Acta radiologica. Oncology最新文献

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Changes in energy metabolism following roentgen irradiation of in vivo growing Ehrlich ascites tumour cells studied by 31P magnetic resonance spectroscopy. 31P磁共振波谱法研究了体内生长的埃利希腹水肿瘤细胞在x射线照射后能量代谢的变化。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136380
S Skog, B Nordell, A Ericsson, B Tribukait, T Nishida
{"title":"Changes in energy metabolism following roentgen irradiation of in vivo growing Ehrlich ascites tumour cells studied by 31P magnetic resonance spectroscopy.","authors":"S Skog,&nbsp;B Nordell,&nbsp;A Ericsson,&nbsp;B Tribukait,&nbsp;T Nishida","doi":"10.3109/02841868609136380","DOIUrl":"https://doi.org/10.3109/02841868609136380","url":null,"abstract":"<p><p>The energy metabolism in Ehrlich ascites tumour cells following in vivo irradiation of a dose of 5.0 Gy was studied in vitro in their ascites fluid up to 48 hours using 31P magnetic resonance spectroscopy measuring ATP, ADP and inorganic phosphate (Pi). The results are also related to radiation induced changes in cell cycle composition. ATP was reduced by more than 50 per cent 20 to 24 hours after irradiation but normalized at 48 hours. ADP was reduced to about half the normal level 24 to 48 hours after irradiation. When the ATP and ADP had reduced levels, the inorganic phosphate increased correspondingly. Addition of glucose to the ascites cell suspension at the time of minimum ATP level immediately raised the ATP:Pi ratio. Since the glucose concentrations in blood and in ascites fluid following irradiation were also reduced, lack of glucose for energy production might have been a major contributing factor for the reduced ATP production.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Reliability of record linkage in the Swedish Cancer-Environment Register. 瑞典癌症环境登记中记录链接的可靠性。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136369
K Wiklund, G Eklund
{"title":"Reliability of record linkage in the Swedish Cancer-Environment Register.","authors":"K Wiklund,&nbsp;G Eklund","doi":"10.3109/02841868609136369","DOIUrl":"https://doi.org/10.3109/02841868609136369","url":null,"abstract":"<p><p>The Swedish Cancer-Environment Register (CER) is intended to be used for studies on occupational cancer. CER was established by a computerized record linkage between the Swedish National Cancer Register (SCR) for 1961-1973 and the 1960 Population and Housing Census (PH 60) in order to obtain information on occupation, occupational status, economic activity (industry), place of work, domicile, etc. that might be useful for epidemiologic studies on cancer. Accurate inter-register linkage at individual level necessitates high quality of identification in both registers. The hit completeness in this respect was evaluated as 98.8 per cent, a figure regarded as acceptable for most studies based on the CER. Since a hit between SCR and PH 60 did not guarantee accuracy, the reliability of the record linkage was studied in random sample. With the aid of local and national population registries, 0.45 per cent (95% confidence interval 0.21-0.86%) false linkages were revealed in the sample. The CER was in 1982 supplemented with data notified to the SCR 1974-1979, and the hit completeness was 99.2 per cent for the total period. There are good grounds for assuming a lower rate of false linkages for the later period.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"11-4"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Interstitial 125I implantation in the retreatment of retroperitoneal soft tissue sarcoma. Report of a case. 125I间质植入在腹膜后软组织肉瘤再治疗中的应用。报告一个病例。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136375
P P Kumar, R R Good
{"title":"Interstitial 125I implantation in the retreatment of retroperitoneal soft tissue sarcoma. Report of a case.","authors":"P P Kumar,&nbsp;R R Good","doi":"10.3109/02841868609136375","DOIUrl":"https://doi.org/10.3109/02841868609136375","url":null,"abstract":"<p><p>Interstitial 125I was successfully used in the retreatment of a large recurrent malignant schwannoma in the retroperitoneum. After an average tumor dose of 160 Gy the tumor calcified and the patient is well, without disease 2 years later.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"37-9"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136375","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Early effects of preoperative irradiation upon the cell cycle composition in rectal adenocarcinomas. A flow-cytometric DNA investigation. 术前照射对直肠腺癌细胞周期组成的早期影响。流式细胞术DNA检测。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136377
C Hammarberg, B Tribukait, U Ohman
