{"title":"Induction of antibodies to pseudorabies virus by immunization with antiidiotypic antibodies","authors":"M.F. Gurish , T. Ben-Porat , A. Nisonoff","doi":"10.1016/0769-2625(88)90056-6","DOIUrl":"10.1016/0769-2625(88)90056-6","url":null,"abstract":"<div><p>We have induced the expression of high titres of antibodies to pseudorabies virus (PRV) by immunization of A/J mice with polyclonal antiidiotypic antibodies directed against each of 2 BALB/c monoclonal, neutralizing anti-PRV antibodies. The anti-PRV antibodies induced by one of the antiidiotypic antibody preparations had an affinity for PRV comparable to that of the original monoclonal antibody. Mice immunized with antiidiotypic antibodies were protected to a significant degree against viral infection but the degree of protection was lower than that conferred by passive transfer of monoclonal neutralizing antibody or by immunization with attenuated virus.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 6","pages":"Pages 677-687"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90056-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13986999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Urbain, F. Andris, M. Brait, C. Demeur, D. De Wit, O. Leo, J. Marvel, F. Mertens, M. Moser, M. Slaoui, J. Tassignon, G. Urbain-Vansanten, M. Wikler, F. Willems, C. Wuilmart
{"title":"Some aspects of idiotypic networks: Self/non-self discrimination, selection of available repertoires and broken mirrors","authors":"J. Urbain, F. Andris, M. Brait, C. Demeur, D. De Wit, O. Leo, J. Marvel, F. Mertens, M. Moser, M. Slaoui, J. Tassignon, G. Urbain-Vansanten, M. Wikler, F. Willems, C. Wuilmart","doi":"10.1016/0769-2625(88)90050-5","DOIUrl":"10.1016/0769-2625(88)90050-5","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 6","pages":"Pages 609-618"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90050-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14392791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Table des mots-clés","authors":"","doi":"10.1016/0769-2625(88)90060-8","DOIUrl":"10.1016/0769-2625(88)90060-8","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 6","pages":"Pages 715-720"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90060-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77079274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histamine-induced regulation of IL-2 synthesis in man: Characterization of two pathways of inhibition","authors":"R. Huchet, D. Grandjon","doi":"10.1016/0769-2625(88)90094-3","DOIUrl":"10.1016/0769-2625(88)90094-3","url":null,"abstract":"<div><p>Histamine at molar concentrations ranging from 10<sup>−5</sup> to 10<sup>−7</sup> exerted an inhibitory effect upon IL-2 synthesis by peripheral blood mononuclear cells in normal man; two pathways of inhibition are described. The first pathway was found to alter the T4 lymphocytes which, in the system used in this study, synthesized nearly 90 % of the total IL-2 production and had no suppressive activity. This suggests that histamine can act at the level of IL-2-producing cells. The second pathway of inhibition was related to induction of suppressor cells. Peripheral blood lymphocytes pre-incubated for 1 h with histamine 10<sup>−5</sup>–10<sup>−7</sup> M inhibited the IL-2 synthesis of normal autologous lymphocytes in a co-culture system. This activity was radio-resistant (1200 r) and mediated by T8 lymphocytes. These two pathways of inhibition were mediated by the specific interaction of histamine with H1- and H2-receptor-bearing mononuclear cells.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 5","pages":"Pages 485-499"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90094-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14041580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbiologie des poecilothermes","authors":"","doi":"10.1016/0769-2625(88)90125-0","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90125-0","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 5","pages":"Page 4"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90125-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92084538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PRIX du GREMI","authors":"","doi":"10.1016/0769-2625(88)90120-1","DOIUrl":"https://doi.org/10.1016/0769-2625(88)90120-1","url":null,"abstract":"","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":"139 5","pages":"Page 3"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90120-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92085110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}