{"title":"Effect of arachidonic acid metabolites on thymocyte proliferation","authors":"S. Delebassée, N. Gualde","doi":"10.1016/0769-2625(88)90065-7","DOIUrl":"10.1016/0769-2625(88)90065-7","url":null,"abstract":"<div><p>The influences of prostaglandin E2 (PGE2), 15-hydroxyeicosatetraenoic acid (15-HETE) and leukotrienes (LT) on the proliferative response of mature (PNA<sup>−</sup>) and immature (PNA<sup>+</sup>) mouse thymocytes was investigated. Both PNA<sup>+</sup> and PNA<sup>−</sup> thymocytes proliferated when cultured with concanavalin A plus interleukin-2. PGE2 in concentrations of 10<sup>−6</sup> to 10<sup>−9</sup> M caused significant inhibition of proliferation of both PNA<sup>+</sup> and PNA<sup>−</sup> thymocytes in these cultures. In contrast, the lipoxygenase products 15-HETE, LTB4, LTC4 and LTD4 caused marked increases in proliferation of PNA<sup>+</sup> thymocytes while having no effect on PNA<sup>−</sup> cells. Therefore, the effect of leukotrienes on thymocyte proliferation depends upon the level of cell maturation and mainly affects immature PNA<sup>+</sup> thymocytes.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 383-399"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90065-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14269779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of the humoral immune response by polyspecific natural autoantibodies","authors":"W Mahana, B Guilbert, S Avrameas","doi":"10.1016/0769-2625(88)90063-3","DOIUrl":"10.1016/0769-2625(88)90063-3","url":null,"abstract":"<div><p>Two different BALB/c IgMk polyspecific monoclonal natural autoantibodies E7 and D23 were administered to neonatal BALB/c mice. When adults, these mice were immunized and challenged with calf myosin, BALB/c actin, human transferrin, calf thymus DNA or TNP-coupled bovine serum albumin (TNP/BSA), in complete Freund's adjuvant. The levels of serum antibody were evaluated by enzyme immunoassay.</p><p>No differences in anti-actin, anti-transferrin and anti-DNA antibody titres were noted between control and antibody-treated mice. However, anti-myosin antibody titres significantly increased in mice treated with either the E7 or D23 antibody, and anti-TNP antibody titres significantly decreased in mice treated with E7 but not with D23. These differences persisted after antigenic challenge and involved only the IgG response of treated mice. These results suggest that polyspecific natural autoantibodies may be involved in the regulation of the humoral immune response.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 349-360"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90063-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14297050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Activated lymphocyte cytotoxicity: concepts and confusions.","authors":"J A Wolf, E A Grimm","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"435-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protection against fatal Klebsiella pneumoniae sepsis in the squirrel monkey Saimiri sciureus after immunization with a capsular polysaccharide vaccine","authors":"J.M. Postal, J. Gysin, Y. Crenn","doi":"10.1016/0769-2625(88)90066-9","DOIUrl":"10.1016/0769-2625(88)90066-9","url":null,"abstract":"<div><p>An anti-<em>Klebsiella pneumoniae</em> K5a capsular polysaccharide vaccine was evaluated as a preventive approach for protecting squirrel monkeys, <em>Saimiri sciureus</em>, in our breeding colony. Based on an 8-month vaccination schedule over a period of more than two years, this vaccine, regardless of the animal's age, resulted in a reduction of this particular bacterial infection and its generally associated fatal outcome. IgG antibody responses in naive and vaccinated animals were monitored over an extended period by radioimmunoassay and showed a marked increase above the initial naturally occurring antibody titres. No side-effects were observed after repeated vaccination of several hundred animals during a two-year period.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 401-407"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90066-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"1er congrès mondial de l'association mondiale des vétérinaires microbiologistes, immunologistes et spécialistes des maladies infectieuses","authors":"","doi":"10.1016/0769-2625(88)90084-0","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90084-0","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Page 2"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90084-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136553354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Programme communautaire d'éducation et de formation en matière de technologie: Cultures de cellules animales principles et applications","authors":"","doi":"10.1016/0769-2625(88)90086-4","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90086-4","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Page 2"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90086-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136553343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Les progrés de la mise au point et de l'utilisation des antiviraux et de l'interféron","authors":"","doi":"10.1016/0769-2625(88)90079-7","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90079-7","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Page 481"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90079-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136553342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}