Anais brasileiros de dermatologia最新文献

{"title":"Interleukin-6 as a predictive biomarker of systemic progression and therapeutic target in cutaneous plasmacytosis","authors":"Yuan-Yu Hong , Peng-Yu Chen , Hui-Ting New, Sui-Qing Cai","doi":"10.1016/j.abd.2026.501306","DOIUrl":"10.1016/j.abd.2026.501306","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501306"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life assessment in vitiligo patients: a cross-sectional study","authors":"Natália Maria Neves Simões , Gabrielle Cassulo Franciscatti , Luis Alberto Ribeiro Froes Junior , Maria Victória Quaresma","doi":"10.1016/j.abd.2026.501305","DOIUrl":"10.1016/j.abd.2026.501305","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501305"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147546452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients – Part 1","authors":"Heba Saed El-Amawy ,&nbsp;Basma Mourad Mohamed Ali ,&nbsp;Mohamed Moustafa Shareef ,&nbsp;Lamia Elgarhy","doi":"10.1016/j.abd.2026.501299","DOIUrl":"10.1016/j.abd.2026.501299","url":null,"abstract":"<div><h3>Background</h3><div>Mycosis fungoides is the commonest type of cutaneous T-Cell lymphoma. Janus kinases are intracellular tyrosine kinases that have recently been proven to have a crucial role in the pathogenesis and progression of several dermatological and malignant diseases.</div></div><div><h3>Objective</h3><div>The aim of this study was to investigate the immunohistochemical expression of Janus Kinase-1 (JAK1) and Janus Kinase-3 (JAK3) in the skin of mycosis fungoides .</div></div><div><h3>Methods</h3><div>The current study included 46 patients with early-stage MF, and 7 patients with late-stage MF, and 53 control samples. Immunohistochemical staining using JAK1 and JAK3 monoclonal antibodies was done in the skin specimens obtained from patients and controls. The evaluation of JAK1 and JAK3 gene expression using RT-PCR will be included in part 2 of the study.</div></div><div><h3>Results</h3><div>JAK1 immunohistochemical expression was nuclear, and JAK3 was cytoplasmic in MF patients. Immunoreactivity scores for JAK1 and JAK3 in MF patients were significantly increased compared to healthy controls (p &lt; 0.001 and &lt; 0.001, respectively). JAK1 and JAK3 immunoreactivity scores were significantly higher in the tumor than in the patch and plaque stages of MF (P7 = 0.001 and 0.004, respectively).</div></div><div><h3>Study limitations</h3><div>This study is limited by the relatively small sample size of some clinical variants of mycosis fungoides, particularly advanced forms such as erythrodermic and tumor-stage MF. Further studies are needed to evaluate JAK1 and JAK3 expression following therapeutic interventions, including phototherapy and JAK inhibitors.</div></div><div><h3>Conclusions</h3><div>JAK1 and JAK3 were significantly expressed in MF skin lesions in comparison to normal controls. JAK1 and JAK3 were more expressed in the tumor stage than patch and plaque stage MF, suggesting that JAK1 and JAK3 could play a crucial role in MF pathogenesis, progression, and prognosis.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501299"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147418676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fragrance components in cosmetic products: an analysis of labels","authors":"Ana Carolina Rodrigues ,&nbsp;Mariana de Figueiredo Silva Hafner ,&nbsp;Rosana Lazzarini","doi":"10.1016/j.abd.2026.501325","DOIUrl":"10.1016/j.abd.2026.501325","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501325"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147546451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter study by the Brazilian Society of Dermatology on a new standard patch test series","authors":"Renan Rangel Bonamigo ,&nbsp;Vanessa Barreto Rocha ,&nbsp;Vitor Manoel Silva dos Reis ,&nbsp;Dulcilea Ferraz Rodrigues ,&nbsp;Rosana Lazzarini ,&nbsp;Mario Cezar Pires ,&nbsp;Renato Shintani Hikawa ,&nbsp;Ana Elisa Kiszewski ,&nbsp;Andrea Fernandes Eloy da Costa França ,&nbsp;Renata Heck ,&nbsp;Maria Antonieta Rios Scherrer ,&nbsp;Luciana Paula Samorano ,&nbsp;Isabella Campos