Anales de pediatria最新文献

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Visitas virtuales en pediatría: experiencias, preferencias y expectativas de pacientes y cuidadores 儿科虚拟访问:患者和护理人员的经验、偏好和期望
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503993
Miren Ibarzabal Arregi , Tregony Simoneau , Jonathan M. Gaffin , María Gimeno Castillo , Isabel Castro Garrido , Claudia María Chaverri Reparaz , Laura Moreno-Galarraga
{"title":"Visitas virtuales en pediatría: experiencias, preferencias y expectativas de pacientes y cuidadores","authors":"Miren Ibarzabal Arregi ,&nbsp;Tregony Simoneau ,&nbsp;Jonathan M. Gaffin ,&nbsp;María Gimeno Castillo ,&nbsp;Isabel Castro Garrido ,&nbsp;Claudia María Chaverri Reparaz ,&nbsp;Laura Moreno-Galarraga","doi":"10.1016/j.anpedi.2025.503993","DOIUrl":"10.1016/j.anpedi.2025.503993","url":null,"abstract":"<div><h3>Introduction</h3><div>Virtual visits (VVs) were used during the pandemic as an alternative to face-to-face visits. Following this experience, the implementation of this type of telemedicine in pediatric care may offer clear advantages and benefits, but it is important to understand the perspectives of both patients and caregivers.</div></div><div><h3>Material and methods</h3><div>Cross-sectional descriptive with data collection through an online questionnaire distributed via QR code and hosted on REDCap completed anonymously by parents/legal guardians and adolescents (n<!--> <!-->=<!--> <!-->426). We obtained data on sociodemographic characteristics, previous experience with telemedicine and the perceived usefulness of VVs from 316 caregivers and 110 adolescents. We analyzed the associations with demographic variables and performed comparative analyses.</div></div><div><h3>Results</h3><div>Both groups considered VVs a useful alternative, particularly when it came to primary care and hospital-based follow-up. Caregivers highlighted saving time (53%) and reducing school absenteeism (40%) as the main advantages, whereas adolescents emphasized reducing the environmental impact associated with the visit (48%). The ideal duration was estimated at 5 to15<!--> <!-->minutes, and more than 95% agreed that VVs should be offered as a voluntary option. We found a higher level of acceptance among caregivers who were younger, with higher educational attainment, who did not have a private vehicle or who had greater difficulty accessing the hospital. The main concern did not involve data breaches or aspects related to confidentiality (10%), but the possibility of missing the call and therefore the appointment (33%).</div></div><div><h3>Conclusions</h3><div>Both patients and caregivers support the integration of VVs in pediatric care, provided they remain a voluntary and complementary alternative to in-person care. Future programs should consider user preferences, suggestions and the actual barriers they perceive.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503993"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemangioma infantil orbitario: a propósito de un caso 儿童眼眶血管瘤:以一个病例为例
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503967
Rachid Bouchikh-El Jarroudi , Hugo González-Valdivia , Mariana Planells-Alduvín , Mariana Alvarez-Vukov
{"title":"Hemangioma infantil orbitario: a propósito de un caso","authors":"Rachid Bouchikh-El Jarroudi ,&nbsp;Hugo González-Valdivia ,&nbsp;Mariana Planells-Alduvín ,&nbsp;Mariana Alvarez-Vukov","doi":"10.1016/j.anpedi.2025.503967","DOIUrl":"10.1016/j.anpedi.2025.503967","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503967"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cistoadenoma mucinoso borderline gigante de ovario 卵巢巨边缘粘膜囊腺瘤
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503985
María Ruiz Medina , Fernando Vázquez Rueda , María Rosa Ibarra Rodríguez , Rosa Ortega Salas , Rosa María Paredes Esteban
{"title":"Cistoadenoma mucinoso borderline gigante de ovario","authors":"María Ruiz Medina ,&nbsp;Fernando Vázquez Rueda ,&nbsp;María Rosa Ibarra Rodríguez ,&nbsp;Rosa Ortega Salas ,&nbsp;Rosa María Paredes Esteban","doi":"10.1016/j.anpedi.2025.503985","DOIUrl":"10.1016/j.anpedi.2025.503985","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503985"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actividades basadas en simulación: ¿cómo empezar? 基于模拟的活动:如何开始?
