Anais brasileiros de dermatologia最新文献

{"title":"A progressive sclerotic depigmenting congenital melanocytic nevus in a Chinese patient","authors":"Yufan Chen , Yuqing Wang , Juanmei Cao , Tianqi Zhao , Jing Yang , Changzheng Huang","doi":"10.1016/j.abd.2026.501341","DOIUrl":"10.1016/j.abd.2026.501341","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501341"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and mortality of cutaneous melanoma stratified by sex, age, and age group – An analysis of the Brazilian population from 2013 to 2023","authors":"Débora Terra Cardial ,&nbsp;Francisco Macedo Paschoal ,&nbsp;Luiz Vinicius de Alcantara Sousa","doi":"10.1016/j.abd.2026.501338","DOIUrl":"10.1016/j.abd.2026.501338","url":null,"abstract":"<div><h3>Background</h3><div>Cutaneous melanoma remains the leading cause of skin cancer-related mortality worldwide. Despite national awareness campaigns launched by the Brazilian Society of Dermatology since 1999, morbidity and mortality in Brazil remain substantially high.</div></div><div><h3>Methods</h3><div>We conducted an ecological study using secondary data from DATASUS (Hospital Information System – SIH/SUS, Mortality Information System – SIM/SUS, and population estimates from IBGE). Melanoma cases were identified using ICD-10 code C43 between 2013 and 2023. Incidence rates were calculated per 100,000 inhabitants.</div></div><div><h3>Results</h3><div>A total of 20,087 melanoma cases were reported during the study period. Men accounted for 57.5% of cases, a proportion that remained stable throughout the decade. Annual case counts increased from 1,547 in 2013 to 2,047 in 2023, representing a 32% rise. The South and Southeast regions — historically shaped by European immigration and concentrating the majority of White individuals — reported the highest incidence and mortality, consistent with prior population-based cohort data from southern Brazil.</div></div><div><h3>Conclusions</h3><div>These findings highlight a multifactorial scenario in which demographic, behavioral, biological, and structural healthcare determinants converge to shape melanoma burden in Brazil. Sex-specific behavioral factors (lower photo protection adherence, delayed dermatological evaluation among men) and biological differences may contribute to male predominance. Expanding access to early-detection strategies and equitable resource allocation remains essential in a country marked by vast territorial, climatic, and socioeconomic heterogeneity.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501338"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indeterminate cell histiocytosis with ETV3::NCOA2 fusion detected by optical genome mapping","authors":"Miguel Mansilla-Polo ,&nbsp;Rafael Andreu-Lapiedra ,&nbsp;Irene Luna-del Valle ,&nbsp;Esperanza Such-Taboada ,&nbsp;Montserrat Évole-Buselli","doi":"10.1016/j.abd.2026.501342","DOIUrl":"10.1016/j.abd.2026.501342","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 3","pages":"Article 501342"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Certolizumab pegol ınduced paradoxical psoriatic alopecia with therapeutic response to bimekizumab","authors":"Gamze Taş Aygar ,&nbsp;Furkan Keleş ,&nbsp;Feyzanur Elif Biber ,&nbsp;Unsal Han ,&nbsp;Selda Pelin Kartal","doi":"10.1016/j.abd.2026.501320","DOIUrl":"10.1016/j.abd.2026.501320","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501320"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Predictive factors for distant metastasis in early cutaneous melanoma: a 20-year experience of a Turkish tertiary referral hospital”","authors":"Shyam Sundar Sah ,&nbsp;Abhishek Kumbhalwar","doi":"10.1016/j.abd.2026.501328","DOIUrl":"10.1016/j.abd.2026.501328","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501328"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial minimally invasive aesthetic procedures and quality of life in transgender individuals: a prospective study","authors":"Walter Refkalefsky Loureiro ,&nbsp;Francisca Regina Oliveira Carneiro ,&nbsp;Letícia Rezende da Silva Sobral","doi":"10.1016/j.abd.2026.501316","DOIUrl":"10.1016/j.abd.2026.501316","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501316"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of immunohistochemical and gene expression of Janus kinase1 and Janus kinase3 in the skin of different clinical types of mycosis fungoides patients – Part II: reverse transcriptase–polymerase chain reaction","authors":"Heba Saed El-Amawy ,&nbsp;Basma Mourad Mohamed Ali ,&nbsp;Mohamed Labib Salem ,&nbsp;Lamia Elgarhy","doi":"10.1016/j.abd.2026.501300","DOIUrl":"10.1016/j.abd.2026.501300","url":null,"abstract":"<div><h3>Background</h3><div>Mycosis Fungoides (MF) is the commonest type of primary cutaneous T-Cell lymphomas representing about 50% of all lymphomas arising primarily in the skin. Janus kinases are non-receptor intracellular tyrosine kinases that play an important role in the pathogenesis of variant skin disorders and several hematological malignancies.