Intracytoplasmic immunoglobulins in the differential diagnosis of lymphocytic lymphomas of the B-CLL type and immunocytic lymphomas.

U Martinsson, B Glimelius, H Hagberg, B Simonsson, C Sundström
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引用次数: 8

Abstract

One hundred and thirty-three consecutive cases originally classified either as a lymphocytic lymphoma of the B-CLL type or as an immunocytic (IC) lymphoma could be reclassified morphologically and analyzed for the presence of cytoplasmic immunoglobulins (cIg) with the PAP-technique. The morphologic reclassification confirmed the initial diagnosis in most cases, whereas after staining for cIg, the diagnosis was changed in a large number of cases, i.e. from B-CLL to IC, or the reverse, or from IC of the polymorphic subtype (ICp) to 'high-grade' non-Hodgkin lymphoma (NHL). Cases classified as IC were often localized (stage I+II: 22/43) with a long disease-free survival after local radiation therapy, while B-CLL were usually generalized. For patients in stage IV, the prognosis of B-CLL was significantly superior to that of IC, which in turn was superior to the prognosis of cases referred to as 'high-grade' NHL. The difficulties in the morphologic distinction between B-CLL and IC on one hand and between ICp and some 'high-grade' NHL on the other hand, as well as the clinical significance of these distinctions, are discussed.

胞浆内免疫球蛋白在B-CLL型淋巴细胞淋巴瘤和免疫细胞淋巴瘤鉴别诊断中的应用。
连续133例原分类为B-CLL型淋巴细胞性淋巴瘤或免疫细胞性淋巴瘤的病例,可以用pap技术从形态学上重新分类并分析细胞质免疫球蛋白(cIg)的存在。形态学重新分类证实了大多数病例的初始诊断,而在进行cIg染色后,大量病例的诊断发生了变化,即从B-CLL到IC,或相反,或从多态亚型(ICp)的IC到“高级”非霍奇金淋巴瘤(NHL)。分类为IC的病例通常是局部的(I+II期:22/43),局部放疗后无病生存期长,而B-CLL通常是全身性的。对于IV期患者,B-CLL的预后明显优于IC, IC反过来又优于“高级”NHL病例的预后。本文讨论了B-CLL与IC、ICp与某些“高级别”NHL在形态学上区分的困难,以及这些区分的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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