Anais brasileiros de dermatologia最新文献

{"title":"Pyoderma gangrenosum-like sporotrichosis: case series of three patients and literature review","authors":"Lucas Campos Garcia , Marianne de Sousa Nunes Soares , Gustavo Gomes Resende , Luciana Baptista Pereira","doi":"10.1016/j.abd.2024.10.005","DOIUrl":"10.1016/j.abd.2024.10.005","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 619-623"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilocus sequence typing of Treponema pallidum in male patients with genital ulcers in a public sexually transmitted infections clinic: a new allele and almost complete macrolide resistance","authors":"Leonardo Souza Esteves , Vera Mileide Trivellato Grassi , Liliane Trivellato Grassi , Maria Rita Castilhos Nicola , Marcia Susana Nunes Silva , Maria Lucia Rosa Rossetti , Mauro Cunha Ramos","doi":"10.1016/j.abd.2024.10.008","DOIUrl":"10.1016/j.abd.2024.10.008","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 569-573"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired syphilis: update on clinical, diagnostic and therapeutic aspects⋆","authors":"Carolina Talhari ,&nbsp;Kaique Arriel ,&nbsp;Marcio Soares Serra ,&nbsp;John Verrinder Veasey","doi":"10.1016/j.abd.2024.11.002","DOIUrl":"10.1016/j.abd.2024.11.002","url":null,"abstract":"<div><div>Syphilis, an infection caused by <em>Treponema pallidum</em>, transmitted predominantly through sexual contact, affects several organs, causing skin, mucous membranes and systemic lesions. Despite being a secular disease, it still poses a major challenge for the public health system, since the number of cases continues to increase after years of warnings from the scientific community. Recognizing the clinical manifestations is essential for formulating the clinical hypothesis and diagnostic confirmation with complementary exams. However, recognizing skin lesions is not always simple, given the diversity of clinical manifestations which resemble other diseases. This review presents an overview of the disease, with current epidemiological data, a representation of the various clinical manifestations, a description of the pertinent diagnostic methods for laboratory confirmation, and appropriate therapeutic approaches for each clinical form.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 407-421"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pembrolizumab-induced Stevens-Johnson syndrome","authors":"Hiram Larangeira de Almeida Junior ,&nbsp;Debora Sarzi Sartori ,&nbsp;Aline Paganelli ,&nbsp;Karen Francisca Borges Sias ,&nbsp;Luísa Coelho Capuá ,&nbsp;Darlan Cleverson Farezin","doi":"10.1016/j.abd.2024.08.011","DOIUrl":"10.1016/j.abd.2024.08.011","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 629-633"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized pustular psoriasis (von Zumbusch) flares successfully treated with Spesolimab. Report of two cases and review of the literature","authors":"Raquel Steglich ,&nbsp;Felipe Saboia ,&nbsp;Lincoln Helder Zambaldi Fabricio ,&nbsp;Eoda Steglich ,&nbsp;Anber Tanaka","doi":"10.1016/j.abd.2024.10.010","DOIUrl":"10.1016/j.abd.2024.10.010","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 624-628"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative impact of striae gravidarum in maternal mental health","authors":"Talita Pereira Calheiros,&nbsp;Bárbara Borges Rubin,&nbsp;Jéssica Puchalski Trettim,&nbsp;Laura Medeiros de Oliveira,&nbsp;Ricardo Tavares Pinheiro,&nbsp;Hiram Larangeira de Almeida Jr.","doi":"10.1016/j.abd.2024.09.012","DOIUrl":"10.1016/j.abd.2024.09.012","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 573-576"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis and cardiovascular risk: associated and protective factors","authors":"Luciana Agoglia ,&nbsp;Helena Peixoto ,&nbsp;Ana Carolina Cardoso ,&nbsp;Lívia Barbosa ,&nbsp;Cecília S.X.L. Victer ,&nbsp;Sueli Carneiro ,&nbsp;Gil F. Salles ,&nbsp;Cristiane A. Villela-Nogueira ,&nbsp;Maria Chiara Chindamo","doi":"10.1016/j.abd.2024.07.013","DOIUrl":"10.1016/j.abd.2024.07.013","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is an inflammatory skin disease associated with Metabolic Syndrome (MetS), Steatotic Liver Disease (SLD) and cardiovascular risk. However, the effect of anti-inflammatory therapy on cardiovascular risk is uncertain.</div></div><div><h3>Objectives</h3><div>To determine the relationship between anti-inflammatory therapy and subclinical atherosclerosis in individuals with psoriasis, using the gold standard carotid-femoral Pulse Wave Velocity (cf-PWV) measurement. Additionally, to evaluate the association between cf-PWV, steatosis and Advanced Fibrosis (AF) using Transient Elastography (TE) by Fibroscan®.