{"title":"Thyroid function after postoperative radiation therapy in patients with breast cancer.","authors":"H Joensuu, J Viikari","doi":"10.3109/02841868609136397","DOIUrl":"https://doi.org/10.3109/02841868609136397","url":null,"abstract":"<p><p>Thyroid stimulating hormone (S-TSH) and thyroxine (S-T4) were measured in sera from 80 patients with breast cancer using radioimmunoassay. The patients had been irradiated after mastectomy 7.2 +/- 1.0 years earlier with 45 Gy in 3 to 4 weeks to parasternal, ipsilateral supraclavicular and axillary areas. Five patients (6%) had hypothyroidism with low S-T4 and elevated S-TSH levels. In addition, 12 patients (15%) had elevated (greater than 5 mU/l) S-TSH levels and normal S-T4 values. Shielding of the thyroid during irradiation and long-term follow-up of thyroid function with repeated hormone assays are recommended.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"167-70"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Different fractionation schedules in radiation treatment of cerebral metastases.","authors":"F D'Elia, I Bonucci, G P Biti, L Pirtoli","doi":"10.3109/02841868609136400","DOIUrl":"https://doi.org/10.3109/02841868609136400","url":null,"abstract":"<p><p>Multiple daily fractionation (MDF) was compared, in a cooperative study, with conventional fractionation (CF) in the radiation treatment of brain metastases. The 103 patients treated by MDF and the 44 given CF showed a similar response, in terms of neurologic improvement, survival, quality of residual life, and treatment-related morbidity. The hypothesis that MDF might give a better therapeutic ratio than CF was not confirmed in the present series. The short time period required gives MDF advantages in clinical practice.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"181-4"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary extraosseous osteogenic sarcoma in the retroperitoneal space. A case report and review of the literature.","authors":"H Skensved, G Søndergaard","doi":"10.3109/02841868609136403","DOIUrl":"https://doi.org/10.3109/02841868609136403","url":null,"abstract":"<p><p>One case of primary, extraosseous osteogenic sarcoma in the retroperitoneal region is presented, which is the tenth case hitherto reported in the literature. The 3 females and 7 males reported had a median age at diagnosis of 59 1/2 years. The tumours were all large at diagnosis and the symptoms short and uncharacteristic. There was no characteristic set of laboratory or roentgenologic findings; 2 of the 10 cases had elevation of alkaline phosphatase, and in 4 cases roentgen examination revealed tumour calcifications. The prognosis was poor and 8 of the 10 patients died, with a median survival of 9 1/2 months. In 3 cases, surgery was supplemented by chemotherapy without obvious improvement in survival.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"191-4"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative radiation therapy and adjuvant chemoimmunotherapy in breast cancer. Aspects of timing and immune competence.","authors":"P Klefström, L Nuortio, E Taskinen","doi":"10.3109/02841868609136396","DOIUrl":"https://doi.org/10.3109/02841868609136396","url":null,"abstract":"<p><p>The effects of radiation therapy and adjuvant chemoimmunotherapy on the immune competence of patients with breast cancer were investigated. The tests performed included intradermal tuberculin tests, T- and B-lymphocyte counts, and lymphocyte blast transformation tests; phytohemagglutinin (PHA), concanavalin A (ConA) and pokeweed mitogen (PWM) were used as mitogens. Enhancement in lymphocyte proliferative response to mitogenic stimulation by PHA and PWM was seen in patients after 3 courses of chemotherapy + levamisole, whereas irradiation given after chemotherapy caused long-lasting depression in response to PHA (p = 0.039) and PWM (not significant). T-lymphocyte counts were also lower after irradiation than after chemoimmunotherapy (p = 0.007). Clinically, the 16 patients treated with radiation therapy after chemotherapy exhibited a higher recurrence rate than the 24 patients treated first by irradiation. Enhanced reactivity to tuberculin tests occurred generally in patients receiving a planned treatment including irradiation, chemotherapy (5-fluorouracil, doxorubicin, cyclophosphamide) and levamisole. Enhancement of reactivity was seen more often in patients who had not relapsed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"161-6"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dosimetry and quality specification of high energy photon beams.","authors":"A Brahme, P Andreo","doi":"10.3109/02841868609136408","DOIUrl":"https://doi.org/10.3109/02841868609136408","url":null,"abstract":"<p><p>A number of quality descriptors are defined characterizing the photon attenuation and lepton contamination properties of high energy photon beams for radiation therapy. The dependence of the quality parameters on the design of the clinical beams such as the incident electron energy, target and filter thicknesses, field size and depth in the phantom are analyzed in some detail using analytical and Monte Carlo techniques. It is shown that the mean attenuation coefficient of the beam for a standard field size of 10 cm X 10 cm is related very accurately to the mean stopping power ratio for ionizing chamber dosimetry but also approximately to the equilibrium absorbed dose in the beam for a given photon energy fluence. This means that accurate photon dosimetry can be performed without knowing the acceleration potential, target design or filter thickness for the beam in use. Furthermore, the mechanism behind beam hardening and softening in the phantom are quantitized and suitable quality parameters for the lepton contamination are identified. The latter allow a determination of the lepton contamination for correction of the stopping power ratio near the surface if the contamination is large.