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Effects of dietary supplementation with selenomethionine on the teratogenic effect of ionizing radiation in mice. 硒代蛋氨酸对小鼠电离辐射致畸作用的影响。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134417
E Cekan, P Slanina, K Bergman, B Tribukait
{"title":"Effects of dietary supplementation with selenomethionine on the teratogenic effect of ionizing radiation in mice.","authors":"E Cekan,&nbsp;P Slanina,&nbsp;K Bergman,&nbsp;B Tribukait","doi":"10.3109/02841868509134417","DOIUrl":"https://doi.org/10.3109/02841868509134417","url":null,"abstract":"<p><p>Female C3H mice were fed a standard pellet diet (containing 0.2 ppm Se and 30 ppm vit. E) or the same diet supplemented with 0.8 ppm (low dose) or 3.4 ppm (high dose) of selenomethionine for 10 weeks. After mating with males receiving the standard diet the mice were subjected, on the 9th day of pregnancy, to whole body roentgen irradiation of 1.75 Gy. On day 18 of gestation the frequency of resorptions, mortality and the incidence of fetal malformations were studied. Supplementation with Se-methionine resulted in a significant but dose-independent decrease (p less than 0.005) of the number of malformed fetuses from 62 per cent in the irradiated controls to 47 per cent in the low Se-group and high Se-group, respectively. In addition, the number of total malformations as well as fetal resorptions were significantly decreased in a dose-independent manner in the supplemented groups. The decrease in fetal malformations occurred proportionally for all the major malformations observed, i.e. short or kinked tail, rib and vertebral malformations, coloboma and deformation of retina and iris. Glutathione peroxidase activity in whole blood of Se-methionine fed mice was significantly increased. Thus, Se-rich diet may result in scavenaging of radiation-induced hydroperoxides.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"459-63"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Radiation sensitivity of human malignant lymphocytes. 人恶性淋巴细胞的辐射敏感性。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134410
R Seshadri, C Matthews, A A Morley
{"title":"Radiation sensitivity of human malignant lymphocytes.","authors":"R Seshadri,&nbsp;C Matthews,&nbsp;A A Morley","doi":"10.3109/02841868509134410","DOIUrl":"https://doi.org/10.3109/02841868509134410","url":null,"abstract":"<p><p>A simple and rapid in vitro technique to assess the sensitivity of human malignant lymphocytes to roentgen irradiation is described. A variety of established malignant lymphocyte cell lines were cloned in microwells and clone survival was used as the end-point. The survival of the clonogenic malignant lymphocyte down to a fraction of approximately 0.001 could be measured accurately. Except for a T-cell line, the radiation sensitivities of the cell lines were similar to that of normal T-lymphocytes.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"411-4"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Dynamics of irradiation injury to bone tissue. A vital microscopic investigation. 辐照对骨组织损伤的动力学。重要的显微研究。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136063
M Jacobsson, T Albrektsson, I Turesson
{"title":"Dynamics of irradiation injury to bone tissue. A vital microscopic investigation.","authors":"M Jacobsson,&nbsp;T Albrektsson,&nbsp;I Turesson","doi":"10.3109/02841868509136063","DOIUrl":"https://doi.org/10.3109/02841868509136063","url":null,"abstract":"<p><p>The dynamic changes after a single dose of 15, 25 or 40 Gy 60Co were followed in a titanium vital microscopic bone chamber which permitted observation of the same tissue compartment for over 2 years. The chamber consists of a hollow screw containing 2 glass rods 100 micron apart. The device was inserted into the cortex of the proximal tibial metaphysis of a rabbit. During a healing period of 4 to 6 weeks the space between the glass rods became filled with bone and vessels and in some cases fat. Once a steady state in bone remodelling had been achieved, the animals were irradiated. Vital microscopy was then performed at regular intervals. Mature bone was relatively radioresistant since remodelling continued at a normal rate. In contrast, immature woven bone remained unlamellarized and in some animals tended to increase in amount. The vascular architecture was largely unaltered, even after 40 Gy. Thrombosis or hemorrhage clearly attributable to irradiation was not noted. Initially, the number of fat cells was reduced but repopulation was later seen in several cases.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"343-50"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Changes in lymphoid cell distribution after intraperitoneal administration of 32P colloids. 腹腔注射32P胶体后淋巴样细胞分布的变化。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136061
M Onsrud, V Bosnes, I Grahm, A Engeset
