Anais brasileiros de dermatologia最新文献

{"title":"Oxcarbazepine induced systemic lupus erythematosus: a clinical challenge","authors":"Eduardo López Vera , Elisabeth Gómez Moyano , María Ayala Blanca , María Salas Cassinello","doi":"10.1016/j.abd.2025.501154","DOIUrl":"10.1016/j.abd.2025.501154","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501154"},"PeriodicalIF":2.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stabilization of a recalcitrant and aggressive necrobiotic xanthogranuloma with tofacitinib","authors":"Miguel Mansilla-Polo , Carlos Abril-Pérez , Daniel Martín-Torregrosa , Rafael Botella-Estrada","doi":"10.1016/j.abd.2025.501159","DOIUrl":"10.1016/j.abd.2025.501159","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501159"},"PeriodicalIF":2.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammasome pathways in atopic dermatitis: insights into inflammatory mechanisms and therapeutic targets","authors":"Yasmim Álefe Leuzzi Ramos,&nbsp;Anna Julia Pietrobon,&nbsp;Franciane Mouradian Emidio Teixeira,&nbsp;Valeria Aoki,&nbsp;Maria Notomi Sato,&nbsp;Raquel Leão Orfali","doi":"10.1016/j.abd.2025.501136","DOIUrl":"10.1016/j.abd.2025.501136","url":null,"abstract":"<div><div>Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex interaction between genetic, immunological, and environmental factors. The combination of immune dysregulation and skin barrier dysfunction plays a crucial role in the pathogenesis of the disease. The inflammasome, an important intracellular complex of pattern recognition receptors (PRRs), plays a crucial role in the cutaneous inflammatory response, activating caspase-1 and promoting the release of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18. The role of inflammasome components in regulating the inflammatory response in AD highlights how the activation of these complexes exacerbates inflammation and contributes to the worsening of the disease and tissue damage. The review included observational and experimental studies investigating inflammasome activation in AD and other inflammatory skin diseases. The main mechanisms of inflammasome activation and their impact on the inflammatory environment and skin barrier integrity were discussed. Understanding the role of the inflammasome in AD is essential for the development of new therapeutic approaches aimed at both modulating the immune response and restoring the skin barrier, improving more effective clinical management and patients' quality of life.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501136"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of reactive allergens in contact patch testing studies using the Brazilian standard battery: a systematic review","authors":"Ana Laura Andrade Bueno ,&nbsp;Nathalia Hoffmann Guarda Aguzzoli ,&nbsp;Renan Rangel Bonamigo","doi":"10.1016/j.abd.2025.501126","DOIUrl":"10.1016/j.abd.2025.501126","url":null,"abstract":"<div><h3>Background</h3><div>Contact dermatitis is a common dermatosis in dermatology. The patch test is the gold standard for diagnosis, using a panel of common allergens and irritants. In Brazil, a standardized battery of 30 substances is used. However, comprehensive epidemiological data on contact dermatitis are limited, and no studies have compiled and compared nationwide results.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the positivity rate of patch tests using the Brazilian Standard Battery in suspected contact dermatitis cases from 2000 to 2022. We also evaluated associations between reactive substances and clinical and demographic variables and examined the variation in reactivity frequency to allergenic substances over the study period.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted using PubMed, Scielo, and LILACS. We evaluated the prevalence of positive tests for each substance, examined associations between variables such as gender, region, and age, and assessed variations in patch test positivity over time.</div></div><div><h3>Results</h3><div>Initially, 55 articles were identified, and 10 were included in the review. Nickel sulfate was the most frequently positive allergen, while triclosan, P-tertiary buthyphenol, and anthraquinone were the least prevalent. Test positivity increased every 5-years for kathon CG, neomycin, and nickel sulfate, while it decreased for quaternion 15 and thimerosal.