Machado Cordeiro ,&nbsp;Ida Alzira Duarte ,&nbsp;Mariana de Figueiredo Silva Hafner ,&nbsp;Renata Marli Gonçalves Pires ,&nbsp;Lilith Sodré Eller ,&nbsp;Juliana Barros Rodrigues ,&nbsp;Daniela Benzano Bumaguin ,&nbsp;Ruppert Ludwig Hahnstadt","doi":"10.1016/j.abd.2026.501327","DOIUrl":"10.1016/j.abd.2026.501327","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of allergic contact dermatitis (ACD) differs across various populations, and the sensitization rate can change constantly as new products are introduced to the market. The current Brazilian standard series of patch tests has been used for over two decades. Therefore, the development of a new Brazilian standard series is important to ensure that contact tests remain a reliable diagnostic tool.</div></div><div><h3>Methods</h3><div>A Brazilian multicenter, cross-sectional, prospective study was conducted using a modified series of patch tests between 2023 and 2025. The factors under study were the substances used in the contact tests, and the outcomes were the frequencies of positivity and relevance. Demographic and clinical variables of the participants, who had contact dermatitis without a defined etiology prior to the tests, were evaluated. The required sample size was defined as 523 patients, estimating the prevalence of positivity with a 1.8% confidence interval. Wald's test was considered a 95% confidence level and a 1% expected prevalence of positivity.</div></div><div><h3>Results</h3><div>A total of 567 participants were included, 77.3% female, with a mean age of 53.3 years, and most belonged to phototypes II, III, and IV. Cleaning services were the most frequent occupational activity, and 43.3% of patients had a personal history of atopy. The overall reactivity of the tests was 69.3%, with 70.2% relevance. Nickel sulfate was the most frequently reactive allergen (28.9%), and 29 substances reached at least 1% positivity.</div></div><div><h3>Limitations</h3><div>Lack of representatives from all regions of Brazil and absence of prospective follow-up.</div></div><div><h3>Conclusion</h3><div>The authors propose a new Brazilian standard series of patch tests, with 40 substances, considering the 29 that achieved 1% positivity and another 11 with clinical importance and supported by current literature as emerging and current allergens.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501327"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147546469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ki-67 staining pattern as a prognostic biomarker for advanced acral melanoma","authors":"Marcel Arakaki Asato ,&nbsp;Isabeli Joaquim Contel ,&nbsp;Francisco Alves Moraes Neto ,&nbsp;Juliana Polizel Ocanha-Xavier ,&nbsp;Nathália Silva Carlos Oliveira ,&nbsp;Maxwell A. Fung ,&nbsp;Mariangela Esther Alencar Marques ,&nbsp;José Cândido Caldeira Xavier-Júnior","doi":"10.1016/j.abd.2026.501298","DOIUrl":"10.1016/j.abd.2026.501298","url":null,"abstract":"<div><h3>Background</h3><div>Acral cutaneous melanoma (ACM) is an aggressive skin cancer, especially when diagnosed in the advanced stage. The Ki-67 is a rapid tool for proliferation rate analysis. Previous data indicated that its staining pattern is distinct during the several stages of the cell cycle among epithelial cells.</div></div><div><h3>Objective</h3><div>To evaluate the prognostic impact of Ki-67 expression pattern classification among advanced acral cutaneous melanoma cases.</div></div><div><h3>Methods</h3><div>Two pathologists classified staining nuclear patterns of Ki-67 in the hot spot of scanning slides of advanced ACM (pT4): NP1 (randomly Ki-67 immunopositive fine or coarse granules), NP2 (Ki-67 stained in one or two well defined and centralized nodules), NP3 (Ki-67 seen as granules or nodules occupying most of the nucleus), NP4 (nucleoplasm with intense and homogeneous Ki-67 staining) and NP5 (empty central area with peripheral Ki-67). For analysis, seven cases per group ‒ Alive (Al) and Melanoma-Related Death (De) ‒ were randomly selected.