Anais brasileiros de dermatologia最新文献

{"title":"Use of biologics in pediatric-onset hidradenitis suppurativa: a case series","authors":"Gilberto Pires da Rosa , Sofia Magina , Carmen Lisboa , Filomena Azevedo , Alberto Mota , Maria João Cruz","doi":"10.1016/j.abd.2025.501188","DOIUrl":"10.1016/j.abd.2025.501188","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501188"},"PeriodicalIF":3.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory myelodysplasia cutis in a patient with progression to acute myeloid leukaemia","authors":"Miguel Mansilla-Polo , Daniel Martín-Torregrosa","doi":"10.1016/j.abd.2025.501185","DOIUrl":"10.1016/j.abd.2025.501185","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501185"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xeroderma Pigmentosum: a 12-year experience in digital dermoscopy and reflectance confocal microscopy follow-up at a Cancer Center in Brazil","authors":"Joyce Gouvêa Freire,&nbsp;Tatiana Cristina Moraes Pinto Blumetti,&nbsp;Rafaela Brito de Paula,&nbsp;Juliana Casagrande Tavoloni Braga","doi":"10.1016/j.abd.2025.501182","DOIUrl":"10.1016/j.abd.2025.501182","url":null,"abstract":"<div><h3>Background</h3><div>Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder characterized by a defect in the nucleotide excision repair (NER) pathway, responsible for repairing DNA damage induced by ultraviolet rays. The most common symptom in affected patients is an increased photosensitivity associated with early development of cutaneous and internal malignancies.</div></div><div><h3>Objective</h3><div>To describe whether the follow-up of xeroderma pigmentosum patients using total body mapping (TBM) with digital dermoscopy (DD) and <em>in vivo</em> reflectance confocal microscopy (RCM) increases early detection of melanoma and reduces unnecessary biopsies of benign melanocytic lesions.</div></div><div><h3>Methods</h3><div>Twelve XP patients were followed-up with TBM and DD from February 2008 until March 2020. The number of melanocytic lesions excised (NNE) was counted before and after the surveillance with TBM, DD, and RCM.</div></div><div><h3>Results</h3><div>In the 12-year surveillance period, twelve XP patients were followed-up with TBM, DD, and RCM. The proportion of thinner and <em>in situ</em> melanomas diagnosed increased after the implementation of TBM and DD in the follow-up of this group (from 67% to 82%). The association of technologies caused a reduction in the NNE from 4.02 to 2.88 and promoted early detection of melanoma.</div></div><div><h3>Study limitations</h3><div>Maintaining regular follow-up with some XP patients can be challenging due to comorbidities and social issues. Although XP is a rare disease, this represents an especially small number of cases.</div></div><div><h3>Conclusion</h3><div>XP patients are generally submitted to multiple surgical excisions, with high morbidity. Based on this experience, TBM, DD and RCM have improved the early detection of melanoma and reduced the NNE with a positive impact on health and quality of life.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501182"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relevance of clinical-pathological correlation in the diagnosis of Cutaneous Rosai-Dorfman disease","authors":"Carolina Ferreira Baldecerra,&nbsp;Patrícia Imai Zanardi,&nbsp;Rafaella Cristine Zanatta,&nbsp;Silvio Cesar Franco Giovanni Filho,&nbsp;Cássio Rafael Moreira","doi":"10.1016/j.abd.2025.501180","DOIUrl":"10.1016/j.abd.2025.501180","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501180"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of recalcitrant Sneddon-Wilkinson disease with secukinumab","authors":"Miguel Mansilla-Polo ,&nbsp;Daniel Martín-Torregrosa ,&nbsp;Vicent Martínez-Cozar ,&nbsp;Rafael Botella-Estrada","doi":"10.1016/j.abd.2025.501178","DOIUrl":"10.1016/j.abd.2025.501178","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501178"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence for the diagnosis of erythematous-squamous dermatological diseases: technological contributions to primary care","authors":"Raiza Brito Cipriano ,&nbsp;Wilson Falco Neto ,&nbsp;Fabiano N. Barcellos Filho ,&nbsp;Alexandre Dias Porto Chiavegatto Filho","doi":"10.1016/j.abd.2025.501169","DOIUrl":"10.1016/j.abd.2025.501169","url":null,"abstract":"<div><h3>Background</h3><div>Accurate diagnoses in dermatology can be challenging for general practitioners. In this context, the support of artificial intelligence tools can be beneficial in the Brazilian primary care setting.</div></div><div><h3>Objectives</h3><div>To develop an interpretable machine-learning algorithm capable of assisting in the diagnosis of erythematous-squamous dermatological diseases through clinical data, without histopathological support.</div></div><div><h3>Methods</h3><div>The random-forest algorithm was trained with the public Dermatology database of 366 patients diagnosed with: chronic dermatitis, lichen planus, pityriasis rosea, pityriasis rubra pilaris, psoriasis, or seborrheic dermatitis. The model was evaluated by performance metrics and interpretability techniques.