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503957
Gema Martínez Espinosa , David Muñoz-Santanach , en representación del Grupo de Trabajo de Simulación de la Sociedad Española de Urgencias de Pediatría
{"title":"Actividades basadas en simulación: ¿cómo empezar?","authors":"Gema Martínez Espinosa ,&nbsp;David Muñoz-Santanach ,&nbsp;en representación del Grupo de Trabajo de Simulación de la Sociedad Española de Urgencias de Pediatría","doi":"10.1016/j.anpedi.2025.503957","DOIUrl":"10.1016/j.anpedi.2025.503957","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503957"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vacunación antigripal en la infancia y la adolescencia. Consenso AEV, CAV-AEP y SEIP 儿童和青少年接种流感疫苗。《环境评估共识》、《环境影响评估-环境影响评估》和《环境影响评估》
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503965
Javier Alvarez Aldeán , Francisco José Alvarez García , Marta Cruz Cañete , María Fernández Prada , Laura Francisco González , Ana María Grande Tejada , Antonio Iofrío de Arce , Alejandra Méndez Sánchez , Fernando Moraga Llop , Ignacio Salamanca de la Cueva , en representación del Comité Asesor de Vacunas de la Asociación Española, de Pediatría (CAV-AEP), Sociedad Española de Infectología Pediátrica (SEIP) y Asociación Española de Vacunología (AEV)
{"title":"Vacunación antigripal en la infancia y la adolescencia. Consenso AEV, CAV-AEP y SEIP","authors":"Javier Alvarez Aldeán ,&nbsp;Francisco José Alvarez García ,&nbsp;Marta Cruz Cañete ,&nbsp;María Fernández Prada ,&nbsp;Laura Francisco González ,&nbsp;Ana María Grande Tejada ,&nbsp;Antonio Iofrío de Arce ,&nbsp;Alejandra Méndez Sánchez ,&nbsp;Fernando Moraga Llop ,&nbsp;Ignacio Salamanca de la Cueva ,&nbsp;en representación del Comité Asesor de Vacunas de la Asociación Española, de Pediatría (CAV-AEP), Sociedad Española de Infectología Pediátrica (SEIP) y Asociación Española de Vacunología (AEV)","doi":"10.1016/j.anpedi.2025.503965","DOIUrl":"10.1016/j.anpedi.2025.503965","url":null,"abstract":"<div><div>Influenza is an important public health problem that puts healthcare systems to the test each year with outbreaks that constitute a significant social and economic burden. The proportion of the pediatric population affected during the annual influenza season ranges between 30% and 40% worldwide, with 2 to 4 million severe cases in children under 18 years of age globally. Children and adolescents are also the main transmitters of the disease.</div><div>The consensus document presented here was developed jointly by three scientific societies: the Spanish Association of Vaccinology (AEV), the Spanish Association of Pediatrics, through its Advisory Committee on Vaccines and Immunizations (CAV-AEP), and the Spanish Society of Pediatric Infectious Diseases (SEIP). Routine influenza vaccination is recommended for children from 6 months of age and for adolescents up to 17 years of age (both included). Vaccination is also recommended for any individual that could transmit the virus to groups at increased risk of developing severe forms of disease and for household or close contacts of infants aged less than 6 months. Vaccination against influenza of all health care professionals as well as pregnant women (at any time during pregnancy) is especially important. For children aged 2 years or older and adolescents, unless contraindicated, vaccination with attenuated intranasal vaccine is preferred. Efforts should be made to improve influenza vaccination coverage in all the recommended groups, with particular emphasis on at-risk groups.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503965"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidentes de seguridad en urgencias pediátricas: incidencia, características y variabilidad entre centros. Estudio multicéntrico nacional 儿科急诊安全事件:发生率、特征和各中心之间的可变性。国家多中心研究
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503998
Dolores Beteta Fernández , Carlos Pérez Cánovas , Rosa Belén Martínez Egea , Julián Alcaraz Martínez , Adriana Catarina De Souza Oliveira , Manuel Pardo Ríos
{"title":"Incidentes de seguridad en urgencias pediátricas: incidencia, características y variabilidad entre centros. Estudio multicéntrico nacional","authors":"Dolores Beteta Fernández ,&nbsp;Carlos Pérez Cánovas ,&nbsp;Rosa Belén Martínez Egea ,&nbsp;Julián Alcaraz Martínez ,&nbsp;Adriana Catarina De Souza Oliveira ,&nbsp;Manuel Pardo Ríos","doi":"10.1016/j.anpedi.2025.503998","DOIUrl":"10.1016/j.anpedi.2025.503998","url":null,"abstract":"<div><h3>Introduction</h3><div>Pediatric emergency departments are high-risk environments for patient safety due to the workload, time pressure and clinical vulnerability of the population. However, there is limited evidence regarding the prevalence, characteristics and associated factors of safety incidents in this setting. Understanding these events is essential to design effective improvement strategies.</div></div><div><h3>Objective</h3><div>To estimate the incidence of patient safety incidents in pediatric emergency departments, describe their characteristics and identify associated factors. Multicenter, observational and descriptive study based on retrospective chart review and structured incident reporting.