Anales de pediatria最新文献

{"title":"Efectividad de la liraglutida en el tratamiento de la obesidad del adolescente","authors":"Mónica Ruiz Pons ,&nbsp;Marina Gutiérrez Vilar ,&nbsp;Celia García Zurita ,&nbsp;Manuel Enrique Fuentes Ferrer ,&nbsp;Alejandra Pérez Rodríguez ,&nbsp;Cristina Rosado Alonso","doi":"10.1016/j.anpedi.2025.503856","DOIUrl":"10.1016/j.anpedi.2025.503856","url":null,"abstract":"<div><h3>Introduction</h3><div>In the management of adolescent obesity, therapeutic options are limited and the outcomes of lifestyle modification (LM) alone are poor. Liraglutide, a GLP-1 receptor agonist, was the first drug approved in Spain for the management of obesity in adolescents aged 12 years or older.</div></div><div><h3>Objective</h3><div>To evaluate the effectiveness of liraglutide combined with LM in adolescents with obesity compared to LM alone.</div></div><div><h3>Methods</h3><div>Retrospective observational study of 62 adolescents (12-18 years) with a body mass index (BMI) at or above the 95th percentile. The intervention group (n<!--> <!-->=<!--> <!-->31) received liraglutide plus LM, while controls (n<!--> <!-->=<!--> <!-->31) matched for age, sex and treatment duration were managed with LM alone. We analyzed anthropometric, cardiovascular and body composition variables at three time points: baseline (T1), end of treatment (T2: mean, 6.9 months; SD, 4.7), and followup (T3: mean, 12.5 months; SD, 4.9 months). Comparisons between groups were performed using adjusted analysis of covariance model for changes in quantitative variables and logistic regression for BMI reductions of 5% or greater and 10% or greater.</div></div><div><h3>Results</h3><div>In the intervention group, the BMI <em>z</em> score decreased significantly (mean,<!--> <!-->−1.09 [SD, 0.24] vs<!--> <!-->−0.10 [SD, 0.25] in controls; <em>P</em> <!-->=<!--> <!-->.001). This corresponded to a BMI reduction of 5% or greater in 48.4% of patients and 10% or greater in 29%, compared to 3% and 1%, respectively, in the control group (<em>P</em> <!-->&lt;<!--> <!-->.05). The weight loss was maintained at six months of followup (T3). There was a significant reduction in insulin levels, the HOMA-IR, triglyceride levels, systolic hypertension, and the number of prediabetic patients.</div></div><div><h3>Conclusions</h3><div>Liraglutide combined with LM achieved a greater reduction in the BMI <em>z</em> score, waist/height ratio and cardiometabolic parameters compared to the LM alone. Further research is needed to assess its long-term effects and difficulties in its implementation.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 1","pages":"Article 503856"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recomendaciones para el uso seguro de los medicamentos de alto riesgo en pediatría","authors":"María José Otero ,&nbsp;Belén Rodríguez Marrodan ,&nbsp;Nuria Prieto Santos ,&nbsp;Enrique Villalobos Pinto ,&nbsp;Silvia Manrique Rodríguez ,&nbsp;Rebeca Padilla Peinado ,&nbsp;Cecilia M. Fernández-Llamazares ,&nbsp;Aurora Madrid Rodríguez ,&nbsp;en representación de la Asociación Española de Pediatría, Sociedad Española de Farmacia Hospitalaria y representantes de las comunidades autónomas","doi":"10.1016/j.anpedi.2025.503815","DOIUrl":"10.1016/j.anpedi.2025.503815","url":null,"abstract":"<div><h3>Objective</h3><div>The objectives of this consensus document were to establish a standardized list of high-risk medications for the pediatric population and to compile the recommended practices for their safe use with the aim of promoting the implementation of medication error prevention programs in health care centers.</div></div><div><h3>Method</h3><div>The Ministry of Health, the Spanish Institute for Safe Medication Practices, the Spanish Association of Pediatrics and the Spanish Society of Hospital Pharmacy and regional administration representatives participated in the project. The <em>Recommendations for the Safe Use of High-Risk Medications</em> was used as reference, and its contents adapted and expanded to address specific issues in the pediatric population based on the current evidence.</div></div><div><h3>Results</h3><div>The document provides a reference list of high-risk medicines in pediatric care. It recommends that health care centers, in addition to prioritizing interventions in relation to anticoagulants, insulins, opioids, neuromuscular blockers, IV potassium, oral methotrexate and cytostatic agents, also consider interventions for IV adrenergic agonists, aminoglycosides and vancomycin, drugs for moderate and minimal sedation, parenteral nutrition and IV paracetamol in pediatric patients. The document emphasizes the need to implement multiple safe practices at every stage of the medication use process, prioritizing those with the greatest effectiveness, and involving pediatricians, pharmacists and other healthcare professionals. It also highlights the importance of active involvement by patients and caregivers. Finally, it provides general guidelines common to all these medications, as well as specific practices for each prioritized pharmacological group or medication, which should be combined to enhance pediatric patient safety.</div></div><div><h3>Conclusion</h3><div>Developing programs to increase the safety of high-risk medications in pediatric patients is essential in order to reduce medication errors in this vulnerable population. The implementation of safe practices should be accompanied by continuous monitoring and periodic updates to guarantee effectiveness and strengthen the safety culture in health care centers.