{"title":"Early effects of preoperative irradiation upon the cell cycle composition in rectal adenocarcinomas. A flow-cytometric DNA investigation.","authors":"C Hammarberg,&nbsp;B Tribukait,&nbsp;U Ohman","doi":"10.3109/02841868609136377","DOIUrl":"https://doi.org/10.3109/02841868609136377","url":null,"abstract":"<p><p>The DNA patterns were studied by means of flow cytometric analysis in 43 rectal adenocarcinomas. Ploidy level and cell cycle distribution were related to clinical stage and histopathology. The frequency of grossly aneuploid tumours and tumours with multiple aneuploid cell populations increased with more advanced clinical stages and with the degree of dedifferentiation. In 15 cases the DNA pattern was studied before and after preoperative irradiation. The ploidy level was not affected by irradiation. A pronounced increase in the proportion of G2 cells was found after irradiation. This G2 blockage was proportional to the amount of S-phase cells before irradiation. Since following irradiation the proportion of S-phase cells was low and the proportion of G1 cells unchanged, the existence of a high fraction of resting G1 tumour cells can be assumed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Chordoma. Report on treatment results in eighteen cases. 脊索瘤。18例治疗结果报告。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136376
M L Lybeert, J H Meerwaldt
{"title":"Chordoma. Report on treatment results in eighteen cases.","authors":"M L Lybeert,&nbsp;J H Meerwaldt","doi":"10.3109/02841868609136376","DOIUrl":"https://doi.org/10.3109/02841868609136376","url":null,"abstract":"<p><p>Eighteen patients with a proven histologic diagnosis of chordoma were treated between 1949 and 1982. Four patients received only surgery, 4 patients only radiation therapy, and 10 patients received surgery and postoperative radiation therapy to a varying dose. The results suggest that a higher radiation dose gives longer recurrence-free survival, and that the best long term results can be achieved by combining surgery--as radically as possible--with radiation therapy to a dose level of 60 to 65 Gy. In view of the number of marginal recurrences (2 out of the 14 patients who received radiation therapy), the importance of choosing the right treatment volume is stressed.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"41-3"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Radiation biology of malignant melanoma. 恶性黑色素瘤的辐射生物学。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136368
E K Rofstad
{"title":"Radiation biology of malignant melanoma.","authors":"E K Rofstad","doi":"10.3109/02841868609136368","DOIUrl":"https://doi.org/10.3109/02841868609136368","url":null,"abstract":"<p><p>The survival curves for melanoma cells exposed to single radiation doses in vitro and the specific growth delays for melanoma xenografts irradiated with single doses in vivo were found to differ considerably among individual cell lines and tumours. In fact, the differences could be almost as large as the largest differences observed among cell lines and xenografts from tumours of different histology with very different clinical radiocurability. Moreover, radiobiologic parameters that may have significant influence on tumour response to fractionated irradiation, e.g. growth rate, hypoxic fraction, reoxygenation ability, PLD-repair capacity and contact repair capacity, were found to differ greatly in magnitude among individual melanomas. This review therefore concludes that malignant melanoma is a tumour type that is very heterogeneous in radioresponsiveness, i.e. malignant melanomas should no longer be considered to be radiation resistant in general. The values of the alpha/beta ratio derived from cell survival curves for melanoma cells irradiated in vitro and melanoma xenografts irradiated in vivo were found to cover a wide range relative to those for acutely and late responding normal tissues. Although these alpha/beta ratios are no more than estimates of the effective alpha/beta ratios in a clinical situation, they still indicated that hyperfractionation may be beneficial in the treatment of some melanomas, whereas others may be more efficiently treated by use of conventional fractionation regimes, either based on 2 Gy or higher doses per fraction. Consequently, optimum radiation therapy of malignant melanoma will probably require an individualized treatment strategy. In vitro assays for prediction of radiocurability and choice of treatment strategy for individual melanoma patients seem therefore highly warranted.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 128
Provoked repetitive healing of mature bone tissue following irradiation. A quantitative investigation. 辐照引起成熟骨组织的重复愈合。定量调查。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136379
M Jacobsson, P Kälebo, T Albrektsson, I Turesson
{"title":"Provoked repetitive healing of mature bone tissue following irradiation. A quantitative investigation.","authors":"M Jacobsson,&nbsp;P Kälebo,&nbsp;T Albrektsson,&nbsp;I Turesson","doi":"10.3109/02841868609136379","DOIUrl":"https://doi.org/10.3109/02841868609136379","url":null,"abstract":"<p><p>A titanium implant, the bone harvest chamber (BHC), was used to investigate the regenerative capacity of mature bone after irradiation. One BHC was inserted in each proximal tibial metaphysis of a rabbit. One of these implant sites was irradiated (60Co single dose) to either 15 or 25 Gy while the other served as control. Newly formed bone grew through a canal that penetrated the implant. This newly formed bone was harvested from the implant every three weeks following irradiation and then quantified by microradiography and computer-assisted densitometry. In this way a ratio between bone formed on the irradiated side in comparison with the control could be established. An immediate depression in bone formation compared with the non-irradiated controls, was seen at both dose levels. A recovery in bone regenerative capacity was seen at 15 weeks after 15 Gy while the decrease in bone formation remained constant after 25 Gy during the 30 week follow-up period.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Radiation therapy of primary malignant lymphoma of the brain. 原发性脑恶性淋巴瘤的放射治疗。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136372
