Ísis Fiorello de Oliveira Mesquita, Larissa Pierri Carvalho Fonseca, Maria Rita Parise Fortes, Hélio Amante Miot, Luciana Patricia Fernandes Abbade
{"title":"Prevalence of positivity in patch tests and reactivity to substances present in the main dressings in patients with chronic leg ulcers.","authors":"Ísis Fiorello de Oliveira Mesquita, Larissa Pierri Carvalho Fonseca, Maria Rita Parise Fortes, Hélio Amante Miot, Luciana Patricia Fernandes Abbade","doi":"10.1016/j.abd.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.abd.2024.05.003","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of segmental acquired reactive perforating collagenosis: case report and literature review of the unique presentation.","authors":"Yudai Yamauchi, Noritaka Oyama, Minoru Hasegawa","doi":"10.1016/j.abd.2024.03.010","DOIUrl":"https://doi.org/10.1016/j.abd.2024.03.010","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucas Campos Garcia, Nicole Vieira Schwan, Jésus Faria Rosa Júnior, Andrea Machado Coelho Ramos
{"title":"Plaque psoriasis on the tongue: case report.","authors":"Lucas Campos Garcia, Nicole Vieira Schwan, Jésus Faria Rosa Júnior, Andrea Machado Coelho Ramos","doi":"10.1016/j.abd.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.abd.2024.01.008","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula Rosa Coutinho Goulart Borges Mariottoni, Leonardo Spagnol Abraham, Leopoldo Duailibe Nogueira Santos, Daniel Fernandes Melo, Rodrigo Pirmez, Paulo Müller Ramos, Hélio Amante Miot
{"title":"Translation, cultural adaptation and validation of the Brazilian version of the Frontal Fibrosing Alopecia Quality of Life Index (FFA-QLI-BRA).","authors":"Paula Rosa Coutinho Goulart Borges Mariottoni, Leonardo Spagnol Abraham, Leopoldo Duailibe Nogueira Santos, Daniel Fernandes Melo, Rodrigo Pirmez, Paulo Müller Ramos, Hélio Amante Miot","doi":"10.1016/j.abd.2024.03.014","DOIUrl":"https://doi.org/10.1016/j.abd.2024.03.014","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulo Ricardo Criado, Mayra Ianhez, Hélio Amante Miot, Roberta Fachini Jardim Criado, Carolina Talhari, Paulo Müller Ramos
{"title":"DRESS syndrome: an interaction between drugs, latent viruses, and the immune system.","authors":"Paulo Ricardo Criado, Mayra Ianhez, Hélio Amante Miot, Roberta Fachini Jardim Criado, Carolina Talhari, Paulo Müller Ramos","doi":"10.1016/j.abd.2023.12.010","DOIUrl":"https://doi.org/10.1016/j.abd.2023.12.010","url":null,"abstract":"<p><p>Drug-induced hypersensitivity syndrome, also known as DRESS syndrome, is a serious and potentially fatal reaction that occurs in response to prolonged use (generally between 14 and 60 days) of certain drugs, and which has no predilection for gender or age group. It is believed that DRESS syndrome has a genetic basis and results from the interaction between metabolites of certain pharmacological groups, reactivation of latent viruses (especially from the Herpesviridae family), and a cellular immune response. The classic manifestation of DRESS syndrome includes a generalized rash accompanied by fever, eosinophilia, lymphadenopathy, and systemic involvement such as hepatitis, nephritis, or pneumonitis. With the continuous increase in the availability of drugs and the aging of the population, there is a favorable scenario for the development of adverse drug reactions. Physicians should be prepared for the early diagnosis of DRESS syndrome, the identification and immediate suspension of the drug involved, and also manage systemic involvement, which may require prolonged immunosuppressive therapy. This article provides an update on the clinical, physiopathological and therapeutic aspects of DRESS syndrome.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuany R Schmidt, Belkiss C Mármora, Fernanda T Brochado, Lucas Gonçalves, Paloma S Campos, Marcelo L Lamers, Aurigena A de Araújo, Caroline A C X de Medeiros, Susana B Ribeiro, Marco A T Martins, Emily F S Pilar, Manoela D Martins, Vivian P Wagner
