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Flow cytometric DNA patterns in cervical carcinoma. 子宫颈癌的流式细胞DNA图谱。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136414
P Strang, U Stendahl, B Frankendal, A Lindgren
{"title":"Flow cytometric DNA patterns in cervical carcinoma.","authors":"P Strang,&nbsp;U Stendahl,&nbsp;B Frankendal,&nbsp;A Lindgren","doi":"10.3109/02841868609136414","DOIUrl":"https://doi.org/10.3109/02841868609136414","url":null,"abstract":"<p><p>Flow cytometric measurements of the DNA content were performed in a prospective study of 167 women with invasive squamous cell carcinoma of the uterine cervix. Ploidy level and the proportion of S-phase cells were correlated to age, menopausal age, staging according to FIGO and histopathology. With increasing age a successive shift from a dominance of peri-diploid and peri-tetraploid values to marked aneuploidy was found. Peri-diploid and peri-tetraploid tumors were more often found in premenopausal than in post-menopausal women (p less than 0.001). The mean S-phase rate was significantly higher in women aged 60-89 years than in women aged 20-59 years (p less than 0.01). More aneuploid tumors were found in stages III and IV than in stages IB and II (p less than 0.01). The mean S-phase rate was higher in stages III and IV (20.8%) than in stages IB and II (17.2%) (p less than 0.01). No statistically significant correlation was shown between ploidy level and histopathology or between S-phase rate and histopathology. In 37 patients polyclonal tumors were found. The reproducibility of the method was good (r = 0.99).</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"249-54"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Combined effects of ultrasound and ionizing radiation on lymphocyte chromosomes. 超声和电离辐射对淋巴细胞染色体的联合影响。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136421
Y Kuwabara, S Matsubara, S Yoshimatsu, S Suzuki
{"title":"Combined effects of ultrasound and ionizing radiation on lymphocyte chromosomes.","authors":"Y Kuwabara,&nbsp;S Matsubara,&nbsp;S Yoshimatsu,&nbsp;S Suzuki","doi":"10.3109/02841868609136421","DOIUrl":"https://doi.org/10.3109/02841868609136421","url":null,"abstract":"<p><p>The effects of ionizing radiation and ultrasound upon the induction of chromosomal-type aberrations and sister chromatid exchanges were investigated. No statistically significant increase in the frequencies of dicentric and ring chromosomes or sister chromatid exchanges was discovered after ultrasound exposure alone at the diagnostic level. Nor could elevated frequencies of these phenomena be found following exposure to ultrasound before or after ionizing radiation, compared with those resulting from an equivalent dose of ionizing radiation alone. However, simultaneous exposure to ultrasound and ionizing radiation seemed to induce a slight enhancement of sister chromatid exchanges, although no significant change was noted in the yields of dicentric and ring chromosomes.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"291-4"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Neutron dosimetry with detectors of finite size. I. Theory. 有限尺寸探测器的中子剂量测定。即理论。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136422
A Montelius
{"title":"Neutron dosimetry with detectors of finite size. I. Theory.","authors":"A Montelius","doi":"10.3109/02841868609136422","DOIUrl":"https://doi.org/10.3109/02841868609136422","url":null,"abstract":"<p><p>A theory for detector response in fields of fast neutrons has been developed. The theory is valid for convex detectors of all sizes exposed to isotropic fields of neutrons. In the theory the detector shape is characterized by distributions of chord lengths along which the neutron produced charged particles travel and deposit energy. Chord length distributions for charged particles generated in the surrounding medium (externals) and in the detector itself (internals) are presented for spheres, spheroids, cylinders and parallel plane geometries. The form on which the theory is written makes it possible to evaluate the theory with simplified assumptions, such as characterizing the detector with a single mean chord length for the external particles. Specifically, the response of ionization chambers has been considered, taking into account the energy dependence of the W-values for the different charged particles. In a following article (part II) the theory will be subjected to experimental test.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Radiobiologic response of CHO-KI cells treated with vitamin A. 维生素A处理CHO-KI细胞的放射生物学反应。
Acta radiologica. Oncology Pub Date : 1986-07-01 DOI: 10.3109/02841868609136418
C Mothersill, M J Moriarty, C B Seymour
