{"title":"[Stimulation of cell division by Ehrlich carcinoma cell surface antibodies].","authors":"M Segarra, M Alfonso, J L Subiza, J Coll","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Some Ehrlich ascites cancer cells of the mouse show nuclear division as a response to cell surface signals. Antibodies to plasma membrane produce a membrane molecular redistribution, but only 25 per 100 proceed to nuclear division. This division is not associated to DNA synthesis, showing that the effect is produced in G0 phase cells originated from G2 phase cells.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"205-13"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17502313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Hyperthermic radiosensitization of a strain of hematopoietic cells from mouse bone marrow, CFU-S].","authors":"J G Maganto, J A Bueren, M Nieto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Employing the technique of the spleen colony-formation the authors investigated the survival curve of the mouse hematopoietic stem cells resulting from increasing doses of X rays (D0 = 0.79 Gy and n = 1.59). The effect of the hyperthermic radiosensitization was measured by comparison with the effects observed in the irradiated CFU-S population previously exposed to hyperthermia. The treatment lasted 60 minutes at 42 degrees C and 12 minutes at 44 degrees C considering the thermal inactivation kinetics in such a way that the survival rate were the same in both cases. The results obtained for D0 = 0.52 Gy and n = 1.0 during 60 minutes at 42 degrees C, and for D00 = 0.61 Gy and n = 1.0 during 12 minutes at 44 degrees C showed that: 1) a synergic effect upon the CFU-S population is produced by the combination of hyperthermia and radiation, 2) for the same survival rate, the radiosensitivity increase produced after the thermic treatment a 42 degrees C and 44 degrees C is of the same order, and 3) such treatments, in both cases, produced a loss of a radioinduced sublethal damage accumulation.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17601609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Statistical research and epidemiology in oncology].","authors":"A Zubiri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The author indicates briefly the results from the statistical and epidemiological studies of cancer in Spain. Between 1903 and 1978 cancer mortality passed from 39.00 per 100.000 to 152.4 per 100.000, and sex distribution from 43% men and 56% women to 57% men and 42% women. Cancer represented 1.52% of the total mortality in 1903 and 18.95% in 1978. The largest incidence of cancer diseases is observed for ages between 45 and 75 years in men, with a maximum at 60, and between 40 and 71 years in women, with a maximum at 55. In all Spanish regions the most frequent mortal localizations are lung cancer among men and mammary cancer among women. The second place corresponds to stomach cancer in both sexes. Other important causes of death are the tumors of the prostate, liver, urinary bladder, larynx, colon and rectum, hematopoietic system, and esophagus in man, and the neoplasms of liver, lung, body of the uterus, colon and rectum, hematopoietic system and gallbladder and bile ducts in women. It is surprising the high frequency of primitive liver cancer in some regions, reaching an incidence of 4.39% in Tarragona and 6.07% in Zaragoza.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"379-91"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17601746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Chemical radiosensitizers in radiotherapy].","authors":"M C López Zumel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 1","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Nieto García, E Sternfeld Mata, M J Bengoechea, J L Almazán, R M Corot, G Maganto Fernández
{"title":"[Circadian variations of Ns and Nm values in the intestinal epithelium of the fish C. auratus and of mice, and its effect on radiosensitivity].","authors":"M Nieto García, E Sternfeld Mata, M J Bengoechea, J L Almazán, R M Corot, G Maganto Fernández","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studying the small bowel mucosa crypts of the mouse, the authors indicate a method to calculate cell production that does not need to know the mitotic proliferation and labeling indexes, employing instead the values for NS and Nm, or size of S and M phases. While NS and Nm vary during the day, TS and Tm remain practically constant, so that cell production is related to the values of NS and Nm. Calculations starting from NS and Nm give per cent cells h-1.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"215-26"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Sanchis-Belenguer, L Cuadrado-Méndez, A B Ortiz Muńoz
