Anais brasileiros de dermatologia最新文献

{"title":"Comment on “Predictive factors for distant metastasis in early cutaneous melanoma: a 20-year experience of a Turkish tertiary referral hospital”","authors":"Shyam Sundar Sah , Abhishek Kumbhalwar","doi":"10.1016/j.abd.2026.501328","DOIUrl":"10.1016/j.abd.2026.501328","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501328"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial minimally invasive aesthetic procedures and quality of life in transgender individuals: a prospective study","authors":"Walter Refkalefsky Loureiro , Francisca Regina Oliveira Carneiro , Letícia Rezende da Silva Sobral","doi":"10.1016/j.abd.2026.501316","DOIUrl":"10.1016/j.abd.2026.501316","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501316"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of immunohistochemical and gene expression of Janus kinase1 and Janus kinase3 in the skin of different clinical types of mycosis fungoides patients – Part II: reverse transcriptase–polymerase chain reaction","authors":"Heba Saed El-Amawy ,&nbsp;Basma Mourad Mohamed Ali ,&nbsp;Mohamed Labib Salem ,&nbsp;Lamia Elgarhy","doi":"10.1016/j.abd.2026.501300","DOIUrl":"10.1016/j.abd.2026.501300","url":null,"abstract":"<div><h3>Background</h3><div>Mycosis Fungoides (MF) is the commonest type of primary cutaneous T-Cell lymphomas representing about 50% of all lymphomas arising primarily in the skin. Janus kinases are non-receptor intracellular tyrosine kinases that play an important role in the pathogenesis of variant skin disorders and several hematological malignancies.</div></div><div><h3>Objective</h3><div>The aim of this study was to investigate the gene expression of Janus Kinase-1 (JAK1) and Janus Kinase-3 (JAK3) in the skin of different types of MF patients using Real-time Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR).</div></div><div><h3>Methods</h3><div>The current study included 53 patients with MF, and 53 control samples. RT-PCR for JAK1 and JAK3 was done in the skin specimens obtained from patients and controls.</div></div><div><h3>Results</h3><div>Both JAK1 and JAK3 fold changes showed stepwise upregulation in lesional MF skin than normal control skin, with statistically significant increase in MF patients than healthy controls (p &lt; 0.001 and &lt; 0.001 respectively). JAK1 was significantly upregulated in early-stage MF than JAK3 (p &lt; 0.001).</div></div><div><h3>Study limitations</h3><div>Limitations of this study include the small sample size of some mycosis fungoides variants, such as erythrodermic MF. Further studies are needed to clarify the functional role of Janus kinase signaling pathways in MF pathogenesis.</div></div><div><h3>Conclusions</h3><div>Both JAK1 and JAK3 play a role in the pathogenesis of MF. JAK1 may have a pathogenic role, particularly in the early stage of cutaneous T-cell lymphoma. This potentiates the idea of using JAK1 and JAK3 inhibitors for MF treatment.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501300"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory and functional tests in leprosy diagnosis: a practical guide for clinical decision-making","authors":"Luis Alberto Ribeiro Fróes Júnior ,&nbsp;Mirian Nacagami Sotto ,&nbsp;José Antônio Garbino ,&nbsp;João Avancini ,&nbsp;Maria Ângela Bianconcini Trindade","doi":"10.1016/j.abd.2026.501297","DOIUrl":"10.1016/j.abd.2026.501297","url":null,"abstract":"<div><div>Early diagnosis of leprosy remains primarily clinical, based on recognition of skin lesions with altered sensation and peripheral nerve involvement. However, complementary tests play crucial roles in confirming uncertain cases, guiding operational classification, detecting subclinical neural involvement, and distinguishing late reactions from relapse. This review synthesizes the practical application of diagnostic methods available to dermatologists. Slit-skin smear microscopy demonstrates high specificity but limited sensitivity in paucibacillary forms, while histopathology reveals the characteristic