these early-stage tumors. Despite their favorable prognosis, MIS and TM represent an opportunity for improving patient outcomes through early detection, accurate risk stratification, and long-term surveillance for metastasis and new skin neoplasms.</div></div><div><h3>Objective</h3><div>Provide an update of current evidence regarding epidemiology, risk factors, prognostic indicators, genetic background, and clinical management of MIS and TM.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature and international guidelines was conducted, integrating epidemiologic data, clinical prognostic parameters, and molecular insights relevant to MIS and TM.</div></div><div><h3>Results</h3><div>MIS and TM account for over 80% of all melanomas, with increasing incidence and relatively stable mortality rates. Prognosis is primarily determined by Breslow depth and ulceration, while factors such as mitotic rate, anatomic site, and age further refine risk assessment. Genetic alterations contribute to tumorigenesis but are not yet integrated into routine management. Long-term dermatological surveillance is needed, as new neoplasms, recurrence, and metastasis can develop during follow-up.</div></div><div><h3>Conclusions</h3><div>MIS and TM are increasingly diagnosed, and dermatologists need to be a part of early detection, multidisciplinary management, and lifelong surveillance, which remain the cornerstone of reducing melanoma-related mortality.</div></div><div><h3>Study limitations</h3><div>The substantial heterogeneity among the included studies limits direct comparison and quantitative synthesis of the available data.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501349"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL18 gene variants rs187238 and rs360717 and their associations with psoriasis susceptibility and severity in a Brazilian case-control study IL18基因变异rs187238和rs360717及其与牛皮癣易感性和严重程度的关联：巴西病例对照研究

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-13 DOI: 10.1016/j.abd.2026.501364

Cássio Rafael Moreira , Edna Maria Vissoci Reiche , Marcell Alysson Batisti Lozovoy , Andréa Name Colado Simão

引用次数: 0

Comment on “The Brazilian Portuguese version of the psoriasis epidemiology screening tool (PEST-bp) is reliable and accurate: a cross-sectional study from southern Brazil” – Reply 评论“巴西葡萄牙语版牛皮癣流行病学筛查工具（PEST-bp）是可靠和准确的：来自巴西南部的横断面研究”-回复。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-05 DOI: 10.1016/j.abd.2026.501370

Vanessa Thomé , Marcia Regina Rosa Scalcon , Denise Teresinha Antonelli da Veiga , Luciane Prado de Vargas , Patrícia Chagas , Camila Sales Fagundes , Gabriel Caruso Novaes Tudella , Mateus Diniz Marques , André Avelino Costa Beber , Raíssa Massaia Londero Chemello , Diego Chemello

引用次数: 0

Therapeutic synergy in long-standing plasma cell gingivitis: integrating photobiomodulation and immunomodulatory management 长期浆细胞性牙龈炎的治疗协同作用：整合光生物调节和免疫调节管理。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-13 DOI: 10.1016/j.abd.2026.501354

Josefina Hurtado , Víctor Meza , Fernando Valenzuela , Isidora Mujica

引用次数: 0

Congenital mastocytoma: clinical and histopathological aspects of a case with unusual presentation 先天性肥大细胞瘤：临床和病理方面的情况下，不寻常的表现。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-13 DOI: 10.1016/j.abd.2026.501371

Daniela da Guarda Ribeiro, Larissa Toledo de Lima Duarte Souza, Ângela Cristina Leitão de Souza, Juliany Lima Estefan

引用次数: 0

How to minimize pain with local anesthesia and improve patient experiences: a review 如何减少局部麻醉疼痛并改善患者体验：综述

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-09 DOI: 10.1016/j.abd.2026.501366

Umer Nadir , Isadora Rinaldo Scaburi , Felipe Bochnia Cerci , George Michael Jeha , Stanislav Nickolaevich Tolkachjov

