Anais brasileiros de dermatologia最新文献

{"title":"Atypical presentation of Schwannoma mimicking squamous cell carcinoma","authors":"Pedro Rolo de Matos , Miguel Silva , Gilberto Rosa , Pedro Canão , Filomena Azevedo","doi":"10.1016/j.abd.2024.07.011","DOIUrl":"10.1016/j.abd.2024.07.011","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 360-362"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear IgA bullous dermatosis: 32 years of experience","authors":"Tugba Atci ,&nbsp;Gizem Pehlivan Ulutas ,&nbsp;Ecem Güreler Sirkeci ,&nbsp;Rıfkiye Küçükoğlu","doi":"10.1016/j.abd.2024.03.015","DOIUrl":"10.1016/j.abd.2024.03.015","url":null,"abstract":"<div><h3>Background</h3><div>Linear IgA bullous dermatosis (LABD) is an uncommon disease with only a few reported studies in large series with long follow-up periods.</div></div><div><h3>Objectives</h3><div>To evaluate the clinical presentation, immunopathological features, management, and disease course in LABD patients.</div></div><div><h3>Methods</h3><div>Data including demographics, clinical features, histopathological and immunofluorescence findings of LABD patients, in addition to the preferred treatments and responses to treatments were evaluated.</div></div><div><h3>Results</h3><div>Among 26 patients diagnosed with LABD, 17 (65.4%) were female. The mean age was 40.3 ± 22.4 (6‒80) years of whom 21 were adults. The most common mucosal involvement was oral (n = 9, 34.6%). Continuous linear IgA deposition was present on the basement membrane zone of all patients in addition to C3 (n = 13), IgG (n = 9), IgM (n = 4), and fibrinogen (n = 4). Three patients were lost to follow-up without any treatment. Dapsone was the treatment of choice in most (n = 21, 91.3%) patients in addition to systemic corticosteroids (n = 17), azathioprine (n = 3), tetracycline and nicotinamide (n = 2). Complete and partial remissions were achieved in 11 (47.8%) and 12 (52.2%) patients, respectively, in a mean follow-up period of 45.9 ± 43.9 (3‒158) months. Furthermore, 17 patients were still under treatment at the end of the follow-up period.</div></div><div><h3>Study limitations</h3><div>Retrospective study conducted in a single center.</div></div><div><h3>Conclusions</h3><div>LABD may occur at two separate peaks, one in the second and the other in the sixth decade of life with a female predominance. Other immunoglobulins may be associated with dominant IgA antibody deposition and the most commonly used therapeutic option for LABD patients was oral dapsone.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 277-282"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab, corticosteroids and their combination for the treatment of bullous pemphigoid","authors":"Guirong Liang ,&nbsp;Hua Qian ,&nbsp;Chao Sun ,&nbsp;Hanmei Zhang ,&nbsp;Zhiliang Li ,&nbsp;Suo Li ,&nbsp;Ke Jing ,&nbsp;Chenjing Zhao ,&nbsp;Yuan Wang ,&nbsp;Ruiyu Xiang ,&nbsp;Xiaoguang Li ,&nbsp;Suying Feng","doi":"10.1016/j.abd.2024.04.012","DOIUrl":"10.1016/j.abd.2024.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Conventional systemic corticosteroid therapy for bullous pemphigoid (BP) has been challenged due to severe adverse events. Dupilumab has emerged as an alternative therapeutical option of BP patients.</div></div><div><h3>Objectives</h3><div>To evaluate the efficacy of dupilumab monotherapy and the combination with medium/low-dose corticosteroids for BP treatment.</div></div><div><h3>Methods</h3><div>Thirteen, twenty-four and thirty-two BP patients treated with Dupilumab monotherapy (Dupi group), dupilumab combined with corticosteroids (Dupi + CS group), and corticosteroid monotherapy (CS group), respectively, were retrospectively analyzed for various clinical and laboratory parameters.</div></div><div><h3>Results</h3><div>In the Dupi group, the total Bullous Pemphigoid Disease Area Index (BPDAI) Total, Erosion/Blister, Urticaria/Erythema and Itching NRS scores were all reduced significantly after 2–4 weeks of treatment, but the BPDAI Mucosal Score was not changed significantly at the end of the overextended time of treatment. All the above clinical parameters and many laboratory parameters (including the serum anti-BP180 autoantibodies [IgG] level, blood eosinophil count, and percentage) were significantly reduced in both Dupi + CS and CS groups after treatment, but no statistical differences were found in the reduction rates of these parameters between the two groups. However, the Dupi + CS group had less baseline dose and cumulative dosage of prednisone at the time of disease control, and fewer adverse effects were reported than the CS group.