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Peripheral blood lymphocyte subsets in radiologists exposed to ionizing radiation. 暴露于电离辐射的放射科医生外周血淋巴细胞亚群。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134411
T Forslund, M G Welin, L Laasonen, T H Weber, J Edgren
{"title":"Peripheral blood lymphocyte subsets in radiologists exposed to ionizing radiation.","authors":"T Forslund,&nbsp;M G Welin,&nbsp;L Laasonen,&nbsp;T H Weber,&nbsp;J Edgren","doi":"10.3109/02841868509134411","DOIUrl":"https://doi.org/10.3109/02841868509134411","url":null,"abstract":"<p><p>To investigate whether low dose ionizing radiation caused perturbation of peripheral blood lymphocytes in radiology unit staff, the T-helper/suppressor ratio was examined in eight radiologists exposed to low dose radiation over a period of 6 to 27 years (mean 12 years). No significant difference was noted in the T-cell subsets between exposed radiologists and non-exposed control subjects. The effect of low dose ionizing radiation on peripheral blood lymphocyte subsets seems to be virtually negligible. Further, measurement of the T-helper/suppressor ratio is not a reliable way of demonstrating any damage to bone marrow caused by low dose ionizing radiation.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"415-7"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Protection against radiation induced chromosome injury by sulfhydryl compounds. 巯基化合物对辐射诱导染色体损伤的保护作用。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134412
R Gupta, P Uma Devi
{"title":"Protection against radiation induced chromosome injury by sulfhydryl compounds.","authors":"R Gupta,&nbsp;P Uma Devi","doi":"10.3109/02841868509134412","DOIUrl":"https://doi.org/10.3109/02841868509134412","url":null,"abstract":"<p><p>The radiation induced changes in a critically radiation-sensitive tissue, bone marrow of Swiss albino mice and its modification by two sulfhydryl compounds, MPG and WR-2721, were studied cytogenetically after whole body exposure to 0.5, 1.5, 3.0, 4.5 and 6.0 Gy of 60Co gamma radiation. The changes in the structural arrangements of chromosomes in the bone marrow were studied at various post-irradiation times from 1 to 28 days. Both the control (irradiated) and experimental (drug + irradiation) animals showed qualitatively similar types of aberrations; the severity of lesions increased with the radiation dose. The maximum damage in all the groups was seen on day 1, post-irradiation. Both the drugs afforded better protection at lower doses of exposure, their effectiveness decreasing with an increasing radiation dose. Of the two drugs, WR-2721 was more effective than MPG against initial aberration yield but the former, at the present drug dose, showed some toxic effect at the later post-irradiation intervals (2 weeks onward) as manifested by an increase in the chromatid breaks and polyploidy.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"419-25"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
The protective effect of intra-arterial vasopressin injections on the small bowel during fractionated abdominal irradiation. A study in pigs. 动脉内注射加压素对腹部分次照射时小肠的保护作用。猪的研究。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134408
S Borgström, K F Aronsen, N E Augustsson, G Bjelkengren, C Lindström, G Nylander
{"title":"The protective effect of intra-arterial vasopressin injections on the small bowel during fractionated abdominal irradiation. A study in pigs.","authors":"S Borgström,&nbsp;K F Aronsen,&nbsp;N E Augustsson,&nbsp;G Bjelkengren,&nbsp;C Lindström,&nbsp;G Nylander","doi":"10.3109/02841868509134408","DOIUrl":"https://doi.org/10.3109/02841868509134408","url":null,"abstract":"<p><p>The radioprotective effect of vasopressin-induced intestinal ischemia was investigated in pigs. A bolus injection in the cranial mesenteric artery, of a vasopressin solution, 0.05 IU/kg body weight, was followed by irradiation of the small intestine with 6 MV roentgen rays. Three different fraction schedules were used. Weight changes in the animals and the histologic appearance of their intestines were recorded two weeks after irradiation and compared with the findings in untreated animals. Intra-arterial vasopressin was very effective in protecting the intestine. Vasopressin treatment given before 2 fractions with relatively high radiation doses in a 6-fraction regimen was so effective that it may form the basis of a treatment model applicable in man.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"401-5"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Response of rat brain tissue for the extraction of 125I antipyrine after single and fractionated roentgen ray doses. A comparison of fractionation models applied to the central nervous system. 单次和分次x线剂量对大鼠脑组织提取125I安替比林的影响。应用于中枢神经系统的分馏模型的比较。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134415
M A Pitkänen, J W Hopewell
