Anais brasileiros de dermatologia最新文献

{"title":"A case of labyrinthine pattern basal cell carcinoma.","authors":"Takehiro Nakamura, Toshiyuki Yamamoto","doi":"10.1016/j.abd.2024.09.009","DOIUrl":"https://doi.org/10.1016/j.abd.2024.09.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of upadacitinib in the management of atopic dermatitis, Crohn's disease, and hidradenitis suppurativa: one treatment, multiple indications.","authors":"Roberto Bueno-Filho, Daniel Lorenzini, Rogério Serafim Parra","doi":"10.1016/j.abd.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.abd.2024.10.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyoderma gangrenosum: a 22-year follow-up of patients in a tertiary reference hospital in Brazil.","authors":"Livia Maria Oliveira Salviano, Denise Miyamoto, Claudia Giuli Santi, Tatiana Mina Yendo, Maria Cecilia Rivitti-Machado","doi":"10.1016/j.abd.2024.07.014","DOIUrl":"https://doi.org/10.1016/j.abd.2024.07.014","url":null,"abstract":"<p><strong>Background: </strong>Pyoderma gangrenosum (PG) is a rare dermatosis often associated with systemic diseases. There are autoinflammatory mechanisms with neutrophilic infiltrate and necrosis. Due to the high morbidity, variable response to therapy and lack of treatment standardization, PG constitutes a highly burdensome condition.</p><p><strong>Objectives: </strong>To evaluate the epidemiological, clinical and laboratory features and response to therapy of patients with PG followed at HCFMUSP.</p><p><strong>Methods: </strong>This retrospective and descriptive study included patients with confirmed PG under follow-up at HCFMUSP from January 2000 to August 2021. Data were retrieved from medical records.</p><p><strong>Results: </strong>Fifty patients were included. The mean time from the onset of symptoms to diagnosis was 26.5 months. Lesions predominated on the lower extremity in 72% (n = 36/50), and the ulcerative type was the most common (n = 43/50; 86%). Local pain was mentioned in 39/50 (78%) and 12/50 (24%) presented pathergy. The most frequently associated diseases were inflammatory bowel disease (n = 10/20; 20%) and hidradenitis suppurativa (n = 10/20; 20%). High-dose systemic corticosteroid was mostly the first therapy (88%), either alone (n = 7/50; 14%) or in association with classic immunosuppressants or immunobiologicals (n = 37; 74%). Most patients (n = 32/50; 64%) had at least one hospitalization. Disease control was achieved in 44/50 (88%), with recurrences in 48% (n = 24/50) and total healing without medication in 24% (n = 12). Sixteen patients (32%) were treated with at least 1 immunobiological agent in addition to classic drugs.</p><p><strong>Study limitations: </strong>Retrospective, descriptive design and number of patients.</p><p><strong>Conclusions: </strong>There was delay in diagnosis, association with systemic and cutaneous conditions, and the need for prolonged immunomodulatory or immunosuppressive therapy (classic agents and also biologic agents) to control PG.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent tuberculosis infection in patients with psoriasis using immunobiologicals: an observational study.","authors":"Mariana Baptista Angeluci, Marilda Aparecida Milanez Morgado de Abreu, Ana Cláudia Cavalcante Esposito Lemos, Eduardo Vinicius Mendes Roncada, Cristhiana Kise Saito, Felipe Puga Barbosa","doi":"10.1016/j.abd.2024.09.011","DOIUrl":"https://doi.org/10.1016/j.abd.2024.09.011","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pembrolizumab-induced Stevens-Johnson syndrome.","authors":"Hiram Larangeira de Almeida Junior, Debora Sarzi Sartori, Aline Paganelli, Karen Francisca Borges Sias, Luísa Coelho Capuá, Darlan Cleverson Farezin","doi":"10.1016/j.abd.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.abd.2024.08.011","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired syphilis: update on clinical, diagnostic and therapeutic aspects^⋆.","authors":"Carolina Talhari, Kaique Arriel, Marcio Soares Serra, John Verrinder Veasey","doi":"10.1016/j.abd.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.abd.2024.11.002","url":null,"abstract":"<p><p>Syphilis, an infection caused by Treponema pallidum, transmitted predominantly through sexual contact, affects several organs, causing skin, mucous membranes and systemic lesions. Despite being a secular disease, it still poses a major challenge for the public health system, since the number of cases continues to increase after years of warnings from the scientific community. Recognizing the clinical manifestations is essential for formulating the clinical hypothesis and diagnostic confirmation with complementary exams. However, recognizing skin lesions is not always simple, given the diversity of clinical manifestations which resemble other diseases. This review presents an overview of the disease, with current epidemiological data, a representation of the various clinical manifestations, a description of the pertinent diagnostic methods for laboratory confirmation, and appropriate therapeutic approaches for each clinical form.