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Acta radiologica. Oncology最新文献

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Chest irradiation as an attempt to improve the response after induction chemotherapy in small cell lung carcinoma. 胸部照射改善小细胞肺癌诱导化疗后疗效的尝试。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134419
G Giaccone, R Musella, M Donadio, A Boidi-Trotti, O Bertetto, F Fracchia, A Tardy, A Calciati
{"title":"Chest irradiation as an attempt to improve the response after induction chemotherapy in small cell lung carcinoma.","authors":"G Giaccone,&nbsp;R Musella,&nbsp;M Donadio,&nbsp;A Boidi-Trotti,&nbsp;O Bertetto,&nbsp;F Fracchia,&nbsp;A Tardy,&nbsp;A Calciati","doi":"10.3109/02841868509134419","DOIUrl":"https://doi.org/10.3109/02841868509134419","url":null,"abstract":"<p><p>Forty-six patients with small cell lung carcinoma received cyclic chemotherapy with cisplatin-VP 16 and vincristine, doxorubicin, and cyclophosphamide. The responding patients were given prophylactic cranial irradiation. Patients without metastases not achieving a complete response (CR) following induction chemotherapy were given chest irradiation. The response rate was 73.9 per cent. Response was improved by radiation therapy in only 9 per cent of the patients with limited disease. Median survival was 39 weeks, with 2 patients surviving for longer than 24 months. The duration of response and survival in complete and partial responders was similar; absence of radiation therapy in the patients with CR might explain this finding.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"475-9"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Radical irradiation of T2 and T3 bladder carcinoma. A retrospective investigation. T2和T3膀胱癌的放射治疗。回顾性调查。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134423
S D Fosså, S Ous, O S Knudsen
{"title":"Radical irradiation of T2 and T3 bladder carcinoma. A retrospective investigation.","authors":"S D Fosså,&nbsp;S Ous,&nbsp;O S Knudsen","doi":"10.3109/02841868509134423","DOIUrl":"https://doi.org/10.3109/02841868509134423","url":null,"abstract":"<p><p>The relative 5-year survival was 32 per cent in 97 patients with T2 or T3 bladder carcinoma (1972-1978) treated with high dose radiation therapy (CRE greater than or equal to 1700 reu). A slight but significant difference was noted between the two T categories. Fifty-three patients who were tumour-free 3 to 4 months after irradiation had a 55 per cent survival. No other prognostic parameters were identified on the basis of histologic or radiologic findings. In 14 patients severe radiation complications were observed (bladder 9, small bowel 3, combined 2). In patients with radiation sensitive bladder carcinoma, radical radiation therapy seems to be a comparable alternative to total cystectomy.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"497-501"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Intracytoplasmic immunoglobulins in the differential diagnosis of lymphocytic lymphomas of the B-CLL type and immunocytic lymphomas. 胞浆内免疫球蛋白在B-CLL型淋巴细胞淋巴瘤和免疫细胞淋巴瘤鉴别诊断中的应用。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134427
U Martinsson, B Glimelius, H Hagberg, B Simonsson, C Sundström
{"title":"Intracytoplasmic immunoglobulins in the differential diagnosis of lymphocytic lymphomas of the B-CLL type and immunocytic lymphomas.","authors":"U Martinsson,&nbsp;B Glimelius,&nbsp;H Hagberg,&nbsp;B Simonsson,&nbsp;C Sundström","doi":"10.3109/02841868509134427","DOIUrl":"https://doi.org/10.3109/02841868509134427","url":null,"abstract":"<p><p>One hundred and thirty-three consecutive cases originally classified either as a lymphocytic lymphoma of the B-CLL type or as an immunocytic (IC) lymphoma could be reclassified morphologically and analyzed for the presence of cytoplasmic immunoglobulins (cIg) with the PAP-technique. The morphologic reclassification confirmed the initial diagnosis in most cases, whereas after staining for cIg, the diagnosis was changed in a large number of cases, i.e. from B-CLL to IC, or the reverse, or from IC of the polymorphic subtype (ICp) to 'high-grade' non-Hodgkin lymphoma (NHL). Cases classified as IC were often localized (stage I+II: 22/43) with a long disease-free survival after local radiation therapy, while B-CLL were usually generalized. For patients in stage IV, the prognosis of B-CLL was significantly superior to that of IC, which in turn was superior to the prognosis of cases referred to as 'high-grade' NHL. The difficulties in the morphologic distinction between B-CLL and IC on one hand and between ICp and some 'high-grade' NHL on the other hand, as well as the clinical significance of these distinctions, are discussed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"527-35"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Quantitative evaluation of spontaneous and radiation-induced polyploidisation processes in human and murine testes. 人类和小鼠睾丸自发和辐射诱导的多倍体化过程的定量评价。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134424
U Hacker-Klom, W Göhde, J Schumann