{"title":"Changes in lymphoid cell distribution after intraperitoneal administration of 32P colloids.","authors":"M Onsrud,&nbsp;V Bosnes,&nbsp;I Grahm,&nbsp;A Engeset","doi":"10.3109/02841868509136061","DOIUrl":"https://doi.org/10.3109/02841868509136061","url":null,"abstract":"<p><p>The effect of intraperitoneal administration of 32P colloids on the distribution of T lymphocyte subpopulations and monocytes was studied using monoclonal antibodies and a flow cytometry technique. Thirty-nine patients with ovarian carcinoma without residual tumor after primary operation were examined either before the administration of 260 to 370 MBq of 32P, 4 to 6 days after therapy, or 4 to 10 months after therapy. A significant reduction of circulating OKT4+ (T helper) cells occurred after therapy, and the reduction lasted throughout the observation period. Monocyte numbers were not significantly changed. It is concluded that intraperitoneal instillation of the 32P isotope may induce the same type of changes in circulating lymphoid cells as those seen after external field irradiation.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"331-5"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Breast retraction assessment. Multiple variable analysis of factors responsible for cosmetic retraction in patients treated conservatively for stage I or II breast carcinoma. 乳房内收评估。I期或II期乳腺癌患者保守治疗导致美容后缩的多变量分析。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136060
R D Pezner, M P Patterson, L R Hill, N L Vora, K R Desai, J A Lipsett
{"title":"Breast retraction assessment. Multiple variable analysis of factors responsible for cosmetic retraction in patients treated conservatively for stage I or II breast carcinoma.","authors":"R D Pezner,&nbsp;M P Patterson,&nbsp;L R Hill,&nbsp;N L Vora,&nbsp;K R Desai,&nbsp;J A Lipsett","doi":"10.3109/02841868509136060","DOIUrl":"https://doi.org/10.3109/02841868509136060","url":null,"abstract":"<p><p>A method for objective evaluation of cosmetic outcome of patients treated conservatively for breast carcinoma allowed the location of the nipples on two coordinates. The method was applied in 41 patients, 5 to 41 months following the completion of radiation therapy. Multiple variable analysis revealed that extensiveness of resection of the primary breast tumor was the major factor associated with breast retraction. The only other factor of significance was patient age at diagnosis. Neither the radiation therapy parameters, the use of adjuvant chemotherapy, nor any other analyzed factor was found to be associated with cosmetic breast retraction.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"327-30"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
A therapeutic approach to early vocal cord carcinoma. 早期声带癌的治疗方法。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136059
R Amornmarn, T Prempree, T Viravathana, V Donavanik, M J Wizenberg
{"title":"A therapeutic approach to early vocal cord carcinoma.","authors":"R Amornmarn,&nbsp;T Prempree,&nbsp;T Viravathana,&nbsp;V Donavanik,&nbsp;M J Wizenberg","doi":"10.3109/02841868509136059","DOIUrl":"https://doi.org/10.3109/02841868509136059","url":null,"abstract":"<p><p>One hundred and twenty patients with early glottic carcinoma received radiation therapy at the University of Maryland Hospital from 1959 to 1977. The radiation dose ranged from 55 Gy in 4 weeks for small T1a lesions to 65 Gy in 61/2 weeks for T2 lesions. The local control rates by irradiation alone for stages T1a, T1b, and T2 were 92, 91 and 88 per cent, respectively, while 5-year determinate disease-free survival rates were 96 per cent for stage I disease and 88 per cent for stage II disease. Most of the local failures were salvaged by surgery, with a low complication rate. Regional metastases were uncommon, and occurred in 7 per cent in stage I and in 6 per cent in stage II disease. Factors increasing the risk of failures appeared to be bulky tumor, anterior commissure involvement and subglottic extension.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"321-5"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 66
Intermittent feeding as a factor enhancing hemopoietic stem cell proliferation and spleen colony formation in irradiated mice. 间歇性喂养对辐照小鼠造血干细胞增殖和脾脏集落形成的促进作用。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136065
A Kozubík, M Pospísil
{"title":"Intermittent feeding as a factor enhancing hemopoietic stem cell proliferation and spleen colony formation in irradiated mice.","authors":"A Kozubík,&nbsp;M Pospísil","doi":"10.3109/02841868509136065","DOIUrl":"https://doi.org/10.3109/02841868509136065","url":null,"abstract":"<p><p>The influence of metabolic stimulation induced by a 3 weeks' adaptation of the animals to intermittent food intake on hemopoietic stem cells was investigated in mice. The methods used included transplantation of bone marrow to lethally irradiated recipients, assay of CFUs number, seeding efficiency, and incorporation of 125iododeoxyuridine into the DNA of spleen cells. A stimulatory effect of the metabolically influenced hemopoietic environment on the proliferative activity in stem cell compartments and on the recovery of hemopoietic organs was demonstrated. These stimulatory effects were most marked when the bone marrow of metabolically influenced donors was transplanted to similarly influenced recipients.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"357-61"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Glucose analogues alter the response of CHO-KI cells to gamma irradiation. 葡萄糖类似物改变CHO-KI细胞对γ辐射的反应。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136064
