Anais brasileiros de dermatologia最新文献

{"title":"Successful treatment of severe diffuse alopecia areata with abrocitinib","authors":"Jinran Lin , Zheng Li , Linxia Shen , Jui-Ming Lin , Ke Tao , Ying Miao , Chunya Ni , Youyu Sheng , Wenyu Wu","doi":"10.1016/j.abd.2024.11.004","DOIUrl":"10.1016/j.abd.2024.11.004","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 580-582"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case of Trichophyton indotineae in Brazil: clinical and mycological criteria and genetic identification of terbinafine resistance","authors":"John Verrinder Veasey , Renata Diniz Jacques Gonçalves , Guilherme Camargo Julio Valinoto , Gustavo de Sá Menezes Carvalho , Giovanna Azevedo Celestrino , Ana Paula Carvalho Reis , Ana Paula Cordeiro Lima , Antonio Charlys da Costa , Marcia de Souza Carvalho Melhem , Gil Benard , Maria Gloria Teixeira Sousa","doi":"10.1016/j.abd.2025.01.001","DOIUrl":"10.1016/j.abd.2025.01.001","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 557-560"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Merkel cell carcinoma coexisting with squamous cell carcinoma⋆","authors":"Mariana Abdo de Almeida , Neusa Yuriko Sakai Valente , Mariangela Cristina Crispino Barata , Emílio Martins Curcelli , Bruna Nascimento Arruda Scabello","doi":"10.1016/j.abd.2024.10.006","DOIUrl":"10.1016/j.abd.2024.10.006","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 612-614"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of labyrinthine pattern basal cell carcinoma","authors":"Takehiro Nakamura, Toshiyuki Yamamoto","doi":"10.1016/j.abd.2024.09.009","DOIUrl":"10.1016/j.abd.2024.09.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 609-611"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical-histological characteristics and therapeutic management of primary cutaneous melanoma in elderly patients","authors":"Juan-Manuel Morón-Ocaña ,&nbsp;Isabel-María Coronel-Pérez ,&nbsp;Ana-Isabel Lorente-Lavirgen ,&nbsp;Carmen-Victoria Almeida-González ,&nbsp;Amalia Pérez-Gil","doi":"10.1016/j.abd.2024.07.017","DOIUrl":"10.1016/j.abd.2024.07.017","url":null,"abstract":"<div><h3>Background</h3><div>Life expectancy is rising in developed countries. The impact of age on melanoma characteristics is unclear, but it seems that melanomas in the elderly have distinct features affecting management and outcomes.</div></div><div><h3>Objectives</h3><div>To compare clinical and histopathological melanoma characteristics and management in elderly and younger patients.</div></div><div><h3>Methods</h3><div>A retrospective population-based study analyzed melanomas observed between 2007 and 2022 was made in the southern Seville health area (Spain). Patients were divided into two age groups: &lt;65 and ≥65. Data were collected from clinical histories.</div></div><div><h3>Results</h3><div>Among 431 primary cutaneous melanomas, 33% were in patients ≥65-years. Elderly patients had more head and neck melanomas (37.8% vs. 14.9%; p &lt; 0.001), larger lesions (1.3 vs. 0.9 cm; p &lt; 0.001), more ulcerated melanomas (17.8% vs. 8.8%; p &lt; 0.012), and higher Breslow thickness (1.03 vs. 0.65 mm; p &lt; 0.01) than younger patients. No differences were found in the number of mitoses or histopathological invasions. Stage 0 and more advanced stages (II/III/IV) were observed more frequently in ≥65-years (29.3% vs. 23% and 27.1% vs. 15.7%, p &lt; 0.001 respectively). Fewer wide excisions (28.4% vs. 5.6%, p &lt; 0.001), sentinel lymph node biopsy (17.6% vs. 2.4%, p &lt; 0.001), and adjuvant therapy (11.9% vs. 2.1%, p &lt; 0.001) were performed in patients ≥65-years.</div></div><div><h3>Study limitations</h3><div>The study was retrospective, primarily covering the last 10-years, with older data missing. Key risk factors like the number of nevi and family history of melanoma were not collected.</div></div><div><h3>Conclusions</h3><div>Melanomas in the elderly were diagnosed more frequently at initial and advanced stages despite having worse prognostic characteristics compared melanomas occurring in younger people.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 422-428"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent tuberculosis infection in patients with psoriasis using immunobiologicals: an observational study","authors":"Mariana Baptista Angeluci,&nbsp;Marilda Aparecida Milanez Morgado de Abreu,&nbsp;Ana Cláudia Cavalcante Esposito Lemos,&nbsp;Eduardo Vinicius Mendes Roncada,&nbsp;Cristhiana Kise Saito,&nbsp;Felipe Puga Barbosa","doi":"10.1016/j.abd.2024.09.011","DOIUrl":"10.1016/j.abd.2024.09.011","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 563-565"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Golimumab-induced lichen planus pigmentosus in a patient with ulcerative colitis","authors":"Daniela Alfaro-Sepúlveda,&nbsp;Claudio Escanilla,&nbsp;Fernando Valenzuela,&nbsp;Dominga Peirano","doi":"10.1016/j.abd.2024.10.002","DOIUrl":"10.1016/j.abd.2024.10.002","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 587-589"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real-world burden of atopic dermatitis: MEASURE-AD results from Brazil, Mexico, and Argentina","authors":"Catalina Rincón Pérez ,&nbsp;Valeria Aoki ,&nbsp;Roberta F. Criado ,&nbsp;Martti Antila ,&nbsp;Maria Valeria Angles ,&nbsp;Tania Ferreira Cestari ,&nbsp;Delfina Guadalupe Villanueva Quintero ,&nbsp;Gabriel Magariños ,&nbsp;Carla Castro ,&nbsp;Adriana López Tello-Santillán ,&nbsp;Magda Weber ,&nbsp;Daniel Lorenzini ,&nbsp;Caio Cesar Silva de Castro ,&nbsp;Jorge Maspero ,&nbsp;Linda García-Hidalgo ,&nbsp;Limei Zhou ,&nbsp;Shereen Hammad ,&nbsp;Lucila de Campos ,&nbsp;Tatiane Cristina Rodrigues ,&nbsp;Carolina Arzelán ,&nbsp;Paula C. Luna","doi":"10.1016/j.abd.2024.05.011","DOIUrl":"10.1016/j.abd.2024.05.011","url":null,"abstract":"<div><h3>Background</h3><div>Atopic dermatitis (AD) burden increases with disease severity.