Annales de l'Institut Pasteur. Immunology最新文献

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Characterization and functions of natural killer cells 自然杀伤细胞的特性和功能
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90070-0
J.R. Ortaldo, B.J. Mathieson, R.H. Wiltrout
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引用次数: 9
Effect of arachidonic acid metabolites on thymocyte proliferation 花生四烯酸代谢物对胸腺细胞增殖的影响
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90065-7
S. Delebassée, N. Gualde
{"title":"Effect of arachidonic acid metabolites on thymocyte proliferation","authors":"S. Delebassée,&nbsp;N. Gualde","doi":"10.1016/0769-2625(88)90065-7","DOIUrl":"10.1016/0769-2625(88)90065-7","url":null,"abstract":"<div><p>The influences of prostaglandin E2 (PGE2), 15-hydroxyeicosatetraenoic acid (15-HETE) and leukotrienes (LT) on the proliferative response of mature (PNA<sup>−</sup>) and immature (PNA<sup>+</sup>) mouse thymocytes was investigated. Both PNA<sup>+</sup> and PNA<sup>−</sup> thymocytes proliferated when cultured with concanavalin A plus interleukin-2. PGE2 in concentrations of 10<sup>−6</sup> to 10<sup>−9</sup> M caused significant inhibition of proliferation of both PNA<sup>+</sup> and PNA<sup>−</sup> thymocytes in these cultures. In contrast, the lipoxygenase products 15-HETE, LTB4, LTC4 and LTD4 caused marked increases in proliferation of PNA<sup>+</sup> thymocytes while having no effect on PNA<sup>−</sup> cells. Therefore, the effect of leukotrienes on thymocyte proliferation depends upon the level of cell maturation and mainly affects immature PNA<sup>+</sup> thymocytes.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 383-399"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90065-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14269779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Regulation of the humoral immune response by polyspecific natural autoantibodies 多特异性天然自身抗体对体液免疫反应的调节
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90063-3
W Mahana, B Guilbert, S Avrameas
{"title":"Regulation of the humoral immune response by polyspecific natural autoantibodies","authors":"W Mahana,&nbsp;B Guilbert,&nbsp;S Avrameas","doi":"10.1016/0769-2625(88)90063-3","DOIUrl":"10.1016/0769-2625(88)90063-3","url":null,"abstract":"<div><p>Two different BALB/c IgMk polyspecific monoclonal natural autoantibodies E7 and D23 were administered to neonatal BALB/c mice. When adults, these mice were immunized and challenged with calf myosin, BALB/c actin, human transferrin, calf thymus DNA or TNP-coupled bovine serum albumin (TNP/BSA), in complete Freund's adjuvant. The levels of serum antibody were evaluated by enzyme immunoassay.</p><p>No differences in anti-actin, anti-transferrin and anti-DNA antibody titres were noted between control and antibody-treated mice. However, anti-myosin antibody titres significantly increased in mice treated with either the E7 or D23 antibody, and anti-TNP antibody titres significantly decreased in mice treated with E7 but not with D23. These differences persisted after antigenic challenge and involved only the IgG response of treated mice. These results suggest that polyspecific natural autoantibodies may be involved in the regulation of the humoral immune response.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 349-360"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90063-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14297050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Prix ⤤IgA secrétoires↫ ⤤价格IgA secrétoires↫
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90089-X
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引用次数: 0
Are cognitive receptors involved in ⪡non-specific⪢ MHC-unrestricted lytic activity? 认知受体是否参与⪡非特异性⪢mhc不受限制的裂解活性?