{"title":"Quantitative evaluation of spontaneous and radiation-induced polyploidisation processes in human and murine testes.","authors":"U Hacker-Klom,&nbsp;W Göhde,&nbsp;J Schumann","doi":"10.3109/02841868509134424","DOIUrl":"https://doi.org/10.3109/02841868509134424","url":null,"abstract":"<p><p>Flow cytometric analysis of human and murine testicular tissue was performed in order to determine whether cells exist with a DNA content differing from the expected categories 1 c, 2 c and 4 c, and to estimate the frequencies of diploid elongated spermatids. About 1.5 per cent of the murine testicular cells had an 8 c DNA content. In human testis, no 8 c cells were detected. A slight increase of 8 c cells was observed in the murine testis, following irradiation. An average of 1.8 per cent of the elongated spermatids in 10 control mice were diploid. In 12 human testicular biopsies, an average of 4.7 per cent of diploid elongated spermatids was observed among all elongated spermatids in mice. Acute or split-dose exposure, with 15 Gy roentgen rays, to spermatocytes increased the spontaneously occurring level of diploid elongated spermatids 25-fold.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"503-7"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Detection of neoplastic lymph nodes in Hodgkin's disease and non-Hodgkin lymphoma. Comparison between tomography and lymphography. 霍奇金病和非霍奇金淋巴瘤肿瘤淋巴结的检测。层析成像与淋巴造影的比较。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134422
B Enig, B Bjerregaard Jensen, E Hjøllund Madsen, J Jørgensen, K Thorling
{"title":"Detection of neoplastic lymph nodes in Hodgkin's disease and non-Hodgkin lymphoma. Comparison between tomography and lymphography.","authors":"B Enig,&nbsp;B Bjerregaard Jensen,&nbsp;E Hjøllund Madsen,&nbsp;J Jørgensen,&nbsp;K Thorling","doi":"10.3109/02841868509134422","DOIUrl":"https://doi.org/10.3109/02841868509134422","url":null,"abstract":"<p><p>During a period of 17 months, 98 consecutive patients with malignant lymphoma were examined for initial staging before therapy. Both CT and lymphography were performed in 58 patients (19 patients with Hodgkin's disease (HD) and 39 patients with non-Hodgkin lymphoma (NHL], and these were included in the investigation. The results were discrepant in 26 cases where lymph node lesions were detected by only one of the two methods. In 10 patients, 5 with HD and 5 with NHL, the positive finding by one of the methods was taken as determinant of the stage. The conclusion drawn was that CT cannot completely replace lymphography without losing important information. Owing to limited resources for lymphography and CT a reduced staging programme is proposed. Judging by the present results, this reduced programme would probably mean only a minimal loss of information.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"491-5"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Human blood granulocyte macrophage progenitors (GM-CFU) during extended field radiation therapy. 人血液粒细胞巨噬细胞祖细胞(GM-CFU)在扩大野放疗期间。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134426
D Thierry, D Jullien, O Rigaud, M Hardy, J R Vilcoq, H Magdelenat
{"title":"Human blood granulocyte macrophage progenitors (GM-CFU) during extended field radiation therapy.","authors":"D Thierry,&nbsp;D Jullien,&nbsp;O Rigaud,&nbsp;M Hardy,&nbsp;J R Vilcoq,&nbsp;H Magdelenat","doi":"10.3109/02841868509134426","DOIUrl":"https://doi.org/10.3109/02841868509134426","url":null,"abstract":"<p><p>The rate of the clonogenicity of granulocyte macrophage forming cells (GM-CFU) in agar was analysed using mononuclear cells from the peripheral blood of cancer patients undergoing total body irradiation (TBI, 5 patients, 1.5 Gy in 15 days) or hemicorporal irradiation of the lower (LHBI, 5 patients, 15 Gy in 15 days) or upper (UHBI, 4 patients, 15 Gy in 15 days) part of the body. Although the GM-CFU level in the blood is low compared with that in the bone marrow, and shows considerable variability, the preliminary results demonstrated that in most cases the GM-CFU level was increased around the 10th day after the beginning of irradiation, followed by a return to base level within a few days, for LHBI and TBI but not for UHBI. The question of whether the observed peak for the clonogenicity was due to stem cells leaving a radiation-injured compartment of the bone marrow or to vicarious stem cells migrating from non-irradiated regions, or was the result of enhanced activity of colony-stimulating factors, remains to be investigated.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"521-6"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Use of formalin fixed, paraffin embedded tumours for estimation of cellular DNA content and S-phase fraction by static cytofluorometry. 使用福尔马林固定、石蜡包埋肿瘤，通过静态细胞荧光法估计细胞DNA含量和s相分数。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134428
B Risberg, O Stål, K Bjelkenkrantz, T Hatschek, G Franzén, S Arvidsson, B Nordenskjöld
{"title":"Use of formalin fixed, paraffin embedded tumours for estimation of cellular DNA content and S-phase fraction by static cytofluorometry.","authors":"B Risberg,&nbsp;O Stål,&nbsp;K Bjelkenkrantz,&nbsp;T Hatschek,&nbsp;G Franzén,&nbsp;S Arvidsson,&nbsp;B Nordenskjöld","doi":"10.3109/02841868509134428","DOIUrl":"https://doi.org/10.3109/02841868509134428","url":null,"abstract":"<p><p>Sections with a thickness of 50 micron from 34 formalin fixed, and paraffin embedded tumours were deparaffinized and hydrated and the cells were disaggregated with pepsin. The cells were stained with Hoechst 33258 and a rapid method for static fluorometry was used. DNA ploidy and the fraction of cells in S-phase were estimated and compared with results obtained with freshly prepared cells. The coefficients of variation for the tumour stemlines for both the fresh and the embedded material were approximately 6 per cent. There was a good correlation between DNA ploidy determined from fresh and embedded material, respectively; there was also a close correlation between the fractions of S-phase cells estimated from fresh and embedded tumours. It was also possible to cut out small histologically defined lesions, such as carcinoma in situ of the breast from thick paraffin sections and obtain DNA histograms with high resolution.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"537-44"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13568760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
