Anais brasileiros de dermatologia最新文献

{"title":"Dermatofibroma: clinicopathological analysis of 239 cases","authors":"Dilara İlhan Erdil , Cem Leblebici , Duygu Erdil , Vildan Manav , Vefa Aslı Erdemir , Ayşe Esra Koku Aksu","doi":"10.1016/j.abd.2024.03.012","DOIUrl":"10.1016/j.abd.2024.03.012","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 150-155"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DRESS syndrome: an interaction between drugs, latent viruses, and the immune system","authors":"Paulo Ricardo Criado ,&nbsp;Mayra Ianhez ,&nbsp;Hélio Amante Miot ,&nbsp;Roberta Fachini Jardim Criado ,&nbsp;Carolina Talhari ,&nbsp;Paulo Müller Ramos","doi":"10.1016/j.abd.2023.12.010","DOIUrl":"10.1016/j.abd.2023.12.010","url":null,"abstract":"<div><div>Drug-induced hypersensitivity syndrome, also known as DRESS syndrome, is a serious and potentially fatal reaction that occurs in response to prolonged use (generally between 14 and 60 days) of certain drugs, and which has no predilection for gender or age group. It is believed that DRESS syndrome has a genetic basis and results from the interaction between metabolites of certain pharmacological groups, reactivation of latent viruses (especially from the <em>Herpesviridae</em> family), and a cellular immune response. The classic manifestation of DRESS syndrome includes a generalized rash accompanied by fever, eosinophilia, lymphadenopathy, and systemic involvement such as hepatitis, nephritis, or pneumonitis. With the continuous increase in the availability of drugs and the aging of the population, there is a favorable scenario for the development of adverse drug reactions. Physicians should be prepared for the early diagnosis of DRESS syndrome, the identification and immediate suspension of the drug involved, and also manage systemic involvement, which may require prolonged immunosuppressive therapy. This article provides an update on the clinical, physiopathological and therapeutic aspects of DRESS syndrome.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 104-120"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurothecoma in the tibial region","authors":"Mariana Abdo de Almeida ,&nbsp;Neusa Yuriko Sakai Valente ,&nbsp;Eduardo César Diniz Macêdo ,&nbsp;Bruna Nascimento Arruda Scabello ,&nbsp;Patrícia Porto de Oliveira Grossi","doi":"10.1016/j.abd.2024.02.009","DOIUrl":"10.1016/j.abd.2024.02.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 194-197"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red light-emitting diode on skin healing: an in vitro and in vivo experimental study","authors":"Tuany R. Schmidt ,&nbsp;Belkiss C. Mármora ,&nbsp;Fernanda T. Brochado ,&nbsp;Lucas Gonçalves ,&nbsp;Paloma S. Campos ,&nbsp;Marcelo L. Lamers ,&nbsp;Aurigena A. de Araújo ,&nbsp;Caroline A.C.X. de Medeiros ,&nbsp;Susana B. Ribeiro ,&nbsp;Marco A.T. Martins ,&nbsp;Emily F.S. Pilar ,&nbsp;Manoela D. Martins ,&nbsp;Vivian P. Wagner","doi":"10.1016/j.abd.2024.02.008","DOIUrl":"10.1016/j.abd.2024.02.008","url":null,"abstract":"<div><h3>Background</h3><div>The clinical advantages of light-emitting diode (LED) therapy in skin healing and its underlying mechanism remain subjects of ongoing debate.</div></div><div><h3>Objective</h3><div>This study aims to explore the impact of LED therapy on normal skin keratinocytes (HaCaT) and in the repair of full-thickness dorsal wounds in Wistar rats.</div></div><div><h3>Methods</h3><div>HaCaT cell viability (SRB assay) and migration (scratch assay) were assessed under LED therapy, comparing stress conditions (2.5% FBS) with sham irradiation and optimal conditions (10% FBS). In vivo, 50 rats with induced wounds were divided into Sham and LED (daily treatment) groups. Euthanasia occurred at 3, 5, 10, 14, and 21 days for clinical, morphological, oxidative stress (MDA, SOD, and GSH), and cytokine analyses (IL-1β, IL-10, TNF-α).</div></div><div><h3>Results</h3><div>LED therapy significantly enhanced keratinocytes viability compared to sham irradiation, with minimal impact on cell migration. Clinical benefits were prominent on day 10, influencing inflammation progression and resolution on days 3 and 10. Re-epithelization remained unaffected. Reduced MDA and increased GSH levels were observed throughout, while SOD levels varied temporally. Notably, on day 10, LED significantly decreased IL-1β, IL-10, and TNF-α.</div></div><div><h3>Study limitations</h3><div>Although translational, clinical trial confirmation of observed benefits is warranted.</div></div><div><h3>Conclusions</h3><div>LED therapy expedites cutaneous healing in the experimental model, primarily modulating inflammation and enhancing antioxidant activity.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 54-62"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis cutis dyschromica caused by compound heterozygous GPNMB mutations in a Chinese pedigree","authors":"Ci-Juan Zhong ,&nbsp;Fang-Gu Li ,&nbsp;Wen Li ,&nbsp;Yi-Ming Fan","doi":"10.1016/j.abd.2024.01.009","DOIUrl":"10.1016/j.abd.2024.01.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 174-178"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric surgery complicating the treatment of choice for Sporotrichosis: report of two cases","authors":"Maria Eduarda Resende Melo ,&nbsp;Melissa Orzechowski Xavier ,&nbsp;Rossana Patricia Basso ,&nbsp;Karine Ortiz Sanchotene ,&nbsp;Fabiana Fedatto Bernardon ,&nbsp;Vanice Rodrigues Poester","doi":"10.1016/j.abd.2024.07.005","DOIUrl":"10.1016/j.abd.2024.07.005","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 198-200"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous pemphigoid mimicking toxic epidermal necrolysis","authors":"Hiram Larangeira de Almeida Jr. ,&nbsp;Rodrigo Piltcher da Silva ,&nbsp;Valéria Magalhães Jorge","doi":"10.1016/j.abd.2024.03.009","DOIUrl":"10.1016/j.abd.2024.03.