Anais brasileiros de dermatologia最新文献

{"title":"Testicular seminoma in patients receiving adalimumab: two case reports","authors":"Beatriz Figueira Vilela, Inês Aparício Martins, Nélia Cunha, Joana Cabete","doi":"10.1016/j.abd.2026.501317","DOIUrl":"10.1016/j.abd.2026.501317","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501317"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiogram abnormalities in patients with acne undergoing isotretinoin therapy: a focused review","authors":"Afra Wasama Islam ,&nbsp;Prarthana Motdhare ,&nbsp;Shreya Mohan ,&nbsp;Swapna Bejoy ,&nbsp;Harsahaj Singh Wilkhoo","doi":"10.1016/j.abd.2026.501304","DOIUrl":"10.1016/j.abd.2026.501304","url":null,"abstract":"<div><div>Isotretinoin is an extremely successful treatment for acne, widely prescribed for moderate to severe cases unresponsive to conventional therapy that is commonly used in dermatology. While its systemic side effects, particularly those related to hepatic and lipid metabolism, are extensively documented, its impact on cardiac electrophysiology is little understood. Metabolic abnormalities are frequent, with hypertriglyceridemia occurring in up to 44% of patients, elevated total cholesterol in 30%, and transient liver enzyme elevation in approximately 10%–11%. This focused review summarizes the existing research on electrocardiographic (ECG) alterations associated with isotretinoin medication. Reported cardiac abnormalities are rare, with isolated case reports and small studies describing transient arrhythmias in fewer than 1%–2% of users, including premature ventricular contractions (PVCs), atrial tachycardia, and, in exceptionally rare instances, cardiomyopathy &lt; 0.01%. Mechanistic ideas suggest changes in human ether-a-go-go-related gene (hERG) potassium channels, dyslipidemia-induced atherosclerosis, electrolyte imbalances, and sympathetic overactivity. However, large population-based studies have not found a significant increase in major cardiovascular events. Most ECG abnormalities, when noted, appear to be reversible with discontinuing isotretinoin. This review is unique in that it focuses on isotretinoin from both dermatological and cardiac viewpoints. It identifies important shortcomings in standardized ECG monitoring procedures and underscores the scarcity of large, prospective, controlled trials. Future research should focus on longitudinal, multicenter trials using serial ECG evaluations to better define risk profiles and guide clinical monitoring. Understanding infrequent but potentially serious cardiac effects is critical for improving isotretinoin's safety profile and guiding evidence-based therapy.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501304"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of psoriasis with ruxolitinib in a patient with myeloproliferative neoplasm: a therapeutic observation","authors":"Luciana Vilela Gomide,&nbsp;Ana Maria Quinteiro Ribeiro","doi":"10.1016/j.abd.2026.501319","DOIUrl":"10.1016/j.abd.2026.501319","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501319"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma associated with leprosy among patients, contacts, and the general population in an endemic region of Brazil","authors":"Patrícia Tavares Cruz ,&nbsp;Hélio Amante Miot ,&nbsp;Carolina Talhari ,&nbsp;Valderiza Lourenço Pedrosa ,&nbsp;Raquel da Mata Serique ,&nbsp;Amanda Gabrielle dos Santos Cordeiro ,&nbsp;Jaqueline da Silva Mendes ,&nbsp;Susan Smith Doria ,&nbsp;Jorge Ewerton dos Santos Sales ,&nbsp;Alexandra de Freitas Costa ,&nbsp;Sinésio Talhari","doi":"10.1016/j.abd.2026.501301","DOIUrl":"10.1016/j.abd.2026.501301","url":null,"abstract":"<div><h3>Background</h3><div>Leprosy is associated with social exclusion and discrimination. Historical records of compulsory isolation, severe clinical manifestations, and fear of contagion have contributed to the perpetuation of prejudice and discriminatory attitudes. In Brazil, the psychosocial impact of leprosy among patients, contacts, and the general population remains poorly understood.</div></div><div><h3>Objective</h3><div>To assess the stigma associated with leprosy and to identify factors influencing its impact among patients, contacts, and the General Population (GP).