C B Seymour, C Mothersill, M J Moriarty
{"title":"Glucose analogues alter the response of CHO-KI cells to gamma irradiation.","authors":"C B Seymour,&nbsp;C Mothersill,&nbsp;M J Moriarty","doi":"10.3109/02841868509136064","DOIUrl":"https://doi.org/10.3109/02841868509136064","url":null,"abstract":"<p><p>Pretreatment of CHO-KI cells with 2-deoxy-D-glucose or L-glucose, two glucose analogues, reduces their survival if subsequently exposed to 60Co irradiation. The reduction in survival is constant irrespective of the time the cells are in contact with the analogues before irradiation and occurred even when cells were irradiated 6 hours after plating, suggesting that cell cycle effects are probably not involved. Interestingly, split-dose recovery was not affected to the expected degree, despite a reduction in the extrapolation number of the primary curve. It is suggested that interference with energy production from glucose is responsible for the reduced capacity of cells to survive the irradiation.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"351-6"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
RNA and protein synthesis of irradiated Ehrlich ascites tumour cells. I. In vivo investigations related to the cell cycle. 辐照埃利希腹水肿瘤细胞的RNA和蛋白质合成。与细胞周期相关的体内研究。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136068
S Skog, B Tribukait, G Sundius
{"title":"RNA and protein synthesis of irradiated Ehrlich ascites tumour cells. I. In vivo investigations related to the cell cycle.","authors":"S Skog,&nbsp;B Tribukait,&nbsp;G Sundius","doi":"10.3109/02841868509136068","DOIUrl":"https://doi.org/10.3109/02841868509136068","url":null,"abstract":"<p><p>The effects of roentgen irradiation on the incorporation of 3H-uridine and 14C-leucine into RNA and protein and the RNA and protein contents of in vivo growing Ehrlich ascites tumour cells were studied. The results were related to changes in the composition of cells in cell cycle and compared with the synthesis of RNA and protein in cell material from various parts of the cell cycle obtained by means of elutriator centrifuging. The incorporation expressed by the ratio between acid insoluble/acid soluble activity was unchanged for RNA during the observation period up to 24 hours after a dose of 5.0 Gy. The ratio for protein was markedly decreased between 4 and 24 hours. This decrease was partly due to a decrease of the pool size of leucine as studied by changing the amounts of 14C leucine used. From these studies, the existence of at least two pools, an expandable and a non-expandable fixed pool can be concluded. There were no differences in the decrease of protein-synthesis between cells from the various parts of the cell cycle. The RNA and protein contents of the irradiated cells from various parts of the cell cycle corresponded to those of non-irradiated cells except for G1/early S-phase cells at 15 and 24 hours after irradiation. Possible reasons for this discrepancy are discussed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"375-82"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Squamous cell carcinoma of the nasopharynx. An analysis of failure patterns after radiation therapy. 鼻咽部鳞状细胞癌。放射治疗后的失败模式分析。
Acta radiologica. Oncology Pub Date : 1985-07-01 DOI: 10.3109/02841868509136058
S Yamashita, M Kondo, S Hashimoto
{"title":"Squamous cell carcinoma of the nasopharynx. An analysis of failure patterns after radiation therapy.","authors":"S Yamashita,&nbsp;M Kondo,&nbsp;S Hashimoto","doi":"10.3109/02841868509136058","DOIUrl":"https://doi.org/10.3109/02841868509136058","url":null,"abstract":"<p><p>Seventy-seven patients with nasopharyngeal squamous cell carcinoma were treated with irradiation, with or without chemotherapy. Sixty-three (82%) developed a relapse in some part of the body; the first relapse appeared at primary, cervical and distant sites in 45 (71%), 30 (48%) and 12 (19%) of the 63 relapsing patients, respectively. In 22 of the 63 relapsing patients, the first relapse occurred simultaneously in two or more sites. Local recurrence-free survival was higher for the T1 + T2 group than for the T3 + T4 group (p less than 0.02). Cervical relapse-free survival was higher for N0 patients than for N+ patients (p less than 0.02). Distant metastases frequently developed as a component of the first relapse. Distant metastases were more common in N+ patients than in N0 patients. Forty-two patients received adjuvant chemotherapy. Although local recurrence-free survival tended to be higher in patients with chemotherapy than without chemotherapy, survival rates and relapse-free survival rates did not differ in the two groups.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 4","pages":"315-20"},"PeriodicalIF":0.0,"publicationDate":"1985-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509136058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14127591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
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