</div></div><div><h3>Results</h3><div>The model showed good predictive performance, with ROC-AUC ranging from 0.89 to 1.00, and overall accuracy of 0.86. The best results were for the diagnosis of pityriasis rubra pilaris (f1-score: 1.00) and the worst for chronic and seborrheic dermatitis (f1-score: 0.77 and 0.76, respectively). The clinical characteristics that most influenced the model's decision were, in decreasing order: involvement of knees and elbows, involvement of scalp, Koebner phenomenon, polygonal papules, and involvement of oral mucosa.</div></div><div><h3>Study limitations</h3><div>The model was not validated with Brazilian data.</div></div><div><h3>Conclusion</h3><div>The developed technology obtained good predictive performance and clinical coherence. There is a need for adaptation for implementation, using national data. The results indicate the potential for similar models to be improved and adapted to clinical practice for the benefit of the Unified Heath System.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501169"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of the aryl hydrocarbon receptor (AhR) in facial melasma skin compared to healthy perilesional skin","authors":"Carolina Nunhez da Silva ,&nbsp;Tony Fernando Grassi ,&nbsp;Hélio Amante Miot ,&nbsp;Ana Cláudia Cavalcante Espósito","doi":"10.1016/j.abd.2025.501181","DOIUrl":"10.1016/j.abd.2025.501181","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501181"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tyrosine Kinase-2 (TYK2) signaling pathway gene expression and the presence of the single-nucleotide polymorphism rs12720356 in the peripheral blood of patients with severe psoriasis and loss of systemic treatment response","authors":"Paola Borges Eckstein Canabrava ,&nbsp;Roll Stanley Beauge ,&nbsp;Samir de Figueiredo Azouz ,&nbsp;Renata Velozo Timbó ,&nbsp;Luciana Pereira Freire Martins ,&nbsp;Bruna Côrtes Rodrigues ,&nbsp;Naiara Daris dos Santos ,&nbsp;Marcella Palhano Medeiros ,&nbsp;Andréa Monteiro de Araújo ,&nbsp;Agenor de Castro Moreira dos Santos Júnior ,&nbsp;Carla Nunes de Araújo ,&nbsp;Otávio de Toledo Nóbrega ,&nbsp;Patrícia Shu Kurizky ,&nbsp;Licia Maria Henrique da Mota ,&nbsp;Ciro Martins Gomes","doi":"10.1016/j.abd.2025.501165","DOIUrl":"10.1016/j.abd.2025.501165","url":null,"abstract":"<div><h3>Background</h3><div>RNA sequencing-based studies have identified the transcription processes that contribute to psoriasis development, but the associations of these processes with specific phenotypes need further investigation.</div></div><div><h3>Objective</h3><div>The authors aimed to determine the associations of specific Peripheral Blood Mononuclear Cell (PBMC) endotypic profiles with loss of treatment response in psoriasis patients.</div></div><div><h3>Methods</h3><div>A Psoriasis Area and Severity Index (PASI) &gt; 10 was the main outcome. The gene expression of <em>Tyrosine Kinase-2 (TYK)</em>, <em>Interleukin (IL)-12A</em>, <em>IL-12B</em>, <em>IL-23A</em>, <em>IL-23 Receptor (IL-23R)</em>, <em>IL-6</em>, <em>IL-6R</em>,<em>IL-17A</em> and <em>Tumor Necrosis Factor (TNF)</em> in PBMCs was quantified as possible risk factors. Single-Nucleotide Polymorphisms (SNP) were screened using a genotyping technique. Hierarchical clustering of the gene expression results was performed.</div></div><div><h3>Results</h3><div>The authors included 178 psoriasis patients. <em>TYK2</em> was upregulated in the PBMCs of patients with a PASI score &gt; 10, but its distribution was widely variable. A cluster of 19 patients exhibited upregulated expression of most <em>TYK2</em>-dependent mediators and increased PASI (p = 0.021) and Dermatology Life Quality Index (DLQI) scores (p = 0.034). Three patients harbored the TYK2I684S variant.</div></div><div><h3>Study limitations</h3><div>The utility of using single markers for psoriasis diagnosis is limited due to the wide variability of results, but the utility of the simultaneous evaluation of a set of markers has promise.</div></div><div><h3>Conclusions</h3><div>The present study suggests an association between multiple TYK2 pathway markers and loss of systemic treatment response.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501165"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological profile and main allergens identified in cases of allergic contact cheilitis","authors":"Bruna Cavaleiro de Macedo Souza ,&nbsp;Laiza Bertolucci Ferrero ,&nbsp;Mariana de Figueiredo Silva Hafner ,&nbsp;Rosana Lazzarini","doi":"10.1016/j.abd.2025.501170","DOIUrl":"10.1016/j.abd.2025.501170","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501170"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omalizumab for cholinergic pruritus in a renal transplant and hemodialysis patient","authors":"Qing Shu ,&nbsp;Xiang Zhong ,&nbsp;Lixia Zhang ,&nbsp;Qian Wang","doi":"10.1016/j.abd.2025.501167","DOIUrl":"10.1016/j.abd.2025.501167","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501167"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}