</div></div><div><h3>Objective</h3><div>The aim of this study was to investigate the gene expression of Janus Kinase-1 (JAK1) and Janus Kinase-3 (JAK3) in the skin of different types of MF patients using Real-time Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR).</div></div><div><h3>Methods</h3><div>The current study included 53 patients with MF, and 53 control samples. RT-PCR for JAK1 and JAK3 was done in the skin specimens obtained from patients and controls.</div></div><div><h3>Results</h3><div>Both JAK1 and JAK3 fold changes showed stepwise upregulation in lesional MF skin than normal control skin, with statistically significant increase in MF patients than healthy controls (p &lt; 0.001 and &lt; 0.001 respectively). JAK1 was significantly upregulated in early-stage MF than JAK3 (p &lt; 0.001).</div></div><div><h3>Study limitations</h3><div>Limitations of this study include the small sample size of some mycosis fungoides variants, such as erythrodermic MF. Further studies are needed to clarify the functional role of Janus kinase signaling pathways in MF pathogenesis.</div></div><div><h3>Conclusions</h3><div>Both JAK1 and JAK3 play a role in the pathogenesis of MF. JAK1 may have a pathogenic role, particularly in the early stage of cutaneous T-cell lymphoma. This potentiates the idea of using JAK1 and JAK3 inhibitors for MF treatment.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501300"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory and functional tests in leprosy diagnosis: a practical guide for clinical decision-making","authors":"Luis Alberto Ribeiro Fróes Júnior ,&nbsp;Mirian Nacagami Sotto ,&nbsp;José Antônio Garbino ,&nbsp;João Avancini ,&nbsp;Maria Ângela Bianconcini Trindade","doi":"10.1016/j.abd.2026.501297","DOIUrl":"10.1016/j.abd.2026.501297","url":null,"abstract":"<div><div>Early diagnosis of leprosy remains primarily clinical, based on recognition of skin lesions with altered sensation and peripheral nerve involvement. However, complementary tests play crucial roles in confirming uncertain cases, guiding operational classification, detecting subclinical neural involvement, and distinguishing late reactions from relapse. This review synthesizes the practical application of diagnostic methods available to dermatologists. Slit-skin smear microscopy demonstrates high specificity but limited sensitivity in paucibacillary forms, while histopathology reveals the characteristic immunopathological spectrum, with perineural acid-fast bacilli being pathognomonic for leprosy. Molecular detection by PCR enhances diagnosis in paucibacillary cases (34%‒80% sensitivity) but cannot distinguish viable from non-viable bacilli, limiting its utility in post-treatment assessment. Anti-PGL-1 serology aids contact surveillance, with seropositive individuals showing 3.5-fold increased risk of developing disease, though sensitivity remains below 30% in tuberculoid forms. For neural evaluation, Semmes-Weinstein monofilament testing provides a standardized tactile threshold assessment, while the histamine test maps autonomic dysfunction, particularly valuable in indeterminate forms. Electrodiagnostic studies reveal early subclinical changes and monitor reaction-related neural deterioration. Peripheral nerve ultrasonography demonstrates superior sensitivity over palpation for detecting thickening (97.4% vs. 30% concordance) and identifies inflammatory activity through Doppler assessment. When evaluating post-treatment complications, an integrated approach combining bacteriological index trajectory, histopathological patterns, PCR cycle threshold values, and serological trends enables reliable differentiation between therapeutic failure, late reactions, and relapse. No single laboratory test confirms early leprosy in isolation; clinical dermato-neurological expertise remains paramount, with complementary tests interpreted within the epidemiological context to optimize diagnostic accuracy and therapeutic decisions.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501297"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. Report of three cases","authors":"Pablo Vargas-Mora ,&nbsp;Gonzalo Vera-Santis ,&nbsp;David Godoy-Sánchez ,&nbsp;Mathias Yagnam-Díaz ,&nbsp;Amaranta Luzoro-Vial ,&nbsp;Karol Baksai-Elespuru","doi":"10.1016/j.abd.2026.501307","DOIUrl":"10.1016/j.abd.2026.501307","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501307"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK inhibitors in livedoid vasculopathy associated with thrombophilia and refractory to anticoagulation: report and literature review","authors":"Giulia Jardim Criado ,&nbsp;Paulo Ricardo Criado ,&nbsp;Daniel Lorenzini ,&nbsp;Hélio Amante Miot","doi":"10.1016/j.abd.2026.501324","DOIUrl":"10.1016/j.abd.2026.501324","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501324"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}