{"title":"Effect of arachidonic acid metabolites on thymocyte proliferation","authors":"S. Delebassée, N. Gualde","doi":"10.1016/0769-2625(88)90065-7","DOIUrl":null,"url":null,"abstract":"<div><p>The influences of prostaglandin E2 (PGE2), 15-hydroxyeicosatetraenoic acid (15-HETE) and leukotrienes (LT) on the proliferative response of mature (PNA<sup>−</sup>) and immature (PNA<sup>+</sup>) mouse thymocytes was investigated. Both PNA<sup>+</sup> and PNA<sup>−</sup> thymocytes proliferated when cultured with concanavalin A plus interleukin-2. PGE2 in concentrations of 10<sup>−6</sup> to 10<sup>−9</sup> M caused significant inhibition of proliferation of both PNA<sup>+</sup> and PNA<sup>−</sup> thymocytes in these cultures. In contrast, the lipoxygenase products 15-HETE, LTB4, LTC4 and LTD4 caused marked increases in proliferation of PNA<sup>+</sup> thymocytes while having no effect on PNA<sup>−</sup> cells. Therefore, the effect of leukotrienes on thymocyte proliferation depends upon the level of cell maturation and mainly affects immature PNA<sup>+</sup> thymocytes.</p></div>","PeriodicalId":77665,"journal":{"name":"Annales de l'Institut Pasteur. Immunology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0769-2625(88)90065-7","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales de l'Institut Pasteur. Immunology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0769262588900657","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
The influences of prostaglandin E2 (PGE2), 15-hydroxyeicosatetraenoic acid (15-HETE) and leukotrienes (LT) on the proliferative response of mature (PNA−) and immature (PNA+) mouse thymocytes was investigated. Both PNA+ and PNA− thymocytes proliferated when cultured with concanavalin A plus interleukin-2. PGE2 in concentrations of 10−6 to 10−9 M caused significant inhibition of proliferation of both PNA+ and PNA− thymocytes in these cultures. In contrast, the lipoxygenase products 15-HETE, LTB4, LTC4 and LTD4 caused marked increases in proliferation of PNA+ thymocytes while having no effect on PNA− cells. Therefore, the effect of leukotrienes on thymocyte proliferation depends upon the level of cell maturation and mainly affects immature PNA+ thymocytes.
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