</div></div><div><h3>Results</h3><div>This pilot study analyzed 5676 Ki-67 positive nuclei. Means comparison between the two groups revealed differences in nuclear patterns NP1 (p = 0.0014), NP4 (p = 0.038), NP5 (p = 0.0193), and the total number of stained nuclei (p = 0.0258).</div></div><div><h3>Study limitations</h3><div>Small number of cases and biased value of 6.35 through the Bland-Altman analysis.</div></div><div><h3>Conclusion</h3><div>The present analysis highlights the importance of Ki-67 staining patterns as a potential prognostic marker among ACM. High Ki-67 positive nuclei were associated with worse outcomes (death), particularly in staining patterns before and after mitosis (NP1, NP4, and NP5).</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501298"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral paracoccidioidomycosis in a young male from northeastern Brazil, a non-endemic region","authors":"Gerhilde Callou Sampaio ,&nbsp;Marianne de Vasconcelos Carvalho ,&nbsp;Jéssica da Silva Cunha ,&nbsp;Bruno Augusto Benevenuto de Andrade ,&nbsp;Ricardo Alves Mesquita ,&nbsp;José Alcides Almeida de Arruda","doi":"10.1016/j.abd.2026.501311","DOIUrl":"10.1016/j.abd.2026.501311","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501311"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichen planopilaris versus frontal fibrosing alopecia: histopathologically distinct diseases or not?","authors":"Deren Özcan ,&nbsp;Deniz Seçkin ,&nbsp;A.T. Güleç ,&nbsp;Özlem Özen","doi":"10.1016/j.abd.2026.501302","DOIUrl":"10.1016/j.abd.2026.501302","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501302"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with chronic cutaneous graft-versus-host disease following hematopoietic stem cell transplantation: a pediatric cohort","authors":"Daniela Carvajal ,&nbsp;Teresa Dossi ,&nbsp;Camila Downey ,&nbsp;Daniela Krämer ,&nbsp;Natalia González ,&nbsp;Javier Fernández ,&nbsp;Paula Muñoz","doi":"10.1016/j.abd.2026.501296","DOIUrl":"10.1016/j.abd.2026.501296","url":null,"abstract":"<div><h3>Background</h3><div>Graft-versus-host disease (GVHD) is a frequent complication of hematopoietic stem cell transplantation (HSCT), with the skin being the most commonly affected organ. However, its risk factors remain poorly defined.</div></div><div><h3>Objective</h3><div>To assess the risk factors associated with chronic cutaneous GVHD (ccGVHD) in a children’s hospital in Chile.</div></div><div><h3>Methods</h3><div>This retrospective cohort study examined children under 18-years who underwent HSCT between 2007 and 2017, with a follow-up period of at least 2-years. Survival analysis and Cox regression analysis were performed.</div></div><div><h3>Results</h3><div>150 children with HSCT were included with a median age of 7.3 (3.7‒10.6) years. 17.3% of the children developed ccGVHD, with a median onset after HSCT of 8 (4‒11) months. In the univariate analysis, patients with ccGVHD were significantly older at transplantation, with a higher proportion of bone marrow as graft source, related donor, and acute GVHD compared to those who did not develop ccGVHD (for all <em>p</em> &lt; 0.05). In the multivariate analysis, the main risk factors were male sex (Hazard Ratio [HR] 2.51), total body irradiation as conditioning regimen (HR = 3.53), and bone marrow as graft source (HR = 7.28).</div></div><div><h3>Study limitations</h3><div>Its retrospective, single-center design may reduce generalizability and introduce selection bias.</div></div><div><h3>Conclusions</h3><div>This study is one of the largest series of ccGVHD in children. Early identification of patients at higher risk of ccGVHD allows for timely initiation of treatment, thereby reducing the morbidity associated with this debilitating complication.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501296"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of generative artificial intelligence models in the theoretical exam for the Brazilian Board-Certified Dermatology title (TED): a comparative study","authors":"Matheus Alves Pacheco,&nbsp;Athos Paulo Santos Martini","doi":"10.1016/j.abd.2026.501326","DOIUrl":"10.1016/j.abd.2026.501326","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501326"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}