Anais brasileiros de dermatologia最新文献

{"title":"Complementary strategies in Psoriasis – non-pharmacological approaches for comprehensive management","authors":"Fernando Valenzuela ,&nbsp;Eine Benavides ,&nbsp;Esther Verónica Echeverry ,&nbsp;Dan Hartmann ,&nbsp;Daniza Bilicic","doi":"10.1016/j.abd.2026.501356","DOIUrl":"10.1016/j.abd.2026.501356","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic immune-mediated inflammatory disease linked to systemic comorbidities such as obesity, diabetes, cardiovascular disease, and inflammatory bowel disease. Non-pharmacological interventions, such as dietary modifications, nutritional supplementation, exercise, and psychological interventions, have emerged as complementary therapies in the management of psoriasis.</div></div><div><h3>Objectives</h3><div>Review the current and recent evidence and the role of trace elements, vitamins, diet, exercise, and psychological interventions as complementary approaches in the management of patients with psoriasis.</div></div><div><h3>Materials and methods</h3><div>A narrative review was conducted, analyzing clinical trials, meta-analyses, and cohort studies from major databases.</div></div><div><h3>Results</h3><div>Trace elements such as zinc, copper, and selenium, and vitamins including D, E, B-complex, and A, play roles in oxidative stress modulation, immune regulation, and keratinocyte biology. However, the clinical efficacy of micronutrient supplementation remains uncertain due to inconsistent and conflicting findings. Dietary interventions, particularly Mediterranean diet adherence and weight loss through caloric restriction or bariatric surgery, have been associated with reductions in psoriasis severity, although clear clinical protocols are lacking. Aerobic exercise appears beneficial but is underutilized, partially due to psychological and disease-related barriers. Furthermore, psoriasis is associated with a high prevalence of psychological disorders, with the necessity to integrate psychological interventions to optimize disease management.</div></div><div><h3>Study limitations</h3><div>The available evidence is limited and with heterogeneity in study design, with small sample sizes, observational methodologies, and inconsistent intervention protocols, restricting causal inference and generalizability.</div></div><div><h3>Conclusion</h3><div>While non-pharmacological strategies show promise as complementary interventions in psoriasis management, they cannot replace conventional therapy. Further studies are required to confirm their clinical impact. These approaches should be considered as complementary strategies, with individualized patient assessments and continuous follow-up being essential.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501356"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin and in situ melanoma: an update for the dermatologist","authors":"João Renato Vianna Gontijo ,&nbsp;Flávia Vasques Bittencourt ,&nbsp;Jacob H. Nelson ,&nbsp;Lucas Campos Garcia ,&nbsp;Sancy A. Leachman","doi":"10.1016/j.abd.2026.501349","DOIUrl":"10.1016/j.abd.2026.501349","url":null,"abstract":"<div><h3>Background</h3><div>Thin melanoma (TM, ≤1.0 mm Breslow thickness) and Melanoma In Situ (MIS) constitute the majority of melanoma diagnoses worldwide and are responsible for melanoma-related deaths in these early-stage tumors. Despite their favorable prognosis, MIS and TM represent an opportunity for improving patient outcomes through early detection, accurate risk stratification, and long-term surveillance for metastasis and new skin neoplasms.</div></div><div><h3>Objective</h3><div>Provide an update of current evidence regarding epidemiology, risk factors, prognostic indicators, genetic background, and clinical management of MIS and TM.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature and international guidelines was conducted, integrating epidemiologic data, clinical prognostic parameters, and molecular insights relevant to MIS and TM.</div></div><div><h3>Results</h3><div>MIS and TM account for over 80% of all melanomas, with increasing incidence and relatively stable mortality rates. Prognosis is primarily determined by Breslow depth and ulceration, while factors such as mitotic rate, anatomic site, and age further refine risk assessment. Genetic alterations contribute to tumorigenesis but are not yet integrated into routine management. Long-term dermatological surveillance is needed, as new neoplasms, recurrence, and metastasis can develop during follow-up.</div></div><div><h3>Conclusions</h3><div>MIS and TM are increasingly diagnosed, and dermatologists need to be a part of early detection, multidisciplinary management, and lifelong surveillance, which remain the cornerstone of reducing melanoma-related mortality.</div></div><div><h3>Study limitations</h3><div>The substantial heterogeneity among the included studies limits direct comparison and quantitative synthesis of the available data.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501349"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “The Brazilian Portuguese version of the psoriasis epidemiology screening tool (PEST-bp) is reliable and accurate: a cross-sectional study from southern Brazil” – Reply","authors":"Vanessa Thomé ,&nbsp;Marcia Regina Rosa Scalcon ,&nbsp;Denise Teresinha Antonelli da Veiga ,&nbsp;Luciane Prado de Vargas ,&nbsp;Patrícia Chagas ,&nbsp;Camila Sales Fagundes ,&nbsp;Gabriel Caruso Novaes Tudella ,&nbsp;Mateus Diniz Marques ,&nbsp;André Avelino Costa Beber ,&nbsp;Raíssa Massaia Londero Chemello ,&nbsp;Diego Chemello","doi":"10.1016/j.abd.2026.501370","DOIUrl":"10.1016/j.abd.2026.501370","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501370"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to minimize pain with local anesthesia and improve patient experiences: a review","authors":"Umer Nadir ,&nbsp;Isadora Rinaldo Scaburi ,&nbsp;Felipe Bochnia Cerci ,&nbsp;George Michael Jeha ,&nbsp;Stanislav Nickolaevich Tolkachjov","doi":"10.1016/j.abd.2026.501366","DOIUrl":"10.1016/j.abd.2026.501366","url":null,"abstract":"<div><h3>Background</h3><div>Local anesthesia is essential in common procedures in dermatology, but injection and infiltration of anesthetic often cause significant pain, reducing patient comfort and satisfaction.