Anales de pediatria最新文献

{"title":"Lesión cutánea: la importancia de los antecedentes epidemiológicos","authors":"María Aldaba , Teresa del Rosal , Iker Falces-Romero , María de Ceano-Vivas","doi":"10.1016/j.anpedi.2025.504086","DOIUrl":"10.1016/j.anpedi.2025.504086","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 3","pages":"Article 504086"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147413938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicación de cistografía en la edad pediátrica. Anomalías morfológicas y defectos funcionales","authors":"Víctor M. García Nieto ,&nbsp;María Candelaria Darias Martin ,&nbsp;Teresa Moraleda Mesa ,&nbsp;Matilde Clara Gil Villena ,&nbsp;Antonio López Figueroa ,&nbsp;María Isabel Luis Yanes","doi":"10.1016/j.anpedi.2026.504133","DOIUrl":"10.1016/j.anpedi.2026.504133","url":null,"abstract":"<div><h3>Objective</h3><div>Until the introduction of ultrasound in clinical practice, routine performance of a cystography and urethrography was the standard of care following a first urinary tract infection (UTI). Current indications for this technique are based on clinical features, age or sex. This study aims to assess the importance of basic kidney function tests in determining the indication for cystography in the pediatric population.</div></div><div><h3>Patients and methods</h3><div>we conducted a cross-sectional observational and analytical, diagnostic accuracy study in 175 children who underwent ultrasound examinations for assessment of morphological abnormalities or with a history of one or more UTIs. We applied the term “significant morphological abnormalities” (SMAs) excluding cases with an anteroposterior diameter of the pelvis of less than 2<!--> <!-->cm. The basic kidney function tests used in the assessment were the maximum urinary osmolality (UOsm) and urinary albumin/creatinine and NAG/creatinine ratios.</div></div><div><h3>Results</h3><div>The number of patients with normal cystography was 118; the remaining 57 had vesicoureteral reflux (VUR). We found a statistically significant association between UTI and VUR. Significant morphological abnormalities were present in 32/57 cases of VUR (56.1%) and the maximum UOsm was abnormal in 75% of cases with VUR (43/57). The association of “UTI + significant SMA” offered a negative predictive value (NPV) of 89% and a positive predictive value of 49%, leaving two cases of grade IV VUR undiagnosed. The association of UTI with “SMAs or reduced maximum UOsm” predicted all severe cases of VUR (grades IV-V).</div></div><div><h3>Conclusions</h3><div>In children who have had UTI, in the presence of SMAs, prior determination of the maximum UOsm does not seem necessary to indicate a cystography. In patients who have not suffered from UTI, determining the maximum UOsm is useful for ruling out the presence of severe VUR. Renal tubular function tests, combined with other clinical, laboratory and sonographic variables, can guide decision-making to avoid unnecessary cystography.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 3","pages":"Article 504133"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147413927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hipoventilación: un término fisiológico no semiológico","authors":"Manuel Oltra Benavent","doi":"10.1016/j.anpedi.2025.504031","DOIUrl":"10.1016/j.anpedi.2025.504031","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 3","pages":"Article 504031"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147413936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descubriendo el accidente cerebrovascular isquémico: el corazón como clave","authors":"Joana Afonso Neto ,&nbsp;Catarina Almeida ,&nbsp;Joana Lima ,&nbsp;Raquel Sousa","doi":"10.1016/j.anpedi.2025.504081","DOIUrl":"10.1016/j.anpedi.2025.504081","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 3","pages":"Article 504081"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147413939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrar la mejor evidencia disponible: una hoja de ruta metodológica para el pediatra clínico","authors":"Paz González-Rodríguez ,&nbsp;María Aparicio-Rodrigo ,&nbsp;Josep Vicent Balaguer-Martínez","doi":"10.1016/j.anpedi.2025.504129","DOIUrl":"10.1016/j.anpedi.2025.504129","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 2","pages":"Article 504129"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodegeneración en histiocitosis de células de Langerhans: más que una secuela","authors":"Vicente Santa-María López ,&nbsp;Ignacio Gutiérrez-Carrasco ,&nbsp;Antonio Pérez-Martínez ,&nbsp;Carmen Rodríguez-Vigil Iturrate ,&nbsp;Susana García-Obregón ,&nbsp;Mikael Lorite Reggiori ,&nbsp;Thais Murciano Carrillo ,&nbsp;Lorena Valero-Arrese ,&nbsp;Montse Torrent ,&nbsp;Itziar Astigarraga ,&nbsp;en representación del Grupo de Histiocitosis de la Sociedad Española de Hematología y Oncología Pediátricas (SEHOP)","doi":"10.1016/j.anpedi.2025.504058","DOIUrl":"10.1016/j.anpedi.2025.504058","url":null,"abstract":"<div><div>Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm with heterogeneous organ and system involvement. Neurodegenerative LCH (ND-LDH) is an uncommon late manifestation with progressive clinical and radiological features, substantial morbidity and an unpredictable course. Historically it was considered a paraneoplastic sequela for which treatment was largely ineffective. Multisystemic disease, central diabetes and orbital and/or skull base bone lesions are risk factors associated with the development of ND-LCH. Early diagnosis, guided by clinical, radiological, electrophysiological and neurocognitive evaluations, may enable timely treatment to halt or slow its progression. Recent identification of activating mutations in the mitogen-activated protein kinase (MAPK) pathway and the development of murine models have redefined ND-LCH as an active neuroinflammatory and neurodegenerative form of LCH, changing our understanding of its etiopathogenesis and identifying novel risk factors and targets for therapy.