</div></div><div><h3>Methods</h3><div>We identified a total of 1102 pediatric patients treated in the emergency departments of nine Spanish hospitals during the second quarter of 2021 were identified. After excluding 49 patients who could not be reached for follow-up, the final sample included 1056 cases. Of these, 90 children experienced incidents related to healthcare, with a total of 94 incidents, as four patients experienced two incidents each. A previously validated tool was used to collect demographic, clinical and organizational data, as well as information on safety incidents.</div></div><div><h3>Results</h3><div>The overall proportion of patients with at least one safety incident was 8.5% (95%<span>C</span>I: 6.0-9.0). Most incidents caused no harm (39%) or mild to moderate harm (46%), and 13% were deemed clearly preventable. Incidents mainly occurred during emergency care and were attributed to organizational, communication or human factors. There were significant differences between hospitals (<em>P</em>&lt;.01), but we found no associations with shift, triage level, or mode of arrival. The hospital continued to be a significant predictor in the multivariate analysis.</div></div><div><h3>Conclusions</h3><div>Patient safety incidents in pediatric emergency departments are frequent and partly preventable. The variability observed between centers, which persisted after adjusting for the catchment pediatric population and staffing characteristics, suggests the influence of structural and cultural factors specific to each institution. Context-adapted institutional strategies need to be implemented to foster a proactive safety culture and effective risk management.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503998"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lectura crítica (ii): aplicación en artículos científicos sobre intervenciones terapéuticas, revisiones sistemáticas y metanálisis 评论阅读(ii):在关于治疗干预措施、系统综述和荟萃分析的科学论文中的应用
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503891
Álvaro Gimeno Díaz de Atauri , María Salomé Albi Rodríguez , Elena Pérez González , Jaime Javier Cuervo Valdés , Juan Ruiz-Canela Cáceres , Javier González de Dios , Comité de Trabajo de Pediatría Basada en la Evidencia
{"title":"Lectura crítica (ii): aplicación en artículos científicos sobre intervenciones terapéuticas, revisiones sistemáticas y metanálisis","authors":"Álvaro Gimeno Díaz de Atauri ,&nbsp;María Salomé Albi Rodríguez ,&nbsp;Elena Pérez González ,&nbsp;Jaime Javier Cuervo Valdés ,&nbsp;Juan Ruiz-Canela Cáceres ,&nbsp;Javier González de Dios ,&nbsp;Comité de Trabajo de Pediatría Basada en la Evidencia","doi":"10.1016/j.anpedi.2025.503891","DOIUrl":"10.1016/j.anpedi.2025.503891","url":null,"abstract":"<div><div>In this article, we discuss the methodology for the critical appraisal of clinical trials and systematic reviews. Studies of either type, when well designed and executed, provide the best evidence for clinical decision-making. Clinical trials are the primary source of evidence for evaluating therapeutic interventions, and systematic reviews analyze and synthesize research of a certain quality to answer a specific clinical question. To assess their validity, it is essential that they aim to answer a specific question in terms of population, intervention and outcomes, and that the risk of bias is reduced as much as possible during their development, from design to publication. The article addresses the steps to take to assess whether a clinical trial or systematic review meets the criteria for its results to be considered reliable (valid). Once their validity is confirmed, the magnitude and clinical relevance of the results must be assessed, in addition to their applicability to our patients in particular.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503891"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experiencia con el bloqueo de interleucina-1 en la enfermedad de Kawasaki refractaria 在难治性川崎病中阻断白细胞介素-1的经验
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503988
Carlos Baena-Palomino , Lorena Estepa-Pedregosa , Ana Castellano-Martínez , Moisés Rodríguez-González
{"title":"Experiencia con el bloqueo de interleucina-1 en la enfermedad de Kawasaki refractaria","authors":"Carlos Baena-Palomino ,&nbsp;Lorena Estepa-Pedregosa ,&nbsp;Ana Castellano-Martínez ,&nbsp;Moisés Rodríguez-González","doi":"10.1016/j.anpedi.2025.503988","DOIUrl":"10.1016/j.anpedi.2025.503988","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503988"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Documento consenso SEIP/AEPap/SEPEAP/SEGHNP/SEUP sobre el diagnóstico y tratamiento etiológico de las gastroenteritis agudas de origen infeccioso SEIP/AEPap/SEPEAP/SEGHNP/SEUP关于感染性急性胃肠炎诊断和病因治疗的共识文件
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.503984
Alicia Berghezan-Suárez , David López-Martín , Ángel José Carbajo Ferreira , Parisá Khodayar-Pardo , Luis Ortiz González , Belén Aguirrezabalaga González , Ricardo Torres-Peral , Roi Piñeiro Pérez , María Natali Campo Fernández , Begoña Pérez-Moneo , Grupo de Trabajo de Gastroenteritis Aguda en Pediatría