T Yasunaga, M Takahashi, H Uozumi, C Takada, S Kawano, Y Baba, I Nakamura, H Sonoda, Y Matsukado
{"title":"Radiation therapy of primary malignant lymphoma of the brain.","authors":"T Yasunaga,&nbsp;M Takahashi,&nbsp;H Uozumi,&nbsp;C Takada,&nbsp;S Kawano,&nbsp;Y Baba,&nbsp;I Nakamura,&nbsp;H Sonoda,&nbsp;Y Matsukado","doi":"10.3109/02841868609136372","DOIUrl":"https://doi.org/10.3109/02841868609136372","url":null,"abstract":"<p><p>Primary malignant lymphoma of the brain (PMLB) is uncommon. Between 1975 and 1982, the authors observed 11 patients with histologically confirmed PMLB. Mean survival after radiation therapy was 7 months with 5 patients surviving for more than 2 years. Multifocal lesions were seen in 9 patients and spontaneous regression was seen at computed tomography in 2 patients. Radiation doses in excess of 30 Gy controlled the primary tumor, but intracranial recurrences occurred even after whole brain irradiation to 40 Gy. Only one patient had a relapse outside the central nervous system, and none had clinical evidence of seeding to the spinal canal. The authors postulate that PMLB usually is a multifocal intracranial disease, and that whole brain irradiation of at least 30 to 40 Gy should be given to all patients with this disease.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"23-8"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Energy and protein intake and nutritional status in non-surgically treated patients with small cell anaplastic carcinoma of the lung. 非手术治疗的肺小细胞间变性癌患者的能量和蛋白质摄入及营养状况。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136371
B Enig, E Winther, I Hessov
{"title":"Energy and protein intake and nutritional status in non-surgically treated patients with small cell anaplastic carcinoma of the lung.","authors":"B Enig,&nbsp;E Winther,&nbsp;I Hessov","doi":"10.3109/02841868609136371","DOIUrl":"https://doi.org/10.3109/02841868609136371","url":null,"abstract":"<p><p>The spontaneous food intake and nutritional status was assessed in 23 patients with small cell anaplastic carcinoma of the lung before and two times during a treatment period of 6 weeks. Radiation therapy was given for 2 weeks followed by a course of chemotherapy and another 2 weeks of radiation therapy. The energy intake decreased during the treatment from 146 to 130 per cent of basal metabolic rate (p greater than 0.10). The protein intake remained unchanged (mean 0.9 g/kg body weight). There were insignificant and small losses of weight, body fat, free body mass and arm muscle circumference, and no changes were seen in serum albumin and serum transferrin. However, 6 patients suffered a weight loss of 5 per cent or more. No correlation existed between the nutritional parameters measured before treatment and the changes during treatment. Patients who suffered a loss of body weight could therefore not be singled out before the treatment.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cell proliferation and differentiation in the small intestine after irradiation with multiple fractions. 多组分辐照后小肠细胞的增殖和分化。
Acta radiologica. Oncology Pub Date : 1986-01-01 DOI: 10.3109/02841868609136378
A Becciolini, D Cremonini, D Fabbrica, M Balzi
{"title":"Cell proliferation and differentiation in the small intestine after irradiation with multiple fractions.","authors":"A Becciolini,&nbsp;D Cremonini,&nbsp;D Fabbrica,&nbsp;M Balzi","doi":"10.3109/02841868609136378","DOIUrl":"https://doi.org/10.3109/02841868609136378","url":null,"abstract":"<p><p>Qualitative and quantitative morphologic changes in rat small intestine were studied after abdominal exposure to multiple fractions of gamma radiation. One group of animals received 3 X 2 Gy with one fraction every 4 hours. Another group received two courses of this type with a 16 hour interval between the courses (total dose 6 X 2 Gy). A marked decrease in the number of crypt epithelial cells, and in mitotic and labelling indices, was observed up to 24 to 36 hours after the end of both regimens. Repair and recovery occurred within 72 hours after the end of the last exposure, and the epithelium regained normal morphology. At 1 and 4 hours after the end of the treatment the frequency of S-phase cells along the crypt was greatly reduced and at the following intervals labelled cells occupied the region where differentiation occurs in control animals. During recovery labelled cell distribution showed a gradual return to normal. No substantial differences between the effects of total doses of 6 and 12 Gy were shown except for a greater reduction in crypt epithelial cells at the early time intervals after the larger dose.</p>","PeriodicalId":77655,"journal":{"name":"Acta radiologica. Oncology","volume":"25 1","pages":"51-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841868609136378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14143410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
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