{"title":"Response of rat brain tissue for the extraction of 125I antipyrine after single and fractionated roentgen ray doses. A comparison of fractionation models applied to the central nervous system.","authors":"M A Pitkänen,&nbsp;J W Hopewell","doi":"10.3109/02841868509134415","DOIUrl":"https://doi.org/10.3109/02841868509134415","url":null,"abstract":"<p><p>Changes in the cerebral blood flow in rats were studied 9 months after irradiation with single and fractionated doses of 250 kV roentgen rays. The single doses used were 11.9, 14.5, 17.0, 19.6 and 22.1 Gy. Corresponding fractionated doses (FD) were calculated by the formula: FD = single dose X N0.42, where N is the number of fractions. The fractionated doses were given as 4, 7 and 10 dose fractions in the same overall treatment time of 3 weeks. The blood flow changes were estimated by the 125I antipyrine extraction technique. In the non-irradiated control group the extraction in the brain was 0.93 per cent of the injected dose of 125I antipyrine per g of tissue. In the irradiated rats the corresponding extraction was on average 20.4 per cent higher than that in the control group. The extraction was significantly increased in 7 of the 20 irradiated groups of animals. The fractionation model used in these experimental studies is compared with other published fractionation models for radiation tolerance of the rat and human brain and spinal cord.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"445-50"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Variation in the lung inhomogeneity correction factor with beam energy. Clinical implications. 肺不均匀性校正因子随光束能量的变化。临床意义。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134409
D S Shimm, K P Doppke, J C Leong, E Gregory, D E Dosoretz
{"title":"Variation in the lung inhomogeneity correction factor with beam energy. Clinical implications.","authors":"D S Shimm,&nbsp;K P Doppke,&nbsp;J C Leong,&nbsp;E Gregory,&nbsp;D E Dosoretz","doi":"10.3109/02841868509134409","DOIUrl":"https://doi.org/10.3109/02841868509134409","url":null,"abstract":"In order to determine the magnitude of the dosimetry error introduced by failing to correct for increased transmission through lung tissue in treating thoracic malignancies, measurements in a phantom were taken using different field sizes, inhomogeneity thicknesses and photon qualities. The results indicate that the error introduced by neglecting the inhomogeneity correction is greatest at lower photon energies, smaller field sizes and greater thickness of inhomogeneity. Correction factors to account for the lung inhomogeneity were obtained from phantom measurements and were compared with those calculated using the tissue-air ratio and Batho-Young algorithms; correlation coefficients describing the relationship between measured and calculated values exceeded 0.995. The calculated values tended to overestimate the correction factor and differed most from the measured correction factors at lower energies, smaller field sizes, and greater inhomogeneity thicknesses. The importance of these results in clinical radiation therapy is discussed.","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"407-10"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Temporary ischaemia of a large bowel segment induced by degradable starch microspheres in man. 可降解淀粉微球致人大肠段暂时性缺血。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134407
K Lote, J Lekven, J F Halvorsen, A Skarstein, A Myking, B Rosengren
{"title":"Temporary ischaemia of a large bowel segment induced by degradable starch microspheres in man.","authors":"K Lote,&nbsp;J Lekven,&nbsp;J F Halvorsen,&nbsp;A Skarstein,&nbsp;A Myking,&nbsp;B Rosengren","doi":"10.3109/02841868509134407","DOIUrl":"https://doi.org/10.3109/02841868509134407","url":null,"abstract":"<p><p>Degradable starch microspheres were used to induce temporary ischaemia measured by electromagnetic flowmetry in colon segments during bowel resection. Severe reversible ischaemia free from unwanted side effects was induced in eight of nine patients. In one of the five patients where the tumour was included in the microsphere-embolised tissue volume no reduction in blood flow was seen. Segmental enteric ischaemia induced by degradable starch microspheres in man seems safe and may be useful for radioprotective purposes in clinical radiation therapy.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"395-9"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotherapy in advanced breast carcinoma. Comparison between doxorubicin-cyclophosphamide and cyclophosphamide-methotrexate-5-fluorouracil-vincristine-prednisone. 晚期乳腺癌的化疗。阿霉素-环磷酰胺与环磷酰胺-甲氨蝶呤-5-氟尿嘧啶-长春新碱-强的松的比较。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134406
L M Parvinen, S Numminen
