Anais brasileiros de dermatologia最新文献

{"title":"Profile of dermatoses in extreme weather events: case series during floods in the state of Rio Grande do Sul, Brazil","authors":"Analupe Webber ,&nbsp;Cíntia Cristina Pessin ,&nbsp;Gabriela Agne Magnus ,&nbsp;Guilherme Ladwig Tejada ,&nbsp;Isadora da Rosa Hoefel ,&nbsp;Jacqueline Sarmento Fernandes ,&nbsp;Juliana Catucci Boza ,&nbsp;Juliano Peruzzo ,&nbsp;Marcelo Balbinot Lucca ,&nbsp;Mariele Bevilaqua ,&nbsp;Monica Zechmeister Berg ,&nbsp;Nathália Hoffmann Guarda Aguzzoli ,&nbsp;Renata Alves Sanseverino ,&nbsp;Rosemarie Mazzuco ,&nbsp;Taciana Dal’Forno Dini ,&nbsp;Vanessa Santos Cunha ,&nbsp;Veronica Hamann Aita ,&nbsp;Renan Rangel Bonamigo","doi":"10.1016/j.abd.2024.12.001","DOIUrl":"10.1016/j.abd.2024.12.001","url":null,"abstract":"<div><h3>Background</h3><div>The skin is the first organ of the human body to be exposed to flood water, with local and possibly systemic consequences. There are no Brazilian data on dermatological diseases during recent climate catastrophes related in the country.</div></div><div><h3>Objectives</h3><div>To assess the demographic profile and dermatological diagnoses in people displaced from their homes and sheltered in collective housing and among rescue workers during the extreme climate crisis in the state of Rio Grande do Sul, Brazil, in 2024.</div></div><div><h3>Methods</h3><div>This was a cross-sectional and observational study. Information was collected in person or through records, retrospectively.</div></div><div><h3>Results</h3><div>Data were collected from 371 people with dermatological complaints, and a total of 423 dermatoses were diagnosed. The most prevalent dermatological diseases were dermatoparasitosis, pyoderma, and skin conditions due to trauma and/or injuries. The male gender was statistically associated with traumatic dermatoses/injuries, and females with pyoderma (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>In the recent episode of extreme climate crisis in Brazil, infectious and traumatic dermatoses were the most prevalent among the affected persons. The role of dermatologists in providing care for this population, as well as guiding other colleagues in the management of skin diseases during the floods is highlighted.</div></div><div><h3>Study limitations</h3><div>The study was conducted in shelters, and some data were evaluated retrospectively. No complementary exams were used for diagnosis.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 548-556"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Parry-Romberg syndrome with hyaluronic acid: insights after 2.5 years of successive treatments","authors":"Roberta Vasconcelos-Berg ,&nbsp;Barbara Varella Maire ,&nbsp;Alexander A. Navarini","doi":"10.1016/j.abd.2024.08.007","DOIUrl":"10.1016/j.abd.2024.08.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 606-608"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into pyroptosis in pemphigus: from cellular structure to therapeutic targeting","authors":"Jiazhen Chen ,&nbsp;Zezhi He ,&nbsp;Xiangnong Dai ,&nbsp;Sifan Lin ,&nbsp;Jiahui Liu ,&nbsp;Xingdong Ye","doi":"10.1016/j.abd.2024.07.015","DOIUrl":"10.1016/j.abd.2024.07.015","url":null,"abstract":"<div><h3>Background</h3><div>Pemphigus is an autoimmune blistering disease where autoantibodies target desmoglein (Dsg) antigens on keratinocytes, triggering the p38 MAPK pathway, Dsg internalization, desmosomal dissolution, and keratinocyte apoptosis, are essential for blister formation. Recent research indicates keratinocyte pyroptosis may exacerbate acantholysis and delay wound healing. Current treatments, including corticosteroids and immunosuppressants, are effective but have significant side effects, such as prolonged wound healing and increased infection risk. Understanding these inflammatory processes is crucial for developing effective treatments for pemphigus.</div></div><div><h3>Methods</h3><div>The authors conducted a comprehensive review of the literature, analyzing recent findings regarding the upregulation of pyroptosis-related proteins in pemphigus.</div></div><div><h3>Results</h3><div>The present findings highlight a significant upregulation of pyroptosis-related proteins, which play a crucial role in the inflammatory response and blister formation characteristic of pemphigus. Key proteins such as cytokines IL-1β, IL-18, High Mobility Group Box-1 (HMGB1), and Parkin, along with NOD-like receptors and P2<!--> <!-->×<!--> <!-->7 receptors, were identified as pivotal in facilitating pyroptosis. The study also discusses potential therapeutic approaches targeting these proteins to modulate the disease pathway effectively.</div></div><div><h3>Study limitations</h3><div>This study aimed to investigate the role of pyroptosis in the pathogenesis of pemphigus, focusing on its potential as a novel therapeutic target.</div></div><div><h3>Conclusions</h3><div>Pyroptosis significantly contributes to the pathogenesis of pemphigus and presents a promising target for therapy. Targeting specific molecules involved in the pyroptosis pathway offers the potential for developing more precise and less toxic treatments, allowing the shift from traditional therapies towards targeted therapeutic strategies.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 520-526"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of vitamin D in people with albinism from Brazil","authors":"Carolina Reato Marçon,&nbsp;Lilian Lemos Costa,&nbsp;Maria Paula Ribeiro Mazzon,&nbsp;Nathalia Terumi Kawakami,&nbsp;Camila Cardoso Paes Carvalho","doi":"10.1016/j.abd.2024.10.003","DOIUrl":"10.1016/j.abd.2024.10.003","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 577-579"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand dermatitis: a 6-year experience in a tertiary referral Brazilian hospital","authors":"Larissa Relva da Fonte Gonçalves Endlich,&nbsp;Luciana Paula Samorano,&nbsp;Ricardo Spina Nunes,&nbsp;Vitor Manoel Silva dos Reis","doi":"10.1016/j.abd.2024.08.010","DOIUrl":"10.1016/j.abd.2024.08.010","url":null,"abstract":"<div><h3>Background</h3><div>Hand dermatitis (HD) is a prevalent inflammatory skin disease with a significant socioeconomic impact.