慢性自发性荨麻疹：发病机制和治疗意义的最新进展

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia Pub Date : 2025-08-21 DOI:10.1016/j.abd.2025.501198

Paulo Ricardo Criado , Roberta Fachini Jardim Criado , Hélio Amante Miot , Beatrice Martinez Zugaib Abdalla , Helena Zenedin Marchioro , Renan Rangel Bonamigo

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引用次数: 0

摘要

背景近年来，人们对慢性自发性荨麻疹发病机制的了解越来越多。肥大细胞的中心作用正在得到加强，但多种细胞、途径和介质参与了复杂的相互关系。其管理的现代疗法反映了需要包含不同的机制，并承诺改变荨麻疹的病程和那些难治性疾病的漫长旅程。这些方面的持续更新对于优化患者护理是必要的。目的回顾慢性自发性荨麻疹发病机制的概念和进展，以及有前景的治疗药物选择。方法对1977 - 2024年间发表在科学文献中的相关文章进行叙述性回顾，纳入PubMed系统索引。结果共发现文献25732篇。纳入标准由作者决定其对进一步了解慢性自发性荨麻疹发病机制和治疗领域的重要性，优先考虑荟萃分析、系统评价和随机试验。在治疗方面，除了ClinicalTrials.gov上的记录外，过去15年的138篇文章被优先考虑，这些药物可能处于临床试验阶段。免疫生物制剂和小分子药物有望成为未来慢性自发性荨麻疹的治疗方案。研究局限性叙述性综述不能为研究的结果和结果提供统计价值。结论对慢性自发性荨麻疹的发病机制进行了综述，并从这些方面介绍了治疗荨麻疹的有前景的药物选择，特别是免疫生物制剂和小分子药物。

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Chronic spontaneous urticaria: update on pathogenesis and therapeutic implications

Background

The understanding of chronic spontaneous urticaria pathogenesis has been increasing recently. The central role of mast cells is being reinforced, but multiple cells, pathways, and mediators are involved in a complex interrelationship. Modern therapies for its management reflect the need to encompass different mechanisms and promise to alter the course of urticaria and the long journey of those with refractory disease. Continuous updating of these aspects is necessary to optimize patient care.

Objectives

To review concepts and advances in the pathogenesis of chronic spontaneous urticaria, in addition to contextualizing promising drug options for its management.

Method

A narrative review was conducted between 1977 and 2024, including relevant articles published in the scientific literature, indexed in the PubMed system.

Results

A total of 25,732 articles were found. Inclusion criteria were determined by the authors' decision regarding their level of importance for furthering knowledge in the areas of pathogenesis and treatment of chronic spontaneous urticaria, with preference given to meta-analyses, systematic reviews, and randomized trials. Regarding therapeutics, 138 articles from the last 15 years were prioritized, in addition to records on ClinicalTrials.gov, and the drugs could be in the clinical trial phase. Immunobiologicals and small molecules hold promise for future treatment regimens for chronic spontaneous urticaria.

Study limitations

Narrative reviews do not provide statistical value to the results and outcomes studied.

Conclusion

A review of the pathogenesis of chronic spontaneous urticaria was conducted, contextualizing these aspects with promising drug options for its treatment, particularly immunobiologicals and small molecules.

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来源期刊

Anais brasileiros de dermatologia DERMATOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

184

审稿时长

32 days

期刊介绍： The journal is published bimonthly and is devoted to the dissemination of original, unpublished technical-scientific study, resulting from research or reviews of dermatological topics and related matters. Exchanges with other publications may be accepted.