Acta radiologica. Oncology最新文献

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Radiation treatment of testicular relapse in acute lymphoblastic leukemia. 急性淋巴细胞白血病睾丸复发的放射治疗。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136373
V Tombolini, E Banelli, A Capua, F Giona, A Vitturini
{"title":"Radiation treatment of testicular relapse in acute lymphoblastic leukemia.","authors":"V Tombolini,&nbsp;E Banelli,&nbsp;A Capua,&nbsp;F Giona,&nbsp;A Vitturini","doi":"10.3109/02841868609136373","DOIUrl":"https://doi.org/10.3109/02841868609136373","url":null,"abstract":"<p><p>Ten patients with testicular relapse among 128 cases of acute lymphoblastic leukemia are reported. At the time of the initial diagnosis of leukemia all patients with later testicular relapse showed one or more risk factors as predictive for leukemic infiltration of the testicles. All patients except one, who underwent orchiectomy and died 11 weeks after surgical intervention, received radiation therapy with doses ranging from 12 to 20 Gy and chemotherapy. The local control was excellent. Average survival time from testicular relapse to death was 68 weeks in 8 of 9 patients treated by irradiation and chemotherapy. One patient is still alive without signs of disease after 6 years.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Partial prevention of tritium induced uterine involution in mice by 2-mercaptopropionylglycine. 2-巯基丙基甘氨酸部分预防氚诱导小鼠子宫复旧。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136382
S P Mathur, N Patni, M K Popli, P K Dev
{"title":"Partial prevention of tritium induced uterine involution in mice by 2-mercaptopropionylglycine.","authors":"S P Mathur,&nbsp;N Patni,&nbsp;M K Popli,&nbsp;P K Dev","doi":"10.3109/02841868609136382","DOIUrl":"https://doi.org/10.3109/02841868609136382","url":null,"abstract":"<p><p>Pregnant Swiss albino mice were given on day 11.25 post conception a priming intraperitoneal (i.p.) injection of tritiated water at the activity levels 37, 74 or 185 kBq/ml body water, in the absence (control) or presence (experimental) of 2-mercaptopropionylglycine (MPG), 20 mg/kg body weight, given intraperitoneally 30 minutes before the tritium administration. The females were subsequently maintained on tritiated drinking water until term, at the above activity level, in the control series. The animals of the experimental series received in addition a daily i.p. injection of MPG at the same time of the day, until term. A third series received a daily injection of the drug, but no tritium, at the same dose rate. None of the females from the control series had parturition, and a gradual decline in their weight was recorded, exhibiting resorption. Treatment with MPG led to an obvious increase in embryonic survival in all groups, and even in the 185 kBq group two-thirds of the females had parturition.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paternity after irradiation for testicular cancer. 睾丸癌放射治疗后的亲子关系。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136374
S D Fosså, B Almaas, V Jetne, T Bjerkedal
{"title":"Paternity after irradiation for testicular cancer.","authors":"S D Fosså,&nbsp;B Almaas,&nbsp;V Jetne,&nbsp;T Bjerkedal","doi":"10.3109/02841868609136374","DOIUrl":"https://doi.org/10.3109/02841868609136374","url":null,"abstract":"<p><p>According to the Medical Birth Registry (MBR) of Norway, 69 of about 430 patients irradiated for testicular cancer (stage I + II) during 1966-1978 fathered at least one child after radiation therapy (median observation time 136 months, range 36-191 months). A total of 95 children were born. Between 10 and 122 months elapsed between discontinuation of irradiation and the birth of the first child born after radiation therapy. Though the total doses to the abdominal irradiation field were higher in patients irradiated by a linear accelerator (1971-1978), than in those treated by a betatron (1966-1970), the gonadal doses were generally lower in the former group due to better gonadal shielding. In the children, the sex ratio and the median weight and length at birth were comparable to those values seen in a control group from the MBR. No increased frequency of malformations was observed. It is concluded that modern radiation therapy techniques allow post-irradiation fathership in a significant number of patients, without increased risk of neonatal problems or malformations in the children.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"33-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Effect of lactate on the recovery of CHO-KI cells from gamma radiation damage. 乳酸对γ射线损伤CHO-KI细胞恢复的影响。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136381
C Mothersill, C B Seymour