</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted, including three groups (patients, contacts, and GPs) from the metropolitan region of Manaus – AM (Brazil). Demographic and clinical data were collected, and stigma was evaluated using the Explanatory Model Interview Catalogue-Affected People (EMIC-AP) for patients and the EMIC-Community Stigma Scale (EMIC-CSS) for contacts and GPs. The impact of different aspects was assessed within each group, and clinicodemographic factors associated with higher stigma were explored.</div></div><div><h3>Results</h3><div>A total of 214 patients, 104 contacts, and 393 GPs were evaluated. The EMIC-AP mean (SD) score among patients was 16 (9), whereas the EMIC-CSS scores were 15 (7) for contacts and 12 (6) for the GP group. Network analysis revealed that feelings of shame, negative self-opinion, and social avoidance were central elements of stigma across groups. Female sex among patients (β = -2.9; p = 0.03), higher education among contacts (β = 3.2; p = 0.03); and younger age and religious practice among the GPs (β = -1.3 and 1.3; p &lt; 0.05) were associated with higher stigma scores. After standardization, contacts and GP exhibited greater stigma perception than patients (θ = 0.02 and -0.06 vs. -0.26; p &lt; 0.05).</div></div><div><h3>Study Limitations</h3><div>Non-randomized sample from a single center.</div></div><div><h3>Conclusions</h3><div>Leprosy-related stigma persists across patients, contacts, and GPs, reflecting deep-rooted social and cultural misconceptions. Beyond medical cure, achieving the “Zero Leprosy” goals demands integrated actions that promote education, community engagement, and psychosocial support to reduce prejudice and promote social inclusion.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501301"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147418677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented epithelioid melanocytoma: two cases with dermoscopic findings","authors":"Luísa Homem de Mello Maciel Campilongo ,&nbsp;Julian Gonzales Fraga ,&nbsp;Gilles Landman ,&nbsp;Francisco Macedo Paschoal","doi":"10.1016/j.abd.2026.501309","DOIUrl":"10.1016/j.abd.2026.501309","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501309"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of erlotinib and acitretin for the treatment of Olmsted syndrome with erythromelalgia in a pediatric patient","authors":"Luna Azulay-Abulafia ,&nbsp;Joice Rodrigues Fagundes ,&nbsp;Edgar Efren Ollague Cordova ,&nbsp;Karla Diniz Pacheco ,&nbsp;Alain Hovnanian","doi":"10.1016/j.abd.2026.501313","DOIUrl":"10.1016/j.abd.2026.501313","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501313"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaposiform hemangioendothelioma associated with coagulopathy and treated with low-dose aspirin: a three-case series","authors":"Luciana Baptista Pereira ,&nbsp;Guilhane Maria Magalhães ,&nbsp;Daniel Dias Ribeiro ,&nbsp;Marcelo de Mattos Garcia ,&nbsp;Katherynne Bezerra Marques ,&nbsp;João Renato Vianna Gontijo","doi":"10.1016/j.abd.2026.501323","DOIUrl":"10.1016/j.abd.2026.501323","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501323"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive and anxious symptoms in melasma during pregnancy: a cross-sectional study","authors":"Talita Pereira Calheiros,&nbsp;Bárbara Borges Rubin,&nbsp;Jéssica Puchalski Trettim,&nbsp;Laura Medeiros de Oliveira,&nbsp;Ricardo Tavares Pinheiro,&nbsp;Hiram Larangeira de Almeida Junior","doi":"10.1016/j.abd.2026.501321","DOIUrl":"10.1016/j.abd.2026.501321","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501321"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous squamous cell carcinomas secondary to hydroxyurea: a case report","authors":"Renata Guerra Galvão Santos,&nbsp;Marcio Martins Lobo Jardim,&nbsp;Lais Guerra Guedes,&nbsp;Isis Carla de Lima Pereira","doi":"10.1016/j.abd.2026.501322","DOIUrl":"10.1016/j.abd.2026.501322","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501322"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147546450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory linear IgA dermatosis in childhood: a successful response to rituximab","authors":"Pedro Sciammarella Wakisaka ,&nbsp;Larissa Maria Cardoso Lima Rodrigues ,&nbsp;Denise Miyamoto ,&nbsp;Celina W. Maruta ,&nbsp;Claudia Giuli Santi ,&nbsp;Valeria Aoki","doi":"10.1016/j.abd.2026.501308","DOIUrl":"10.1016/j.abd.2026.501308","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501308"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}