immunopathological spectrum, with perineural acid-fast bacilli being pathognomonic for leprosy. Molecular detection by PCR enhances diagnosis in paucibacillary cases (34%‒80% sensitivity) but cannot distinguish viable from non-viable bacilli, limiting its utility in post-treatment assessment. Anti-PGL-1 serology aids contact surveillance, with seropositive individuals showing 3.5-fold increased risk of developing disease, though sensitivity remains below 30% in tuberculoid forms. For neural evaluation, Semmes-Weinstein monofilament testing provides a standardized tactile threshold assessment, while the histamine test maps autonomic dysfunction, particularly valuable in indeterminate forms. Electrodiagnostic studies reveal early subclinical changes and monitor reaction-related neural deterioration. Peripheral nerve ultrasonography demonstrates superior sensitivity over palpation for detecting thickening (97.4% vs. 30% concordance) and identifies inflammatory activity through Doppler assessment. When evaluating post-treatment complications, an integrated approach combining bacteriological index trajectory, histopathological patterns, PCR cycle threshold values, and serological trends enables reliable differentiation between therapeutic failure, late reactions, and relapse. No single laboratory test confirms early leprosy in isolation; clinical dermato-neurological expertise remains paramount, with complementary tests interpreted within the epidemiological context to optimize diagnostic accuracy and therapeutic decisions.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501297"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. Report of three cases","authors":"Pablo Vargas-Mora ,&nbsp;Gonzalo Vera-Santis ,&nbsp;David Godoy-Sánchez ,&nbsp;Mathias Yagnam-Díaz ,&nbsp;Amaranta Luzoro-Vial ,&nbsp;Karol Baksai-Elespuru","doi":"10.1016/j.abd.2026.501307","DOIUrl":"10.1016/j.abd.2026.501307","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501307"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK inhibitors in livedoid vasculopathy associated with thrombophilia and refractory to anticoagulation: report and literature review","authors":"Giulia Jardim Criado ,&nbsp;Paulo Ricardo Criado ,&nbsp;Daniel Lorenzini ,&nbsp;Hélio Amante Miot","doi":"10.1016/j.abd.2026.501324","DOIUrl":"10.1016/j.abd.2026.501324","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501324"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital pseudomyogenic hemangioendothelioma: case report and literature review","authors":"Javier de la Iglesia-Martin ,&nbsp;Irene Fuertes de Vega ,&nbsp;Agustí Toll-Abello ,&nbsp;Alba Catala-Gonzalo ,&nbsp;Raquel Albero-Gonzalez","doi":"10.1016/j.abd.2026.501303","DOIUrl":"10.1016/j.abd.2026.501303","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501303"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHACE syndrome: report of five cases","authors":"Julia Maria de Oliveira Neumayer,&nbsp;Ana Clara Maia Palhano,&nbsp;Milene Tiburcio Narenti Ferradoza,&nbsp;Luciana Paula Samorano,&nbsp;Maria Cecília Rivitti-Machado,&nbsp;Zilda Najjar Prado de Oliveira","doi":"10.1016/j.abd.2026.501310","DOIUrl":"10.1016/j.abd.2026.501310","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501310"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous leukocytoclastic vasculitis mimicking IgA vasculitis in a patient with intestinal Behçet’s disease: a diagnostic challenge","authors":"Takehiro Nakamura ,&nbsp;Ko-Ron Chen ,&nbsp;Toshiyuki Yamamoto","doi":"10.1016/j.abd.2026.501315","DOIUrl":"10.1016/j.abd.2026.501315","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501315"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of pleomorphic dermal sarcoma","authors":"Yin Lv ,&nbsp;Xudong Mou ,&nbsp;Yuelin Li ,&nbsp;Jian Li ,&nbsp;Hong Ren ,&nbsp;Renqiong Chen","doi":"10.1016/j.abd.2026.501318","DOIUrl":"10.1016/j.abd.2026.501318","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"101 2","pages":"Article 501318"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}