Anais brasileiros de dermatologia最新文献

{"title":"Generalized pustular psoriasis (von Zumbusch) flares successfully treated with Spesolimab. Report of two cases and review of the literature","authors":"Raquel Steglich , Felipe Saboia , Lincoln Helder Zambaldi Fabricio , Eoda Steglich , Anber Tanaka","doi":"10.1016/j.abd.2024.10.010","DOIUrl":"10.1016/j.abd.2024.10.010","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 624-628"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative impact of striae gravidarum in maternal mental health","authors":"Talita Pereira Calheiros, Bárbara Borges Rubin, Jéssica Puchalski Trettim, Laura Medeiros de Oliveira, Ricardo Tavares Pinheiro, Hiram Larangeira de Almeida Jr.","doi":"10.1016/j.abd.2024.09.012","DOIUrl":"10.1016/j.abd.2024.09.012","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 573-576"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis and cardiovascular risk: associated and protective factors","authors":"Luciana Agoglia ,&nbsp;Helena Peixoto ,&nbsp;Ana Carolina Cardoso ,&nbsp;Lívia Barbosa ,&nbsp;Cecília S.X.L. Victer ,&nbsp;Sueli Carneiro ,&nbsp;Gil F. Salles ,&nbsp;Cristiane A. Villela-Nogueira ,&nbsp;Maria Chiara Chindamo","doi":"10.1016/j.abd.2024.07.013","DOIUrl":"10.1016/j.abd.2024.07.013","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is an inflammatory skin disease associated with Metabolic Syndrome (MetS), Steatotic Liver Disease (SLD) and cardiovascular risk. However, the effect of anti-inflammatory therapy on cardiovascular risk is uncertain.</div></div><div><h3>Objectives</h3><div>To determine the relationship between anti-inflammatory therapy and subclinical atherosclerosis in individuals with psoriasis, using the gold standard carotid-femoral Pulse Wave Velocity (cf-PWV) measurement. Additionally, to evaluate the association between cf-PWV, steatosis and Advanced Fibrosis (AF) using Transient Elastography (TE) by Fibroscan®.</div></div><div><h3>Methods</h3><div>Cross-sectional study including psoriasis patients submitted to cf-PWV and TE. Steatosis was defined as a controlled attenuation parameter ≥ 275 dB/m, AF as liver stiffness measurement ≥ 10 kPa, and increased Aortic Stiffness (AoS) as cf-PWV ≥ 10 m/s. Significant cumulative methotrexate dose was ≥ 1500 mg (MTX1500). Logistic regression analysis evaluated the independent variables associated with increased AoS.</div></div><div><h3>Results</h3><div>Eighty patients were included (mean age 56.2 ± 11.5-years, 57.5% female, BMI 28.6 ± 5.3 kg/m²). Prevalences of MetS, diabetes mellitus, dyslipidemia, systemic arterial hypertension, steatosis and AF were 57.5%, 40.0%, 67.5%, 70.0%, 50.0% and 16.3%, respectively. MTX1500 was present in 45%, immunobiological treatment in 33.8%, and cf-PWV ≥ 10 m/s in 21.2%. On logistic regression analysis, age was independently related to cf-PWV ≥ 10 m/s (OR = 1.21; 95% CI 1.06‒1.38; p = 0.003) and MTX1500 was a protective cardiovascular factor (OR = 0.18; 95% CI 0.038‒0.87; p = 0.033). No association was observed between steatosis, AF or immunobiological therapy and cf-PWV ≥10 m/s.</div></div><div><h3>Study limitations</h3><div>Sample size.</div></div><div><h3>Conclusion</h3><div>In patients with psoriasis, increased AoS was associated with age, but not with steatosis or AF. A protective cardiovascular effect of MTX was found in a psoriasis population with a high prevalence of MetS and its components.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 456-461"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of dupilumab in patients with moderate-to-severe bullous pemphigoid: a systematic review and meta-analysis","authors":"Júlia Opolski Nunes da Silva ,&nbsp;Rodrigo Ribeiro e Silva ,&nbsp;Paulo Victor Zattar Ribeiro ,&nbsp;Patrícia Silva Farah ,&nbsp;Raquel Bissacotti Steglich","doi":"10.1016/j.abd.2024.08.008","DOIUrl":"10.1016/j.abd.2024.08.008","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate the safety and efficacy of dupilumab in treating moderate-to-severe bullous pemphigoid.</div></div><div><h3>Methods</h3><div>The authors performed a systematic review and meta-analysis of comparative studies of Dupilumab combined with corticosteroids and conventional corticosteroid therapy alone in patients with moderate-to-severe bullous pemphigoid. PubMed, Embase and Cochrane databases were searched for studies published up to December 2023. Data were extracted from published reports and quality assessment was performed according to Cochrane recommendations.</div></div><div><h3>Results</h3><div>A total of four studies involving 127 patients were included, of which 53 received Dupilumab combined with corticosteroids, while the other 74 were administered corticosteroids alone. Regarding efficacy, Dupilumab the time before new blister formation stopped (MD = −5.13 days; 95% CI −7.12 to −3.15; p &lt; 0.0001) and demonstrated a greater reduction in Bullous Pemphigoid Disease Area Index (MD = −3.90; 95% CI −5.52 to −2.27; p &lt; 0.0001) and Numeric Rating Scale for Pruritus (SMD = −1.37; 95% CI −2.02 to −0.72; p &lt; 0.0001) compared with patients who received conventional therapy. However safety endpoints, adverse events (RR = 0.78; 95% CI 0.58 to 1.05; p = 0.10) and relapses (RR = 0.50; 95% CI 0.19 to 1.36; p = 0.17) showed no significance. The main limitations were retrospective studies with small samples and limited results in clinical practice and a moderate overall risk of bias.