{"title":"[Possible interactions between Toxoplasma gondii infection and the presence of carcinomas of female genitalia and the breast].","authors":"R Sanchis-Belenguer, L Cuadrado-Méndez, A B Ortiz Muńoz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors made a serologic study for the existence of antibodies to Toxoplasma gondii in women with genital tract and breast cancer. Antibodies to the parasite were found in 93.7 per 100 of the cases; 20.46 per 100 of the patients showed titers of 1:400 or higher, probably due to active toxoplasmosis. Considering the group of cancer patients with lymph node metastases, antibodies to Toxoplasma gondii were found in 97.33 per 100 of them.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"247-55"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17603290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Liver regeneration in mice bearing a transplanted hepatoma.","authors":"A F Badran, F R Moreno, J M Echave Llanos","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hepatocyte mitotic index curve in hepatectomized hepatoma-bearing mice, rises earlier, has a greater amplitude and is less synchronized than that of normal hepatectomized mice. This indicates a stimulation (more mitosis in a shorter time period) produced by the presence of the tumors. The sinusoid litoral cells mitotic index curve in hepatectomized hepatoma-bearing mice appears earlier and is much less synchronized than that of normal hepatectomized mice. Nevertheless both curves have the same amplitude for the whole sampling period and the early stimulation is quickly compensated by lower values (apparent inhibition) appearing in the resting (light) period.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 4","pages":"591-600"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17627994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Predictive value of the determination of receptors in carcinoma of the prostate].","authors":"J M Castellanos, A Galán, M A Calvo, S Schwartz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The assay of hormone receptors in neoplastic tissues recognizes their sensitivity or autonomy with regard to the hormonal action. The hormone dependency of the activity of neoplastic tissues can be employed to select the cases having the highest probability to be benefited by the treatment with anti-hormones, castration or hypophysectomy, as in breast and prostatic cancers. Examining the case for prostatic cancer, the authors indicate that there is a good correlation between the predictive assay and the clinical evolution of the treated prostatic carcinoma employing the determination of cell receptors for 5-alpha-dihydrotestosterone (DHT) by exchange at 15 degrees C with the synthetic steroid methyltrienolone. The electrophoretic determination of binding of DHT to cell receptor a 4 degree C is a much less efficacious procedure.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"265-77"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17152729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Ruibal, R Comet, F J Alvarez Moro, A Lafuerza, F M Domenech-Torné, L Salvador
{"title":"[Pregnancy-specific beta-1 glycoprotein (SP1) as a marker for tumors with or without trophoblastic character].","authors":"A Ruibal, R Comet, F J Alvarez Moro, A Lafuerza, F M Domenech-Torné, L Salvador","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pregnancy specific beta-1-glycoprotein (SP1) was measured by radioimmunoassay in 854 persons (control group 103, non-tumoral diseases 212, germinal tumors 30, and non-germinal tumors 509). Amounts higher than 2.5 ng/ml (upper normal limit) were observed in 35 cases with non tumoral diseases (specially chronic liver diseases), 97 of the non-germinal tumors (specially mammary, respiratory and digestive tumors), and 10 of the germinal tumors (pure and mixed choriocarcinomas, and embryonic carcinoma with yolk sac component). SP1 rarely is higher than 5 ng/ml in non-tumoral diseases and non-germinal tumors, while it is higher than 5 ng/ml in germinal tumors. SP1 is a good marker for trophoblastic neoplasms and shows a correlation with HCG-beta.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 3","pages":"427-34"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17167705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M de la Fuente, E Aranda, I Molina, P Sánchez Guijo, J Peña
{"title":"[Serum factors present in patients with carcinoma of the bladder: effect on cell-mediated immunity].","authors":"M de la Fuente, E Aranda, I Molina, P Sánchez Guijo, J Peña","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of the sera from patients with bladder carcinoma upon the blastic transformation of T lymphocytes and the antibody-dependent K cell cytotoxicity is studied. The sera from cancer patients inhibits both the T cell blastic transformation and the antibody-dependent K cell cytotoxicity, the effect is attained by a different mechanism, and the degree of inhibition correlates with the histologic malignancy and infiltration.</p>","PeriodicalId":77791,"journal":{"name":"Revista espanola de oncologia","volume":"31 2","pages":"257-64"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17397172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}