Anales de pediatria最新文献

{"title":"Recomendaciones de manejo de la dispepsia funcional del Grupo de Trabajo de Motilidad y Trastornos Gastrointestinales Funcionales de la SEGHNP","authors":"Miguel Ángel Carro Rodríguez ,&nbsp;Inmaculada Hidalgo Montes ,&nbsp;Carmen Jovani Casano ,&nbsp;Aránzazu Recio Linares ,&nbsp;Etna Masip Simó ,&nbsp;Gloria Rodrigo Garcia ,&nbsp;Andrés Bodas Pinedo ,&nbsp;en representación del Grupo de Trabajo de Motilidad y Trastornos Gastrointestinales funcionales de la SEGHNP","doi":"10.1016/j.anpedi.2025.503860","DOIUrl":"10.1016/j.anpedi.2025.503860","url":null,"abstract":"<div><h3>Introduction</h3><div>Functional dyspepsia (FD) is a functional gastrointestinal disorder that affects a significant number of patients, especially adolescents. Diagnosis is often challenging on account of both the differential diagnosis with organic diseases and the overlap with other disorders involving the gut-brain axis. Furthermore, there is a lack of scientific evidence on the effectiveness of the different treatments. As a result, there is evidence of substantial heterogeneity in the management of these patients due, in part, to the absence of clinical practice guidelines on this disease.</div></div><div><h3>Material and methods</h3><div>A group was formed that consisted of 19 members of the working group on motility and functional gastrointestinal disorders (FGIDS) of the SEGHNP. The group defined 27 clinical questions regarding the management of FD. After a review of the literature and two rounds of anonymous voting, the group elaborated a document summarizing the current evidence and offering recommendations.</div></div><div><h3>Results</h3><div>The group produced a summary of the evidence and developed 27 recommendations on FD.</div></div><div><h3>Conclusion</h3><div>We developed an algorithm with the aim of standardizing the management of patients with FD.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503860"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de resistencia a las hormonas tiroideas: detección prenatal y manejo posnatal en un recién nacido","authors":"Beatriz Parreira de Andrade ,&nbsp;Marta Barbosa ,&nbsp;Patrícia Tavares ,&nbsp;Maria Adriana Rangel ,&nbsp;Rosa Arménia Campos","doi":"10.1016/j.anpedi.2025.503772","DOIUrl":"10.1016/j.anpedi.2025.503772","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503772"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dolor por procedimientos en pediatría: óxido nitroso y efecto invernadero","authors":"Itziar Marsinyach Ros ,&nbsp;Marta Pérez Alba ,&nbsp;en representación del Comité de Dolor Infantil de la Asociación Española de Pediatría (AEP)","doi":"10.1016/j.anpedi.2025.503839","DOIUrl":"10.1016/j.anpedi.2025.503839","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503839"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolución de los pacientes con cribado de cardiopatías congénitas críticas alterado en función del momento de realización","authors":"Elena Granda ,&nbsp;Silvia Pérez-Porra ,&nbsp;Silvia Martín-Ramos ,&nbsp;Sara Marín-Urueña ,&nbsp;Sonia Caserío-Carbonero","doi":"10.1016/j.anpedi.2025.503799","DOIUrl":"10.1016/j.anpedi.2025.503799","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503799"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mejoría de la inflamación intestinal tras tratamiento con moduladores de la proteína CFTR en pacientes con fibrosis quística","authors":"Ruth García Romero ,&nbsp;Concepción López Cárdenes ,&nbsp;Elena Crehuá Gaudiza ,&nbsp;Marina Álvarez Beltrán ,&nbsp;Mercedes Murray Hurtado ,&nbsp;Carlos Tutau Gómez ,&nbsp;Inés Loverdos Eseverri ,&nbsp;Encarni Torcuato Rubio ,&nbsp;Camila García Volpe ,&nbsp;Enrique Salcedo Lobato ,&nbsp;María Medina Martínez ,&nbsp;Carmen Martin Fernández ,&nbsp;Ana Moreno Álvarez ,&nbsp;Ana Reyes Domínguez ,&nbsp;David González Jiménez ,&nbsp;Grupo de trabajo de Fibrosis Quística y Páncreas de la SEGHNP","doi":"10.1016/j.anpedi.2025.503836","DOIUrl":"10.1016/j.anpedi.2025.503836","url":null,"abstract":"<div><h3>Introduction</h3><div>Treatments with CFTR protein modulators have improved respiratory and digestive health in patients with cystic fibrosis.