</div></div><div><h3>Conclusion</h3><div>Compared with conventional therapy, Dupilumab decreased the time before new blister formation stopped in 5.13 days, as well as Disease Area Index and Pruritus, without interfering with adverse events and relapse.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 429-438"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail involvement due to immunoglobulin G4 (IgG4)-related disease in a person living with HIV⋆","authors":"Valéria Lukenczuk Said ,&nbsp;Monique Freire dos Reis ,&nbsp;Tiago Vencato da Silva ,&nbsp;Virgínia Vilasboas Figueiras ,&nbsp;Nathália Matos Gomes","doi":"10.1016/j.abd.2024.09.007","DOIUrl":"10.1016/j.abd.2024.09.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 598-601"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro characterization of biofilm produced by Fusarium oxysporum, an onychomycosis agent","authors":"Isabella Letícia Esteves Barros ,&nbsp;Flávia Franco Veiga ,&nbsp;Terezinha Inez Estivalet Svidzinski","doi":"10.1016/j.abd.2024.11.005","DOIUrl":"10.1016/j.abd.2024.11.005","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 560-563"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of severe diffuse alopecia areata with abrocitinib","authors":"Jinran Lin ,&nbsp;Zheng Li ,&nbsp;Linxia Shen ,&nbsp;Jui-Ming Lin ,&nbsp;Ke Tao ,&nbsp;Ying Miao ,&nbsp;Chunya Ni ,&nbsp;Youyu Sheng ,&nbsp;Wenyu Wu","doi":"10.1016/j.abd.2024.11.004","DOIUrl":"10.1016/j.abd.2024.11.004","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 580-582"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case of Trichophyton indotineae in Brazil: clinical and mycological criteria and genetic identification of terbinafine resistance","authors":"John Verrinder Veasey ,&nbsp;Renata Diniz Jacques Gonçalves ,&nbsp;Guilherme Camargo Julio Valinoto ,&nbsp;Gustavo de Sá Menezes Carvalho ,&nbsp;Giovanna Azevedo Celestrino ,&nbsp;Ana Paula Carvalho Reis ,&nbsp;Ana Paula Cordeiro Lima ,&nbsp;Antonio Charlys da Costa ,&nbsp;Marcia de Souza Carvalho Melhem ,&nbsp;Gil Benard ,&nbsp;Maria Gloria Teixeira Sousa","doi":"10.1016/j.abd.2025.01.001","DOIUrl":"10.1016/j.abd.2025.01.001","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 557-560"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of labyrinthine pattern basal cell carcinoma","authors":"Takehiro Nakamura,&nbsp;Toshiyuki Yamamoto","doi":"10.1016/j.abd.2024.09.009","DOIUrl":"10.1016/j.abd.2024.09.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 609-611"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical-histological characteristics and therapeutic management of primary cutaneous melanoma in elderly patients","authors":"Juan-Manuel Morón-Ocaña ,&nbsp;Isabel-María Coronel-Pérez ,&nbsp;Ana-Isabel Lorente-Lavirgen ,&nbsp;Carmen-Victoria Almeida-González ,&nbsp;Amalia Pérez-Gil","doi":"10.1016/j.abd.2024.07.017","DOIUrl":"10.1016/j.abd.2024.07.017","url":null,"abstract":"<div><h3>Background</h3><div>Life expectancy is rising in developed countries. The impact of age on melanoma characteristics is unclear, but it seems that melanomas in the elderly have distinct features affecting management and outcomes.</div></div><div><h3>Objectives</h3><div>To compare clinical and histopathological melanoma characteristics and management in elderly and younger patients.</div></div><div><h3>Methods</h3><div>A retrospective population-based study analyzed melanomas observed between 2007 and 2022 was made in the southern Seville health area (Spain). Patients were divided into two age groups: &lt;65 and ≥65. Data were collected from clinical histories.</div></div><div><h3>Results</h3><div>Among 431 primary cutaneous melanomas, 33% were in patients ≥65-years. Elderly patients had more head and neck melanomas (37.8% vs. 14.9%; p &lt; 0.001), larger lesions (1.3 vs. 0.9 cm; p &lt; 0.001), more ulcerated melanomas (17.8% vs. 8.8%; p &lt; 0.012), and higher Breslow thickness (1.03 vs. 0.65 mm; p &lt; 0.01) than younger patients. No differences were found in the number of mitoses or histopathological invasions. Stage 0 and more advanced stages (II/III/IV) were observed more frequently in ≥65-years (29.3% vs. 23% and 27.1% vs. 15.7%, p &lt; 0.001 respectively). Fewer wide excisions (28.4% vs. 5.6%, p &lt; 0.001), sentinel lymph node biopsy (17.6% vs. 2.4%, p &lt; 0.001), and adjuvant therapy (11.9% vs. 2.1%, p &lt; 0.001) were performed in patients ≥65-years.</div></div><div><h3>Study limitations</h3><div>The study was retrospective, primarily covering the last 10-years, with older data missing. Key risk factors like the number of nevi and family history of melanoma were not collected.</div></div><div><h3>Conclusions</h3><div>Melanomas in the elderly were diagnosed more frequently at initial and advanced stages despite having worse prognostic characteristics compared melanomas occurring in younger people.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 422-428"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}