{"title":"Effect of lactate on the recovery of CHO-KI cells from gamma radiation damage.","authors":"C Mothersill,&nbsp;C B Seymour","doi":"10.3109/02841868609136381","DOIUrl":"https://doi.org/10.3109/02841868609136381","url":null,"abstract":"<p><p>The effect of pre-exposure of CHO-KI cells to lactate on their capacity to recover from or repair radiation damage was examined. Prolonged pre-exposure to lactate and a number of inhibitors of glycolysis has previously been shown to reduce the cell survival after irradiation. Following a split dose of irradiation, cells pre-treated with lactate for 18 hours had a higher relative recovery factor than controls even though survival following a single dose was reduced. Where lactate was added just before irradiation it had a radiation protective effect on the single dose survival curve and no effect on recovery. To investigate a possible involvement of NADH generation via lactate dehydrogenase in the mechanism, oxamate, a non-metabolisable analogue of lactate, was investigated. It reduced the survival of irradiated CHO-KI cells following prolonged and short pre-exposure and did not significantly affect the recovery factor. It is suggested that since lactate and oxamate both inhibit glucose breakdown, their radiobiologic effects may be due to depletion of cellular energy substrates necessary for repair. In contrast, the increased recovery and short term radiation protective effect seen with lactate only may involve LDH activity.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Chest radiography in the follow-up of breast cancer. 胸部x线摄影在乳腺癌随访中的应用。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136370
P Hietanen
{"title":"Chest radiography in the follow-up of breast cancer.","authors":"P Hietanen","doi":"10.3109/02841868609136370","DOIUrl":"https://doi.org/10.3109/02841868609136370","url":null,"abstract":"<p><p>The significance of routine chest radiography in the follow-up of breast cancer was evaluated. This evaluation also included correlation of symptoms with site of intrathoracic relapse. Ten per cent of the patients developed intrathoracic recurrence; 54 per cent thereof were asymptomatic. Eighty-six per cent of the intrathoracic relapses appeared within five years. The significance of prognostic factors was obvious: a higher stage or grade gave a higher risk of intrathoracic relapses. The presence of symptoms was dependent on the site of relapse. The disease-free survival and survival after recurrence were not significantly different in symptomatic and asymptomatic patients. The contribution of routine chest radiography to the detection of relapses in asymptomatic patients was poor: one positive finding among 263 chest radiographic examinations. Routine chest radiography should be limited to high risk groups (stage II, III and grade III), preferably within the first five years after the primary treatment.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The effect of surgery, radiation therapy, and combined radiation therapy and chemotherapy on immunocompetence in patients with lung carcinoma. 手术、放疗及放化疗联合治疗对肺癌患者免疫功能的影响。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134420
M Jakobsson, P J Taskinen, P Ryhänen, A Hollmén, E Herva, P Kärkölä, M Saloheimo
{"title":"The effect of surgery, radiation therapy, and combined radiation therapy and chemotherapy on immunocompetence in patients with lung carcinoma.","authors":"M Jakobsson,&nbsp;P J Taskinen,&nbsp;P Ryhänen,&nbsp;A Hollmén,&nbsp;E Herva,&nbsp;P Kärkölä,&nbsp;M Saloheimo","doi":"10.3109/02841868509134420","DOIUrl":"https://doi.org/10.3109/02841868509134420","url":null,"abstract":"<p><p>The immunologic status of 59 patients with lung carcinoma was determined by analysis of peripheral venous blood samples. The following tests were performed: total leucocyte and lymphocyte counts, the number of acid alpha-naphthyl acetate esterase (ANAE) positive cells (T-cells), and phytohaemagglutinin (PHA) and tuberculin (PPD) transformation tests. The patients were divided into three treatment groups: a surgery group (S), a radiation therapy group (R), and a combined cytostatic and radiation therapy group (C). A follow-up was carried out 4 to 6 months after treatment. The therapeutic measures, resection, irradiation, and chemotherapy, produced a decrease in the total leucocyte and lymphocyte counts, in the number of T-cells, and in the leucocyte transformation response to PPD. In the surgically treated group the decrease was transient. In the groups treated with radiation therapy and combined cytostatic and radiation therapy the values remained low throughout the follow-up. The lymphocyte response to PHA was not altered in any of the groups during initial treatment or follow-up. The results did not suggest a correlation between the immunologic parameters used and the stage and histologic type of lung cancer. The tests were of no clinical value in the determination of the individual prognosis.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"481-6"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Combined bleomycin treatment and radiation therapy in squamous cell carcinoma of the head and neck region. 博来霉素联合放疗治疗头颈部鳞状细胞癌。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134421
L M Parvinen, M Parvinen, E Nordman, A E Kortekangas
{"title":"Combined bleomycin treatment and radiation therapy in squamous cell carcinoma of the head and neck region.","authors":"L M Parvinen,&nbsp;M Parvinen,&nbsp;E Nordman,&nbsp;A E Kortekangas","doi":"10.3109/02841868509134421","DOIUrl":"https://doi.org/10.3109/02841868509134421","url":null,"abstract":"<p><p>Forty-six patients with squamous cell carcinoma of the head and neck region were randomized to either irradiation or irradiation plus bleomycin. If possible, the patients later underwent radical surgery. In the bleomycin group, significantly fewer patients had remaining tumour cells in the tissue removed at operation, and a longer time elapsed before recurrences occurred. However, bleomycin had no significant effect on the 3-and 5-year survival rates, and it did not significantly reduce the incidence of local recurrences.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"487-9"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13568763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Cycling S-phase cells in animal and spontaneous tumours. I. Comparison of the BrdUrd and 3H-thymidine techniques and flow cytometry for the estimation of S-phase frequency. 动物和自发性肿瘤循环s期细胞。1 . BrdUrd和3h -胸苷技术与流式细胞术估计s相频率的比较。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134429