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 2","pages":"Article 504058"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reacciones adversas a la vacuna COVID-19 en población pediátrica en España","authors":"M. Ángeles Rivas Paterna ,&nbsp;Carla Pérez Ingidua ,&nbsp;Ana B. Rivas Paterna ,&nbsp;David Ortega Martínez ,&nbsp;Esther Aleo Luján ,&nbsp;Emilio Vargas Castrillón","doi":"10.1016/j.anpedi.2025.504088","DOIUrl":"10.1016/j.anpedi.2025.504088","url":null,"abstract":"<div><h3>Introduction</h3><div>In December 2021, Spain launched its COVID-19 vaccination campaign for children aged 5 to 11<!--> <!-->years. Although the Comirnaty® vaccine exhibited a favorable safety profile in premarketing trials, its rapid deployment and novel mRNA technology raised concerns among the public, leading to parental hesitancy. Real-world postmarketing data are limited but crucial for guiding clinical and public health policy decisions.</div></div><div><h3>Objective</h3><div>To assess the incidence and nature of adverse drug reactions (ADRs) following pediatric COVID-19 vaccination.</div></div><div><h3>Methods</h3><div>Prospective, observational and descriptive study conducted at a tertiary care hospital in Spain. The sample consisted of a total of 2126 children aged 5 to 11<!--> <!-->years. Data on ADRs were collected through telephone interviews, health record reviews and institutional registries. An expert committee evaluated each ADR using predefined criteria for causality and severity.</div></div><div><h3>Results</h3><div>Overall, 35.6% of participants reported at least one ADR, totaling 1437 reactions. Most were mild (99.5%) and resolved spontaneously. Only one case was classified as severe. The most common ADRs were injection site pain (57.1%), fever (11.1%) and headache (5.7%). There was no evidence of increased reactogenicity after the second dose. Of all ADRs, 65.1% were considered «definite» or «probable.»</div></div><div><h3>Conclusions</h3><div>The Comirnaty® vaccine maintains a favorable safety profile in children under real-world conditions, with predominantly mild, self-limiting reactions and minimal need for medical care.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 2","pages":"Article 504088"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio de la fuerza muscular mediante dinamometría de prensión manual en pacientes pediátricos con obesidad","authors":"Álvaro Martín Rivada ,&nbsp;Mercedes Murray Hurtado ,&nbsp;Elena Sánchez Camacho ,&nbsp;Yolanda Ramallo Fariña","doi":"10.1016/j.anpedi.2025.504103","DOIUrl":"10.1016/j.anpedi.2025.504103","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate muscle strength based on grip strength in children and adolescents with obesity and comparing it with reference values. To analyse the association with body composition findings obtained by bioelectrical impedance analysis as well as clinical and biochemical variables.</div></div><div><h3>Material and methods</h3><div>Retrospective observational cohort study in pediatric patients with obesity (6-16 years) followed up in an outpatient clinic in a tertiary care hospital. We collected data on physical activity and anthropometric, biochemical, sonographic, bioimpedance and dynamometry parameters.</div></div><div><h3>Results</h3><div>The sample included 125 patients (mean age, 12.06 years; 50.4% female; body mass index [BMI] <em>Z-</em>score, 3.87 [SD, 1.46]). Male participants were less severely obese and had a healthier body composition. Prepubertal patients were less physically active and had a higher fat mass (FM) percentage. The prevalence of metabolic comorbidities, such as hyperuricemia and insulin resistance, increased with the degree of obesity. Children with obesity had a mean muscle strength <em>Z-</em>score of +0.71 in the dominant hand, with differences based on sex and stage of pubertal development. We found dynapenia in 4.8%, with a greater prevalence in prepubertal children. Muscle strength was positively correlated to physical activity, fat-free mass and phase angle and negatively correlated to FM percentage. Fat-free mass was the strongest predictor of muscle strength.</div></div><div><h3>Conclusions</h3><div>In this sample of children with obesity, muscle strength was not decreased compared to the healthy reference population. Fat-free mass is the strongest predictor of muscle strength. The findings highlight the positive influence of physical activity and the amount of lean mass on strength in children and adolescents with obesity.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 2","pages":"Article 504103"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hernia muscular en miembros inferiores en un adolescente","authors":"Lidia Jiménez García,&nbsp;Javier Vicente Hernández,&nbsp;Jorge Andrés López-Torrijos Florez,&nbsp;Gabriela Valentina Cattabriga León","doi":"10.1016/j.anpedi.2025.504062","DOIUrl":"10.1016/j.anpedi.2025.504062","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 2","pages":"Article 504062"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Una arteria, dos circulaciones: retos diagnósticos del origen anómalo de una rama de la arteria pulmonar desde la aorta en neonatos","authors":"Laia Brunet-Garcia ,&nbsp;Flavio Zuccarino ,&nbsp;Juan Manuel Carretero Bellon","doi":"10.1016/j.anpedi.2025.504109","DOIUrl":"10.1016/j.anpedi.2025.504109","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"104 2","pages":"Article 504109"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}