Anais brasileiros de dermatologia最新文献

{"title":"Clinical, phenotypic and oncologic background differences in patients with sporadic, familial and multiple primary melanoma","authors":"Irene López-Riquelme,&nbsp;Silvestre Martínez-García,&nbsp;Marina Romero-Bravo,&nbsp;Miguel-Ángel Berciano-Guerrero","doi":"10.1016/j.abd.2026.501472","DOIUrl":"10.1016/j.abd.2026.501472","url":null,"abstract":"<div><h3>Background</h3><div>Sporadic Melanoma (SM) refers to patients with a single melanoma and no family history. Multiple Primary Melanoma (MPM) includes individuals with two or more primary melanomas. Familial Melanoma (FM) is defined as melanoma occurring in two first-degree relatives, or in three or more affected family members of any degree. Previous studies describe distinct phenotypic and clinical profiles in each subgroup, and a high proportion of personal and familial cancer history in patients with melanoma.</div></div><div><h3>Objective</h3><div>To compare phenotype, clinicopathological features, and oncological history in the three groups.</div></div><div><h3>Methods</h3><div>Data from 442 patients were collected and divided into three groups: FM, MPM, and SM.</div></div><div><h3>Results</h3><div>The MPM group showed light eye color (p = 0.01), more tan 50 nevi (p = 0.00014), actinic keratoses (p = 0.0025), and melanomas arising from pre-existing nevi (p = 0.0031). FM patients were younger (p = 0.01) and had a higher burden of personal and family cancer history, particularly breast neoplasms (p = 0.01). SM presented ≥ 2 mitoses (p ≤ 0.0001). Multivariate analysis confirmed independent associations specific to each group.</div></div><div><h3>Study limitations</h3><div>Long term-follow-up for secondary melanoma is needed for validation. Also, some participants may not recall certain family history.</div></div><div><h3>Conclusion</h3><div>Patients with MPM display fair phototypes, numerous nevi, and markers of chronic sun damage, suggesting a central role of phenotype and cumulative UV exposure. In FM, younger age and a higher burden of oncologic history point toward an underlying genetic predisposition. SM is characterized by fewer nevi and aggressive melanomas, reflecting a distinct biological entity. These findings highlight the complex interplay between genetic and environmental factors.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501472"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149317219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea capitis in children: changes in the epidemiological profile over 22-years of study","authors":"Esther Alves de Araujo Nunes,&nbsp;Mariana Aparecida Pasa Morgan,&nbsp;Beatriz Carvalho,&nbsp;Alon Coutinho Nascimento,&nbsp;Talita Sana Valério Fontana,&nbsp;Marjorie Uber,&nbsp;Kerstin Taniguchi Abagge,&nbsp;Renata Robl Imoto,&nbsp;Vânia Oliveira Carvalho","doi":"10.1016/j.abd.2026.501476","DOIUrl":"10.1016/j.abd.2026.501476","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501476"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149284794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of subjective quality of life with emotion dysregulation and binge-eating pathology in acne vulgaris: a cross-sectional study","authors":"Cagdas Boyvadoglu,&nbsp;Cagla Boyvadoglu,&nbsp;Ayse Serap Karadag","doi":"10.1016/j.abd.2026.501487","DOIUrl":"10.1016/j.abd.2026.501487","url":null,"abstract":"<div><h3>Background</h3><div>Acne vulgaris (AV) imposes psychosocial burden beyond lesion severity, yet the specific psychological profiles it produces remain incompletely characterized.</div></div><div><h3>Objective</h3><div>To examine emotion dysregulation (DER) and binge-eating disorder (BED) psychopathology in AV patients, and evaluate whether subjective quality of life (QoL) mediates the association between objective severity and psychological outcomes.</div></div><div><h3>Methods</h3><div>This cross-sectional study enrolled 100 AV patients and 105 matched controls. Objective severity (GAGS), QoL (AQLS), DER (DERS-16), and eating psychopathology (EDE-Q-13/BED subscale) were assessed. Bootstrapped mediation analyses and multivariate regression were performed.