Anais brasileiros de dermatologia最新文献_第4页

Hand dermatitis: a 6-year experience in a tertiary referral Brazilian hospital 手皮炎：巴西三级转诊医院6年经验。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.08.010

Larissa Relva da Fonte Gonçalves Endlich, Luciana Paula Samorano, Ricardo Spina Nunes, Vitor Manoel Silva dos Reis

{"title":"Hand dermatitis: a 6-year experience in a tertiary referral Brazilian hospital","authors":"Larissa Relva da Fonte Gonçalves Endlich, Luciana Paula Samorano, Ricardo Spina Nunes, Vitor Manoel Silva dos Reis","doi":"10.1016/j.abd.2024.08.010","DOIUrl":"10.1016/j.abd.2024.08.010","url":null,"abstract":"<div><h3>Background</h3><div>Hand dermatitis (HD) is a prevalent inflammatory skin disease with a significant socioeconomic impact.</div></div><div><h3>Objectives</h3><div>To characterize the population of HD patients followed up at the Department of Dermatology of a tertiary hospital.</div></div><div><h3>Methods</h3><div>A cross-sectional, retrospective and descriptive study was carried out through the analysis of medical records of HD patients assisted at the Allergy Clinic of the Department of Dermatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, between March 1, 2016 and August 31, 2022.</div></div><div><h3>Results</h3><div>Of the 175 patients, 73.3% were women, and the mean age at the onset of the condition was 41.7 years. There was a statistically significant association between occupation categories and the presence of occupational dermatitis. Cases were classified as irritant contact dermatitis (49.7%), allergic contact dermatitis (57.1%) and endogenous vesicular HD (3.4%). It was observed a statistically significant higher frequency of patch tests positivity for methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) and nickel sulfate in women and for potassium bichromate and carba mix in men. DLQI was assessed in 77 patients, and the average score was 7.8 points.</div></div><div><h3>Study limitations</h3><div>As limitations, the authors point out data collection from medical records, which lacked some information. Furthermore, as this was a cross-sectional study, it was not possible to assess cause-and-effect relationships between the variables.</div></div><div><h3>Conclusions</h3><div>The present data reinforces the importance of patch tests in HD investigation and highlights the high sensitivity rates to MCI/MI and nickel sulfate in Brazilian women and to potassium bichromate and carba mix in Brazilian men patients.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 439-446"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic pruritus: a narrative review 慢性瘙痒症：述评。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.09.008

Paulo Ricardo Criado , Roberta Fachini Jardim Criado , Mayra Ianhez , Hélio Amante Miot

{"title":"Chronic pruritus: a narrative review","authors":"Paulo Ricardo Criado , Roberta Fachini Jardim Criado , Mayra Ianhez , Hélio Amante Miot","doi":"10.1016/j.abd.2024.09.008","DOIUrl":"10.1016/j.abd.2024.09.008","url":null,"abstract":"<div><div>Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous approach, guided by the identification of skin lesions or signs/symptoms of underlying systemic diseases. A comprehensive evaluation, including a detailed medical history, thorough physical examination, and appropriate laboratory and imaging tests, often supplemented by skin biopsy and direct immunofluorescence, is essential. Treatment strategies for chronic pruritus should be individualized based on the etiology identified. General measures, such as emollients, serve as initial interventions, followed by targeted approaches. Topical corticosteroids, calcineurin inhibitors, phototherapy, and systemic immunosuppressants address cutaneous inflammation. Antihistamines, antidepressants, and immunosuppressants may be employed based on the specific etiology. Emerging therapies, including biologic drugs and JAK inhibitors, have potential in refractory cases.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 487-519"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma gangrenosum diagnosed in a high-risk myelodysplastic neoplasm patient with trisomy 8: a rare case report 8三体高危骨髓增生异常肿瘤患者诊断为坏疽性脓皮病：罕见病例报告。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.11.003

Renato Mendes Martins , Howard Lopes Ribeiro-Junior , Natália Feitosa Arrais Minete Mendonça , Fábio Rocha Fernandes Távora , Ronald Feitosa Pinheiro

引用次数: 0

Rapid improvement in a recurrent generalized pustular psoriasis patient ineffective to Ixekizumab following Spesolimab therapy 复发性广泛性脓疱性银屑病患者在史匹利单抗治疗后对伊谢珠单抗无效的快速改善。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.09.003

Wenjie Li , Fan Cui , Lixia Zhang , Ge Yang , Zhen Rang , Minyan Xu , Yangying Liu , Siyu Wang

引用次数: 0

Anais Brasileiros de Dermatologia: who wrote this century-old history? Anais Brasileiros de Dermatologia：谁写了这段百年历史？