</div></div><div><h3>Objective</h3><div>Characterize the real-world burden of AD in Brazil, Mexico, and Argentina.</div></div><div><h3>Methods</h3><div>MEASURE-AD enrolled patients (≥12-years old) with moderate to severe AD receiving or candidates for systemic therapy between December 2019-December 2020. Patient characteristics, treatments, and outcomes were recorded during one office visit. Primary outcome measures included worst itch/past 24<!--> <!-->hours (Worst Pruritus Numerical Rating Scale [WP-NRS]), quality of life (QoL, Dermatology Life Quality Index [DLQI] and Children's DLQI [CDLQI]).</div></div><div><h3>Results</h3><div>Of 180 patients (adults, n<!--> <!-->=<!--> <!-->157; adolescents, n<!--> <!-->=<!--> <!-->23), 52.2% were male, the mean (SD) age was 33.8 (17.0) years, and all were receiving AD treatment (65.6% systemic therapy). Severe pruritus (WP-NRS ≥ 7) was reported by 54.4% (adults, 57.3%; adolescents, 34.8%). A very/extremely large effect on QoL (DLQI/CDLQI<!--> <!-->≥<!--> <!-->11) was reported among 50.0% of patients ≥ 16 years old and 42.9% of patients 12–15 years old. The mean Eczema Area Severity Index (EASI) was 17.0 (adults, 17.7; adolescents, 12.4); 3.9% of patients had clear skin (EASI 0) and 26.7% had severe AD (EASI 23–72). Over the previous 6 months, 0, 1–2, 3–4, 5–6, and &gt; 6 flares were reported by 8.3%, 27.2%, 31.1%, 11.7%, and 15.6% of patients, respectively. On average, flares lasted 15.2 days (adults, 15.9 days; adolescents, 11.1 days).</div></div><div><h3>Study limitations</h3><div>Patient self-reported information and recall during one office visit.</div></div><div><h3>Conclusions</h3><div>Despite treatment, disease severity and impact on QoL were high, suggesting that AD is not adequately controlled in all patients, highlighting a considerable unmet need for effective treatments to reduce AD burden.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 470-486"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyoderma gangrenosum: a 22-year follow-up of patients in a tertiary reference hospital in Brazil","authors":"Livia Maria Oliveira Salviano,&nbsp;Denise Miyamoto,&nbsp;Claudia Giuli Santi,&nbsp;Tatiana Mina Yendo,&nbsp;Maria Cecilia Rivitti-Machado","doi":"10.1016/j.abd.2024.07.014","DOIUrl":"10.1016/j.abd.2024.07.014","url":null,"abstract":"<div><h3>Background</h3><div>Pyoderma gangrenosum (PG) is a rare dermatosis often associated with systemic diseases. There are autoinflammatory mechanisms with neutrophilic infiltrate and necrosis. Due to the high morbidity, variable response to therapy and lack of treatment standardization, PG constitutes a highly burdensome condition.</div></div><div><h3>Objectives</h3><div>To evaluate the epidemiological, clinical and laboratory features and response to therapy of patients with PG followed at HCFMUSP.</div></div><div><h3>Methods</h3><div>This retrospective and descriptive study included patients with confirmed PG under follow-up at HCFMUSP from January 2000 to August 2021. Data were retrieved from medical records.</div></div><div><h3>Results</h3><div>Fifty patients were included. The mean time from the onset of symptoms to diagnosis was 26.5 months. Lesions predominated on the lower extremity in 72% (n = 36/50), and the ulcerative type was the most common (n = 43/50; 86%). Local pain was mentioned in 39/50 (78%) and 12/50 (24%) presented pathergy. The most frequently associated diseases were inflammatory bowel disease (n = 10/20; 20%) and hidradenitis suppurativa (n = 10/20; 20%). High-dose systemic corticosteroid was mostly the first therapy (88%), either alone (n = 7/50; 14%) or in association with classic immunosuppressants or immunobiologicals (n = 37; 74%). Most patients (n = 32/50; 64%) had at least one hospitalization. Disease control was achieved in 44/50 (88%), with recurrences in 48% (n = 24/50) and total healing without medication in 24% (n = 12). Sixteen patients (32%) were treated with at least 1 immunobiological agent in addition to classic drugs.</div></div><div><h3>Study limitations</h3><div>Retrospective, descriptive design and number of patients.</div></div><div><h3>Conclusions</h3><div>There was delay in diagnosis, association with systemic and cutaneous conditions, and the need for prolonged immunomodulatory or immunosuppressive therapy (classic agents and also biologic agents) to control PG.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 462-469"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of upadacitinib in the management of atopic dermatitis, Crohn’s disease, and hidradenitis suppurativa: one treatment, multiple indications","authors":"Roberto Bueno-Filho ,&nbsp;Daniel Lorenzini ,&nbsp;Rogério Serafim Parra","doi":"10.1016/j.abd.2024.10.007","DOIUrl":"10.1016/j.abd.2024.10.007","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 3","pages":"Pages 583-586"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}