{"title":"Red light-emitting diode on skin healing: an in vitro and in vivo experimental study.","authors":"Tuany R Schmidt, Belkiss C Mármora, Fernanda T Brochado, Lucas Gonçalves, Paloma S Campos, Marcelo L Lamers, Aurigena A de Araújo, Caroline A C X de Medeiros, Susana B Ribeiro, Marco A T Martins, Emily F S Pilar, Manoela D Martins, Vivian P Wagner","doi":"10.1016/j.abd.2024.02.008","DOIUrl":"https://doi.org/10.1016/j.abd.2024.02.008","url":null,"abstract":"<p><strong>Background: </strong>The clinical advantages of light-emitting diode (LED) therapy in skin healing and its underlying mechanism remain subjects of ongoing debate.</p><p><strong>Objective: </strong>This study aims to explore the impact of LED therapy on normal skin keratinocytes (HaCaT) and in the repair of full-thickness dorsal wounds in Wistar rats.</p><p><strong>Methods: </strong>HaCaT cell viability (SRB assay) and migration (scratch assay) were assessed under LED therapy, comparing stress conditions (2.5% FBS) with sham irradiation and optimal conditions (10% FBS). In vivo, 50 rats with induced wounds were divided into Sham and LED (daily treatment) groups. Euthanasia occurred at 3, 5, 10, 14, and 21 days for clinical, morphological, oxidative stress (MDA, SOD, and GSH), and cytokine analyses (IL-1β, IL-10, TNF-α).</p><p><strong>Results: </strong>LED therapy significantly enhanced keratinocytes viability compared to sham irradiation, with minimal impact on cell migration. Clinical benefits were prominent on day 10, influencing inflammation progression and resolution on days 3 and 10. Re-epithelization remained unaffected. Reduced MDA and increased GSH levels were observed throughout, while SOD levels varied temporally. Notably, on day 10, LED significantly decreased IL-1β, IL-10, and TNF-α.</p><p><strong>Study limitations: </strong>Although translational, clinical trial confirmation of observed benefits is warranted.</p><p><strong>Conclusions: </strong>LED therapy expedites cutaneous healing in the experimental model, primarily modulating inflammation and enhancing antioxidant activity.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Facial cutaneous Rosai-Dorfman disease treated with pulsed dye laser: a case report and literature review.","authors":"Qin-Xiao Wang, Si-Yu Luo, Kai-Yi Zhou, Sheng Fang","doi":"10.1016/j.abd.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.abd.2024.05.002","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of long term efficacy and cost-effectiveness of omalizumab in 150 mg and 300 mg doses in patients with chronic spontaneous urticaria.","authors":"Fikriye Kalkan, Sait Yeşillik, Fevzi Demirel, Ezgi Sönmez, Yasemin Balaban, Mustafa İlker İnan, Özgür Kartal","doi":"10.1016/j.abd.2024.02.006","DOIUrl":"https://doi.org/10.1016/j.abd.2024.02.006","url":null,"abstract":"<p><strong>Background: </strong>Chronic spontaneous urticaria (CSU) is a clinical condition that affects patients quality of life. Omalizumab is preferred in antihistamines resistant CSU cases. Urticaria activity score-7 (UAS-7) is a scale that shows the severity of the disease.</p><p><strong>Objectives: </strong>The authors aimed to compare the long-term (60 months) efficacy and side effects of 150 mg and 300 mg doses of omalizumab in patients with CSU.</p><p><strong>Methods: </strong>108 patients followed up at the clinic with the diagnosis of CSU were included. Omalizumab was started in patients who were resistant to conventional CSU treatment. Two groups were formed to receive 150 mg and 300 mg doses of omalizumab. Urticaria activity score (UAS-7), antihistamine usage, time to achieve disease-free stage, relapse after treatment, and side effects of omalizumab treatment were compared in the two groups.</p><p><strong>Results: </strong>There were no statistically significant differences between the groups regarding basal characteristics and laboratory findings. Average follow-up time was sixty months. UAS-7 scores were similar in the follow-up. There were no adverse events in both groups.</p><p><strong>Study limitations: </strong>Retroactive design and single-center nature to reach a more significant number of patients. Lack of patients receiving the lowest dose 75 mg and the highest dose 600 mg of omalizumab. Absence of total body mass indexes of all patients. Besides, the use of distinct drugs may contribute to non confident results and is another limitation of this study.</p><p><strong>Conclusion: </strong>Since there is no significant difference between 150-300 mg omalizumab doses regarding long-term treatment efficacy and side effects in CSU patients, starting treatment with a 150 mg dose may be suitable. In patients who do not respond to 150 mg, the omalizumab dose can be increased to 300 mg. It will prevent unpredictable dose and time-dependent complications and will be a cost-effective approach even in strong economies.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}