</div></div><div><h3>Study limitations</h3><div>The retrospective design and small clinical sample size of the Dupi group.</div></div><div><h3>Conclusions</h3><div>For BP patients, dupilumab monotherapy based on the treatment of atopic dermatitis can significantly improve skin lesions and pruritus symptoms but may be ineffective for oral mucosal lesions. The combination of dupilumab and medium/low-dose corticosteroids can achieve the same effect of corticosteroid therapy with superior safety.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 243-252"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of risankizumab versus methotrexate in patients with moderate-to-severe plaque psoriasis: results from IMMbrace, a randomized, double-blind, phase 3 study with an open-label extension period in Brazil","authors":"Tania F. Cestari ,&nbsp;Cacilda da Silva Souza ,&nbsp;Luna Azulay-Abulafia ,&nbsp;Ricardo Romiti ,&nbsp;André V.E. Carvalho ,&nbsp;Caio César Silva de Castro ,&nbsp;Sílvio Alencar Marques ,&nbsp;João Roberto Antonio ,&nbsp;Lincoln Fabrício ,&nbsp;Ahmed M. Soliman ,&nbsp;Tianshuang Wu ,&nbsp;Ranjeeta Sinvhal ,&nbsp;Vassilis Stakias ,&nbsp;Alexandra P. Song ,&nbsp;Jasmina Kalabic ,&nbsp;Naomi Martin ,&nbsp;Luiza Keiko Matsuka Oyafuso","doi":"10.1016/j.abd.2024.08.002","DOIUrl":"10.1016/j.abd.2024.08.002","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis, a chronic, inflammatory skin disease, requires long-term therapy. Risankizumab is a humanized immunoglobulin G1 monoclonal antibody that specifically inhibits interleukin 23 by binding to its p19 subunit.</div></div><div><h3>Objective</h3><div>The authors assessed the efficacy and safety of risankizumab compared with methotrexate in adults with moderate-to-severe plaque psoriasis.</div></div><div><h3>Methods</h3><div>IMMbrace was a phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled study. Patients received subcutaneous risankizumab 150 mg at weeks 0, 4, and 16 plus oral placebo weekly, or oral methotrexate 5 mg weekly (with dose escalation up to 25 mg based on response and tolerability) plus subcutaneous placebo at weeks 0, 4, and 16. Primary efficacy endpoints were the proportions of patients who achieved ≥ 90% improvement in Psoriasis Area and Severity Index (PASI90) and static Physician’s Global Assessment of clear/almost clear (sPGA 0/1) at week 28. Safety was also assessed.</div></div><div><h3>Results</h3><div>Among 98 patients randomized (risankizumab, n = 50; methotrexate, n = 48), 95 completed the double-blind period. At week 28, significantly higher proportions of patients treated with risankizumab versus methotrexate achieved PASI90 (84.0% vs. 35.4%; p &lt; 0.001); sPGA 0/1 was achieved by 90.0% and 64.6% of patients in the risankizumab and methotrexate groups (p ≤ 0.001). Risankizumab efficacy was maintained throughout week 112. Adverse event rates were similar in the two groups.</div></div><div><h3>Study limitations</h3><div>The sample size was small due to the difficulty of recruiting patients without methotrexate use.</div></div><div><h3>Conclusions</h3><div>Risankizumab demonstrated superior efficacy over methotrexate at week 28; efficacy was maintained, and no new safety findings were observed through week 112.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 260-271"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of eosinophilic cellulitis with a short course of Dupilumab","authors":"Hiram Larangeira de Almeida Junior ,&nbsp;Ana Letícia Boff","doi":"10.1016/j.abd.2024.07.010","DOIUrl":"10.1016/j.abd.2024.07.010","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 2","pages":"Pages 401-403"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dermoscopic findings in patients with cutaneous squamous cell carcinoma according to histopathological subtype and lesion morphology.","authors":"Mustafa Ürün, Yıldız Gürsel Ürün, Ömer Faruk Elmas, Nuray Can","doi":"10.1016/j.abd.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.abd.2024.09.005","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous squamous cell carcinoma (cSCC) includes in situ cSCC (Bowen's disease [BD]) and invasive cSCC. By contrast, keratoacanthoma (KA) is a well-differentiated cSCC with self-resolving tendencies. Dermoscopy aids in monitoring vascular and keratin pattern changes to diagnose and track cSCC invasion.</p><p><strong>Objectives: </strong>To examine dermoscopic findings of cSCC according to histopathological differentiation and clinical morphological characteristics.</p><p><strong>Methods: </strong>Clinical and dermoscopic images of 118 cSCCs were retrospectively examined.