Anais brasileiros de dermatologia最新文献_第10页

Dermoscopic changes of tattoos over melanocytic nevi 黑素细胞痣上纹身的皮肤镜变化。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-31 DOI: 10.1016/j.abd.2023.08.015

引用次数: 0

Erdheim-Chester disease BRAF (-) Diagnosis through cutaneous manifestations and good response with anakinra treatment 埃尔德海姆-切斯特病 BRAF。通过皮肤表现确诊，接受阿纳金拉治疗后反应良好。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-31 DOI: 10.1016/j.abd.2023.02.012

引用次数: 0

Role of tangential biopsy in the diagnosis of nail psoriasis 切口活检在指甲银屑病诊断中的作用。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-23 DOI: 10.1016/j.abd.2023.11.005

{"title":"Role of tangential biopsy in the diagnosis of nail psoriasis","authors":"","doi":"10.1016/j.abd.2023.11.005","DOIUrl":"10.1016/j.abd.2023.11.005","url":null,"abstract":"<div><h3>Background</h3><p>Histopathology can be crucial for diagnosis of inflammatory nail diseases. Longitudinal excision and punch biopsies are the most used techniques to obtain the tissue sample. However, there is a low clinical-histopathological correlation, besides the risk of nail dystrophy. Tangential excision biopsy (TB) is a well-established technique for the investigation of longitudinal melanonychia. TB could also be used to evaluate diseases in which histopathological changes are superficial, as in psoriasis.</p></div><div><h3>Objective</h3><p>To study the value of TB in the histopathological diagnosis of nail psoriasis.</p></div><div><h3>Methods</h3><p>This is a prospective and descriptive study of the clinical-histopathological findings of samples from the nail bed or matrix and nail plate of 13 patients with clinical suspicion of nail psoriasis. Biopsies were obtained through partial nail avulsion and TB.</p></div><div><h3>Results</h3><p>In nine patients, the hypothesis of psoriasis was confirmed by histopathology; in one, the criteria for diagnosing nail lichen planus were fulfilled. The tissue sample of only one patient did not reach the dermal papillae, and, in four of 13 patients, the adventitial dermis was not sampled. No patient developed onychodystrophy after the procedure.</p></div><div><h3>Study limitations</h3><p>In three patients, the clinical and, consequently, histopathological nail changes were subtle. Also, in one patient’s TB didn’t sample the dermal papillae.</p></div><div><h3>Conclusions</h3><p>TB is a good option to assist in the histopathological diagnosis of nail psoriasis, especially when appropriate clinical elements are combined. Using this technique, larger and thinner samples, short postoperative recovery time, and low risk of onychodystrophy are obtained.</p></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"99 5","pages":"Pages 696-705"},"PeriodicalIF":2.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0365059624001041/pdfft?md5=9570cbc7a98a85b98876c32dacfaf442&pid=1-s2.0-S0365059624001041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hailey-Hailey disease: clinical, diagnostic and therapeutic update 海利-海利病：临床、诊断和治疗新进展。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-23 DOI: 10.1016/j.abd.2023.12.003

{"title":"Hailey-Hailey disease: clinical, diagnostic and therapeutic update","authors":"","doi":"10.1016/j.abd.2023.12.003","DOIUrl":"10.1016/j.abd.2023.12.003","url":null,"abstract":"<div><p>Hailey-Hailey disease is a rare genodermatosis described in 1939, with an autosomal dominant inheritance pattern, characterized by compromised adhesion between epidermal keratinocytes. It has an estimated prevalence of 1/50,000, with no gender or race predilection. It results from a heterozygous mutation in the <em>ATP2C1</em> gene, which encodes the transmembrane protein hSPA1C, present in all tissues, with preferential expression in keratinocytes. Mutations in the <em>ATP2C1</em> gene cause changes in the synthesis of junctional proteins, leading to acantholysis. It usually begins in adulthood, with isolated cases at the extremes of life. It manifests as vesico-bullous lesions mainly in the flexural areas, which develop into erosions and crusts. Chronic lesions may form vegetative or verrucous plaques. Pruritus, a burning feeling and pain are common. It evolves with periods of remission and exacerbation, generally triggered by humidity, friction, heat, trauma and secondary infections. The diagnosis is based on clinical and histopathological criteria: marked suprabasal acantholysis, loosely joined keratinocytes, giving the appearance of a “dilapidated brick wall”, with a few dyskeratotic cells. The acantholysis affects the epidermis and spares the adnexal epithelia, which helps in the differential diagnosis with pemphigus vulgaris. Direct immunofluorescence is negative. The main differential diagnoses are Darier disease, pemphigus vegetans, intertrigo, contact dermatitis, and inverse psoriasis. There is no cure and the treatment is challenging, including measures to control heat, sweat and friction, topical medications (corticosteroids, calcineurin inhibitors, antibiotics), systemic medications (antibiotics, corticosteroids, immunosuppressants, retinoids and immunobiologicals) and procedures such as botulinum toxin, laser and surgery. There is a lack of controlled clinical trials to support the choice of the best treatment.</p></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"99 5","pages":"Pages 651-661"},"PeriodicalIF":2.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0365059624001065/pdfft?md5=656dcacf357cf888b12e68503a760e94&pid=1-s2.0-S0365059624001065-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular risk analysis in atopic dermatitis patients 特应性皮炎患者的心血管风险分析。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-20 DOI: 10.1016/j.abd.2023.09.008