{"title":"How to minimize pain with local anesthesia and improve patient experiences: a review","authors":"Umer Nadir , Isadora Rinaldo Scaburi , Felipe Bochnia Cerci , George Michael Jeha , Stanislav Nickolaevich Tolkachjov","doi":"10.1016/j.abd.2026.501366","DOIUrl":"10.1016/j.abd.2026.501366","url":null,"abstract":"<div><h3>Background</h3><div>Local anesthesia is essential in common procedures in dermatology, but injection and infiltration of anesthetic often cause significant pain, reducing patient comfort and satisfaction.</div></div><div><h3>Objective</h3><div>To review evidence-based techniques to reduce pain associated with local anesthetic injection and infiltration.</div></div><div><h3>Methods and materials</h3><div>A narrative review of the literature was performed, and techniques were summarized for clinicians to reference.</div></div><div><h3>Results</h3><div>Technical methods to reduce pain include using smaller-gauge needles (30–33G), smaller syringes (1‒3 mL), buffering lidocaine with sodium bicarbonate, inserting the needle at 90 degrees, slow infusion, subcutaneous delivery, and pore-guided injection. Adjuncts such as warming anesthetic, vibration, ice, music, and verbal distraction (“talkesthesia”) also reduce patient perception of pain.</div></div><div><h3>Study limitations</h3><div>Limitations include heterogeneity in study designs, outcomes measures, and clinical contexts across the included literature, precluding quantitative synthesis or direct comparison of individual techniques. Additionally, several recommendations are based on expert opinion or limited evidence.</div></div><div><h3>Conclusion</h3><div>A multimodal approach using both technical refinements and adjunctive measures can make local anesthetic administration less painful. Dermatologists may routinely implement these strategies to improve patient experience and satisfaction.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501366"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on “The Brazilian Portuguese version of the psoriasis epidemiology screening tool (PEST-bp) is reliable and accurate: a cross-sectional study from southern Brazil” 评论“巴西葡萄牙语版牛皮癣流行病学筛查工具（PEST-bp）是可靠和准确的：来自巴西南部的横断面研究”。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-13 DOI: 10.1016/j.abd.2026.501369

Kishankumar Mahida , Snehal Rajendra Jagtap

引用次数: 0

The efficacy and sustainability of a reduced risankizumab dose after achievement of low disease activity of psoriasis: a 24-week study 实现牛皮癣低疾病活动性后减少瑞桑单抗剂量的有效性和可持续性：一项为期24周的研究

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-04-29 DOI: 10.1016/j.abd.2026.501335

Gizem Pehlivan Ulutaş , Tuğba Özkök Akbulut , Algün Polat Ekinci

引用次数: 0

Use of dupilumab in the management of refractory prurigo nodularis in an immunosuppressed double transplanted patient 杜匹单抗在治疗免疫抑制双移植患者难治性结节性痒疹中的应用。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-06 DOI: 10.1016/j.abd.2026.501358

Diego Valenzuela Godoy , Rosario Agüero , Marianne Kolbach

引用次数: 0

Varicella-zoster virus infection: a review about varicella and herpes zoster 水痘-带状疱疹病毒感染：水痘和带状疱疹的研究进展

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2026-05-01 Epub Date: 2026-05-09 DOI: 10.1016/j.abd.2026.501367

Maria Paula Barbieri D'Elia , Carla Riama Lopes de Pádua Moura , Rafael de Deus Moura , Juliana de Sá Pires Carvalho , Henrique Pott

{"title":"Varicella-zoster virus infection: a review about varicella and herpes zoster","authors":"Maria Paula Barbieri D'Elia , Carla Riama Lopes de Pádua Moura , Rafael de Deus Moura , Juliana de Sá Pires Carvalho , Henrique Pott","doi":"10.1016/j.abd.2026.501367","DOIUrl":"10.1016/j.abd.2026.501367","url":null,"abstract":"<div><div>The Varicella-zoster virus (VZV) is a prevalent human pathogen that links dermatology, virology, and immunology. Following primary varicella infection, the virus establishes lifelong latency in the sensory ganglia, with reactivation manifesting as herpes zoster. The clinical spectrum ranges from typical dermatomal vesicular eruptions to atypical or disseminated presentations in older adults or immunocompromised patients, often posing diagnostic challenges. Early recognition and prompt initiation of antiviral therapy are essential to limit lesion progression, reduce viral shedding, and prevent complications. Dermatologists are uniquely positioned to identify these manifestations and distinguish VZV infection from its clinical mimics. Advances in molecular diagnostics have improved the detection of atypical cases, while the introduction of the attenuated-virus vaccine for varicella and recombinant glycoprotein E–based vaccine for herpes zoster has transformed prevention, providing durable protection even in older adults and immunosuppressed populations. Beyond therapy, dermatologists play a key role in integrating vaccination assessment and patient education into routine care. Understanding the biological continuum of VZV (from latency to reactivation) enhances diagnostic precision, guides evidence-based treatment, and supports immunization strategies against VZV. As VZV continues to impose a substantial burden of cutaneous and neuropathic morbidity, an integrated dermatological approach that combines early therapeutic intervention with preventive counseling represents the most effective strategy to reduce its clinical and public health impact.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501367"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0