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Radiosensitizing effects of nicotinamide on a C3H mouse mammary adenocarcinoma. A study on per os drug administration. 烟酰胺对C3H小鼠乳腺腺癌的放射增敏作用。前列腺癌药物管理的研究。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136419
E Kjellén, R W Pero, R Cameron, J Ranstam
{"title":"Radiosensitizing effects of nicotinamide on a C3H mouse mammary adenocarcinoma. A study on per os drug administration.","authors":"E Kjellén,&nbsp;R W Pero,&nbsp;R Cameron,&nbsp;J Ranstam","doi":"10.3109/02841868609136419","DOIUrl":"https://doi.org/10.3109/02841868609136419","url":null,"abstract":"<p><p>Nicotinamide is an inhibitor of adenosine diphosphate ribosyl transferase (ADPRT) which is involved in the mechanism of DNA repair after high doses of ionizing radiation. C3H mice with transplanted mammary adenocarcinomas were treated with low doses of nicotinamide, 10 mg/kg, 5 days a week, and in combination with ionizing radiation, 30 Gy, using different drug dose schedules. Mice given nicotinamide in combination with irradiation took a longer time to reach a tumor volume of 1,000 mm3 and a higher complete response rate (i.e. defined as total disappearance of the tumor for at least 7 days) than those given radiation alone. This was true whether nicotinamide was given daily from one week before tumor transplantation until the animal was killed or from transplantation day until day of irradiation. In addition, nicotinamide given per os at a dose between the recommended maximum daily allowance for human subjects (20 mg/70 kg), and the therapeutic allowance (1 g-12 g daily) 5 days a week for 9 weeks, showed a radiosensitizing effect without any histologically detectable damage to the normal tissues of the mouse, including bone marrow, intestine and the liver.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"281-4"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Breast cancer following multiple chest fluoroscopies among tuberculosis patients. A case-control study in Denmark. 肺结核患者多次胸部透视后的乳腺癌。丹麦的一项病例对照研究。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136411
H H Storm, E Iversen, J D Boice
{"title":"Breast cancer following multiple chest fluoroscopies among tuberculosis patients. A case-control study in Denmark.","authors":"H H Storm,&nbsp;E Iversen,&nbsp;J D Boice","doi":"10.3109/02841868609136411","DOIUrl":"https://doi.org/10.3109/02841868609136411","url":null,"abstract":"<p><p>A case-control study of breast cancer among tuberculosis (TB) patients in Denmark (1937-1954) was conducted to provide additional information on the radiation risk associated with low-dose chest fluoroscopy exposures. Records of 46013 TB patients were linked to the Danish Cancer Registry and 125 subsequent female breast cancers identified. Medical records were located for 89 (71%) of these women who developed breast cancer and on 390 controls, who were individually matched to cases on age and calendar year of TB diagnosis, and survival. Common risk factors for breast cancer such as nulliparity (relative risk (RR) = 2.5) and high relative weight (RR = 2.6) were also identified in this population of TB patients. However no risk was evident with exposure to any type of fluoroscopy (RR = 0.6; 95% CI = 0.2-1.4), or to fluoroscopies performed to monitor lung collapse therapy (RR = 0.8; 95% CI = 0.5-1.4). Although based on only 7 breast cancers, there was a suggestion of an increased risk among women who received greater than 1 Gy to their breasts (RR = 1.6; 95% CI = 0.4-6.3). Because of the infrequent use of fluoroscopy in our study, the breast doses were too low, 0.27 Gy on average, to expect to detect a significant elevation in breast cancer risk overall. The findings do suggest, however, that current estimates of breast cancer risk following radiation are not greater than presently accepted, and that a relative excess of 40 per cent can be excluded with reasonable confidence following breast doses on the order of 0.3 Gy.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"233-8"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Effect of high 131I doses to the thyroid gland on tumorigenicity of 90Sr and 90Y in mice. 高剂量131I对小鼠甲状腺90Sr和90Y致瘤性的影响。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136416
E J Gimeno, G Walinder, R E Feinstein, C Rehbinder