</div></div><div><h3>Methods</h3><div>Cross-sectional study including psoriasis patients submitted to cf-PWV and TE. Steatosis was defined as a controlled attenuation parameter ≥ 275 dB/m, AF as liver stiffness measurement ≥ 10 kPa, and increased Aortic Stiffness (AoS) as cf-PWV ≥ 10 m/s. Significant cumulative methotrexate dose was ≥ 1500 mg (MTX1500). Logistic regression analysis evaluated the independent variables associated with increased AoS.</div></div><div><h3>Results</h3><div>Eighty patients were included (mean age 56.2 ± 11.5-years, 57.5% female, BMI 28.6 ± 5.3 kg/m²). Prevalences of MetS, diabetes mellitus, dyslipidemia, systemic arterial hypertension, steatosis and AF were 57.5%, 40.0%, 67.5%, 70.0%, 50.0% and 16.3%, respectively. MTX1500 was present in 45%, immunobiological treatment in 33.8%, and cf-PWV ≥ 10 m/s in 21.2%. On logistic regression analysis, age was independently related to cf-PWV ≥ 10 m/s (OR = 1.21; 95% CI 1.06‒1.38; p = 0.003) and MTX1500 was a protective cardiovascular factor (OR = 0.18; 95% CI 0.038‒0.87; p = 0.033). No association was observed between steatosis, AF or immunobiological therapy and cf-PWV ≥10 m/s.</div></div><div><h3>Study limitations</h3><div>Sample size.</div></div><div><h3>Conclusion</h3><div>In patients with psoriasis, increased AoS was associated with age, but not with steatosis or AF. A protective cardiovascular effect of MTX was found in a psoriasis population with a high prevalence of MetS and its components.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 456-461"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of dupilumab in patients with moderate-to-severe bullous pemphigoid: a systematic review and meta-analysis","authors":"Júlia Opolski Nunes da Silva ,&nbsp;Rodrigo Ribeiro e Silva ,&nbsp;Paulo Victor Zattar Ribeiro ,&nbsp;Patrícia Silva Farah ,&nbsp;Raquel Bissacotti Steglich","doi":"10.1016/j.abd.2024.08.008","DOIUrl":"10.1016/j.abd.2024.08.008","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate the safety and efficacy of dupilumab in treating moderate-to-severe bullous pemphigoid.</div></div><div><h3>Methods</h3><div>The authors performed a systematic review and meta-analysis of comparative studies of Dupilumab combined with corticosteroids and conventional corticosteroid therapy alone in patients with moderate-to-severe bullous pemphigoid. PubMed, Embase and Cochrane databases were searched for studies published up to December 2023. Data were extracted from published reports and quality assessment was performed according to Cochrane recommendations.</div></div><div><h3>Results</h3><div>A total of four studies involving 127 patients were included, of which 53 received Dupilumab combined with corticosteroids, while the other 74 were administered corticosteroids alone. Regarding efficacy, Dupilumab the time before new blister formation stopped (MD = −5.13 days; 95% CI −7.12 to −3.15; p &lt; 0.0001) and demonstrated a greater reduction in Bullous Pemphigoid Disease Area Index (MD = −3.90; 95% CI −5.52 to −2.27; p &lt; 0.0001) and Numeric Rating Scale for Pruritus (SMD = −1.37; 95% CI −2.02 to −0.72; p &lt; 0.0001) compared with patients who received conventional therapy. However safety endpoints, adverse events (RR = 0.78; 95% CI 0.58 to 1.05; p = 0.10) and relapses (RR = 0.50; 95% CI 0.19 to 1.36; p = 0.17) showed no significance. The main limitations were retrospective studies with small samples and limited results in clinical practice and a moderate overall risk of bias.</div></div><div><h3>Conclusion</h3><div>Compared with conventional therapy, Dupilumab decreased the time before new blister formation stopped in 5.13 days, as well as Disease Area Index and Pruritus, without interfering with adverse events and relapse.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 429-438"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail involvement due to immunoglobulin G4 (IgG4)-related disease in a person living with HIV⋆","authors":"Valéria Lukenczuk Said ,&nbsp;Monique Freire dos Reis ,&nbsp;Tiago Vencato da Silva ,&nbsp;Virgínia Vilasboas Figueiras ,&nbsp;Nathália Matos Gomes","doi":"10.1016/j.abd.2024.09.007","DOIUrl":"10.1016/j.abd.2024.09.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 598-601"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro characterization of biofilm produced by Fusarium oxysporum, an onychomycosis agent","authors":"Isabella Letícia Esteves Barros ,&nbsp;Flávia Franco Veiga ,&nbsp;Terezinha Inez Estivalet Svidzinski","doi":"10.1016/j.abd.2024.11.005","DOIUrl":"10.1016/j.abd.2024.11.005","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 560-563"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}