Anais brasileiros de dermatologia最新文献

{"title":"Facial pemphigus vegetans mimicking squamous cell carcinoma: when dermoscopy confuses the diagnosis","authors":"Nelson Lobos , Francisca Reculé , Macarena Stevenson , Valentina Darlic , Dan Hartmann , Alex Castro","doi":"10.1016/j.abd.2024.05.009","DOIUrl":"10.1016/j.abd.2024.05.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 362-364"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of treatment with clobetasol propionate or bexarotene in early-stage mycosis fungoides","authors":"Aslı Aksu Çerman,&nbsp;Pinar Ozdemir Cetinkaya,&nbsp;Birgül Özkesici Kurt,&nbsp;Artun Kırker,&nbsp;İlknur Altunay","doi":"10.1016/j.abd.2024.04.011","DOIUrl":"10.1016/j.abd.2024.04.011","url":null,"abstract":"<div><h3>Background</h3><div>There are few studies in the literature comparing the effectiveness of topical treatments in early-stage mycosis fungoides (MF).</div></div><div><h3>Objectives</h3><div>It was aimed to evaluate the clinical efficacy, side effects and topical treatment compliance with bexarotene or clobetasol propionate in early-stage MF.</div></div><div><h3>Methods</h3><div>A total of 40 patients with stage IA-IB MF were enrolled in the study. Twenty patients were treated with 1% bexarotene gel and 20 patients were treated with 0.05% clobetasol propionate ointment.</div></div><div><h3>Results</h3><div>In the bexarotene group, 11 patients (55%) had complete clinical response (CCR) and 5 patients (25%) had partial response (PR) while in the clobetasol propionate group, 10 patients (50%) had CCR and 9 patients (45%) had PR. The median duration of remission was 10.5 months in the bexarotene group and 4 months in the clobetasol propionate group. The remission period was statistically significantly longer in the bexarotene group (p = 0.032). Irritation symptoms were statistically significantly more common in the bexarotene group (p = 0.001).</div></div><div><h3>Study limitations</h3><div>The limitation of the study was its retrospective design.</div></div><div><h3>Conclusion</h3><div>Both topical bexarotene and topical clobetasol propionate were found to be effective in MF. Irritation symptoms were more common with topical bexarotene. Moreover, the remission period with topical bexarotene was significantly longer.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 237-242"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features associated with the use of single or combined reconstructions: analysis of 1,124 Mohs surgeries","authors":"Felipe Bochnia Cerci ,&nbsp;Letícia Mari Tashima ,&nbsp;Stephanie Matthews ,&nbsp;Stanislav N. Tolkachjov","doi":"10.1016/j.abd.2024.07.009","DOIUrl":"10.1016/j.abd.2024.07.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 342-345"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An extremely prolonged case of drug reaction with eosinophilia and systemic symptoms (DRESS Syndrome) secondary to a penicillin-based antibiotic","authors":"Florence Robinson ,&nbsp;Lucy Webber ,&nbsp;Emma Ormerod ,&nbsp;Daniel Keith","doi":"10.1016/j.abd.2024.07.007","DOIUrl":"10.1016/j.abd.2024.07.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 358-359"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first case of paraneoplastic pemphigus positive for IgG autoantibodies against integrin α6","authors":"Ying Li ,&nbsp;Yunmei Dong ,&nbsp;Xin Zeng ,&nbsp;Wei Li ,&nbsp;Yu Zhou ,&nbsp;Xiaoguang Li","doi":"10.1016/j.abd.2024.04.016","DOIUrl":"10.1016/j.abd.2024.04.016","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 380-383"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison","authors":"Leyla Baykal Selçuk ,&nbsp;Hande Ermiş Akkuş ,&nbsp;Burak Akşan ,&nbsp;Deniz Aksu Arıca","doi":"10.1016/j.abd.2024.05.005","DOIUrl":"10.1016/j.abd.2024.05.005","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic inflammatory skin disease with a genetic predisposition and autoimmune component, often treated with immunomodulators such as biologic therapies.</div></div><div><h3>Objectives</h3><div>In this study, the authors evaluated the effectiveness and safety of two of these over a 52-week treatment period.</div></div><div><h3>Methods</h3><div>A double-center retrospective cohort study was conducted, enrolling patients with moderate to severe psoriasis who received either guselkumab or risankizumab at dermatology clinics for a minimum of 52-weeks.