{"title":"Effect of high 131I doses to the thyroid gland on tumorigenicity of 90Sr and 90Y in mice.","authors":"E J Gimeno,&nbsp;G Walinder,&nbsp;R E Feinstein,&nbsp;C Rehbinder","doi":"10.3109/02841868609136416","DOIUrl":"https://doi.org/10.3109/02841868609136416","url":null,"abstract":"<p><p>The incidence of tumors was studied in mice injected with 90Sr only or with 90Sr in combination with high amounts of 131I. The high 131I-dose to the thyroid gland was necrotizing to the glandular tissue and the main aim of the investigation was the possible effects of the thyroidal destruction on the formation of bone tumors. After correction for competing mortality, no significant difference in the frequency of bone tumors could be found between 90Sr-treated and (90Sr + 131I)-treated mice. The incidence rate of bone tumors, however, was higher in mice with radiogenically destroyed glands than in those with intact glands. The limitations of using the concept of 'actuarial tumor incidence' in correction for competing mortality in animal experiments are discussed. Large numbers of lymphatic tumors were found in all animal groups. The frequencies of such tumors were independent of the radiation doses but their incidence rates were shortened in a dose dependent manner. Other, directly or indirectly radiation induced tumors were observed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"261-7"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Effect of high 131I doses on the bone uptake and retention of 90Sr and 90Y. 高剂量131I对90Sr和90Y骨吸收和保留的影响。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136415
G Walinder, R E Feinstein, E J Gimeno
{"title":"Effect of high 131I doses on the bone uptake and retention of 90Sr and 90Y.","authors":"G Walinder,&nbsp;R E Feinstein,&nbsp;E J Gimeno","doi":"10.3109/02841868609136415","DOIUrl":"https://doi.org/10.3109/02841868609136415","url":null,"abstract":"<p><p>The uptake and retention of 90Sr and 90Y in mouse bones after injections of the two nuclides in equilibrium were examined after heavy thyroid irradiations from 131I deposited in the glands. The radiation doses to the thyroid glands as well as the gross doses to the femurs and humeri of the mice were calculated. The radiation destruction of the thyroid tissues had no effect on the bone weights nor on the skeletal metabolism of 90Sr. The uptake of 90Y was, however, depressed after thyroidal irradiation but reached the same bone concentration as 90Sr at about 30 days after the administration of the nuclides, i.e. at a time when the corresponding equilibrium between 90Sr and 90Y in the bones was reached in mice without a thyroidal irradiation.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"255-60"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Cell size following irradiation in relation to cell cycle. 辐照后细胞大小与细胞周期的关系。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136417
S Skog, B Tribukait
{"title":"Cell size following irradiation in relation to cell cycle.","authors":"S Skog,&nbsp;B Tribukait","doi":"10.3109/02841868609136417","DOIUrl":"https://doi.org/10.3109/02841868609136417","url":null,"abstract":"<p><p>The cell volume of Ehrlich ascites tumour cells was studied following a radiation dose of 5.0 Gy. The cell volume increased 12 to 30 hours after irradiation by about 20 per cent, was normal at about 50 hours, and increased again at 72 hours. In order to explain these changes the composition of the cells in cell cycle was studied. In addition, the cell volume of irradiated cells from the various parts of the cell cycle, separated by centrifugal elutriation, was measured. The changes in the mean cell volume of unseparated cells could be explained by variations in the cell cycle composition of the cell population. Irradiated cells from the various parts of the cell cycle did not deviate from the volume of non-irradiated cells. The cell volume doubled during the cell cycle. This increase was, however, not linear.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"269-73"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Survival and prognostic factors in thyroid carcinoma. 甲状腺癌的生存和预后因素。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136413
H Joensuu, P J Klemi, R Paul, J Tuominen
{"title":"Survival and prognostic factors in thyroid carcinoma.","authors":"H Joensuu,&nbsp;P J Klemi,&nbsp;R Paul,&nbsp;J Tuominen","doi":"10.3109/02841868609136413","DOIUrl":"https://doi.org/10.3109/02841868609136413","url":null,"abstract":"<p><p>A multivariate analysis of prognostic factors and survival was carried out in a series of 200 patients with thyroid carcinoma. The cumulative survival rate corrected for intercurrent deaths was higher for papillary carcinoma than for follicular carcinoma both at 5 years (92% vs 74%) and at ten years (87% vs 66%) after the diagnosis. Seventeen of the eighteen patients with anaplastic carcinoma died within 24 months after the diagnosis. The most important independent prognostic factor in patients with papillary or follicular carcinoma, by multivariate analysis, was age at time of diagnosis, followed by tumor penetration beyond the thyroid capsule and follicular histologic type. When different types of treatment were included in the analysis, age at diagnosis still remained the most important prognostic factor. Misdiagnosed intercurrent deaths in the elderly did not explain the negative effect of age on survival.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"243-8"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Sarcoma following irradiation for breast cancer. Report of three unusual cases including one malignant mesenchymoma of bone. 乳腺癌放疗后的肉瘤。骨恶性间质瘤三例报告。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136412
S Hatlinghus, L Rode, I Christensen, S Vaage