{"title":"Chemotherapy in advanced breast carcinoma. Comparison between doxorubicin-cyclophosphamide and cyclophosphamide-methotrexate-5-fluorouracil-vincristine-prednisone.","authors":"L M Parvinen,&nbsp;S Numminen","doi":"10.3109/02841868509134406","DOIUrl":"https://doi.org/10.3109/02841868509134406","url":null,"abstract":"Two chemotherapeutic regimens were compared in 102 patients with metastatic breast carcinoma, randomized to either doxorubicin-cyclophosphamide (DC) or cyclophosphamide-methotrexate-5-fluorouracil-vincristine-prednisone (CMFVP). The objective response rates were 32 per cent in the former and 35 per cent in the latter group, the complete response rates 6.4 and 21.8 per cent, and mean duration of the remission 7.7 and 11.2 months, respectively. Most responders had multiple metastases and had received previous hormonal treatment. The DC regimen was found to be slightly more toxic than CMFVP.","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"391-4"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Dose-response studies of single dose ionizing radiation on the ciliated epithelium of the trachea of the rabbit. A physiologic and ultrastructural investigation. 单剂量电离辐射对家兔气管纤毛上皮的剂量反应研究。生理和超微结构的研究。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134414
M Albertsson
{"title":"Dose-response studies of single dose ionizing radiation on the ciliated epithelium of the trachea of the rabbit. A physiologic and ultrastructural investigation.","authors":"M Albertsson","doi":"10.3109/02841868509134414","DOIUrl":"https://doi.org/10.3109/02841868509134414","url":null,"abstract":"<p><p>The effects of ionizing radiation on the ciliated epithelium of the rabbit's trachea were studied by ultrastructural and physiologic examinations during 10 days after single doses of 2 to 30 Gy. Low doses (2 and 2.5 Gy) caused during the first days after irradiation increased ciliary activity which during the following days returned to normal. Ultrastructurally blebs were observed on the cilia. Five and 10 Gy caused slight increment of the ciliary activity, also more marked structural effects with swollen ciliary tips, bent tips and some cilia broken and adhering to each other. Larger single doses (15-30 Gy) caused reduced and irregular ciliary activity; ultrastructurally, most cilia were broken and adhered to each other, but some cilia seemed to be unaffected. The goblet cells increased in number already after 2 and 2.5 Gy. Mucinous granula could be observed on the ciliary surface and after 30 Gy there was an explosive emptying of the goblet cells.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"433-43"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Chemical modification of adrenal response to external whole body irradiation in mice. 小鼠全身外照射对肾上腺反应的化学修饰。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134413
P Uma Devi, M Surana
{"title":"Chemical modification of adrenal response to external whole body irradiation in mice.","authors":"P Uma Devi,&nbsp;M Surana","doi":"10.3109/02841868509134413","DOIUrl":"https://doi.org/10.3109/02841868509134413","url":null,"abstract":"<p><p>Adult Swiss albino mice were exposed to whole body gamma irradiation with 1.5, 3.0, 6.0 and 9.0 Gy in the presence or absence of the protective drugs MPG and WR-2721. The changes in the total cell population, pyknotic nuclei and necrotic cells, and binucleate cells were observed at various post-irradiation times. The degree of damage increased with the radiation dose. The number of total cells decreased with a corresponding increase in pyknotic nuclei, necrotic cells and binucleate cells. Both drugs provided protection against radiation injury, and reduced early post-irradiation cell damage and enhanced recovery after sublethal exposures. After higher doses, especially after lethal doses, the drugs became less effective in protecting the tissue.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"427-31"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Validity of certified causes of death in breast carcinoma patients. 乳腺癌患者死亡原因证明的有效性。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134405
L E Rutqvist
{"title":"Validity of certified causes of death in breast carcinoma patients.","authors":"L E Rutqvist","doi":"10.3109/02841868509134405","DOIUrl":"https://doi.org/10.3109/02841868509134405","url":null,"abstract":"<p><p>The accuracy of the cause of death certification was surveyed in 802 breast carcinoma patients reported to the Swedish Cancer Registry from Stockholm county during 1961-1963. A total of 502 deaths occurred during the follow-up period of which 484 were eligible for the analysis. In 7 per cent the officially recorded underlying cause of death failed to accurately reflect the cancer status at death, which was mostly due to diagnostic errors or errors in the coding of the death certificate data. There seemed to be a net overestimation of intercurrent deaths in the official mortality statistics and a corresponding net underestimation of breast carcinoma deaths. Breast carcinoma was mentioned as a contributory cause of death in only 52 per cent of those certified to have died from intercurrent causes but who had recurrent disease at death. Among those with breast carcinoma as a certified contributory cause, 52 per cent did not have recurrent disease according to the clinical records. It is therefore concluded that official data on breast carcinoma as a contributory cause of death are of limited use in descriptive epidemiology.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"385-90"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
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