</div></div><div><h3>Objectives</h3><div>To characterize the population of HD patients followed up at the Department of Dermatology of a tertiary hospital.</div></div><div><h3>Methods</h3><div>A cross-sectional, retrospective and descriptive study was carried out through the analysis of medical records of HD patients assisted at the Allergy Clinic of the Department of Dermatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, between March 1, 2016 and August 31, 2022.</div></div><div><h3>Results</h3><div>Of the 175 patients, 73.3% were women, and the mean age at the onset of the condition was 41.7 years. There was a statistically significant association between occupation categories and the presence of occupational dermatitis. Cases were classified as irritant contact dermatitis (49.7%), allergic contact dermatitis (57.1%) and endogenous vesicular HD (3.4%). It was observed a statistically significant higher frequency of patch tests positivity for methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) and nickel sulfate in women and for potassium bichromate and carba mix in men. DLQI was assessed in 77 patients, and the average score was 7.8 points.</div></div><div><h3>Study limitations</h3><div>As limitations, the authors point out data collection from medical records, which lacked some information. Furthermore, as this was a cross-sectional study, it was not possible to assess cause-and-effect relationships between the variables.</div></div><div><h3>Conclusions</h3><div>The present data reinforces the importance of patch tests in HD investigation and highlights the high sensitivity rates to MCI/MI and nickel sulfate in Brazilian women and to potassium bichromate and carba mix in Brazilian men patients.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 439-446"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pruritus: a narrative review","authors":"Paulo Ricardo Criado ,&nbsp;Roberta Fachini Jardim Criado ,&nbsp;Mayra Ianhez ,&nbsp;Hélio Amante Miot","doi":"10.1016/j.abd.2024.09.008","DOIUrl":"10.1016/j.abd.2024.09.008","url":null,"abstract":"<div><div>Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous approach, guided by the identification of skin lesions or signs/symptoms of underlying systemic diseases. A comprehensive evaluation, including a detailed medical history, thorough physical examination, and appropriate laboratory and imaging tests, often supplemented by skin biopsy and direct immunofluorescence, is essential. Treatment strategies for chronic pruritus should be individualized based on the etiology identified. General measures, such as emollients, serve as initial interventions, followed by targeted approaches. Topical corticosteroids, calcineurin inhibitors, phototherapy, and systemic immunosuppressants address cutaneous inflammation. Antihistamines, antidepressants, and immunosuppressants may be employed based on the specific etiology. Emerging therapies, including biologic drugs and JAK inhibitors, have potential in refractory cases.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 487-519"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyoderma gangrenosum diagnosed in a high-risk myelodysplastic neoplasm patient with trisomy 8: a rare case report","authors":"Renato Mendes Martins ,&nbsp;Howard Lopes Ribeiro-Junior ,&nbsp;Natália Feitosa Arrais Minete Mendonça ,&nbsp;Fábio Rocha Fernandes Távora ,&nbsp;Ronald Feitosa Pinheiro","doi":"10.1016/j.abd.2024.11.003","DOIUrl":"10.1016/j.abd.2024.11.003","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 602-605"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid improvement in a recurrent generalized pustular psoriasis patient ineffective to Ixekizumab following Spesolimab therapy","authors":"Wenjie Li ,&nbsp;Fan Cui ,&nbsp;Lixia Zhang ,&nbsp;Ge Yang ,&nbsp;Zhen Rang ,&nbsp;Minyan Xu ,&nbsp;Yangying Liu ,&nbsp;Siyu Wang","doi":"10.1016/j.abd.2024.09.003","DOIUrl":"10.1016/j.abd.2024.09.003","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 634-637"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anais Brasileiros de Dermatologia: who wrote this century-old history?","authors":"Helena Cargnelutti Grimaldi ,&nbsp;Sandro da Silva Camargo","doi":"10.1016/j.abd.2025.02.001","DOIUrl":"10.1016/j.abd.2025.02.001","url":null,"abstract":"<div><div>The <em>Anais Brasileiros de Dermatologia</em> (ABD), an official publication of the Brazilian Society of Dermatology, has been published since 1925. ABD is considered the most influential dermatological journal in Latin America. By 2025, the journal will mark a significant milestone, celebrating a century of history. Over this time, it has published 99 volumes and 6,299 contributions from more than 10,800 authors. To analyze the trajectory of the journal, this study employs an applied research approach characterized by descriptive objectives and a quantitative nature. This research was based on a documentary procedure that encompassed all contributions already published in the journal. The main goal of the work was to identify the most prominent authors who have contributed to the journal and to map the largest co-authorship communities. The authors hope that this research serves as a formal recognition of the researchers who have written the history of the ABD.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 527-538"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline lepromatous leprosy with lymph node infiltration: Dermatology helps to clarify challenging diagnoses","authors":"Victor Henrique Murback dos Reis,&nbsp;Anna Carolina Miola,&nbsp;Cesar Augusto Zago Ferreira,&nbsp;Simone de Pádua Milagres,&nbsp;Joel Carlos Lastória,&nbsp;Juliano Vilaverde Schmitt","doi":"10.1016/j.abd.2024.10.004","DOIUrl":"10.1016/j.abd.2024.10.004","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 615-618"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}