E M Langer, H R Röttgers, M G Schliermann, E M Meier, H G Miltenburger, J Schumann, W Göhde
{"title":"Cycling S-phase cells in animal and spontaneous tumours. I. Comparison of the BrdUrd and 3H-thymidine techniques and flow cytometry for the estimation of S-phase frequency.","authors":"E M Langer,&nbsp;H R Röttgers,&nbsp;M G Schliermann,&nbsp;E M Meier,&nbsp;H G Miltenburger,&nbsp;J Schumann,&nbsp;W Göhde","doi":"10.3109/02841868509134429","DOIUrl":"https://doi.org/10.3109/02841868509134429","url":null,"abstract":"Evaluation of the proliferative activities of cell populations has mainly been restricted to the use of autoradiography and flow cytometric measurements. The introduction of a new BrdUrd specific antibody makes it possible to determine exactly the DNA synthesizing cells. The BrdUrd technique is safe with respect to handling and the results are obtained within five hours. The suitability of the BrdUrd labelling procedure has been studied in different cell lines and compared with 3H-thymidine autoradiography and flow cytometry.","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"545-8"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
RNA and protein synthesis of irradiated Ehrlich ascites tumour cells. II. Amount of m-RNA and in vitro investigations. 辐照埃利希腹水肿瘤细胞的RNA和蛋白质合成。2m-RNA的数量和体外研究。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134430
S Skog, B Tribukait, O Nygård
{"title":"RNA and protein synthesis of irradiated Ehrlich ascites tumour cells. II. Amount of m-RNA and in vitro investigations.","authors":"S Skog,&nbsp;B Tribukait,&nbsp;O Nygård","doi":"10.3109/02841868509134430","DOIUrl":"https://doi.org/10.3109/02841868509134430","url":null,"abstract":"<p><p>Poly(A)-containing RNA (m-RNA) was studied in in vivo growing Ehrlich ascites tumour cells following a roentgen irradiation dose of 5 Gy. m-RNA increased significantly during the first 12 hours after irradiation. Thus, the observed decrease in protein synthesis rate during this time seems not to be due to radiation induced changes at the transcriptional level. The protein synthesis rate of in vivo irradiated cells incubated in vitro in culture medium was unchanged. On the other hand, the protein synthesis rate of non-irradiated cells incubated in vitro in ascites fluid from irradiated animals was decreased. We concluded that factor(s) inhibiting protein synthesis or the lack of factor(s) promoting protein synthesis in the ascites fluid is(are) of significance for the reduced protein synthesis of tumour cells found in irradiated in vivo growing cells.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"549-53"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effects of repeated mammographic screening on breast cancer stage distribution. Results from a randomised study of 92 934 women in a Swedish county. 反复乳腺x线检查对乳腺癌分期分布的影响。来自瑞典某县92934名妇女的随机研究结果。
Acta radiologica. Oncology Pub Date : 1985-11-01 DOI: 10.3109/02841868509134418
G Fagerberg, L Baldetorp, O Gröntoft, B Lundström, J C Månson, B Nordenskjöld
{"title":"Effects of repeated mammographic screening on breast cancer stage distribution. Results from a randomised study of 92 934 women in a Swedish county.","authors":"G Fagerberg,&nbsp;L Baldetorp,&nbsp;O Gröntoft,&nbsp;B Lundström,&nbsp;J C Månson,&nbsp;B Nordenskjöld","doi":"10.3109/02841868509134418","DOIUrl":"https://doi.org/10.3109/02841868509134418","url":null,"abstract":"<p><p>A randomised controlled trial of mass screening for breast cancer by single-view mammography was begun in Sweden in 1977. All women aged 40 and older and resident in the counties of Kopparberg and Ostergötland were enrolled. The present report is confined to the Ostergötland study, which started in 1978 and comprised 92 934 women. After randomisation, which was done on the basis of communities rather than individuals, 47 001 women were allocated to the study group and offered repeated mammographic screening; 45 933 were allocated to the control group. As compliance among women over 74 years of age was poor these were excluded from the present report. The yearly incidence of stage II or more advanced breast cancers after the initial screening round up to and including the second was reduced by 40 per cent in the study group compared with the controls. This effect was less marked in the age group 40-49. After 5.5 years average from the date of entry the absolute number of women with stage II-IV disease in the control group exceeded that for the study group by 44, whereas there was a large excess of cancer in situ and stage I cancer in the study group.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"24 6","pages":"465-73"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868509134418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14139850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 77
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