</div></div><div><h3>Results</h3><div>AV patients demonstrated significantly higher DERS-16 (<em>d</em> = 1.82) and BED subscale scores (p = 0.005) than controls. Group membership predicted DERS-16 and EDE-Q-13-BED scores independently of sociodemographic covariates. GAGS severity showed no direct association with DERS-16 or EDE-Q-13. Crucially, AQLS significantly mediated the effect of GAGS on both DERS-16 (β = 2.747, 95% CI [0.164, 5.837]) and EDE-Q-13 (β = 0.336, 95% CI [0.036, 0.836]); these indirect effects remained robust after adjustment for education, occupation, and income.</div></div><div><h3>Study limitations</h3><div>Cross-sectional design limits causal inference. Significant sociodemographic differences existed between groups (controlled via regression). Statistical power for GAGS subgroup comparisons was limited. No structured psychiatric interviews were conducted.</div></div><div><h3>Conclusions</h3><div>Subjective QoL impairment, rather than objective lesion burden, is associated with significant indirect effects on both emotion dysregulation and affect-driven eating pathology in AV patients. Routine dermatological care should integrate QoL assessment and psychological screening, irrespective of clinical severity.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501487"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149351994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic extramammary Paget’s disease initially detected by lymph node metastasis","authors":"Tatsuhiko Mori,&nbsp;Takehiro Nakamura,&nbsp;Riko Ishizaki,&nbsp;Kinuko Irie,&nbsp;Takashi Ito,&nbsp;Toshiyuki Yamamoto","doi":"10.1016/j.abd.2026.501475","DOIUrl":"10.1016/j.abd.2026.501475","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501475"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149332076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor necrosis factor inhibitors and cardiovascular outcomes in adults with moderate-to-severe plaque psoriasis: a systematic review and meta-analysis","authors":"Luisa Fernanda Mesa Rodríguez,&nbsp;Alejandro Zambrano Aristizábal,&nbsp;Juan David Vega Padilla","doi":"10.1016/j.abd.2026.501473","DOIUrl":"10.1016/j.abd.2026.501473","url":null,"abstract":"<div><h3>Background</h3><div>Moderate-to-severe plaque psoriasis is associated with persistent systemic inflammation and increased cardiovascular risk.</div></div><div><h3>Objectives</h3><div>To evaluate the association between anti-TNF therapy and clinical cardiovascular outcomes in adults with moderate-to-severe plaque psoriasis.</div></div><div><h3>Methods</h3><div>The authors conducted a systematic review and meta-analysis in accordance with PRISMA 2020 and prospectively registered the protocol in PROSPERO (CRD420251270784). Randomized controlled trials and comparative observational studies evaluating anti-TNF therapy versus placebo, no anti-TNF exposure, topical therapy and/or phototherapy, or non-biologic systemic therapy were eligible. Outcomes of interest were Major Adverse Cardiovascular Events (MACE), myocardial infarction, stroke, cardiovascular death, heart failure, atrial fibrillation, venous thromboembolism, and all-cause mortality.</div></div><div><h3>Results</h3><div>Fourteen studies were included. In randomized evidence, anti-TNF therapy was not associated with significant differences in the risk of MACE, myocardial infarction, stroke, or heart failure. In observational analyses stratified by comparator, anti-TNF therapy was associated with a lower pooled risk of reported cardiovascular events versus topical therapy, but not versus oral therapy or phototherapy.</div></div><div><h3>Study limitations</h3><div>The available evidence was limited by short follow-up in randomized trials, low cardiovascular event counts, wide confidence intervals, and indirect assessment of cardiovascular outcomes, as most trials were designed primarily for dermatologic efficacy and general safety rather than cardiovascular endpoints.</div></div><div><h3>Conclusions</h3><div>Anti-TNF agents were not associated with a clear increase in major cardiovascular risk and appear to have an acceptable short-term cardiovascular safety profile. However, current evidence does not establish a conclusive cardioprotective effect, and larger prospective studies with longer follow-up are needed.