{"title":"Endogenous and exogenous TNF therapy (EET therapy): conceptual and experimental grounds.","authors":"D Mizuno, G I Soma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"282-5"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Natural lymphocyte activation in postnatal development of germ-free and conventional mice","authors":"L. Forni , C. Heusser , A. Coutinho","doi":"10.1016/0769-2625(88)90138-9","DOIUrl":"10.1016/0769-2625(88)90138-9","url":null,"abstract":"<div><p>The degree of activation of B and T cells in the developing spleen during postnatal life was studied in germ-free (GF) and specific-pathogen-free (SPF) BALB/c mice of the same breeding stock. We found that the progeny of GF mothers up to 3 weeks of age contain higher numbers of activated splenic cells than baby SPF mice, thus suggesting qualitative differences in maternally-derived antibodies. This «advantageå of GF mice is also indicated by anticipated maturation of the splenic lymphoid compartment and is reflected in higher frequencies of B and T lymphocytes in adult life.</p><p>In both kinds of mice, the frequency of activated cells is very high at birth and then declines, reaching minimal valyes by 4 weeks of age. Later, activated B cells increase sharply in SPF mice, suggesting polyclonal activation mediated by bacterial products. Results are discussed on the basis of the mutual influences between B and T cells in the establishment of a functional network.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"Pages 245-256"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90138-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14391528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"23rd forum in immunology. Non-specific lymphoid effectors: characterization and activation mechanisms.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"433-78"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14297048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In vivo anti-tumour activity of recombinant human tumour necrosis factor-alpha against Meth-A sarcoma requires L3T4-positive T cells","authors":"M.A. Palladino, I.S. Figari","doi":"10.1016/0769-2625(88)90144-4","DOIUrl":"10.1016/0769-2625(88)90144-4","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"Pages 299-301"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90144-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14038914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Jothy , A. Abadie , P. Froussard , M. Duphot , J. Thèze
{"title":"Nuclear location of the p55 subunit of the IL-2 receptor following activation of the HT-2 T helper cell line","authors":"S. Jothy , A. Abadie , P. Froussard , M. Duphot , J. Thèze","doi":"10.1016/0769-2625(88)90137-7","DOIUrl":"10.1016/0769-2625(88)90137-7","url":null,"abstract":"<div><p>After mitogenic or antigenic stimulation, T cells express interleukin-2 receptors (IL-2R). The mechanism and control of signal transduction following binding of IL-2 to IL-2R are poorly understood.</p><p>Using two rat monoclonal antibodies (5A2 and 7D4) specific for two distinct epitopes of the p55 subunit of mouse IL-2R, we have studied the cellular localization of this molecule by immunocytochemistry during the IL-2-mediated activation of mouse T helper cell clone HT-2. During the activation cycle, nuclear staining for the p55 subunit of the IL-2 receptor was transiently observed. It is suggested that the transient nuclear location of the IL-2R may play a critical role in the control of T-cell activation, proliferation and/or differentiation.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"Pages 237-244"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90137-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14105546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TNF as an activator of vascular endothelium","authors":"J.S. Pober","doi":"10.1016/0769-2625(88)90149-3","DOIUrl":"10.1016/0769-2625(88)90149-3","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"Pages 317-323"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90149-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Wallach, H. Holtmann, D. Aderka, T. Hahn, H. Engelmann, Y. Nophar
{"title":"Sensitizing effects and mechanisms of desensitization in regulation of the in vivo response to TNF","authors":"D. Wallach, H. Holtmann, D. Aderka, T. Hahn, H. Engelmann, Y. Nophar","doi":"10.1016/0769-2625(88)90150-X","DOIUrl":"10.1016/0769-2625(88)90150-X","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"Pages 323-327"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90150-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The pathophysiologic role of cachectin/TNF in septic shock and cachexia","authors":"K.J. Tracey, S.F. Lowry , A. Cerami","doi":"10.1016/0769-2625(88)90148-1","DOIUrl":"10.1016/0769-2625(88)90148-1","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 3","pages":"Pages 311-317"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90148-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}