</div></div><div><h3>Objective</h3><div>To assess changes in intestinal inflammation through the analysis of fecal calprotectin in patients with cystic fibrosis during treatment with CFTR modulators.</div></div><div><h3>Material and methods</h3><div>Prospective multicenter study of changes in fecal calprotectin in patients with cystic fibrosis treated with CFTR modulators, comparing double combinations (lumacaftor/ivacaftor or tezacaftor/ivacaftor) and triple combinations (elexacaftor/tezacaftor/ivacaftor). We collected data before treatment initiation and at 6<!--> <!-->and 12<!--> <!-->months.</div></div><div><h3>Results</h3><div>Analysis of 117 patients (69% with F508del/F508del). The median baseline fecal calprotectin level was 49<!--> <!-->μg/g (IQR: 23-108); 48.7% had median levels greater than 50<!--> <!-->μg/g and 11% levels greater than 250<!--> <!-->μg/g. Fecal calprotectin decreased in both groups, with a greater decrease in patients treated with elexacaftor/tezacaftor/ivacaftor. We found a progressive decrease in abnormal values (&gt;<!--> <!-->50<!--> <!-->μg/g) at 6<!--> <!-->months (48.7% vs 33.1%; <em>P</em> <!-->=<!--> <!-->.0067) and at 12<!--> <!-->months (54% vs 33.5%; <em>P</em> <!-->=<!--> <!-->.0218). In the elexacaftor/tezacaftor/ivacaftor group, only two patients at 6<!--> <!-->months and one patient at 12<!--> <!-->months had levels greater than 250<!--> <!-->μg/g. The estimated change at 12<!--> <!-->months in the triple therapy group compared to the other group was −133<!--> <!-->μg/g (95%<!--> <!-->CI: −<!--> <!-->254 to −<!--> <!-->13; <em>P</em> <!-->=<!--> <!-->.030); and, adjusting for sex, probiotics and <em>Pseudomonas aeruginosa</em>, −<!--> <!-->130<!--> <!-->μg/g (−259 to −<!--> <!-->1; <em>P</em> <!-->=<!--> <!-->.049).</div></div><div><h3>Conclusions</h3><div>Treatment with CFTR modulators reduces intestinal inflammation in patients with cystic fibrosis, with a greater decrease in patients treated with triple therapy.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503836"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La paradoja de la EMOP, sabemos tratarla, pero no diagnosticarla","authors":"Clara Chover Martínez,&nbsp;María Portolés Morales,&nbsp;Pilar Sáenz González,&nbsp;Álvaro Solaz García","doi":"10.1016/j.anpedi.2025.503801","DOIUrl":"10.1016/j.anpedi.2025.503801","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503801"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malformaciones pulmonares congénitas: ¿Qué impacto tiene la presencia de síntomas preoperatorios en el resultado quirúrgico?","authors":"María López-Díaz ,&nbsp;Ester Fernández Díaz ,&nbsp;Indalecio Cano Novillo ,&nbsp;Elena Bergón ,&nbsp;Rocío Morante Valverde ,&nbsp;Alberto Galindo Izquierdo ,&nbsp;Juan L. Antón-Pacheco","doi":"10.1016/j.anpedi.2025.503835","DOIUrl":"10.1016/j.anpedi.2025.503835","url":null,"abstract":"<div><h3>Introduction</h3><div>The management of congenital lung malformations (CLMs) is controversial because most of them are asymptomatic. The aim of our study was to analyze the association of preoperative symptoms with surgical outcomes in patients with CLMs treated by means of minimally invasive surgery (MIS).</div></div><div><h3>Patients and methods</h3><div>Retrospective study of patients with CLM treated with MIS in our hospital between 2003 and 2023. We recorded data on the following variables: demographic characteristics, size, type and location of the lesion, mediastinal shift, clinical symptoms, surgical time, conversion to open surgery, duration of chest drainage (days), length of stay and postoperative complications.</div></div><div><h3>Results</h3><div>The sample included 116 patients, 98 (84.4%) asymptomatic and 18 (15.5%) with clinically significant symptom: infectious in 10 (55.5%) and respiratory distress in eight. The most frequent histopathological type was congenital pulmonary airway malformation (35.5%), followed by intralobar sequestration (27.3%), and the lower lobes were most commonly involved (78.4%). Larger lesion size on the CT scan was significantly associated with the development of symptoms (<em>P</em> <!