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501473"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149284820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise capacity in patients with psoriasis assessed by cardiopulmonary exercise testing: a case-control study","authors":"Hanife Baykal Şahin,&nbsp;Arzu Ferhatosmanoğlu,&nbsp;Leyla Baykal Selçuk","doi":"10.1016/j.abd.2026.501470","DOIUrl":"10.1016/j.abd.2026.501470","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a systemic inflammatory disease associated with cardiovascular and metabolic comorbidities. Although reduced physical activity is frequently reported in these patients, objective data on physiological exercise capacity remains limited.</div></div><div><h3>Objective</h3><div>To evaluate exercise capacity in patients with psoriasis using Cardiopulmonary Exercise Testing (CPET), the gold standard method, and compare the results with those of healthy controls.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 32 patients with psoriasis (off systemic therapy for ≥6-months) and 33 age- and sex-matched healthy controls. Participants underwent symptom-limited CPET on a cycle ergometer. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI), and Physician Global Assessment (PGA).</div></div><div><h3>Results</h3><div>Patients with psoriasis demonstrated significantly lower exercise capacity compared to controls. Peak VO₂, percentage of predicted peak VO₂, VO₂ at AT, and work rate were all significantly lower (all p &lt; 0.01). Peak VO₂ showed significant negative correlations with BMI, PASI, and PGA (all p ≤ 0.001). In multiple linear regression analysis, age (β = -0.17, p = 0.017), BMI (β = -0.30, p = 0.007), and PASI score (β = -0.47, p = 0.001) were identified as independent predictors of peak VO₂, explaining 63.4% of its variance (R² = 0.634, p &lt; 0.001).</div></div><div><h3>Study limitations</h3><div>The cross-sectional design and relatively small single-center sample limit causal inference.</div></div><div><h3>Conclusions</h3><div>Patients with psoriasis demonstrated reduced exercise capacity compared with healthy controls, and disease severity was independently associated with lower peak VO₂. However, due to the cross-sectional design and the potential influence of unmeasured cardiometabolic and lifestyle-related confounders, causality cannot be established, and further prospective studies are required.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501470"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149317220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial erythema in frontal fibrosing alopecia: clinicopathological and dermoscopic features from a case series","authors":"Paula Gerlero,&nbsp;Marcello Menta Simonsen Nico,&nbsp;Neusa Yuriko Sakai Valente,&nbsp;Isabella Doche,&nbsp;Maria Cecilia Rivitti-Machado","doi":"10.1016/j.abd.2026.501495","DOIUrl":"10.1016/j.abd.2026.501495","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501495"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149352067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deceptive Nonhealing scalp ulcer revealing cutaneous angiosarcoma","authors":"Ilse Yolanda Osorio Aragón,&nbsp;Jorge Alberto Cortez Vila,&nbsp;María Elisa Vega Memije,&nbsp;Roberto Arenas Guzmán,&nbsp;Sonia Toussaint Caire","doi":"10.1016/j.abd.2026.501477","DOIUrl":"10.1016/j.abd.2026.501477","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501477"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149284850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent intercritical microvascular abnormalities in primary erythromelalgia: a quantitative nailfold capillaroscopy observation","authors":"Angelo Nigro","doi":"10.1016/j.abd.2026.501480","DOIUrl":"10.1016/j.abd.2026.501480","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501480"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149294180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plantar cutaneous leiomyosarcoma: an entity of rare presentation and diagnostic challenge","authors":"Edgar Fermín Yan-Quiroz,&nbsp;Thiara Charlene Carranza-Cabanillas,&nbsp;Zaida Urata-Guzmán,&nbsp;Eliani Leydi Silvana Pérez-Moran,&nbsp;Renan Vargas-Morales,&nbsp;José Richard Tenazoa-Villalobos","doi":"10.1016/j.abd.2026.501474","DOIUrl":"10.1016/j.abd.2026.501474","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 6","pages":"Article 501474"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13735170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149284839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}