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90073-6
R.L.H. Bolhuis, E. Braakman, R.J. Van de Griend
{"title":"Are cognitive receptors involved in ⪡non-specific⪢ MHC-unrestricted lytic activity?","authors":"R.L.H. Bolhuis,&nbsp;E. Braakman,&nbsp;R.J. Van de Griend","doi":"10.1016/0769-2625(88)90073-6","DOIUrl":"10.1016/0769-2625(88)90073-6","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 460-465"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90073-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13606837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Activated lymphocyte cytotoxicity: concepts and confusions. 活化淋巴细胞毒性:概念和混淆。
J A Wolf, E A Grimm
{"title":"Activated lymphocyte cytotoxicity: concepts and confusions.","authors":"J A Wolf,&nbsp;E A Grimm","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"435-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protection against fatal Klebsiella pneumoniae sepsis in the squirrel monkey Saimiri sciureus after immunization with a capsular polysaccharide vaccine 荚膜多糖疫苗免疫松鼠猴对致命性肺炎克雷伯菌败血症的保护作用
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90066-9
J.M. Postal, J. Gysin, Y. Crenn
{"title":"Protection against fatal Klebsiella pneumoniae sepsis in the squirrel monkey Saimiri sciureus after immunization with a capsular polysaccharide vaccine","authors":"J.M. Postal,&nbsp;J. Gysin,&nbsp;Y. Crenn","doi":"10.1016/0769-2625(88)90066-9","DOIUrl":"10.1016/0769-2625(88)90066-9","url":null,"abstract":"<div><p>An anti-<em>Klebsiella pneumoniae</em> K5a capsular polysaccharide vaccine was evaluated as a preventive approach for protecting squirrel monkeys, <em>Saimiri sciureus</em>, in our breeding colony. Based on an 8-month vaccination schedule over a period of more than two years, this vaccine, regardless of the animal's age, resulted in a reduction of this particular bacterial infection and its generally associated fatal outcome. IgG antibody responses in naive and vaccinated animals were monitored over an extended period by radioimmunoassay and showed a marked increase above the initial naturally occurring antibody titres. No side-effects were observed after repeated vaccination of several hundred animals during a two-year period.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 401-407"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90066-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Mechanism of K562-induced human natural killer cell inactivation using highly enriched effector cells isolated via a new single-step sheep erythrocyte rosette assay k562诱导人自然杀伤细胞失活的机制是利用一种新的单步绵羊红细胞玫瑰花结法分离的高富集效应细胞
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90064-5
S.I. Abrams , Z. Brahmi
{"title":"Mechanism of K562-induced human natural killer cell inactivation using highly enriched effector cells isolated via a new single-step sheep erythrocyte rosette assay","authors":"S.I. Abrams ,&nbsp;Z. Brahmi","doi":"10.1016/0769-2625(88)90064-5","DOIUrl":"10.1016/0769-2625(88)90064-5","url":null,"abstract":"<div><p>In this study, we used preparations highly enriched in human natural killer (NK) cells to further characterize the mechanism of taget-cell-induced NK inactivation. Highly enriched populations of NK cells were obtained by a newly developed, single-step sheep red blood cell rosette assay. This method, which did not require any incubation steps to facilitate cell contact, permitted a rapid and efficient isolation if NK cells from adherent-cell-depleted peripheral blood lymphocytes. The non-rosetted cells had high NK activity, possessed large granular lymphocyte (LGL) morphology and expressed the NK-associated antigens Leu-11a, Leu-7, OKM1 and NKH-1. In contrast, the rosetted cells had significantly lower NK activity, possessed typical lymphocyte morphology and expressed the T-cell-associated marker OKT3.</p><p>Next, we examined the ability of these NK-enriched effector cells (EC<sub>c</sub>) to become inactivated by K562. Functional studies revealed that EC<sub>c</sub> lost <span><math><mtext>≥95%</mtext></math></span> of their lytic capacity following incubation with K562 at a ratio of 2/1 for 6 h. However, to achieve this level of inactivation, it was essential that the cell suspension be gently mixed every 90–120 min. Inactivation was not due to cell death and did not reflect changes in the percentages of cells bearing the Leu-11a, Leu-7, OKM1 and NKH-1 antigens, but was associated with an increase in cell surface concentration of OKM1. As judged by gross morphology, the percentages of LGL in EC<sub>c</sub> before and after treatment with K562 were essentially the same. Finally, K562-treated EC<sub>c</sub> also lost their ability to mediate antibody-dependent cellular cytotoxicity (ADCC), suggesting that both NK-cell-mediated cytotoxicity and ADCC may involve a common lytic pathway.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Pages 361-381"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90064-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14297051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Culture de cellules animales. Méthodologies applications 动物细胞培养。方法应用
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90077-3
{"title":"Culture de cellules animales. Méthodologies applications","authors":"","doi":"10.1016/0769-2625(88)90077-3","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90077-3","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Page 480"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90077-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136553341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Les progrés de la mise au point et de l'utilisation des antiviraux et de l'interféron 抗病毒药物和干扰素的开发和使用进展
Annales de l'Institut Pasteur. Immunology Pub Date : 1988-07-01 DOI: 10.1016/0769-2625(88)90079-7
{"title":"Les progrés de la mise au point et de l'utilisation des antiviraux et de l'interféron","authors":"","doi":"10.1016/0769-2625(88)90079-7","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90079-7","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 4","pages":"Page 481"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90079-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136553342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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