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Long term effects of ionizing radiation on mouse spermatogenesis. 电离辐射对小鼠精子发生的长期影响。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136066
U Hacker-Klom
{"title":"Long term effects of ionizing radiation on mouse spermatogenesis.","authors":"U Hacker-Klom","doi":"10.3109/02841868509136066","DOIUrl":"https://doi.org/10.3109/02841868509136066","url":null,"abstract":"<p><p>The effects of acute or split dose exposure to radiation on murine stem cell spermatogonia were analysed. Flow cytometry was applied to estimate the percentages of haploid germ cells (round and elongated spermatids) up to 12 months after irradiation. The recovery in the number of haploid germ cells continued gradually during the period under observation. The intervals between the two equal doses in split dose exposures were 0, 4, 8, 24 and 48 hours. Split doses that were 24 h or 48 h apart had more harmful effects on spermatogenesis than split doses with 4 or 8 hours intervals or acute exposures. The repair capacity of the stem cell spermatogonia was remarkably high.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"363-7"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Whole brain irradiation for metastases from lung carcinoma. A clinical investigation. 全脑照射治疗肺癌转移灶。临床调查。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136057
M Chatani, T Teshima, K Hata, T Inoue, T Suzuki
{"title":"Whole brain irradiation for metastases from lung carcinoma. A clinical investigation.","authors":"M Chatani,&nbsp;T Teshima,&nbsp;K Hata,&nbsp;T Inoue,&nbsp;T Suzuki","doi":"10.3109/02841868509136057","DOIUrl":"https://doi.org/10.3109/02841868509136057","url":null,"abstract":"<p><p>Sixty-nine consecutive patients with brain metastases from lung carcinoma were randomly allocated to one of two radiation therapy schedules: 30 Gy/10 fractions/2 weeks or 50 Gy/20 fractions/4 weeks. The improvement rate for neurologic function was similar in the two groups. The median survival times for patients receiving the short course and the long course were 4 months and 3 months, respectively. The half-year survival rate was 42 per cent after the short course and 14 per cent after the long course (p less than 0.05). Performance status and lactate dehydrogenase were other factors which significantly influenced the half-year survival rate.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"311-4"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Comparison between flow cytometry and single cell cytophotometry for DNA content analysis of the uterine cervix. 流式细胞术与单细胞细胞光度法测定子宫颈DNA含量的比较。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136062
P Strang, A Lindgren, U Stendahl
{"title":"Comparison between flow cytometry and single cell cytophotometry for DNA content analysis of the uterine cervix.","authors":"P Strang,&nbsp;A Lindgren,&nbsp;U Stendahl","doi":"10.3109/02841868509136062","DOIUrl":"https://doi.org/10.3109/02841868509136062","url":null,"abstract":"<p><p>The DNA content of tumor cells in imprints and biopsies from 33 patients with invasive squamous cell carcinoma and 5 patients with adenocarcinoma of the uterine cervix were analyzed by flow cytometric and single cell cytophotometric methods. A correlation of r = 0.83 was found between the modal DNA values obtained by the two methods. Both methods discriminated between diploid and aneuploid tumors and gave comparable but not identical results. Single cell cytophotometric measurements were in this study more reliable than flow cytometric measurements in diploid tumors. Multiple stemlines, small aneuploid peaks and the so called S-phase rate could only be determined by the flow cytometric technique. Flow cytometry seems to be the method of choice in determination of the DNA content in cervical carcinoma cells and cytophotometric single cell measurements are of complementary value.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"337-41"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Effect of repeat irradiation on the tracheal ciliary cell activity. 重复照射对气管纤毛细胞活性的影响。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136067
B Baldetorp, L Baldetorp