</div></div><div><h3>Study limitations</h3><div>The results were limited by the small number of articles included in the review.</div></div><div><h3>Conclusions</h3><div>This pioneering study in Brazil provides valuable insights for dermatological allergy practitioners into the prevalence of patch test positivity for each substance in the Brazilian Standard Battery, aiding in informed decision-making and patient management.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501126"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine and Treat-to-Target approach in atopic dermatitis: enhancing personalized care and outcomes","authors":"Dan Hartmann ,&nbsp;Catalina Retamal ,&nbsp;Fernando Valenzuela","doi":"10.1016/j.abd.2025.501135","DOIUrl":"10.1016/j.abd.2025.501135","url":null,"abstract":"<div><h3>Background</h3><div>Atopic Dermatitis (AD) is a chronic inflammatory skin disease affecting a significant portion of the global population. While conventional treatments effectively control and manage symptoms, there is a growing need for more personalized and precise approaches for patients. Precision medicine has emerged as a promising therapeutic strategy that tailors treatment to the individual characteristics of each patient. Complementing this, the Treat-to-Target (T2T) strategy sets specific clinical goals and involves continuous monitoring and treatment adjustments based on real-time patient responses and biomarker data.</div></div><div><h3>Objectives</h3><div>This review aims to explore the latest advancements in precision medicine and the T2T strategy for AD.</div></div><div><h3>Methods</h3><div>A comprehensive literature review was conducted to identify the most recent studies and advancements in precision medicine and the T2T strategy for AD.</div></div><div><h3>Results</h3><div>Recent studies highlight the effectiveness of precision medicine in achieving sustained remission and improving the quality of life for patients. The T2T strategy was shown to be effective in preventing exacerbations and adapting treatments based on real-time patient responses and biomarker data.</div></div><div><h3>Study limitations</h3><div>The lack of a consensus on the clinical implementation of precision medicine and T2T, limited longitudinal studies validating long-term outcomes, challenges in stratifying patients due to biomarker heterogeneity, and barriers to integrating emerging diagnostic technologies into routine practice.</div></div><div><h3>Conclusions</h3><div>Precision medicine and the T2T strategy represent significant advancements in the management of AD. These approaches offer the potential for more personalized, effective, and adaptive treatment protocols, leading to improved patient outcomes. Continuous research and development in these areas are essential to fully realize their potential and integrate them into routine clinical practice.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501135"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of sentinel lymph node biopsy on the prognosis of acral melanoma patients","authors":"Thiago Francischetto ,&nbsp;Ana Clara Falcão ,&nbsp;Adson Santos Neves ,&nbsp;Ana Beatriz Lira ,&nbsp;Robson Freitas de Moura ,&nbsp;Thiago Souza Oliveira Freitas de Moura ,&nbsp;Juvandy Antonio Inacio Santos ,&nbsp;André Bacellar Costa Lima ,&nbsp;Marco Antonio Oliveira Lessa ,&nbsp;Jussamara Britos Santos ,&nbsp;Alexandre Farias de Albuquerque ,&nbsp;Vaner Paulo da Silva Fonseca Pinheiro","doi":"10.1016/j.abd.2025.501129","DOIUrl":"10.1016/j.abd.2025.501129","url":null,"abstract":"<div><h3>Background</h3><div>Sentinel lymph node (SLN) biopsy in melanoma patients has an important role in staging, prognosis assessment, and treatment definition. Few studies have evaluated its role in the Acral Melanoma (AM) subtype.</div></div><div><h3>Objective</h3><div>To evaluate the results of SLN biopsy in 79 patients with acral melanoma treated at a single oncological center and compare them with the data described in the literature.</div></div><div><h3>Methods</h3><div>Between January 2016 and December 2022, the authors analyzed all patients with AM who underwent SLN biopsy in a single institute. The authors analyzed the epidemiological, clinical and histopathological data. Overall Survival (OS) and Disease-Free Survival (DFS) curves were estimated using the Kaplan-Meier method. Multivariate analyses were conducted using the Cox regression model.