引用次数: 0

Oral minoxidil 7.5 mg for hair loss increases heart rate with no change in blood pressure in 24 h Holter and 24 h ambulatory blood pressure monitoring 口服米诺地尔 7.5 毫克治疗脱发会增加心率，但 24 小时 Holter 和 24 小时非卧床血压监测中的血压没有变化。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-20 DOI: 10.1016/j.abd.2023.08.016

引用次数: 0

Clinical-epidemiological profile of leprosy patients undergoing retreatment at a reference center in southeastern Brazil 巴西东南部一家参考中心接受再治疗的麻风病人的临床流行病学概况。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-15 DOI: 10.1016/j.abd.2023.09.006

引用次数: 0

Anais Brasileiros de Dermatologia: on the eve of its centennial year Anais Brasileiros de Dermatologia: on the eve of its centennial year.

IF 1.7 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-11 DOI: 10.1016/j.abd.2024.04.001

Silvio Alencar Marques , Ana Maria Roselino , Hiram Larangeira de Almeida Junior , Luciana Patrícia Fernandes Abbade

引用次数: 0

Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: a multicenter study of 239 patients☆ 脓皮病患者的临床特征和影响治疗反应的因素分析：一项对239名患者进行的多中心研究☆。

IF 2.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-11 DOI: 10.1016/j.abd.2024.02.002

{"title":"Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: a multicenter study of 239 patients☆","authors":"","doi":"10.1016/j.abd.2024.02.002","DOIUrl":"10.1016/j.abd.2024.02.002","url":null,"abstract":"<div><h3>Background</h3><div>Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers.</div></div><div><h3>Objective</h3><div>We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting the treatment responses of patients with PG.</div></div><div><h3>Methods</h3><div>We performed a multicenter study of 12 tertiary care centers. We analyzed the data of the patients who were followed up with a diagnosis of PG between the years 2012‒2022 retrospectively.</div></div><div><h3>Results</h3><div>We included a total of 239 patients of whom 143 were female and 96 were male, with an average age of 54.2 ± 17.4 years. The most common treatment was systemic steroids (n = 181, 75.7%). Among these patients, 50.8% (n = 92) used systemic steroids as the sole systemic agent, while 49.2% (n = 89) used at least one adjuvant immunosuppressive agent. The independent factors determined in regression analysis to influence response to systemic steroids positively were disease onset age ≥ 30-years, negative pathergy, absence of leukocytosis, negative wound culture, presence of a single lesion, and absence of upper extremity involvement. Biological agents were used in 18.4% (n = 44) of the patients in the present study. We also analyzed pathergy positive PG and early onset (onset age < 30) PG separately due to their distinct clinical features which were revealed during statistical analysis.</div></div><div><h3>Study limitations</h3><div>Retrospective nature of the present study.</div></div><div><h3>Conclusions</h3><div>Analyses of the factors influencing treatment responses are addressed in this study. Also, we concluded that investigation for accompanying autoinflammatory diseases of pathergy positive PG and early onset PG is necessary and the patients in these two groups are more resistant to treatment, necessitating more complicated treatments.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"99 6","pages":"Pages 815-825"},"PeriodicalIF":2.6,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic factors and survival of patients with melanoma treated at a reference hospital in the Brazilian Amazon region 在巴西亚马逊地区一家参考医院接受治疗的黑色素瘤患者的预后因素和存活率。

IF 1.7 4区医学

Anais brasileiros de dermatologia Pub Date : 2024-05-01 DOI: 10.1016/j.abd.2022.12.013

Amanda Gabay Moreira , Antonio Vitor da Silva Freitas , Carla Andrea Avelar Pires

引用次数: 0