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"213-23"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14154701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combination chemotherapy with dacarbazine and lomustine in disseminated malignant melanoma.","authors":"H Joensuu, R Asola, H Minn","doi":"10.3109/02841868609136399","DOIUrl":"https://doi.org/10.3109/02841868609136399","url":null,"abstract":"<p><p>Thirty-eight patients with disseminated malignant melanoma (stage IV) who had not received previous chemotherapy were given lomustine 50 to 80 mg/m2 orally on day 1 and dacarbazine 400 mg intravenously on days 1 to 3 with intervals of 6 weeks. Three of the 36 evaluable patients showed complete response (8%), 4 partial response (11%), and 5 had stable disease for at least 3 months (13%). The responding patients had metastases confined to cutaneous, nodal or pulmonary sites. None of the patients with liver, osseous or cerebral metastases, or patients with Karnofsky's status of less than 80, responded. Patients with more than two years from the diagnosis to the start of the chemotherapy were more likely to achieve objective response (p less than 0.05). Eighty-four per cent of the patients had nausea or vomiting, but otherwise toxicity was minimal.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"177-9"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Irradiation of the thoracic esophagus. Prone versus supine treatment positions.","authors":"S Vijayakumar, R Muller-Runkel","doi":"10.3109/02841868609136402","DOIUrl":"https://doi.org/10.3109/02841868609136402","url":null,"abstract":"<p><p>A vast majority of patients with esophageal cancer receive radiation therapy for cure or palliation. Because of the close anatomic proximity of the esophagus to the spinal cord, and unusually long fields used in the irradiation of esophageal cancer, staying within the spinal cord tolerance is crucial. The present investigation shows how this can be achieved by delivering the radiation in prone position.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 3","pages":"187-9"},"PeriodicalIF":0.0,"publicationDate":"1986-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14152901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of 90Sr, adult thymectomy and antilymphocyteglobulin on haematopoietic tissues and peripheral blood leucocytes in CBA mice.","authors":"P Bierke","doi":"10.3109/02841868609136394","DOIUrl":"https://doi.org/10.3109/02841868609136394","url":null,"abstract":"<p><p>The role of long-time immune suppression in carcinogenesis induced by the long-lived internal emitter 90Sr, is investigated in an ongoing study. The experimental design is based on the assumption that impaired immune responsiveness, by other means than 90Sr, might increase the neoplastic response in exposed individuals, and thus reflect a protective function, if existing. Intercomparison is made of the tumour yield in mice exposed to different single doses of 90Sr and simultaneously subjected or not to long-term immune suppression by adult thymectomy (ATx) and/or antilymphocyteglobulin (ALG) treatment. Information on the general condition and responsiveness of the immune system, in the respective models, during tumour expectancy time, is essential for a conclusive evaluation of the results. To meet these demands the present paper reports on histopathologic alterations in immune organs and changes in white blood cell counts, induced by the different combinations of 90Sr, ATx and ALG treatment. The results confirm the prediction, that ATx + ALG is an efficient and, with respect to the purpose of the study, suitable treatment for additive long-term depression of the immune system in 90Sr irradiated mice, evidenced in particular by increased depletion of monomorphonuclear cells (MNC) in lymphoid organs and peripheral blood. Subsequent reports will deal with functional immune parameters.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 2","pages":"147-54"},"PeriodicalIF":0.0,"publicationDate":"1986-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14145983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Nishimura, I Itoh, Y Mouri, K Iwabuchi, S Sakata, K Nakano, H Otsu, K Maruyama, M Nakano, K Ida
{"title":"Computed tomography in the assessment of pancreatic tumor response after intraoperative radiation therapy.","authors":"A Nishimura, I Itoh, Y Mouri, K Iwabuchi, S Sakata, K Nakano, H Otsu, K Maruyama, M Nakano, K Ida","doi":"10.3109/02841868609136389","DOIUrl":"https://doi.org/10.3109/02841868609136389","url":null,"abstract":"<p><p>Computed tomography was used in 7 patients given intraoperative electron beam therapy for advanced carcinoma of the pancreas. The local tumor response was studied quantitatively by defining the tumor contour in consecutive CT scans and then estimating the tumor volume. The maximum diameters of the tumor in 3 planes (X, Y and Z) were also estimated. There was evidence of initial tumor regression in all patients during the first few months after the treatment. No specific behaviour of the diameters in the X, Y and Z planes could be detected. Later on, regrowth of the tumor could sometimes be observed, preferably in one of the 3 planes. On the whole, CT was found to be a useful tool for assessing tumor response to this form of therapy.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 2","pages":"121-6"},"PeriodicalIF":0.0,"publicationDate":"1986-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14145472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary breast cancer. Complications of axillary management.","authors":"E K Yeoh, J W Denham, S A Davies, M F Spittle","doi":"10.3109/02841868609136386","DOIUrl":"https://doi.org/10.3109/02841868609136386","url":null,"abstract":"<p><p>The complications following surgery and postoperative radiation therapy in the management of the axilla in 187 patients with primary breast cancer treated between 1978 and 1982 have been studied. Although no difference in complication rate could be detected between the three different postoperative radiation schedules utilised there was a strong and positive correlation between complication rate and increasing extent of surgical intervention. When the groups were sub-divided according to the extent of surgery performed, no differences in regional recurrence rates were observed but complication rates (defined as significant lymphoedema of the arm and/or restriction of shoulder movements) were significantly different (p less than 0.001) at 30 months between those who had no surgical intervention (25%), those who had had 'sampling' performed (50%) and those who had had formal dissection performed (84%).</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 2","pages":"105-8"},"PeriodicalIF":0.0,"publicationDate":"1986-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14145470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}