{"title":"Documento consenso SEIP/AEPap/SEPEAP/SEGHNP/SEUP sobre el diagnóstico y tratamiento etiológico de las gastroenteritis agudas de origen infeccioso","authors":"Alicia Berghezan-Suárez ,&nbsp;David López-Martín ,&nbsp;Ángel José Carbajo Ferreira ,&nbsp;Parisá Khodayar-Pardo ,&nbsp;Luis Ortiz González ,&nbsp;Belén Aguirrezabalaga González ,&nbsp;Ricardo Torres-Peral ,&nbsp;Roi Piñeiro Pérez ,&nbsp;María Natali Campo Fernández ,&nbsp;Begoña Pérez-Moneo ,&nbsp;Grupo de Trabajo de Gastroenteritis Aguda en Pediatría","doi":"10.1016/j.anpedi.2025.503984","DOIUrl":"10.1016/j.anpedi.2025.503984","url":null,"abstract":"<div><div>Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality in pediatric patients worldwide. Microbiological testing of AGE is reserved for prolonged or complicated cases and for patients with certain risk factors. Diagnostic tests should be selected based on availability and the clinical and epidemiological context. The following tests could be requested, depending on the suspected diagnosis: stool or blood culture, rapid tests, molecular tests, ova and parasite test or serology. Complete blood counts and acute phase reactant (APR) tests are indicated in patients with signs of severe disease. Sociodemographic and climate changes have led to an increase in the incidence of pathogens previously rare in our region (emerging pathogens), which must also be considered. Microorganisms of uncertain significance may also be detected, which should either not be treated or treated only under specific circumstances. In general, empirical antibiotherapy should not be initiated for management of AGE except in specific situations: infants aged less than 3 to 6 months with suspected bacterial AGE, patients with underlying disease, signs of sepsis, institutionalized patients or settings with risk of dissemination. In cases of AGE caused by non-Typhi <em>Salmonella</em> and Shiga toxin-producing <em>Escherichia coli</em> (STEC), targeted antibiotherapy is restricted to patients at risk of systemic infection or with prolonged diarrhea. In Spain, complications of AGE are rare, and dehydration and post-enteritis syndrome are most common.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 503984"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La correlación entre el ratio vitamina D/insulina y la pubertad precoz central en niñas y su potencial para el cribado 维生素D/胰岛素比与女孩核心青春期早期的相关性及其筛查潜力
IF 2.1 4区 医学
Anales de pediatria Pub Date : 2025-10-01 DOI: 10.1016/j.anpedi.2025.504016
Jun Sun, Ya Xiao, Shu-Qin Jiang, Hong-Ru Zhang, Jin-Bo Li, Wen-Hui Shi, Wei Wang
{"title":"La correlación entre el ratio vitamina D/insulina y la pubertad precoz central en niñas y su potencial para el cribado","authors":"Jun Sun,&nbsp;Ya Xiao,&nbsp;Shu-Qin Jiang,&nbsp;Hong-Ru Zhang,&nbsp;Jin-Bo Li,&nbsp;Wen-Hui Shi,&nbsp;Wei Wang","doi":"10.1016/j.anpedi.2025.504016","DOIUrl":"10.1016/j.anpedi.2025.504016","url":null,"abstract":"<div><h3>Introduction</h3><div>There are still no effective biomarkers for the diagnosis of central precocious puberty (CPP), and single metabolic indicators (such as vitamin D or insulin) are susceptible to interference from metabolic interactions. We conducted a study to assess the correlation between the vitamin D/insulin ratio (VDIR) and CPP and the screening potential of the VDIR.</div></div><div><h3>Methods</h3><div>Case-control study in a sample of 170 girls aged 6 to 10 years, including 85 girls with CPP and 85 girls with normal growth and development. We collected data on growth and developmental indicators and laboratory test results for both groups. The association between the VDIR and CPP/gonadal development was assessed by means of multivariate logistic and linear regression analyses. The diagnostic value of VDIR was evaluated by means of receiver operating characteristic (ROC) curve analysis.</div></div><div><h3>Results</h3><div>The VDIR in the CPP group was lower than in the control group (3.45 vs 6.18). The area under the ROC curve (AUC) of the VDIR for diagnosis of CPP was 0.731, with a sensitivity of 70.59% and a specificity of 67.06%, higher compared to vitamin D alone (AUC<!--> <!-->=<!--> <!-->0.682) or insulin alone (AUC<!--> <!-->=<!--> <!-->0.690). The multivariate logistic/linear regression analysis revealed that for every 1-unit increase in VDIR, there was a 0.814-fold decrease in the risk of CPP and a 233.54 mm<sup>3</sup> decrease in uterine volume.</div></div><div><h3>Conclusion</h3><div>By integrating the metabolic interactions between vitamin D and insulin, VDIR shows promising value in assessing the risk of CPP. As a potential biomarker, it may offer dual clinical value by enabling early screening of high-risk individuals prior to the definitive diagnosis, as well as providing guidance for personalized interventions.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 4","pages":"Article 504016"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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