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical-histological characteristics and therapeutic management of primary cutaneous melanoma in elderly patients.","authors":"Juan-Manuel Morón-Ocaña, Isabel-María Coronel-Pérez, Ana-Isabel Lorente-Lavirgen, Carmen-Victoria Almeida-González, Amalia Pérez-Gil","doi":"10.1016/j.abd.2024.07.017","DOIUrl":"https://doi.org/10.1016/j.abd.2024.07.017","url":null,"abstract":"<p><strong>Background: </strong>Life expectancy is rising in developed countries. The impact of age on melanoma characteristics is unclear, but it seems that melanomas in the elderly have distinct features affecting management and outcomes.</p><p><strong>Objectives: </strong>To compare clinical and histopathological melanoma characteristics and management in elderly and younger patients.</p><p><strong>Methods: </strong>A retrospective population-based study analyzed melanomas observed between 2007 and 2022 was made in the southern Seville health area (Spain). Patients were divided into two age groups: <65 and ≥65. Data were collected from clinical histories.</p><p><strong>Results: </strong>Among 431 primary cutaneous melanomas, 33% were in patients ≥65-years. Elderly patients had more head and neck melanomas (37.8% vs. 14.9%; p < 0.001), larger lesions (1.3 vs. 0.9 cm; p < 0.001), more ulcerated melanomas (17.8% vs. 8.8%; p < 0.012), and higher Breslow thickness (1.03 vs. 0.65 mm; p < 0.01) than younger patients. No differences were found in the number of mitoses or histopathological invasions. Stage 0 and more advanced stages (II/III/IV) were observed more frequently in ≥65-years (29.3% vs. 23% and 27.1% vs. 15.7%, p < 0.001 respectively). Fewer wide excisions (28.4% vs. 5.6%, p < 0.001), sentinel lymph node biopsy (17.6% vs. 2.4%, p < 0.001), and adjuvant therapy (11.9% vs. 2.1%, p < 0.001) were performed in patients ≥65-years.</p><p><strong>Study limitations: </strong>The study was retrospective, primarily covering the last 10-years, with older data missing. Key risk factors like the number of nevi and family history of melanoma were not collected.</p><p><strong>Conclusions: </strong>Melanomas in the elderly were diagnosed more frequently at initial and advanced stages despite having worse prognostic characteristics compared melanomas occurring in younger people.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox in a patient with AIDS: clinical management with tecovirimat and surgical correction of unaesthetic scars.","authors":"Kananda Kesye Sousa Nunes, Carlos Alberto Chirano Rodrigues, Beatriz Costa Cardoso, Iêda Lúcia Santos Magno, Mathias Gama de Aguiar Ferreira, Sinésio Talhari","doi":"10.1016/j.abd.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.abd.2024.11.001","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological analysis of the skin of renal transplant recipients submitted to three different immunosuppression regimens.","authors":"Maria Victória Quaresma, Luiz Sergio Azevedo, Elias David-Neto, Mírian Nacagami Sotto","doi":"10.1016/j.abd.2024.07.016","DOIUrl":"https://doi.org/10.1016/j.abd.2024.07.016","url":null,"abstract":"<p><strong>Background: </strong>Renal transplant recipients (RTRs) use a combination of immunosuppressive agents: a corticosteroid; a calcineurin inhibitor (cyclosporine or tacrolimus) and an antimetabolic agent (azathioprine [AZA] or a mycophenolic acid precursor [MPA] ‒ Mycophenolate mofetil or sodium) or an mTOR inhibitor (mTORi) ‒ sirolimus or everolimus. These treatments increase the incidence of various neoplasms, especially non-melanoma skin cancers (NMSCs).</p><p><strong>Objectives: </strong>To evaluate the histopathological alterations in the skin of the RTRs under three different immunosuppressive regimens: one mTORi (sirolimus or everolimus); or one antimetabolic agent (MPA or AZA), comparing them by groups and with healthy controls.</p><p><strong>Methods: </strong>This was an observational, cross-sectional, comparative study of 30 patients selected from the Renal Transplant Service and divided into three groups: mTORi (n = 10), MPA (n = 10), and AZA (n = 10). The control group consisted of 10 immunocompetent non-transplanted volunteers. All RTRs were using tacrolimus and prednisone. Each participant underwent two biopsies of intact skin: one in a sun-protected and another in a sun-exposed area. The specimens were analyzed without previous information on which group they belonged to.</p><p><strong>Results: </strong>The most significant histopathological change was thinning of the epidermis in the mTORi group, both in photoexposed and photoprotected skin.</p><p><strong>Study limitations: </strong>The study was conducted on a limited number of patients, which may influence the representativeness of the results.</p><p><strong>Conclusions: </strong>Only RTRs treated with mTORi presented interruption of epidermal proliferation. These findings help to understand the influence of these different types of immunosuppressive regimens and their subsequent potential effects on carcinogenesis.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail involvement due to immunoglobulin G4 (IgG4)-related disease in a person living with HIV^⋆.","authors":"Valéria Lukenczuk Said, Monique Freire Dos Reis, Tiago Vencato da Silva, Virgínia Vilasboas Figueiras, Nathália Matos Gomes","doi":"10.1016/j.abd.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.abd.2024.09.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}