</div></div><div><h3>Objective</h3><div>To review evidence-based techniques to reduce pain associated with local anesthetic injection and infiltration.</div></div><div><h3>Methods and materials</h3><div>A narrative review of the literature was performed, and techniques were summarized for clinicians to reference.</div></div><div><h3>Results</h3><div>Technical methods to reduce pain include using smaller-gauge needles (30–33G), smaller syringes (1‒3 mL), buffering lidocaine with sodium bicarbonate, inserting the needle at 90 degrees, slow infusion, subcutaneous delivery, and pore-guided injection. Adjuncts such as warming anesthetic, vibration, ice, music, and verbal distraction (“talkesthesia”) also reduce patient perception of pain.</div></div><div><h3>Study limitations</h3><div>Limitations include heterogeneity in study designs, outcomes measures, and clinical contexts across the included literature, precluding quantitative synthesis or direct comparison of individual techniques. Additionally, several recommendations are based on expert opinion or limited evidence.</div></div><div><h3>Conclusion</h3><div>A multimodal approach using both technical refinements and adjunctive measures can make local anesthetic administration less painful. Dermatologists may routinely implement these strategies to improve patient experience and satisfaction.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501366"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and sustainability of a reduced risankizumab dose after achievement of low disease activity of psoriasis: a 24-week study","authors":"Gizem Pehlivan Ulutaş ,&nbsp;Tuğba Özkök Akbulut ,&nbsp;Algün Polat Ekinci","doi":"10.1016/j.abd.2026.501335","DOIUrl":"10.1016/j.abd.2026.501335","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501335"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of dupilumab in the management of refractory prurigo nodularis in an immunosuppressed double transplanted patient","authors":"Diego Valenzuela Godoy ,&nbsp;Rosario Agüero ,&nbsp;Marianne Kolbach","doi":"10.1016/j.abd.2026.501358","DOIUrl":"10.1016/j.abd.2026.501358","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501358"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varicella-zoster virus infection: a review about varicella and herpes zoster","authors":"Maria Paula Barbieri D'Elia ,&nbsp;Carla Riama Lopes de Pádua Moura ,&nbsp;Rafael de Deus Moura ,&nbsp;Juliana de Sá Pires Carvalho ,&nbsp;Henrique Pott","doi":"10.1016/j.abd.2026.501367","DOIUrl":"10.1016/j.abd.2026.501367","url":null,"abstract":"<div><div>The Varicella-zoster virus (VZV) is a prevalent human pathogen that links dermatology, virology, and immunology. Following primary varicella infection, the virus establishes lifelong latency in the sensory ganglia, with reactivation manifesting as herpes zoster. The clinical spectrum ranges from typical dermatomal vesicular eruptions to atypical or disseminated presentations in older adults or immunocompromised patients, often posing diagnostic challenges. Early recognition and prompt initiation of antiviral therapy are essential to limit lesion progression, reduce viral shedding, and prevent complications. Dermatologists are uniquely positioned to identify these manifestations and distinguish VZV infection from its clinical mimics. Advances in molecular diagnostics have improved the detection of atypical cases, while the introduction of the attenuated-virus vaccine for varicella and recombinant glycoprotein E–based vaccine for herpes zoster has transformed prevention, providing durable protection even in older adults and immunosuppressed populations. Beyond therapy, dermatologists play a key role in integrating vaccination assessment and patient education into routine care. Understanding the biological continuum of VZV (from latency to reactivation) enhances diagnostic precision, guides evidence-based treatment, and supports immunization strategies against VZV. As VZV continues to impose a substantial burden of cutaneous and neuropathic morbidity, an integrated dermatological approach that combines early therapeutic intervention with preventive counseling represents the most effective strategy to reduce its clinical and public health impact.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501367"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic annular erythema in a patient with hepatitis B-related cirrhosis","authors":"Beatriz F. Vilela,&nbsp;Maria Cristina Fialho,&nbsp;Ana Ferreirinha,&nbsp;Cândida Fernandes","doi":"10.1016/j.abd.2026.501362","DOIUrl":"10.1016/j.abd.2026.501362","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501362"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission of refractory lichen amyloidosis with baricitinib","authors":"Thiago Lenoir da Silva ,&nbsp;Gleison Vieira Duarte","doi":"10.1016/j.abd.2026.501363","DOIUrl":"10.1016/j.abd.2026.501363","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501363"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voriconazole-induced lentiginosis in a child: a phototoxicity warning sign","authors":"Felipe Henríquez ,&nbsp;Vicente Orellana-Westermeyer ,&nbsp;Amany Chaaban ,&nbsp;Paula Muñoz ,&nbsp;Camila Downey ,&nbsp;María Teresa Dossi","doi":"10.1016/j.abd.2026.501355","DOIUrl":"10.1016/j.abd.2026.501355","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501355"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}