{"title":"Radiobiologic response of CHO-KI cells treated with vitamin A.","authors":"C Mothersill,&nbsp;M J Moriarty,&nbsp;C B Seymour","doi":"10.3109/02841868609136418","DOIUrl":"https://doi.org/10.3109/02841868609136418","url":null,"abstract":"<p><p>Treatment of CHO-KI cells with vitamin A altered their response to subsequent gamma irradiation. In general longterm preincubation with low doses of the vitamin caused a relative increase in the number of cells surviving a given radiation dose. The effect resulted in an increase in the D0 of the survival curve. Long or short term exposure to high concentrations of the vitamin caused a decrease in the number of surviving cells leading to a decrease in the extrapolation number of the survival curve. Recovery of cells from radiation damage, assessed using the split dose technique, was also impaired by vitamin A pretreatment. A mechanism involving repair of potentially lethal damage may explain the protective effect of vitamin A since this was highly dependent on the cell density of cultures at the time of irradiation. However, in view of the data showing that the vitamin A concentrations necessary to alter the radiation survival curve shoulder caused a significant release of sialic acid into the medium, a mechanism involving membrane stability may account for both the reduction in repair/recovery capacity of the treated cells and the radioprotective effect.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 4-6","pages":"275-80"},"PeriodicalIF":0.0,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Evidence of C-cell destruction in the thyroid gland of mice exposed to high 131I doses. 暴露于高剂量131I小鼠甲状腺c细胞破坏的证据。
Acta radiologica. Oncology Pub Date : 1986-05-01 DOI: 10.3109/02841868609136405
R E Feinstein, E J Gimeno, M el-Salhy, E Wilander, G Walinder
{"title":"Evidence of C-cell destruction in the thyroid gland of mice exposed to high 131I doses.","authors":"R E Feinstein,&nbsp;E J Gimeno,&nbsp;M el-Salhy,&nbsp;E Wilander,&nbsp;G Walinder","doi":"10.3109/02841868609136405","DOIUrl":"https://doi.org/10.3109/02841868609136405","url":null,"abstract":"<p><p>The parafollicular cells of the thyroid gland were visualized by means of the Sevier-Munger silver technique in normal mice and in mice receiving 131I in amounts sufficient to completely destroy the thyroid tissue. The destruction of the C-cells was observed in all 131I injected mice, and no histologic signs of recovery were seen during a period of 40 days following the treatment.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"199-202"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14154695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Late radiation enteropathy following split-dose irradiation of rat small intestine. 大鼠小肠分次辐照后的晚期放射性肠病。
Acta radiologica. Oncology Pub Date : 1986-05-01 DOI: 10.3109/02841868609136406
M Hauer Jensen, T Sauer, J B Reitan, K Nygaard
{"title":"Late radiation enteropathy following split-dose irradiation of rat small intestine.","authors":"M Hauer Jensen,&nbsp;T Sauer,&nbsp;J B Reitan,&nbsp;K Nygaard","doi":"10.3109/02841868609136406","DOIUrl":"https://doi.org/10.3109/02841868609136406","url":null,"abstract":"<p><p>In female Wistar rats roentgen irradiation of a 10 cm long exteriorized mid small intestinal segment was performed. The radiation dose was 23 Gy, given as a single exposure or divided in two equal fractions separated by intervals of 4 to 96 hours. Radiation injury was assessed 2, 8 and 26 weeks following irradiation using a semiquantitative histopathologic scoring system. An increased fractionation interval led to a reduced degree of radiation injury at all 3 observation times. The greatest difference was found between the single dose and 4 hour groups, indicating a relatively large capacity for repair of sublethal damage. The degree of radiation injury also decreased significantly when the interval between fractions was increased from 4 hours to 96 hours. This suggests that the phenomenon of slow repair may occur in cells involved in the development of late radiation enteropathy. However, an indirectly protective effect due to mucosal repopulation between fractions may also explain some of the differences.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"203-6"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14154696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Enzyme immuno assay of the estrogen receptor in breast cancer biopsy samples. A comparison with isoelectric focusing. 乳腺癌活检标本中雌激素受体的酶免疫测定。与等电聚焦的比较。
Acta radiologica. Oncology Pub Date : 1986-05-01 DOI: 10.3109/02841868609136398
M Fernö, A Borg, G Sellberg