{"title":"Effect of repeat irradiation on the tracheal ciliary cell activity.","authors":"B Baldetorp,&nbsp;L Baldetorp","doi":"10.3109/02841868509136067","DOIUrl":"https://doi.org/10.3109/02841868509136067","url":null,"abstract":"<p><p>Rabbit tracheas were initially irradiated with 10 Gy in vitro. A second irradiation of 10 Gy was administered 2 hours later. The initial exposure caused a 25 per cent increase of the ciliary beat frequency during the irradiation--a response which was not found during the second irradiation. Between the exposures, the beat frequency dropped to 20 per cent below the reference level, followed by an 11 per cent overshooting before the second irradiation. Tracheas placed untreated in the experimental chamber for 2 hours and subsequently irradiated with 10 Gy showed a similar pattern of ciliary activity as induced by the initial radiation exposure in the first experiment. The storage during 2 hours did thus not affect the condition of the ciliae. The absence of a great increase of the beat frequency during a second irradiation period may be explained by damages caused by the initial exposure, morphologically seen first a few days later.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"369-73"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Primary retroperitoneal sarcomas. A review of 36 cases. 原发性腹膜后肉瘤。36例病例回顾。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136056
E Wist, O P Solheim, A B Jacobsen, P Blom
{"title":"Primary retroperitoneal sarcomas. A review of 36 cases.","authors":"E Wist,&nbsp;O P Solheim,&nbsp;A B Jacobsen,&nbsp;P Blom","doi":"10.3109/02841868509136056","DOIUrl":"https://doi.org/10.3109/02841868509136056","url":null,"abstract":"<p><p>A retrospective study of 36 patients with primary retroperitoneal sarcomas treated at The Norwegian Radium Hospital is presented. The median age at presentation was 57 years. The most common presenting symptom was abdominal pain. Leiomyosarcoma and liposarcoma were the most common histologic subtypes. The median survival in the whole series was 25 months. Patients with completely resected tumors had a longer median survival (59 months) than patients with incomplete resection (16 months) but the difference was not statistically significant. The malignancy grade seemed to be the most important prognostic factor and patients with low grade tumors had a significantly better outlook than those with high grade tumors.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"305-10"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Comparison between the immediate effects of photon and electron radiation on the ciliary activity of the trachea of the rabbit. An in vitro investigation. 光子与电子辐射对家兔气管纤毛活性即时影响之比较。体外研究。
Acta radiologica. Oncology Pub Date : 1985-05-01 DOI: 10.3109/02841868509134401
B Baldetorp
{"title":"Comparison between the immediate effects of photon and electron radiation on the ciliary activity of the trachea of the rabbit. An in vitro investigation.","authors":"B Baldetorp","doi":"10.3109/02841868509134401","DOIUrl":"https://doi.org/10.3109/02841868509134401","url":null,"abstract":"<p><p>The immediate effects of 6 MV roentgen rays and 4 MeV electron rays on the mucociliary activity of the trachea of the rabbit were studied. In spite of the same average LET for the two radiation qualities, there was a clear difference in their effects on the ciliary motility during irradiation. The increase of the mucociliary activity after an absorbed dose of 1.5 Gy roentgen rays reported earlier was confirmed by the present investigation when using 6 MV photons. Electron radiation increased the beat frequency to a corresponding degree already at an administered dose of 0.5 Gy. The differences found in the pattern of the mucociliary activity during irradiation are discussed. The results indicate that the conventional RBE values cannot be used for early physiologic effects of irradiation.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 3","pages":"279-84"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Correction for the angular dependence of a detector in electron and photon beams. 电子和光子光束中探测器角依赖性的校正。
Acta radiologica. Oncology Pub Date : 1985-05-01 DOI: 10.3109/02841868509134404
A Brahme
{"title":"Correction for the angular dependence of a detector in electron and photon beams.","authors":"A Brahme","doi":"10.3109/02841868509134404","DOIUrl":"https://doi.org/10.3109/02841868509134404","url":null,"abstract":"<p><p>Based on experimentally obtained angular response functions a simple analytic function has been found which can be accurately fitted to such data. Using this function formulas are derived for the variation of the detector response as the angular distribution of the electrons are changing with depth in a phantom both in electron and photon beams. The formulas show that for a flat liquid ionization chamber, a response variation of 2 to 4 per cent is normally obtained in the build-up region of electron and photon beams whereas the response is practically constant beyond dose maximum.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 3","pages":"301-4"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Relation between number of hemopoietic stem cells in newborn mice and their radiosensitivity. 新生小鼠造血干细胞数量与放射敏感性的关系。