{"title":"Sarcoma following irradiation for breast cancer. Report of three unusual cases including one malignant mesenchymoma of bone.","authors":"S Hatlinghus,&nbsp;L Rode,&nbsp;I Christensen,&nbsp;S Vaage","doi":"10.3109/02841868609136412","DOIUrl":"https://doi.org/10.3109/02841868609136412","url":null,"abstract":"<p><p>Three cases of sarcoma developing after irradiation for breast cancer are reported. A malignant mesenchymoma in the sternum--a combination of osteogenic sarcoma and rhabdomyosarcoma--is the first documented case of its kind occurring after radiation therapy. Of the other two tumors one was an extraskeletal osteogenic sarcoma in the soft tissues of the thoracic wall and one a rhabdomyosarcoma in the axilla.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"239-42"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Bone metastasis. Prognosis, diagnosis and treatment. 骨转移。预后、诊断和治疗。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136410
K Lote, A Walløe, A Bjersand
{"title":"Bone metastasis. Prognosis, diagnosis and treatment.","authors":"K Lote,&nbsp;A Walløe,&nbsp;A Bjersand","doi":"10.3109/02841868609136410","DOIUrl":"https://doi.org/10.3109/02841868609136410","url":null,"abstract":"<p><p>Carcinoma of the breast, lung or prostate cause the majority of all bone metastases. Prolonged survival is common in patients with breast or prostate tumours. Different types of treatment may significantly increase the quality of life. Single-dose or fractionated radiation therapy may be effective, and 70 to 90 per cent of patients obtain partial or complete relief from pain. Surgery followed by irradiation is indicated in most patients with pathologic femur fractures. Immediate surgical treatment, either alone or combined with radiation therapy, may prevent paraparesis in patients with incipient cord compression. For neoplasms sensitive to systemic therapy such treatment should often be added to local treatment.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"227-32"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13583614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 72
Increased protective effect of hypoxia against radiation following activation of haemopoiesis with dextran sulphate. 用葡聚糖硫酸盐激活造血后，缺氧对辐射的保护作用增强。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136420
A Vacek, A Bartonícková, D Rotkovská, N A Zhukova, G F Palyga
{"title":"Increased protective effect of hypoxia against radiation following activation of haemopoiesis with dextran sulphate.","authors":"A Vacek,&nbsp;A Bartonícková,&nbsp;D Rotkovská,&nbsp;N A Zhukova,&nbsp;G F Palyga","doi":"10.3109/02841868609136420","DOIUrl":"https://doi.org/10.3109/02841868609136420","url":null,"abstract":"<p><p>The effect of pretreatment of mice with a single injection of dextran sulphate (DS) on the protective capacity of moderate hypoxia was analysed. Dextran sulphate activated haemopoietic stem cell populations, and irradiation under hypoxia one day after DS injection increased the number of haemopoietic stem cells surviving in the bone marrow of the femur, their recovery after irradiation, and the number of endogenous spleen colonies. A moderate hypoxia (15% O2 and 12% O2) significantly reduced the lethal effect of gamma rays in mice after DS injection and increased the value of LD 50/30.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"285-9"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13583615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Neutron dosimetry with detectors of finite size. II. Experiments and calculations. 有限尺寸探测器的中子剂量测定。2实验和计算。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136423
A Montelius, T E Burlin, J Briggs
{"title":"Neutron dosimetry with detectors of finite size. II. Experiments and calculations.","authors":"A Montelius,&nbsp;T E Burlin,&nbsp;J Briggs","doi":"10.3109/02841868609136423","DOIUrl":"https://doi.org/10.3109/02841868609136423","url":null,"abstract":"<p><p>In a previous article a theory for detector response in fields of fast neutrons was presented. In the present paper this theory is subjected to experimental tests. For detectors of sizes comparable to the ranges of the neutron produced charged particles the theory predicts the variation of the detector response with detector size and elemental composition of the detector. A tissue-equivalent ionization chamber exposed to a field of 252Cf neutrons was used in the experimental tests of the theory. The size dependence of the response was investigated by varying the chamber gas pressure and the effects of different elemental compositions (mainly hydrogen content) was investigated by using different gases in the chamber (H2, CH4, TE-gas N2, Air, CO2, and Ar). The theory was evaluated both by using chord length distributions to characterize the chamber cavity and with a simplified version using a single mean chord length. The agreement between theory and experiment is generally good.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"303-9"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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