{"title":"Enzyme immuno assay of the estrogen receptor in breast cancer biopsy samples. A comparison with isoelectric focusing.","authors":"M Fernö,&nbsp;A Borg,&nbsp;G Sellberg","doi":"10.3109/02841868609136398","DOIUrl":"https://doi.org/10.3109/02841868609136398","url":null,"abstract":"<p><p>The estrogen receptor (ER) was measured by isoelectric focusing (IF) and enzyme immuno assay (EIA) in 127 breast cancer samples. When comparing the two techniques quantitatively, a very high correlation coefficient was obtained (rs = 0.98; p less than 0.001). ER recovery increased, however, by a mean factor of 2.5 when EIA was used instead of IF. This increase seemed to be influenced by the ER concentration level, being lower at higher levels. The difference between IF and EIA did not seem to be due to menopausal status. A possible field of application for EIA might be measurement of ER in samples from patients on tamoxifen therapy. In five out of nine such samples, a considerably higher measurable amount of ER was found with EIA than with IF. EIA was also found to be a simpler and less time-consuming method than IF. These advantages should, however, be weighed against the present higher costs.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"171-5"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Daily multiple session radiation therapy in advanced oral carcinoma. A preliminary investigation. 晚期口腔癌的每日多次放射治疗。初步调查。
Acta radiologica. Oncology Pub Date : 1986-05-01 DOI: 10.3109/02841868609136401
V Nagarajan, V Parimalarangan, M L Meenakshi
{"title":"Daily multiple session radiation therapy in advanced oral carcinoma. A preliminary investigation.","authors":"V Nagarajan,&nbsp;V Parimalarangan,&nbsp;M L Meenakshi","doi":"10.3109/02841868609136401","DOIUrl":"https://doi.org/10.3109/02841868609136401","url":null,"abstract":"<p><p>Radiation therapy using conventional fractionation schedules has not achieved adequate disease control in patients with advanced oral carcinoma. Hence a trial was conducted to investigate the efficacy of daily multiple session irradiation in this disease. Of the 32 patients entered in the study, 25 were eligible for evaluation. Sixteen of the 25 patients had no evidence of disease during a follow-up period of 24 months. Acute mucosal reactions were observed in all the patients, but they subsided in 2 to 4 weeks after completion of treatment. The results obtained in this pilot study justify evaluation of this method in a larger number of patients with advanced oral carcinoma.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"185-6"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Enhancement of hemopoietic recovery by indomethacin after sublethal whole-body gamma irradiation. 亚致死性全身伽玛照射后吲哚美辛增强造血功能恢复。
Acta radiologica. Oncology Pub Date : 1986-05-01 DOI: 10.3109/02841868609136404
M Pospísil, J Netíková, A Kozubík
{"title":"Enhancement of hemopoietic recovery by indomethacin after sublethal whole-body gamma irradiation.","authors":"M Pospísil,&nbsp;J Netíková,&nbsp;A Kozubík","doi":"10.3109/02841868609136404","DOIUrl":"https://doi.org/10.3109/02841868609136404","url":null,"abstract":"<p><p>The effect of the non-steroid anti-inflammatory drug, indomethacin, a potent prostaglandin synthesis inhibitor, on the recovery of hemopoiesis was investigated in sublethally gamma irradiated mice. Treatment with indomethacin after irradiation was found to increase the granulocyte and lymphocyte counts in peripheral blood. Furthermore, an increased rate of the restitution of bone marrow cellularity and of the spleen weight was observed. Using the method of 125iodo-deoxyuridine uptake in the spleen, the ability of indomethacin to potentiate cell proliferation was demonstrated.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"195-8"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Effect of irradiation on early enzymatic changes in healing mandibular periosteum and bone. A histochemical study on rats. 照射对下颌骨骨膜及骨愈合早期酶促变化的影响。大鼠组织化学研究。
Acta radiologica. Oncology Pub Date : 1986-05-01 DOI: 10.3109/02841868609136407
K Aitasalo
{"title":"Effect of irradiation on early enzymatic changes in healing mandibular periosteum and bone. A histochemical study on rats.","authors":"K Aitasalo","doi":"10.3109/02841868609136407","DOIUrl":"https://doi.org/10.3109/02841868609136407","url":null,"abstract":"<p><p>The influence of irradiation was studied histochemically in healing mandibular periosteum and bone. After a cut line had been made on both sides of the mandible the rats were exposed to roentgen ray irradiation. The single doses were 15, 20, 30, 35 or 40 Gy. The animals were killed 1, 2, 4, 8, 10, 12, 16 and 24 hours after irradiation, for histochemical analysis. All enzymes, acid phosphatase, cytochrome oxidase, lactate, isocitrate, glucose-6-phosphatase and succinate dehydrogenase, showed a greater increase in enzyme staining in the irradiated cut lines than in the non-irradiated control lines. The intensity of the staining increased with time and dose over 24 hours. The observation time included an inflammatory phase with vascular, enzymatic and cellular responses to periosteal and bone injury. The increase in staining was dependent on the time after surgical trauma and radiation dose. The increase in enzyme staining probably represents the initial cell damage after irradiation.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"207-12"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14154699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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