Anais brasileiros de dermatologia最新文献

B-cell subsets in leprosy lesions: unraveling the complex interplay. 麻风病病变中的b细胞亚群：揭示复杂的相互作用。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501184

Luis Alberto Ribeiro Fróes, Carla Pagliari, Maria Angela Bianconcini Trindade, Mirian Nacagami Sotto

{"title":"B-cell subsets in leprosy lesions: unraveling the complex interplay.","authors":"Luis Alberto Ribeiro Fróes, Carla Pagliari, Maria Angela Bianconcini Trindade, Mirian Nacagami Sotto","doi":"10.1016/j.abd.2025.501184","DOIUrl":"10.1016/j.abd.2025.501184","url":null,"abstract":"Background: Leprosy is a chronic infectious disease marked by complex immune interactions, yet the roles of specific B-lymphocyte subsets in its pathology are poorly understood.Objectives: To investigate the presence and distribution of B-cell subsets, including B1 cells, Marginal Zone (MZ) B-cells, Regulatory B-cells (Bregs), and Effector-1 B-cells (Be1), across different clinical forms of leprosy and reactional states.Methods: Immunohistochemical and morphometric analyses were performed on skin lesions from patients with various clinical presentations of leprosy.Results: CD20+ B-cells were abundant in tuberculoid lesions, whereas MZB-1 expression varied significantly among leprosy subtypes. Type 1 Reaction (T1R) lesions exhibited significantly higher counts of B1 and MZ B-cells compared to Type 2 Reaction (T2R), lepromatous leprosy (LL), and indeterminate leprosy (I). Expression patterns of PAX5/MZB-1 and PAX5/CD5 suggested a dominant presence of these cells in the Th1 pole. Be1 cells, strongly linked to Th1 immune response, were also more abundant in Th1 clinical presentations (tuberculoid and T1R leprosy). Although Bregs were generally scarce, they were most frequently observed in T1R.Study limitations: This study was limited by the relatively small number of cases analyzed per clinical subtype and reactional state.Conclusions: This is the first study to document the presence and distribution of these specific B-cell subsets in leprosy lesions. The findings suggest distinct roles for B-lymphocyte subtypes, particularly at the tuberculoid pole and during Type 1 reactions.","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"501184"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penile erosions: an atypical initial manifestation of pemphigus vulgaris. 阴茎糜烂：寻常型天疱疮的非典型初始表现。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501189

Hugo J Leme, José Ramos, António Magarreiro-Silva, Ana Isabel Gouveia, João Alves

引用次数: 0

Composite hemangioendothelioma: report of a rare neoplasm. 复合血管内皮瘤：一罕见肿瘤报告。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501166

Marilda Aparecida Milanez Morgado de Abreu, Carolina Aparecida de Almeida Ferreira, Gisele Alborghetti Nai

引用次数: 0

Appearance of basal cell carcinoma on untreated capillary malformation. 未经治疗的毛细血管畸形的基底细胞癌的表现。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501190

Catalina Buchroithner, Nelson Lobos, Gabriel Neely, Arturo Madrid, Valentina Darlic, Alex Castro

引用次数: 0

Posterior reversible encephalopathy syndrome in a patient treated with ustekinumab. Ustekinumab治疗患者的后部可逆性脑病综合征

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501177

Marilda Aparecida Milanez Morgado de Abreu, Naíra M de A Guaresemin, Murilo de Oliveira Lima Carapeba

引用次数: 0

Sporotrichosis in Amazon: series of 46 cases with emphasis on zoonotic transmission. 亚马逊地区孢子虫病：46例，重点是人畜共患传播。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501171

Luiza Rennó Rocha de Oliveira, Isabela de Nazaré Tavares Cardoso Souza, Murilo Dos Santos Souza, Carla Andrea Avelar Pires, Maria Amélia Lopes Dos Santos, Francisca Regina Oliveira Carneiro

引用次数: 0

Derm dotting technique to detect micro-invasive component in lentigo maligna and subsequent margin control with a modified staged excision technique. 真皮点阵技术检测恶性小晶体的微创成分和随后改良的分期切除技术的边缘控制。

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501191

Nelson Lobos-Guede, Pablo Vargas-Mora, Gabriela Coulon, Chantal Caussade, Valentina Darlic, Magdalena Delgado

引用次数: 0

Phenol in dermatology: updated evidence on efficacy and safety 苯酚在皮肤病学：功效和安全性的最新证据

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-08-25 DOI: 10.1016/j.abd.2025.501200

Carolina Reato Marçon

{"title":"Phenol in dermatology: updated evidence on efficacy and safety","authors":"Carolina Reato Marçon","doi":"10.1016/j.abd.2025.501200","DOIUrl":"10.1016/j.abd.2025.501200","url":null,"abstract":"<div><div>Phenol, or carbolic acid, is an organic compound with caustic and antiseptic properties widely used in dermatology. Since its introduction as an antiseptic in the 19th century, its use has expanded to various areas of medicine, including the treatment of dermatological conditions such as vitiligo, warts, guttate leukoderma, hidradenitis suppurativa, angiosarcoma, acne scars, alopecia areata, onychocryptosis, and actinic keratoses. In deep peels, phenol stands out for its effectiveness in skin rejuvenation, promoting intense and sustained neocollagenesis, with unparalleled results. Its ability to alter dermal structure makes it an essential therapeutic tool in various dermatological approaches. However, its use requires extreme caution due to its rapid cutaneous absorption and unique toxicokinetic profile. The substance can induce serious complications, such as cardiac arrhythmias, renal failure, neurotoxicity, and multiple organ failure, especially when applied to large areas or with inadequate techniques and formulations. Historical and contemporary studies report cases of fatal poisoning due to cutaneous exposure to phenol, highlighting the need for strict precautions in its use. To minimize these risks, it is essential that procedures be performed by highly trained physicians, with constant monitoring and controlled application, to ensure safety and maximize the therapeutic benefits of this substance, whose efficacy is widely recognized.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501200"},"PeriodicalIF":3.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradoxical lichenoid reaction during dupilumab treatment- a case report and literature review 杜匹单抗治疗期间矛盾的地衣样物质反应-一例报告和文献综述

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-08-22 DOI: 10.1016/j.abd.2025.501192

Fuchen Huang , Zequn Tong , Xueting Zeng , Jiawen Chen , Ying Zou , Chao Ji

引用次数: 0

Recurrent metastatic malignant peripheral nerve sheath tumor associated with neurofibromatosis I: a rare case with atypical immunohistochemistry 复发性转移性恶性周围神经鞘肿瘤伴I型神经纤维瘤病：罕见的非典型免疫组织化学病例

IF 3.6 4区医学

Anais brasileiros de dermatologia Pub Date : 2025-08-22 DOI: 10.1016/j.abd.2025.501199

Luis Regagnan Dias , Beatriz Zimermano Coimbra , Marcelo Tiezzi , Mayndra Mychelle Landgraf , Marilda Aparecida Milanez Morgado de Abreu

引用次数: 0