Annales de l'Institut Pasteur. Immunology最新文献

Idiotypes, tailors and networks 独特类型，裁缝和网络

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90049-9

A. Coutinho, A. Grandien, J. Faro-Rivas, T.A. Mota-Santos

引用次数: 8

Idiotypic analyses of anti-DNA antibodies in systemic lupus and monoclonal gammopathy 系统性狼疮和单克隆γ病抗dna抗体的独特型分析

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90053-0

A. Davidson, A. Livneh, A. Manheimer-Lory, R. Shefner, J.B. Katz, K.L. Sewell, B. Diamond

引用次数: 2

Genetics of the induction of antigen-specific immunity in anti-idiotype-treated mice and derivation of monoclonal Ab3 antibodies 抗独特型处理小鼠抗原特异性免疫诱导的遗传学及单克隆Ab3抗体的衍生

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90057-8

S.L. Epstein , S.O. Sharrow , D.H. Sachs

{"title":"Genetics of the induction of antigen-specific immunity in anti-idiotype-treated mice and derivation of monoclonal Ab3 antibodies","authors":"S.L. Epstein , S.O. Sharrow , D.H. Sachs","doi":"10.1016/0769-2625(88)90057-8","DOIUrl":"10.1016/0769-2625(88)90057-8","url":null,"abstract":"<div><p>Antiidiotypic antibodies can be used as a means other than antigen of clone-specific intervention in the immune system. In a number of cases, antiidiotypic antibodies induce potent, antigen-specific responses without exposure of the recipient animals to antigen, and a better understanding of such responses will aid in the application of idiotype manipulation to both immunological and practical problems. The Ia.7 system expresses a major, cross-reactive idiotype on antibodies to an epitope of the mouse I-E antigen. Here, we examine genetic control of the I-E-specific response to anti-idiotype in this model system. Results demonstrate that both heavy chain allotype-linked and non-allotype-linked loci contribute to the control of this response. In addition, monoclonal antibodies representing the non-antigen-specific portion of the Ab3 response were derived. Two idiotype-positive clones were demonstrated to be of IgM isotype, contrasting with previous data showing that the serum Ab3 response is predominantly IgG1.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 6","pages":"Pages 689-700"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90057-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14392799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of in vivo treatment with anti-idiotype on the immune response to anti-human chorionic gonadotropin 体内抗独特型治疗对抗人绒毛膜促性腺激素免疫应答的影响

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90058-X

A. Quadri , S.K. Gupta , P.-A. Cazenave , G.P. Talwar

引用次数: 0

A structural basis for human cross-reacting idiotypes 人类交叉反应独特型的结构基础

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90054-2

R. Makar, I. Sanz , J.W. Thomas , J.D. Capra

引用次数: 10

Table des auteurs 作者表

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90059-1

引用次数: 0

Self-immunity and the autoimmune network: A molecular perspective to ontogeny and regulation of the immune system 自身免疫和自身免疫网络:免疫系统个体发生和调节的分子视角

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90051-7

M. Zanetti

引用次数: 7

Index des livres reçus 收到书籍索引

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90062-1

引用次数: 0

Molecular and immunologic analyses of a functional i internal image formed by an anti-receptor antibody 抗受体抗体形成的功能性i内像的分子和免疫学分析

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90055-4

W.V. Williams , H.R. Guy , J.A. Cohen , D.B. Weiner , M.I. Greene

引用次数: 4

The start of an autoimmune disease: idiotypic network during early progression of myasthenia gravis 自身免疫性疾病的开始:重症肌无力早期进展中的独特型网络

Annales de l'Institut Pasteur. Immunology Pub Date : 1988-11-01 DOI: 10.1016/0769-2625(88)90052-9

A.K. Lefvert

{"title":"The start of an autoimmune disease: idiotypic network during early progression of myasthenia gravis","authors":"A.K. Lefvert","doi":"10.1016/0769-2625(88)90052-9","DOIUrl":"10.1016/0769-2625(88)90052-9","url":null,"abstract":"<div><p>Anti-acetylcholine-receptor antibodies of IgG and IgM classes and antiidiotypic a antibodies were determined in patients with myasthenia gravis at various times after the start of the disease. Patients with a disease duration of less than one year had a higher prevalence of antiidiotypic antibodies (31/32) than patients who had had the disease for more than 5 years (49/79), and the concentration of antiidiotypic antibodies was also higher in patients with early disease (p < 0.005). The concentrations of antiidiotypic antibodies decreased during progression of the disease concomittant with an increase in IgG anti-receptor antibodies. A change from IgM to IgG anti-receptor antibody production was also found. In two patients, who developed myasthenia after bone-marrow grafting and who were followed before start of disease, antiidiotypic antibodies appeared before anti-receptor antibodies and before symptoms of myasthenia were present.</p><p>The high prevalence and concentration of antiidiotypic antibodies in early disease indicate that development and expression of antiidiotypic antibodies are important in early myasthenia gravis.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 6","pages":"Pages 633-643"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90052-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14392794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13