Acta radiologica. Oncology Pub Date : 1985-05-01 DOI: 10.3109/02841868509134398
T Sutter, J Maes, G B Gerber, A Leonard
{"title":"Relation between number of hemopoietic stem cells in newborn mice and their radiosensitivity.","authors":"T Sutter,&nbsp;J Maes,&nbsp;G B Gerber,&nbsp;A Leonard","doi":"10.3109/02841868509134398","DOIUrl":"https://doi.org/10.3109/02841868509134398","url":null,"abstract":"<p><p>Fractionation of a radiation exposure causes greater damage in newborn mice than a single application since it induces radioresistant foetal hemopoietic stem cells to differentiate prematurely to more radiosensitive adult ones. In the present investigation, it was studied whether other agents that give rise to extensive stem cell destruction also lead to such a change in radiosensitivity. Indeed, treatment with cytostatic drugs which reduces the number of spleen colony forming units (CFU-s) and total cells also diminished the D0 value of the surviving cells 3 days later. Adriamycin was most effective in causing damage to hemopoietic stem cells and in inducing micronuclei in bone marrow; it also had the most marked action on the D0 of the surviving stem cells.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 3","pages":"263-5"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Orgotein as a radioprotector in normal tissues. Experiments on mouse skin and a murine adenocarcinoma. Orgotein在正常组织中作为放射性保护剂。小鼠皮肤和小鼠腺癌的实验。
Acta radiologica. Oncology Pub Date : 1985-05-01 DOI: 10.3109/02841868509134400
A Cividalli, M Adami, F De Tomasi, L Palmisano, M C Pardini, M Spanò, F Mauro
{"title":"Orgotein as a radioprotector in normal tissues. Experiments on mouse skin and a murine adenocarcinoma.","authors":"A Cividalli,&nbsp;M Adami,&nbsp;F De Tomasi,&nbsp;L Palmisano,&nbsp;M C Pardini,&nbsp;M Spanò,&nbsp;F Mauro","doi":"10.3109/02841868509134400","DOIUrl":"https://doi.org/10.3109/02841868509134400","url":null,"abstract":"<p><p>The effects of Orgotein (a superoxide dismutase) on the radiation response of normal and malignant murine tissue in vivo were evaluated. The observations were made on the mouse hind leg bearing, in some cases, an adenocarcinoma. The following irradiation protocols were tested: 1) single dose (e.g., 35 and 53 Gy), 2) conventional fractionation (3 Gy/day, 5 days a week) and 3) multiple fractions per day (2 X 3 Gy/day, 3 h fractionation interval, 5 days a week). Radiation was either delivered alone or preceded by a subcutaneous injection of 20, 100 or 400 mg/kg Orgotein administered 1 or 2 h before the beginning of irradiation. No effects of Orgotein on tumor radiation response were detected. A protective effect on normal tissue was observed when radiation was delivered according to aggressive protocols and a relatively high dosage of Orgotein was administered. Furthermore, an accelerated trend of recovery of normal tissue was observed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 3","pages":"273-7"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Effect of reduced perfusion pressure and acetylcholine on local blood flow in tumors in the rat kidney. 降低灌注压和乙酰胆碱对大鼠肾肿瘤局部血流的影响。
Acta radiologica. Oncology Pub Date : 1985-05-01 DOI: 10.3109/02841868509134402
G Gadeholt, A Hope, S T Tvete, G Clausen
{"title":"Effect of reduced perfusion pressure and acetylcholine on local blood flow in tumors in the rat kidney.","authors":"G Gadeholt,&nbsp;A Hope,&nbsp;S T Tvete,&nbsp;G Clausen","doi":"10.3109/02841868509134402","DOIUrl":"https://doi.org/10.3109/02841868509134402","url":null,"abstract":"<p><p>The local blood flow (LBF) in a sarcoma and a hepatoma implanted into the rat kidney was examined during renal vasodilation, with and without increased total renal blood flow (RBF). Both tumor types had a control LBF of about 0.7 ml/min per g, i.e. 35 per cent or less as compared with the renal LBF, as simultaneously determined by the H2 gas clearance technique. The RBF averaged 4.6 ml/min per g as recorded electromagnetically. During about 20 mmHg reduction of renal arterial pressure the tumor LBF was maintained relative to the renal LBF, whether the RBF was autoregulated or not. Provided neoplastic vessels account for most of the vascular resistance to tumor blood flow, they must therefore possess autoregulatory ability. The tumor LBF was maintained when the RBF was maximally increased by continuous renal arterial infusion of acetylcholine. This may suggest that a neoplastic vessel vasodilatory response to acetylcholine prevented reduction of the tumor flow.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 3","pages":"285-9"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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