</div></div><div><h3>Result</h3><div>Out of the 90 patients enrolled in the study, 49 (54.4%) received guselkumab, while 41 (45.6%) received risankizumab. Regarding therapy efficiency, there was no statistically significant difference in PASI90 and PASI100 at week 4 between the two groups (p = 0.428, p = 0.750, respectively). By week 16, PASI90 responses were higher in the guselkumab group (p = 0.039). However, there was no difference in PASI100 response at week 16 (p = 0.957). At weeks 24 and 52, PASI90 and PASI100 responses were similar in both groups. Our results demonstrated that both guselkumab and risankizumab were effective in patients who had previously failed other biologics. Clinical outcomes in both the guselkumab and risankizumab groups had remained unaffected during prior biologic treatments, including anti-TNF, anti-IL17, and/or anti-IL12/23. Treatments yielded consistent outcomes regardless of factors such as obesity, gender, and comorbidities.</div></div><div><h3>Study limitations</h3><div>The small sample size.</div></div><div><h3>Conclusions</h3><div>Our results demonstrated that both guselkumab and risankizumab were effective in patients who had previously failed other biologics. Clinical outcomes in both the guselkumab and risankizumab groups had remained unaffected during prior biologic treatments, including anti-TNF, anti-IL17, and/or anti-IL12/23. Treatments yielded consistent outcomes regardless of factors such as obesity, gender, and comorbidities.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 293-299"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen IV immunohistochemistry and autoimmune bullous diseases: defining the location of the subepidermal bullae","authors":"Lula María Nieto-Benito ,&nbsp;Verónica Parra-Blanco ,&nbsp;Ricardo María Suárez-Fernández","doi":"10.1016/j.abd.2024.04.014","DOIUrl":"10.1016/j.abd.2024.04.014","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 388-390"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulvar ulcers secondary to aortic angiosarcoma in a patient with misdiagnosed cancer of unknown primary origin⋆","authors":"Denis Miyashiro ,&nbsp;Regina Barros Domingues ,&nbsp;Malu Viter da Rosa Barbosa ,&nbsp;Claudia Giuli Santi ,&nbsp;Marcello Menta Simonsen Nico ,&nbsp;José Antonio Sanches","doi":"10.1016/j.abd.2024.07.008","DOIUrl":"10.1016/j.abd.2024.07.008","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 384-387"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of Schwannoma mimicking squamous cell carcinoma","authors":"Pedro Rolo de Matos ,&nbsp;Miguel Silva ,&nbsp;Gilberto Rosa ,&nbsp;Pedro Canão ,&nbsp;Filomena Azevedo","doi":"10.1016/j.abd.2024.07.011","DOIUrl":"10.1016/j.abd.2024.07.011","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 360-362"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear IgA bullous dermatosis: 32 years of experience","authors":"Tugba Atci ,&nbsp;Gizem Pehlivan Ulutas ,&nbsp;Ecem Güreler Sirkeci ,&nbsp;Rıfkiye Küçükoğlu","doi":"10.1016/j.abd.2024.03.015","DOIUrl":"10.1016/j.abd.2024.03.015","url":null,"abstract":"<div><h3>Background</h3><div>Linear IgA bullous dermatosis (LABD) is an uncommon disease with only a few reported studies in large series with long follow-up periods.</div></div><div><h3>Objectives</h3><div>To evaluate the clinical presentation, immunopathological features, management, and disease course in LABD patients.</div></div><div><h3>Methods</h3><div>Data including demographics, clinical features, histopathological and immunofluorescence findings of LABD patients, in addition to the preferred treatments and responses to treatments were evaluated.</div></div><div><h3>Results</h3><div>Among 26 patients diagnosed with LABD, 17 (65.4%) were female. The mean age was 40.3 ± 22.4 (6‒80) years of whom 21 were adults. The most common mucosal involvement was oral (n = 9, 34.6%). Continuous linear IgA deposition was present on the basement membrane zone of all patients in addition to C3 (n = 13), IgG (n = 9), IgM (n = 4), and fibrinogen (n = 4). Three patients were lost to follow-up without any treatment. Dapsone was the treatment of choice in most (n = 21, 91.3%) patients in addition to systemic corticosteroids (n = 17), azathioprine (n = 3), tetracycline and nicotinamide (n = 2). Complete and partial remissions were achieved in 11 (47.8%) and 12 (52.2%) patients, respectively, in a mean follow-up period of 45.9 ± 43.9 (3‒158) months. Furthermore, 17 patients were still under treatment at the end of the follow-up period.</div></div><div><h3>Study limitations</h3><div>Retrospective study conducted in a single center.</div></div><div><h3>Conclusions</h3><div>LABD may occur at two separate peaks, one in the second and the other in the sixth decade of life with a female predominance. Other immunoglobulins may be associated with dominant IgA antibody deposition and the most commonly used therapeutic option for LABD patients was oral dapsone.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 277-282"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}