</p><p><strong>Results: </strong>Compared to other cSCC subtypes, BD more frequently presented with pigmentation (p = 0.028) and a clustered (p = 0.042) or serpiginous (p = 0.006) vascular arrangement. Central keratin plugs were more common in well-differentiated invasive cSCCs (p = 0.021), while white circles surrounding follicles (p < 0.001), ulceration/bleeding (p = 0.001), and red background (p = 0.004) were observed more in poorly differentiated invasive cSCCs. Central keratin plugs (87.5%) and branched vascular arrangements (75%) were observed in patients with nodular KA, with both statistically more frequent than in invasive cSCC (p < 0.001, p = 0.040, respectively). White halos surrounding vessels (p = 0.004) and a clustered vessel arrangement (p = 0.037) were more common in nodular invasive cSCC compared to nodular KA.</p><p><strong>Study limitations: </strong>The number of examined lesions in the subgroups was relatively small.</p><p><strong>Conclusions: </strong>Dermoscopy aids in distinguishing well-differentiated invasive cSCC from poorly differentiated invasive cSCC, distinguishing nodular KA from nodular invasive cSCC, and diagnosing BD. Further studies are needed to identify dermoscopic findings that can distinguish moderately differentiated invasive cSCC from other invasive cSCCs.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of narrowband ultraviolet B phototherapy for prurigo nodularis: a tertiary center experience","authors":"Esra Agaoglu,&nbsp;Hilal Kaya Erdogan,&nbsp;Ersoy Acer,&nbsp;Zeynep Nurhan Saracoglu","doi":"10.1016/j.abd.2024.02.007","DOIUrl":"10.1016/j.abd.2024.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Prurigo nodularis is a chronic pruritic dermatosis and narrowband-UVB (NB-UVB) phototherapy is considered an effective and safe treatment option in patients with multiple comorbidities.</div></div><div><h3>Objective</h3><div>In this study, the authors aimed to evaluate the efficacy and safety of NB-UVB phototherapy in the management of prurigo nodularis and to compare response rates according to lesions localization.</div></div><div><h3>Methods</h3><div>Thirty prurigo nodularis patients who had been treated with NB-UVB phototherapy were included in this study. The data for this study were retrieved retrospectively from patient follow-up forms in the phototherapy unit.</div></div><div><h3>Results</h3><div>NB-UVB phototherapy led to a complete response (CR) in 24 (80%) patients while partial response (PR) was achieved in 6 (20%) patients. Regarding prurigo nodularis localization, the CR rate was statistically higher in those with diffuse and central involvement (p &lt; 0.05). Erythema and/or pruritus were observed in 4 (13.3%) patients with prurigo nodularis.</div></div><div><h3>Study limitations</h3><div>This study is limited because it is single-centered and has a retrospective design.</div></div><div><h3>Conclusions</h3><div>NB-UVB phototherapy is an effective and safe treatment option for prurigo nodularis patients especially those with multiple comorbidities and using several medications. Patients with diffuse and central involvement may respond better to phototherapy than those with peripheral involvement.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 38-44"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazilian experience with oral atenolol in the treatment of infantile hemangiomas","authors":"Tauana Ogata Coelho da Rocha,&nbsp;Beatrice Nóbrega Dantas Berenguer,&nbsp;Camila Barreto Vianna Martins,&nbsp;Vanessa Rolim Bessa,&nbsp;Luciana Paula Samorano,&nbsp;Maria Cecília Rivitti-Machado,&nbsp;Zilda Najjar Prado de Oliveira","doi":"10.1016/j.abd.2024.03.013","DOIUrl":"10.1016/j.abd.2024.03.013","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 141-145"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque psoriasis on the tongue: case report","authors":"Lucas Campos Garcia ,&nbsp;Nicole Vieira Schwan ,&nbsp;Jésus Faria Rosa Júnior ,&nbsp;Andrea Machado Coelho Ramos","doi":"10.1016/j.abd.2024.01.008","DOIUrl":"10.1016/j.abd.2024.01.008","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 188-190"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cultural adaptation and validation of the Brazilian version of the Frontal Fibrosing Alopecia Quality of Life Index (FFA-QLI-BRA)","authors":"Paula Rosa Coutinho Goulart Borges Mariottoni ,&nbsp;Leonardo Spagnol Abraham ,&nbsp;Leopoldo Duailibe Nogueira Santos ,&nbsp;Daniel Fernandes Melo ,&nbsp;Rodrigo Pirmez ,&nbsp;Paulo Müller Ramos ,&nbsp;Hélio Amante Miot","doi":"10.1016/j.abd.2024.03.014","DOIUrl":"10.1016/j.abd.2024.03.014","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 165-168"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}