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2025.02.001

Helena Cargnelutti Grimaldi , Sandro da Silva Camargo

引用次数: 0

Borderline lepromatous leprosy with lymph node infiltration: Dermatology helps to clarify challenging diagnoses 伴有淋巴结浸润的边缘型麻风病：皮肤科帮助明确具有挑战性的诊断。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.10.004

Victor Henrique Murback dos Reis, Anna Carolina Miola, Cesar Augusto Zago Ferreira, Simone de Pádua Milagres, Joel Carlos Lastória, Juliano Vilaverde Schmitt

引用次数: 0

Mpox in a patient with AIDS: clinical management with tecovirimat and surgical correction of unaesthetic scars 1例艾滋病患者的m痘：用替科维司和手术矫正不美观疤痕的临床处理。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.11.001

Kananda Kesye Sousa Nunes, Carlos Alberto Chirano Rodrigues, Beatriz Costa Cardoso, Iêda Lúcia Santos Magno, Mathias Gama de Aguiar Ferreira, Sinésio Talhari

引用次数: 0

Immunotherapy-induced psoriasis successfully treated with Guselkumab in a patient with metastatic gastric cancer Guselkumab成功治疗转移性胃癌患者的免疫疗法诱导的牛皮癣。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.08.009

Denis Miyashiro , Thiago William Carnier Jorge , André Luís da Silva Hirayama , José Antonio Sanches

引用次数: 0

Histopathological analysis of the skin of renal transplant recipients submitted to three different immunosuppression regimens 三种不同免疫抑制方案下肾移植受者皮肤的组织病理学分析。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.07.016

Maria Victória Quaresma , Luiz Sergio Azevedo , Elias David-Neto , Mírian Nacagami Sotto

{"title":"Histopathological analysis of the skin of renal transplant recipients submitted to three different immunosuppression regimens","authors":"Maria Victória Quaresma , Luiz Sergio Azevedo , Elias David-Neto , Mírian Nacagami Sotto","doi":"10.1016/j.abd.2024.07.016","DOIUrl":"10.1016/j.abd.2024.07.016","url":null,"abstract":"<div><h3>Background</h3><div>Renal transplant recipients (RTRs) use a combination of immunosuppressive agents: a corticosteroid; a calcineurin inhibitor (cyclosporine or tacrolimus) and an antimetabolic agent (azathioprine [AZA] or a mycophenolic acid precursor [MPA] ‒ Mycophenolate mofetil or sodium) or an mTOR inhibitor (mTORi) ‒ sirolimus or everolimus. These treatments increase the incidence of various neoplasms, especially non-melanoma skin cancers (NMSCs).</div></div><div><h3>Objectives</h3><div>To evaluate the histopathological alterations in the skin of the RTRs under three different immunosuppressive regimens: one mTORi (sirolimus or everolimus); or one antimetabolic agent (MPA or AZA), comparing them by groups and with healthy controls.</div></div><div><h3>Methods</h3><div>This was a cross-sectional comparative study of 30 patients selected from the Renal Transplant Service and divided into three groups: mTORi (n = 10), MPA (n = 10), and AZA (n = 10). The control group consisted of 10 immunocompetent non-transplanted volunteers. All RTRs were using tacrolimus and prednisone. Each participant underwent two biopsies of intact skin: one in a sun-protected and another in a sun-exposed area. The specimens were analyzed without previous information on which group they belonged to.</div></div><div><h3>Results</h3><div>The most significant histopathological change was thinning of the epidermis in the mTORi group, both in photoexposed and photoprotected skin.</div></div><div><h3>Study limitations</h3><div>The study was conducted on a limited number of patients, which may influence the representativeness of the results.</div></div><div><h3>Conclusions</h3><div>Only RTRs treated with mTORi presented interruption of epidermal proliferation. These findings help to understand the influence of these different types of immunosuppressive regimens and their subsequent potential effects on carcinogenesis.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 447-455"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-term effectiveness, safety, and potential predictors of response of upadacitinib in patients with moderate-to-severe atopic dermatitis: a multicenter observational retrospective study upadacitinib治疗中重度特应性皮炎的中期有效性、安全性和潜在预测因素：一项多中心观察性回顾性研究

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-05-01 DOI: 10.1016/j.abd.2024.10.009

Francisco Javier Melgosa Ramos , Carlos Abril Pérez , Santiago Guillén Climent , María Matellanes Palacios , Juncal Roca Ginés , Javier Sabater Abad , Eduardo Bernia Petit , Andrés Casanova Esquembre , Andrea Estébanez Corrales , Victor González Delgado

引用次数: 0