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 178-180"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and dermoscopic patterns of acquired melanocytic nevi in children and adolescents: a cross-sectional study from Turkey","authors":"Zeynep Keskinkaya ,&nbsp;Özge Kaya ,&nbsp;Selda Işık Mermutlu ,&nbsp;Hilay Garipcan Karaemir ,&nbsp;Sevilay Oğuz Kılıç","doi":"10.1016/j.abd.2024.04.005","DOIUrl":"10.1016/j.abd.2024.04.005","url":null,"abstract":"<div><h3>Background</h3><div>Childhood and adolescence are the most active periods for nevi development, which provide insights into nevogenesis.</div></div><div><h3>Objectives</h3><div>To evaluate the clinical and dermoscopic characteristics of acquired melanocytic nevi in Turkish children (aged ≤ 10-years) and adolescents (aged &gt; 10-years) regarding demographic, constitutional, and environmental factors.</div></div><div><h3>Methods</h3><div>A cross-sectional study on participants aged &lt; 18-years examined for acquired melanocytic nevi between January and June 2023.</div></div><div><h3>Results</h3><div>One hundred participants (female: male ratio = 1:1; median age: 10) were assessed. The median nevi number was significantly higher in adolescents than in children (6 vs. 4; p &lt; 0.05). The upper extremities (n = 68) and trunk (n = 67) were the most commonly involved anatomical regions. Females had a significantly higher nevi rate on the upper extremities than males (80% vs. 56%; p &lt; 0.05). The trunk was involved slightly more frequently in males (76% vs. 58%; p = 0.06). The globular pattern rate was higher in children than in adolescents (70.6% vs. 42.9%; p &lt; 0.05), whereas a striking increase was observed in the reticular pattern from childhood (2%) to adolescence (14.3%) (p &lt; 0.05). The globular pattern was the major dermoscopic pattern in all anatomical locations except lower extremities where the homogeneous pattern prevailed. Sunscreen use had no impact on the nevi number or dermoscopic pattern.</div></div><div><h3>Study limitations</h3><div>Limited number of participants.</div></div><div><h3>Conclusions</h3><div>The age and anatomical site were the most relevant factors influencing the number and dermoscopic patterns of nevi. The gender-related distribution pattern of nevi, without any effect of sunscreen use on either nevus count or dermoscopic pattern, suggests a genetic predisposition.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 22-30"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of positivity in patch tests and reactivity to substances present in the main dressings in patients with chronic leg ulcers","authors":"Ísis Fiorello de Oliveira Mesquita ,&nbsp;Larissa Pierri Carvalho Fonseca ,&nbsp;Maria Rita Parise Fortes ,&nbsp;Hélio Amante Miot ,&nbsp;Luciana Patricia Fernandes Abbade","doi":"10.1016/j.abd.2024.05.003","DOIUrl":"10.1016/j.abd.2024.05.003","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 162-165"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin cancer after heart transplantation: a systematic review","authors":"Nathalia Hoffmann Guarda Aguzzoli ,&nbsp;Ana Laura Bueno ,&nbsp;Yağmur Halezeroğlu ,&nbsp;Renan Rangel Bonamigo","doi":"10.1016/j.abd.2024.05.004","DOIUrl":"10.1016/j.abd.2024.05.004","url":null,"abstract":"<div><h3>Background</h3><div>Cancer is an important cause of morbidity and mortality after solid organ transplants. Skin cancer is the most prevalent non-lymphoid malignancy occurring during heart transplantation follow-up. Due to the complexity of immunosuppressive therapy and the high prevalence and incidence of skin cancer in this population, dermatologists play an important role in the short and long-term follow-up of heart transplant recipients.</div></div><div><h3>Objectives</h3><div>The goal of this study is to present data from a systematic literature review focusing on the occurrence of skin cancer in patients who have undergone heart transplantation.</div></div><div><h3>Methods</h3><div>The authors conducted a systematic review of the literature in the EMBASE and PubMed databases from August to September 2021 to investigate the incidence of skin cancer in heart transplant patients. The authors selected retrospective and prospective cohort studies presenting data on the frequency of skin cancer in patients following heart transplantation. Exclusion criteria included articles that did not stratify the organ transplant type and studies that did not evaluate the frequency of skin cancer in the specific population.</div></div><div><h3>Results</h3><div>Based on the search strategy, the authors found 2589 studies, out of which 37 were eligible for inclusion in this study. Provided data are from 20 different countries, over the period 1974 to 2015. Incidence of non-melanoma skin cancer (NMSC) ranges from 0.97% to 52.8%. The incidence of squamous cell carcinoma (SCC) ranges from 1.19% to 89% and the incidence of basal cell carcinoma (BCC) ranges from 2% to 63%. Malignant Melanoma (MM) incidence ranges from 0.94% to 4.6%</div></div><div><h3>Study limitations</h3><div>The analysis involved an exclusive focus on heart transplant patients, and the statistical analysis of the sample may have been hampered. The significant heterogeneity among the studies emerged as a challenge during the analysis of the results. Furthermore, the study is limited by variations in follow-up periods among the included studies.</div></div><div><h3>Conclusion</h3><div>Although gathering methodologically heterogeneous data, this systematic review was able to show the epidemiological importance of skin cancer in heart transplant patients. This study reinforces the important role dermatologists play in the short and long-term follow-up of heart transplant patients.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 63-86"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}