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 1","pages":"Article 503815"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergencias en las recomendaciones del Servicio de Información Toxicológica y 2 recursos de referencia para el manejo de intoxicaciones pediátricas","authors":"Carlos Miguel Angelats ,&nbsp;Inmaculada Vilaplana-Mora ,&nbsp;Paula Forner-García ,&nbsp;Alberto Lora-Martín ,&nbsp;Beatriz Azkunaga-Santibañez","doi":"10.1016/j.anpedi.2025.503841","DOIUrl":"10.1016/j.anpedi.2025.503841","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 1","pages":"Article 503841"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diferentes presentaciones clínicas de la hemosiderosis pulmonar idiopática","authors":"Javier Sainz García ,&nbsp;Sabina Bona Gazol ,&nbsp;Irene Sancho Marquina ,&nbsp;Javier Martínez Castillón ,&nbsp;Carlos Martín de Vicente","doi":"10.1016/j.anpedi.2025.503813","DOIUrl":"10.1016/j.anpedi.2025.503813","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 1","pages":"Article 503813"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ránulas recidivantes: ¿cuál es el diagnóstico?","authors":"Joana Baptista de Lima ,&nbsp;José Banquart Leitão ,&nbsp;Carla Zilhão ,&nbsp;Sérgio Alves","doi":"10.1016/j.anpedi.2025.503806","DOIUrl":"10.1016/j.anpedi.2025.503806","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 1","pages":"Article 503806"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio de un brote de impétigo por Staphylococcus aureus sensible a meticilina resistente a antibióticos tópicos","authors":"Irene López-Ramos ,&nbsp;Natalia Martín Iranzo ,&nbsp;María José Carrasco Villanueva ,&nbsp;Silvia García-Cobos ,&nbsp;Verónica Casquero-García","doi":"10.1016/j.anpedi.2025.503812","DOIUrl":"10.1016/j.anpedi.2025.503812","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"103 1","pages":"Article 503812"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uso de inhibidores del cotransportador de sodio-glucosa tipo 2 (iSGLT2) en tres adolescentes con insuficiencia cardiaca por miocardiopatía hipertrófica no obstructiva","authors":"Carlos Baena-Palomino,&nbsp;Ana Castellano-Martínez,&nbsp;Moisés Rodríguez-González","doi":"10.1016/j.anpedi.2025.503802","DOIUrl":"10.1016/j.anpedi.2025.503802","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503802"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intoxicaciones por errores de dosificación de fármacos en España","authors":"Johanna Ramírez-Romero,&nbsp;Claudia Cifuentes,&nbsp;Beatriz Azkunaga,&nbsp;Santiago Mintegi,&nbsp;Grupo de Trabajo de Intoxicaciones de la Sociedad Española de Urgencias Pediátricas","doi":"10.1016/j.anpedi.2025.503888","DOIUrl":"10.1016/j.anpedi.2025.503888","url":null,"abstract":"<div><h3>Introduction</h3><div>Dosage errors are a common mechanism of poisoning in childhood. The aim of this study was to analyze the characteristics and management of poisoning secondary to dosage errors in pediatric emergency departments (EDs) in Spain.</div></div><div><h3>Methodology</h3><div>Study based on a prospective register of poisonings documented in 58 Spanish EDs participating in the Toxicology Surveillance Observatory of the Spanish Society of Paediatric Emergency Medicine (SEUP) between 2008 and 2023.</div></div><div><h3>Results</h3><div>The register documented 3429 episodes of exposure to toxic substances, of which 289 (8.4%) were medication dosing errors, with a vast majority occurring in the home setting. Seventy-eight (27.0%) occurred in children aged less than 1 year (amounting to 37.9% of poisonings in this age group and 85.0% of poisonings in infants aged less than 3 months). Overall, the most commonly involved medications were antipyretics/analgesics (35.6%, mainly paracetamol), with significant differences depending on patient age. Forty-nine of the patients (17.0%) were symptomatic, 118 (41.8%) underwent additional testing, 83 (28.7%) received treatment, and 115 (39.8%) were admitted to the ED observation unit or to hospital. All had favorable outcomes.</div></div><div><h3>Conclusions</h3><div>Medication dosing errors constitute an important mechanism of poisoning, especially in children aged less than 1 year, leading to a significant number of interventions in EDs. Preventive measures aimed at educating families to avoid these poisonings should be considered.</div></div>","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503888"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sospecha de maltrato en urgencias: adecuación del tipo de consultas","authors":"Gerard Martínez-Segura ,&nbsp;Silvia Rodríguez Ferradas ,&nbsp;Cristina Macias Borras ,&nbsp;Victoria Trenchs Sainz de la Maza ,&nbsp;Ana Isabel Curcoy Barcenilla","doi":"10.1016/j.anpedi.2025.503808","DOIUrl":"10.1016/j.anpedi.2025.503808","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503808"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invaginación ileocecal secundaria a páncreas heterotópico","authors":"Antonio Palacios Prados ,&nbsp;Rocío Vizcaíno Pérez ,&nbsp;Ana López Prieto ,&nbsp;Madai Curbelo Rodríguez","doi":"10.1016/j.anpedi.2025.503805","DOIUrl":"10.1016/j.anpedi.2025.503805","url":null,"abstract":"","PeriodicalId":7783,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503805"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}