The use of computed tomography numbers in dose calculations for radiation therapy. 计算机断层扫描数字在放射治疗剂量计算中的应用。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134425
H Huizenga, P R Storchi
{"title":"The use of computed tomography numbers in dose calculations for radiation therapy.","authors":"H Huizenga,&nbsp;P R Storchi","doi":"10.3109/02841868509134425","DOIUrl":"https://doi.org/10.3109/02841868509134425","url":null,"abstract":"<p><p>Although corrections for 'beam hardening' and 'scattering' have been implemented in currently available CT scanners, systematic differences exist between a real CT image and an ideal, artefact-free and monochromatic image. The appearance and magnitude of these differences are discussed. Conversion to the ideal image, i.e. conversion from CT number to X-ray attenuation coefficient at diagnostic photon energies, turns out to be possible with an accuracy of 5 per cent. In order to use the CT 'density' information from patients, in clinical photon and electron beam dose calculations, conversions must be made from the X-ray attenuation coefficient at diagnostic energies to relevant high energy radiation interaction properties. These conversions turn out to be possible within an accuracy also of 5 per cent. These limited accuracies cause errors in the photon beam dose calculation of less than 1 per cent of the dose maximum and errors in electron beam dose calculations of less than 2 per cent of the dose maximum.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"509-19"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Influence of pancreatic secretion on late radiation enteropathy in the rat. 胰腺分泌对大鼠晚期放射性肠病的影响。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134431
M Hauer Jensen, T Sauer, T Berstad, K Nygaard
{"title":"Influence of pancreatic secretion on late radiation enteropathy in the rat.","authors":"M Hauer Jensen,&nbsp;T Sauer,&nbsp;T Berstad,&nbsp;K Nygaard","doi":"10.3109/02841868509134431","DOIUrl":"https://doi.org/10.3109/02841868509134431","url":null,"abstract":"<p><p>In female Wistar rats a 10 cm long exteriorized mid small intestinal segment was roentgen irradiated 3 weeks after a pancreatic duct-occluding operation/sham operation. Roentgen doses were 19 and 21 Gy as single exposures. Radiation injury was assessed 2, 8 and 26 weeks after irradiation using one macroscopic and 7 histopathologic parameters. The parameters were graded according to severity, and a radiation injury score was calculated by adding the scores for the individual parameters. Two and 8 weeks following irradiation there was no difference between pancreatic duct-occluded and sham operated animals. Twenty-six weeks after irradiation all parameters of radiation injury except the extent of vascular sclerosis were less marked in pancreatic duct-occluded rats than in controls. It is concluded that exocrine pancreatic secretions may influence the development of late changes following irradiation, and that these changes seem to be mainly independent of the degree of vascular sclerosis.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"555-60"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
Effects of irradiation and inhibition of adenosine diphosphate ribosyl transferase in radiation sensitive and resistant mouse lymphoma (L5178Y) cells. 辐照对辐射敏感和耐药小鼠淋巴瘤(L5178Y)细胞中腺苷二磷酸核糖转移酶的抑制作用。
Acta radiologica. Oncology Pub Date : 1985-09-01 DOI: 10.3109/02841868509134416
K J Johanson, S Sundell-Bergman, I Szumiel, D Wlodek
{"title":"Effects of irradiation and inhibition of adenosine diphosphate ribosyl transferase in radiation sensitive and resistant mouse lymphoma (L5178Y) cells.","authors":"K J Johanson,&nbsp;S Sundell-Bergman,&nbsp;I Szumiel,&nbsp;D Wlodek","doi":"10.3109/02841868509134416","DOIUrl":"https://doi.org/10.3109/02841868509134416","url":null,"abstract":"<p><p>The effects of treatment with benzamide, an inhibitor of adenosine diphosphate (ADP) ribosyl transferase, were studied in two strains of L5178Y lymphoma cells of differential sensitivity to ionizing radiation. Continuous 2 mmol/l benzamide treatment enhanced the killing effect of roentgen irradiation in the sensitive cells, but not in the resistent cells. Three hours' treatment with 2 to 15 mmol/l benzamide sensitized irradiated cells of both strains to a similar extent. Rejoining of DNA breaks was delayed by 2 mmol/l benzamide in sensitive cells more than in resistant cells.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 5","pages":"451-7"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14135014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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