</div></div><div><h3>Results</h3><div>During the period, the authors analyzed 79 cases. The mean age was 60 years and median thickness was 4.5 mm and 67.1% had ulceration. SLN was positive in 27 patients (34.2%). The estimated OS and DFS were 67.7% and 45.2%. OS was better in the negative SLN group compared to the positive SLN group (70.9% vs. 53.2%), but without statistical significance (p = 0.08). Estimated DFS for positive SLN was associated with a significantly worse prognosis (33.8 × 46.7%, p = 0.001).</div></div><div><h3>Study limitations</h3><div>The retrospective nature of the study and the limited number of patients.</div></div><div><h3>Conclusions</h3><div>The present study has significant implications for determining prognosis. Patients with AM and positive SLN had a worst prognosis compared to those with negative SLN.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501129"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exuberant terra firma-forme dermatosis in an elderly patient⋆","authors":"Marinna Sampaio Campos,&nbsp;Loanda Oliveira Fukuma,&nbsp;Juliana Carvalho Delgado,&nbsp;Paulo Ricardo Criado,&nbsp;Karla Calaça Kabbach Prigenzi,&nbsp;Sandra Lopes Mattos e Dinato","doi":"10.1016/j.abd.2025.501131","DOIUrl":"10.1016/j.abd.2025.501131","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501131"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary extramedullary plasmacytoma: a rare case presentation","authors":"Pedro Barbosa,&nbsp;Clara de Diego,&nbsp;Javier Anaya,&nbsp;Corina Busso","doi":"10.1016/j.abd.2025.501137","DOIUrl":"10.1016/j.abd.2025.501137","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501137"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of lymphomatoid papulosis type E","authors":"Máté Attila Bognár ,&nbsp;Csaba Gyömörei ,&nbsp;Zsuzsanna Lengyel","doi":"10.1016/j.abd.2025.501133","DOIUrl":"10.1016/j.abd.2025.501133","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501133"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the clinical and epidemiological profile of leprosy in Brazil and Major Regions","authors":"Alícia de Siqueira Sczmanski,&nbsp;Lucas Pazin,&nbsp;Thiago Mamoru Sakae,&nbsp;Josete Mazon","doi":"10.1016/j.abd.2025.501127","DOIUrl":"10.1016/j.abd.2025.501127","url":null,"abstract":"<div><h3>Background</h3><div>Leprosy is an infectious disease, endemic to Brazil, associated with poor living conditions. Although curable, it is a neglected disease, posing a serious public health problem. The literature lacks comprehensive and recent analyses of the pathology.</div></div><div><h3>Objectives</h3><div>The study aims to describe and analyze the clinical-epidemiological profile of leprosy patients in large Brazilian regions and compare it with regional sociodemographic indicators.</div></div><div><h3>Methods</h3><div>This is an ecological, descriptive, and analytical observational study, carried out through the collection of secondary data from the Disease Notification Information System from 2014 to 2019, the 2010 census, and population estimates from the Brazilian Institute of Geography and Statistics.</div></div><div><h3>Results</h3><div>A total of 215,155 new cases were reported and the annual detection rate was maintained in four Brazilian regions, with only the South showing a significant decrease. The highest rate was observed in the Midwest and the lowest in the South. The predominant profile was male, age range between 60 and 79 years old, literate, and black and brown ethnicity. There was a predominance of the borderline cases, multibacillary form, more than five skin lesions, and zero grade of disability at diagnosis. Bacilloscopy was not performed in 42.8% of the cases and cure was the outcome in 77%.</div></div><div><h3>Study limitations</h3><div>The use of secondary data and the time interval analyzed are restricted by the data source platform and the COVID-19 pandemic.</div></div><div><h3>Conclusions</h3><div>This shows a perpetuated public health problem, mainly in the North, Northeast, and Midwest regions, associated with socioeconomic indicators and has a clinical-epidemiological profile that favors the bacillus transmission.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501127"},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}