-->=<!--> <!-->.027) and with an increased frequency of conversion to open surgery. However, the incidence of postoperative complications was not greater in the symptomatic group.</div></div><div><h3>Conclusions</h3><div>Postoperative complications were not significantly more frequent in the symptomatic group of patients. Larger lesion size on imaging was associated with a significantly increased probability of developing symptoms, so these patients may benefit from early surgical resection.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503835"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Registro nacional multicéntrico sobre ecografía pulmonar en el menor de 26 semanas (MINI-LUS)","authors":"Almudena Alonso-Ojembarrena ,&nbsp;Rebeca Gregorio-Hernández ,&nbsp;Manuel Sánchez-Luna","doi":"10.1016/j.anpedi.2025.503837","DOIUrl":"10.1016/j.anpedi.2025.503837","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503837"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolución de prescripción antibiótica en Atención Primaria según indicadores del PRAN (Plan Nacional frente a la Resistencia a los Antibióticos)","authors":"Carlos Marcilla Vázquez ,&nbsp;Juan Ríos Laorden ,&nbsp;Ángeles Lloret Callejo ,&nbsp;Francisco Tejada Cifuentes ,&nbsp;María José Tirado Peláez ,&nbsp;Ignacio Párraga-Martínez","doi":"10.1016/j.anpedi.2025.503840","DOIUrl":"10.1016/j.anpedi.2025.503840","url":null,"abstract":"<div><h3>Introduction</h3><div>Spain is the fourth European country with the highest antibiotic consumption at the community level, and children aged 0 to 4 years are one of the age groups with the highest consumption. The aim of our study was to analyze the evolution of antibiotic prescribing in the paediatric catchment population of a primary care area in Spain according to the indicators established in the National Plan against Antibiotic Resistance (PRAN) over 10<!--> <!-->years (2014-2023) and to assess the impact of the COVID-19 pandemic by comparing the 2020-2021 period with the preceding and subsequent periods (2014-2019 and 2022-2023).</div></div><div><h3>Material and methods</h3><div>Retrospective observational study of the prescribing of antibiotics for systemic use (J01 group of the Anatomical Therapeutic Chemical Classification) in paediatric patients (0-14 years) covered by the primary care system of the Albacete health care administration between 2014 and 2023.</div></div><div><h3>Results</h3><div>The mean antibiotic prescription was 16.90 defined daily doses (DDD) per 1000 inhabitants per day and 12.10 DOT (days of therapy). The corresponding values in the prepandemic period (2014-2019) were 19.32 DDD/1000 inhabitants/day and 13.92 DOT, which decreased to 8.30 DDD/1000 inhabitants/day and 6.05 DOT during the pandemic (2020-2021) and then increased to 18.05 DDD/1000 inhabitants/day and 12.40 DOT in the pospandemic period (2022-2023). There was an improvement in appropriate prescribing after the COVID-19 pandemic, with a reduction in the consumption of amoxicillin-clavulanic acid and greater consumption of penicillin and amoxicillin during prepandemic and pandemic years (<em>P</em> &lt;<!--> <!-->.05).</div></div><div><h3>Conclusions</h3><div>Throughout the study period, there was improvement in the consumption indicators established in the PRAN, with an increase in the use of beta-lactamase sensitive penicillins and amoxicillin and a reduction in the use of amoxicillin-clavulanic acid.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503840"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poliorquidismo: un hallazgo ecográfico poco frecuente","authors":"Maria Font Roset ,&nbsp;Isabel Sánchez Bueno ,&nbsp;Anton Foguet Vidal ,&nbsp;Stephan Otto Schneider","doi":"10.1016/j.anpedi.2025.503769","DOIUrl":"10.1016/j.anpedi.2025.503769","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503769"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}